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The map label for this gene is hemZ [H]

Identifier: 51893563

GI number: 51893563

Start: 2609569

End: 2611149

Strand: Reverse

Name: hemZ [H]

Synonym: STH2425

Alternate gene names: 51893563

Gene position: 2611149-2609569 (Counterclockwise)

Preceding gene: 51893564

Following gene: 51893562

Centisome position: 73.22

GC content: 71.98

Gene sequence:

>1581_bases
ATGAGCGGGATCCTGCTCCGGGGCAACAGCCCCGTTTTTGCCAGCGACCTGACCCAGATGGGACACGTCTTCTTCCCGGG
GGAGCCCTTCGCGGTCTGGGTGCCGGGAAGCCCGGAGCCCGCCGGCGGGGATGCCGTGTGGCAGGTGGATGTGACCGCGC
GGCCGGGCGGCGCGCCGGCTGCCGACCCCGGCGCGGATGCAGCCGTCCCCCTGCCCCCGGCCGCCCGGCCGTGGCGGGTG
GTCGTCACCGCCCGCGGCCCCGGCGGCTCCCGCCGCGCGGAGGGGGAGCTGGTCCAGGGGGCGGAGGAGAGCCCCCGCAC
CTTTGAGCACCGGCTCCGCCGGCTGGCCAAGGGGCTGCTGGTGGACGCCCTCGCGCCGCTGGCGGGCTTCCGGCCCAAGT
GGGGCATCCTCACCGGCGTGCGGCCCACCAAGCTGGTCCACCAGATGCTGGACGAGGACGAGCCGGACCCGGTGGCGCGC
CTTACCGGTGAGTTCCGGCTGGCGCGGGAGAAGGCGGAGCTGGTGACCGGCGTCGCCCGGCTGCAGCGGCCCTTCCTGGG
GCGCGACCCCCGGGCGGTCTCGCTCTACATCGGGATCCCGTTCTGCCCGTCCATCTGCTCGTTCTGTTCCTTTTCGATCT
ATCCCATCAACCAGCACCGGGATCAGATCTCCCCCTTCCTGGAGGCCCTCGGGCGGGAGATGGCGATCATCGGGCAGGCG
ATCCGGGACCTGGGGCTCCGGGTGGAGTCCATCTACTTCGGCGGCGGCACGCCGACCAGCCCCCGGGATGAGGACTTCGC
CTGGATGCTGCGCACCGCCGCGGAGACCCTGCTCAAAGGCCAGTCCCCGGCGGAGTACACCATCGAGGGCGGACGGCCCG
AGACGTTCAACCGGTACAAGCTGGACGTGATGGCGGCGCACGGCGTGACGCGGGTCAGCGTCAACCCCCAGACCACCGTG
CAGGCCACGCTGATGCACCTGGGCCGCATCCACACGGTGGAGAAGTTCTACCGGGCCTACGACCTGGTGCGGTCCCATCC
GGCCGGCTTCACGGTGAACACGGACATCATCATCGGTCTGCCGGGGGAGGGCCCCGCCGAGGTGCACCACACCCTGGAGG
ACATGCGCCGCCTGGCCCCCGACAACCTCACCGTGCACACCCTGGCCGTCAAGCGGGGCTCCCGCATCCACGCGGCGGGT
GCGGCCGGCGAGGTGCTCCGGGCGCTCACCCCGGCCGAGGCCGAGGCTCTGGTGCAGGACGCGGCGGAGACTGCCCGGGC
CATGGGCCAGCGGCCGTACTACCTGTACCGGCAGAAGTTCATGGTGGGCTCCCTGGAGAACGTGGGCTACGCCCTGCCCG
GGAAGGAGTCGCTCTACAACATCCAGATGATGGAGGAGCGGCAGACCGTCATCGGCCTGGGCGGCGGCGCCACCTCCAAG
TGGTTCAAGCCCCTGGGAGAGGGGCGGGGGTGGCTCCTGAAGGCGCCGGCCAACCCCAACGACCCGCAGGCGTACGTGGA
GCGGGTCGAGGAGCTGGCCCGGCGGAAGGTCGCGGAGCTCAGGCTGCTCTACGGCGAGTAG

Upstream 100 bases:

>100_bases
GGACGAATACGTGCCGGGCCATACGGGCAAGCGTTAATAGCGGATGAAACTGCGGACGGGGGCCGGGCGAGAGCCACGGC
CCCCTTTGAGGTGAGAGCGC

Downstream 100 bases:

>100_bases
GGGGTGGCGCGCATGGCCTTCCGGCGCATTGCGGTCATCTACAATCCGGCCTCCGGGCGGCCCCGGGAGCGGGAGGAGCC
GCTGGCCCGGCTGGCGGCGC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MSGILLRGNSPVFASDLTQMGHVFFPGEPFAVWVPGSPEPAGGDAVWQVDVTARPGGAPAADPGADAAVPLPPAARPWRV
VVTARGPGGSRRAEGELVQGAEESPRTFEHRLRRLAKGLLVDALAPLAGFRPKWGILTGVRPTKLVHQMLDEDEPDPVAR
LTGEFRLAREKAELVTGVARLQRPFLGRDPRAVSLYIGIPFCPSICSFCSFSIYPINQHRDQISPFLEALGREMAIIGQA
IRDLGLRVESIYFGGGTPTSPRDEDFAWMLRTAAETLLKGQSPAEYTIEGGRPETFNRYKLDVMAAHGVTRVSVNPQTTV
QATLMHLGRIHTVEKFYRAYDLVRSHPAGFTVNTDIIIGLPGEGPAEVHHTLEDMRRLAPDNLTVHTLAVKRGSRIHAAG
AAGEVLRALTPAEAEALVQDAAETARAMGQRPYYLYRQKFMVGSLENVGYALPGKESLYNIQMMEERQTVIGLGGGATSK
WFKPLGEGRGWLLKAPANPNDPQAYVERVEELARRKVAELRLLYGE

Sequences:

>Translated_526_residues
MSGILLRGNSPVFASDLTQMGHVFFPGEPFAVWVPGSPEPAGGDAVWQVDVTARPGGAPAADPGADAAVPLPPAARPWRV
VVTARGPGGSRRAEGELVQGAEESPRTFEHRLRRLAKGLLVDALAPLAGFRPKWGILTGVRPTKLVHQMLDEDEPDPVAR
LTGEFRLAREKAELVTGVARLQRPFLGRDPRAVSLYIGIPFCPSICSFCSFSIYPINQHRDQISPFLEALGREMAIIGQA
IRDLGLRVESIYFGGGTPTSPRDEDFAWMLRTAAETLLKGQSPAEYTIEGGRPETFNRYKLDVMAAHGVTRVSVNPQTTV
QATLMHLGRIHTVEKFYRAYDLVRSHPAGFTVNTDIIIGLPGEGPAEVHHTLEDMRRLAPDNLTVHTLAVKRGSRIHAAG
AAGEVLRALTPAEAEALVQDAAETARAMGQRPYYLYRQKFMVGSLENVGYALPGKESLYNIQMMEERQTVIGLGGGATSK
WFKPLGEGRGWLLKAPANPNDPQAYVERVEELARRKVAELRLLYGE
>Mature_525_residues
SGILLRGNSPVFASDLTQMGHVFFPGEPFAVWVPGSPEPAGGDAVWQVDVTARPGGAPAADPGADAAVPLPPAARPWRVV
VTARGPGGSRRAEGELVQGAEESPRTFEHRLRRLAKGLLVDALAPLAGFRPKWGILTGVRPTKLVHQMLDEDEPDPVARL
TGEFRLAREKAELVTGVARLQRPFLGRDPRAVSLYIGIPFCPSICSFCSFSIYPINQHRDQISPFLEALGREMAIIGQAI
RDLGLRVESIYFGGGTPTSPRDEDFAWMLRTAAETLLKGQSPAEYTIEGGRPETFNRYKLDVMAAHGVTRVSVNPQTTVQ
ATLMHLGRIHTVEKFYRAYDLVRSHPAGFTVNTDIIIGLPGEGPAEVHHTLEDMRRLAPDNLTVHTLAVKRGSRIHAAGA
AGEVLRALTPAEAEALVQDAAETARAMGQRPYYLYRQKFMVGSLENVGYALPGKESLYNIQMMEERQTVIGLGGGATSKW
FKPLGEGRGWLLKAPANPNDPQAYVERVEELARRKVAELRLLYGE

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=304, Percent_Identity=27.9605263157895, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI87082341, Length=202, Percent_Identity=31.6831683168317, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789325, Length=304, Percent_Identity=26.6447368421053, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 57410; Mature: 57279

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS00359 RIBOSOMAL_L11

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGILLRGNSPVFASDLTQMGHVFFPGEPFAVWVPGSPEPAGGDAVWQVDVTARPGGAPA
CCCEEEECCCCCHHHHHHHCCCEEECCCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCC
ADPGADAAVPLPPAARPWRVVVTARGPGGSRRAEGELVQGAEESPRTFEHRLRRLAKGLL
CCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHH
VDALAPLAGFRPKWGILTGVRPTKLVHQMLDEDEPDPVARLTGEFRLAREKAELVTGVAR
HHHHHHHHCCCCCCCEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LQRPFLGRDPRAVSLYIGIPFCPSICSFCSFSIYPINQHRDQISPFLEALGREMAIIGQA
HHCCCCCCCCCEEEEEEECCCHHHHHHHHCEEEEECCCCHHHHHHHHHHHCHHHHHHHHH
IRDLGLRVESIYFGGGTPTSPRDEDFAWMLRTAAETLLKGQSPAEYTIEGGRPETFNRYK
HHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCEEE
LDVMAAHGVTRVSVNPQTTVQATLMHLGRIHTVEKFYRAYDLVRSHPAGFTVNTDIIIGL
EEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECEEEEEC
PGEGPAEVHHTLEDMRRLAPDNLTVHTLAVKRGSRIHAAGAAGEVLRALTPAEAEALVQD
CCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEECCCHHHHHHHCCCHHHHHHHHH
AAETARAMGQRPYYLYRQKFMVGSLENVGYALPGKESLYNIQMMEERQTVIGLGGGATSK
HHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCCCCEEEEEEECCCCEEEEECCCCCHH
WFKPLGEGRGWLLKAPANPNDPQAYVERVEELARRKVAELRLLYGE
HHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SGILLRGNSPVFASDLTQMGHVFFPGEPFAVWVPGSPEPAGGDAVWQVDVTARPGGAPA
CCEEEECCCCCHHHHHHHCCCEEECCCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCC
ADPGADAAVPLPPAARPWRVVVTARGPGGSRRAEGELVQGAEESPRTFEHRLRRLAKGLL
CCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHH
VDALAPLAGFRPKWGILTGVRPTKLVHQMLDEDEPDPVARLTGEFRLAREKAELVTGVAR
HHHHHHHHCCCCCCCEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LQRPFLGRDPRAVSLYIGIPFCPSICSFCSFSIYPINQHRDQISPFLEALGREMAIIGQA
HHCCCCCCCCCEEEEEEECCCHHHHHHHHCEEEEECCCCHHHHHHHHHHHCHHHHHHHHH
IRDLGLRVESIYFGGGTPTSPRDEDFAWMLRTAAETLLKGQSPAEYTIEGGRPETFNRYK
HHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCEEE
LDVMAAHGVTRVSVNPQTTVQATLMHLGRIHTVEKFYRAYDLVRSHPAGFTVNTDIIIGL
EEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECEEEEEC
PGEGPAEVHHTLEDMRRLAPDNLTVHTLAVKRGSRIHAAGAAGEVLRALTPAEAEALVQD
CCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEECCCHHHHHHHCCCHHHHHHHHH
AAETARAMGQRPYYLYRQKFMVGSLENVGYALPGKESLYNIQMMEERQTVIGLGGGATSK
HHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCCCCEEEEEEECCCCEEEEECCCCCHH
WFKPLGEGRGWLLKAPANPNDPQAYVERVEELARRKVAELRLLYGE
HHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10568751 [H]