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The map label for this gene is ycsA [H]

Identifier: 51893482

GI number: 51893482

Start: 2532215

End: 2533294

Strand: Reverse

Name: ycsA [H]

Synonym: STH2344

Alternate gene names: 51893482

Gene position: 2533294-2532215 (Counterclockwise)

Preceding gene: 51893483

Following gene: 51893481

Centisome position: 71.04

GC content: 68.43

Gene sequence:

>1080_bases
GTGCAGAACGTATCGGTTGCGGTCATTCCCGGTGACGGAATCGGCAACGAAACGGTACGGGCGGGGCGCCGGGTGCTGGA
CGCGGCGGCGGAACTGGACGGCGGCATCAAGTTCGAGTACACCGAGTTCGAGTGGGGCTGCGCCTACTACCTGCGGCACG
GCGAGATGGCCCCGAAGGGCTTCCTGAACACCCTGGCCAACTTCGACACCATCCTGCTCGGCGCGGTGGGCTACCCGGGC
GTTCCGGACCACGTCTCCCTGTGGGGGCTACTGCTCCCCATCCGGCGCGGCTTCGAGCAGTACGTGAACCTGCGGCCGGT
GCGGATCCTGCGCGGCGTGGTCAGCCCGCTCCGGGGCCGCAACCCCGGCGACGTCAACTTCGTCTGCATCCGGGAGAACA
CCGAGGGCGAGTACTCCAACATGGGTGGCCGGCTGCACGCCGGGCTCCCCCATGAGGTGGTCGTGCAGAACACCGTCTTC
ACCCGGGTGGGCACGGAGCGGATCATCCGCTACGCCTACCAGCTGGCCGCCAACGCCCCCCGGAAGCGGCTGTGCGGCGC
CACCAAGTCCAATGGCATCAACTACACGATGCCCTACTGGGATGAGATCTTCAACGAGATCGGCGAGCGGGAGTTCCCCG
AGGTCAACCGCTGGCTGTGCCACATCGACGCCCTCGCGGCCAACTTCGTGCTGAAGCCGGACGAGTTCGATGTGGTGGTG
GCCTCCAACCTCTTCGGCGACATCCTGACGGACCTCGGCGGGGCGATTATGGGGTCGATCGGCATGGCGGCCTCGGCCAA
CATCAACCCCGAGCGCAGGTACCCGTCCATGTTCGAGCCGGTGCACGGCTCCGCCCCGGACATCGCCGGCAGGGGCATCG
CCAACCCCGTCGGGCAGATCTGGTCGGTGAGCCTGATGCTGGAGCACCTCGGCCGGGCTGACCTGGGTAAGGCGGTGCTG
GACGCGGTGGAGGACGTGCTCGAGGAGGGCCGGGTGCGCACGCCGGACCTGGGCGGCCGCAACACCACCGACGAGATGAC
CGACGCGGTCATCGCCCGGCTCGCCCAGCGCCTCCGCTAG

Upstream 100 bases:

>100_bases
TCGGGGCAACAATCCGTCGGGCCGTTGCAGGCGGCGAACCGTACGGTTTGAATGGAAATGGAAGCTCATCCCCCTGCAGA
GGGCTGAGGAGGAGACGATC

Downstream 100 bases:

>100_bases
GGCAGAGCCGCCAACCGGCGGCAGTGCAGACACCAGGCCGCGGCATGCGGCGTTGAGCGGGCCTGCGCCCCTGATGGGCG
CAGGCCCGCACGCGCCTGTG

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MQNVSVAVIPGDGIGNETVRAGRRVLDAAAELDGGIKFEYTEFEWGCAYYLRHGEMAPKGFLNTLANFDTILLGAVGYPG
VPDHVSLWGLLLPIRRGFEQYVNLRPVRILRGVVSPLRGRNPGDVNFVCIRENTEGEYSNMGGRLHAGLPHEVVVQNTVF
TRVGTERIIRYAYQLAANAPRKRLCGATKSNGINYTMPYWDEIFNEIGEREFPEVNRWLCHIDALAANFVLKPDEFDVVV
ASNLFGDILTDLGGAIMGSIGMAASANINPERRYPSMFEPVHGSAPDIAGRGIANPVGQIWSVSLMLEHLGRADLGKAVL
DAVEDVLEEGRVRTPDLGGRNTTDEMTDAVIARLAQRLR

Sequences:

>Translated_359_residues
MQNVSVAVIPGDGIGNETVRAGRRVLDAAAELDGGIKFEYTEFEWGCAYYLRHGEMAPKGFLNTLANFDTILLGAVGYPG
VPDHVSLWGLLLPIRRGFEQYVNLRPVRILRGVVSPLRGRNPGDVNFVCIRENTEGEYSNMGGRLHAGLPHEVVVQNTVF
TRVGTERIIRYAYQLAANAPRKRLCGATKSNGINYTMPYWDEIFNEIGEREFPEVNRWLCHIDALAANFVLKPDEFDVVV
ASNLFGDILTDLGGAIMGSIGMAASANINPERRYPSMFEPVHGSAPDIAGRGIANPVGQIWSVSLMLEHLGRADLGKAVL
DAVEDVLEEGRVRTPDLGGRNTTDEMTDAVIARLAQRLR
>Mature_359_residues
MQNVSVAVIPGDGIGNETVRAGRRVLDAAAELDGGIKFEYTEFEWGCAYYLRHGEMAPKGFLNTLANFDTILLGAVGYPG
VPDHVSLWGLLLPIRRGFEQYVNLRPVRILRGVVSPLRGRNPGDVNFVCIRENTEGEYSNMGGRLHAGLPHEVVVQNTVF
TRVGTERIIRYAYQLAANAPRKRLCGATKSNGINYTMPYWDEIFNEIGEREFPEVNRWLCHIDALAANFVLKPDEFDVVV
ASNLFGDILTDLGGAIMGSIGMAASANINPERRYPSMFEPVHGSAPDIAGRGIANPVGQIWSVSLMLEHLGRADLGKAVL
DAVEDVLEEGRVRTPDLGGRNTTDEMTDAVIARLAQRLR

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=354, Percent_Identity=31.3559322033898, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4758582, Length=355, Percent_Identity=27.3239436619718, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI28178816, Length=351, Percent_Identity=28.2051282051282, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI28178821, Length=358, Percent_Identity=27.6536312849162, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI28178838, Length=340, Percent_Identity=26.4705882352941, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI28178819, Length=201, Percent_Identity=29.8507462686567, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1788101, Length=357, Percent_Identity=53.781512605042, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI87081683, Length=364, Percent_Identity=36.8131868131868, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1787381, Length=400, Percent_Identity=25.75, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17550882, Length=358, Percent_Identity=30.7262569832402, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71986051, Length=357, Percent_Identity=31.9327731092437, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25144293, Length=363, Percent_Identity=28.099173553719, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17505779, Length=363, Percent_Identity=26.1707988980716, Blast_Score=104, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6322097, Length=365, Percent_Identity=32.3287671232877, Blast_Score=173, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6324291, Length=363, Percent_Identity=31.404958677686, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324709, Length=358, Percent_Identity=33.2402234636872, Blast_Score=145, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6319830, Length=370, Percent_Identity=31.0810810810811, Blast_Score=145, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24643270, Length=354, Percent_Identity=32.2033898305085, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24643268, Length=354, Percent_Identity=32.2033898305085, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24661184, Length=356, Percent_Identity=29.7752808988764, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI281362242, Length=358, Percent_Identity=27.3743016759777, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24648872, Length=358, Percent_Identity=27.3743016759777, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI161078635, Length=270, Percent_Identity=30, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI161078633, Length=270, Percent_Identity=30, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24650122, Length=270, Percent_Identity=30, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI161078639, Length=270, Percent_Identity=30, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI161078637, Length=270, Percent_Identity=30, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI20130355, Length=354, Percent_Identity=27.1186440677966, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 39434; Mature: 39434

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNVSVAVIPGDGIGNETVRAGRRVLDAAAELDGGIKFEYTEFEWGCAYYLRHGEMAPKG
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCHHH
FLNTLANFDTILLGAVGYPGVPDHVSLWGLLLPIRRGFEQYVNLRPVRILRGVVSPLRGR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
NPGDVNFVCIRENTEGEYSNMGGRLHAGLPHEVVVQNTVFTRVGTERIIRYAYQLAANAP
CCCCEEEEEEECCCCCCHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RKRLCGATKSNGINYTMPYWDEIFNEIGEREFPEVNRWLCHIDALAANFVLKPDEFDVVV
HHHHCCCCCCCCCEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEECCCCCCEEE
ASNLFGDILTDLGGAIMGSIGMAASANINPERRYPSMFEPVHGSAPDIAGRGIANPVGQI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHCCCCCCCCCCCCCCCCCHHHHH
WSVSLMLEHLGRADLGKAVLDAVEDVLEEGRVRTPDLGGRNTTDEMTDAVIARLAQRLR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNVSVAVIPGDGIGNETVRAGRRVLDAAAELDGGIKFEYTEFEWGCAYYLRHGEMAPKG
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCHHH
FLNTLANFDTILLGAVGYPGVPDHVSLWGLLLPIRRGFEQYVNLRPVRILRGVVSPLRGR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
NPGDVNFVCIRENTEGEYSNMGGRLHAGLPHEVVVQNTVFTRVGTERIIRYAYQLAANAP
CCCCEEEEEEECCCCCCHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RKRLCGATKSNGINYTMPYWDEIFNEIGEREFPEVNRWLCHIDALAANFVLKPDEFDVVV
HHHHCCCCCCCCCEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEECCCCCCEEE
ASNLFGDILTDLGGAIMGSIGMAASANINPERRYPSMFEPVHGSAPDIAGRGIANPVGQI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHCCCCCCCCCCCCCCCCCHHHHH
WSVSLMLEHLGRADLGKAVLDAVEDVLEEGRVRTPDLGGRNTTDEMTDAVIARLAQRLR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 10568751 [H]