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The map label for this gene is ghrA [H]

Identifier: 51893304

GI number: 51893304

Start: 2309997

End: 2310923

Strand: Reverse

Name: ghrA [H]

Synonym: STH2166

Alternate gene names: 51893304

Gene position: 2310923-2309997 (Counterclockwise)

Preceding gene: 51893305

Following gene: 51893301

Centisome position: 64.8

GC content: 72.28

Gene sequence:

>927_bases
GTGATTCTAGTCTACGAGCCCAAGCGGGCCGGTACGTATGCGGACCTGCTGGAGCGTGCGATCCCTAATCCGGCCGATTA
CCGGCTGATCCCCTGCACCAGCCGGGAGGAGGCCGAGCGCGCCATCGGCGAGGCGGAGATCCTCTTCTGCTTCCGGTTCC
CCGCGGATCTGCTGCAGGGGGCGCACCGGCTGCGCTGGATCCAGGCGATGGCGGCCGGGGTGGATGACCTGGTCGCAGCG
CCGCTGCCGCCGGGCGTGCTGCTGACCCGCATCGAGGGGCTGTTCGGCACGCCCATGAGCGAGTACGCCTTCGCCCACAT
GCTGGCCTACGCCCAGCAGCTGCGCCGGGTCTACGCCGCGCAGGCGGAGCGCCGCTGGGATCCGTTCCGGGCGGAGACGC
TGGCGGGAAAGCGGCTGGGGGTGGCGGGCATCGGGTCCATCGGCCTGGAAGTCGCCGTCAGGGGCAAGGCCTTCGGCATG
GAGGTCTGGGGCCTCGCACGCACGCCCGGGCCGCGGCCGCATGTCGACCGGGTCTTCACCCCTGATCAGGTCCGGGAGTT
CACCGCCGGGGTCGACTTCCTGGTCAGCACCCTGCCGGACACGCCCGAGACCCGCGGGCTCATCGACCCCGAGGGGATGA
AGGAGGGGGCGCTGCTGATCAACGTGGGCCGCGGCGCGACGCTGGACGAGGGCGCGCTCCTGCGGGCGGTGCGCAGCGGC
CGCATCCGGGCGGTGCTGGACGTCTTCGCCGTGGAGCCGCTGCCCGGGGACCACCTCTTCTGGACGGAGCCGGGCATCAC
CGTCACGCCGCACATGAGCGGGCTGAACCGGCCCGATGCGATCGCCGCCTACTGCGCGGAGAACCTGCGCCGGTTCGAGC
GGGGCGAGCCCCTGCGCGGCGTGGTGGATCTGGCCCGCGGGTATTGA

Upstream 100 bases:

>100_bases
CCTTGGGGACGGCCATCGGCGTCGCCTCCGACCGGGTGCGTCGTCGCGCCGCGCAGGCCGCCGGCGCCGCCGGTGGAAAG
GAGGAGTCTGCATGGCCAGG

Downstream 100 bases:

>100_bases
TCGCAACCCGGGCACAGCGCGAGCCAGGCGCCGCGCCGGCGACGCAAGGCAAGGCGGCCGTGGGGAGCCGGCGGGCTCCC
CACGGCCGCCCTGTATCTAC

Product: putative 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MILVYEPKRAGTYADLLERAIPNPADYRLIPCTSREEAERAIGEAEILFCFRFPADLLQGAHRLRWIQAMAAGVDDLVAA
PLPPGVLLTRIEGLFGTPMSEYAFAHMLAYAQQLRRVYAAQAERRWDPFRAETLAGKRLGVAGIGSIGLEVAVRGKAFGM
EVWGLARTPGPRPHVDRVFTPDQVREFTAGVDFLVSTLPDTPETRGLIDPEGMKEGALLINVGRGATLDEGALLRAVRSG
RIRAVLDVFAVEPLPGDHLFWTEPGITVTPHMSGLNRPDAIAAYCAENLRRFERGEPLRGVVDLARGY

Sequences:

>Translated_308_residues
MILVYEPKRAGTYADLLERAIPNPADYRLIPCTSREEAERAIGEAEILFCFRFPADLLQGAHRLRWIQAMAAGVDDLVAA
PLPPGVLLTRIEGLFGTPMSEYAFAHMLAYAQQLRRVYAAQAERRWDPFRAETLAGKRLGVAGIGSIGLEVAVRGKAFGM
EVWGLARTPGPRPHVDRVFTPDQVREFTAGVDFLVSTLPDTPETRGLIDPEGMKEGALLINVGRGATLDEGALLRAVRSG
RIRAVLDVFAVEPLPGDHLFWTEPGITVTPHMSGLNRPDAIAAYCAENLRRFERGEPLRGVVDLARGY
>Mature_308_residues
MILVYEPKRAGTYADLLERAIPNPADYRLIPCTSREEAERAIGEAEILFCFRFPADLLQGAHRLRWIQAMAAGVDDLVAA
PLPPGVLLTRIEGLFGTPMSEYAFAHMLAYAQQLRRVYAAQAERRWDPFRAETLAGKRLGVAGIGSIGLEVAVRGKAFGM
EVWGLARTPGPRPHVDRVFTPDQVREFTAGVDFLVSTLPDTPETRGLIDPEGMKEGALLINVGRGATLDEGALLRAVRSG
RIRAVLDVFAVEPLPGDHLFWTEPGITVTPHMSGLNRPDAIAAYCAENLRRFERGEPLRGVVDLARGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=286, Percent_Identity=30.0699300699301, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI6912396, Length=281, Percent_Identity=29.1814946619217, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI87081824, Length=319, Percent_Identity=30.0940438871473, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI87082289, Length=287, Percent_Identity=28.2229965156794, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=263, Percent_Identity=27.3764258555133, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320925, Length=259, Percent_Identity=29.7297297297297, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322116, Length=259, Percent_Identity=29.3436293436293, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28574286, Length=259, Percent_Identity=26.6409266409266, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19921140, Length=227, Percent_Identity=29.9559471365639, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI45552429, Length=291, Percent_Identity=26.8041237113402, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24585514, Length=288, Percent_Identity=27.0833333333333, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28574282, Length=288, Percent_Identity=27.0833333333333, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI45551003, Length=291, Percent_Identity=26.8041237113402, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28574284, Length=291, Percent_Identity=26.8041237113402, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33811; Mature: 33811

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVYEPKRAGTYADLLERAIPNPADYRLIPCTSREEAERAIGEAEILFCFRFPADLLQG
CEEEECCCCCCCHHHHHHHHCCCCCCEEEECCCCHHHHHHHCCCEEEEEEEECCHHHHHH
AHRLRWIQAMAAGVDDLVAAPLPPGVLLTRIEGLFGTPMSEYAFAHMLAYAQQLRRVYAA
HHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
QAERRWDPFRAETLAGKRLGVAGIGSIGLEVAVRGKAFGMEVWGLARTPGPRPHVDRVFT
HHHHCCCCHHHHHHCCCCCCCCCCCCCCEEEEECCCEECEEEEEECCCCCCCCCCCCCCC
PDQVREFTAGVDFLVSTLPDTPETRGLIDPEGMKEGALLINVGRGATLDEGALLRAVRSG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCC
RIRAVLDVFAVEPLPGDHLFWTEPGITVTPHMSGLNRPDAIAAYCAENLRRFERGEPLRG
CHHHHHHHHHCCCCCCCCEEEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
VVDLARGY
HHHHHCCC
>Mature Secondary Structure
MILVYEPKRAGTYADLLERAIPNPADYRLIPCTSREEAERAIGEAEILFCFRFPADLLQG
CEEEECCCCCCCHHHHHHHHCCCCCCEEEECCCCHHHHHHHCCCEEEEEEEECCHHHHHH
AHRLRWIQAMAAGVDDLVAAPLPPGVLLTRIEGLFGTPMSEYAFAHMLAYAQQLRRVYAA
HHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
QAERRWDPFRAETLAGKRLGVAGIGSIGLEVAVRGKAFGMEVWGLARTPGPRPHVDRVFT
HHHHCCCCHHHHHHCCCCCCCCCCCCCCEEEEECCCEECEEEEEECCCCCCCCCCCCCCC
PDQVREFTAGVDFLVSTLPDTPETRGLIDPEGMKEGALLINVGRGATLDEGALLRAVRSG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCC
RIRAVLDVFAVEPLPGDHLFWTEPGITVTPHMSGLNRPDAIAAYCAENLRRFERGEPLRG
CHHHHHHHHHCCCCCCCCEEEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
VVDLARGY
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]