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The map label for this gene is walR [H]

Identifier: 51893145

GI number: 51893145

Start: 2147902

End: 2148591

Strand: Reverse

Name: walR [H]

Synonym: STH2007

Alternate gene names: 51893145

Gene position: 2148591-2147902 (Counterclockwise)

Preceding gene: 51893146

Following gene: 51893144

Centisome position: 60.25

GC content: 70.14

Gene sequence:

>690_bases
ATGCCGCACATCCTCGTCGTCGACGACGAACCGGGCCTGGTGAAGGGCCTCCGGCTCAGCCTGGAGCAGGAGGGCTTCCA
GGTGACCACCGCGTCCGACGGGCGGGAGGCGCTCAGCAAGTTTCGCGCGGGCGACTTTGACCTGATCGTGCTGGATCTGA
TGTTGCCGGGGGTGGACGGGCTCACCATCTGCCGGGAGGTGCGCGCCGCCGGCATGACGCCGATCATCATGCTCACGGCC
AAGGCGGACGACATTGACAAGATCCTCGGCCTGGAACTGGGGGCCGACGACTACATCACCAAACCCTTCAACACGCGCGA
GCTCATCGCCCGCATCCGGGCCGTCCTGCGCCGGGCCGAGGCGGCCTCCCGGCAGGACCGGGCCGGCCGGCTGGTGGTGG
GCGACCTGGTGCTTCATCCCCGGCAGCGCCGGGCCGAGGTGGCCGGCCGGCCGCTGGAACTGACGGCCCGGGAGTACGAC
CTGCTGGAGCTGCTGGCCCGCCATCCCGGGGTGGTGTACACCCGCCAGGAGCTGCTGGACCTGGTGTGGGGCTACGACTT
TGCCGGTGACGAGCGAACCGTCGACGTCCACGTCCGGCGCATCCGGGAGAAGCTGGAGGAGGATCCCTCCCGGCCCCGGT
ACCTGCGCACCAAGTGGGGCGTGGGCTACTACCTGGAGGCCGAGCCGTGA

Upstream 100 bases:

>100_bases
GGCAAGGACGCGCTGCCGCCCGAACGGCTGGAGATCTGCTGCGGGGTAGCCCGGATATGCTGGCACTGACAGGAATGCAC
CCGGCAGGAGGTGACGCAGG

Downstream 100 bases:

>100_bases
GGCGGCCGGGTCAGTGGCCGCTGGCCGTCCAGCTGGCCCTGGCGTTTGCGCTGGTCACGGTCCTGGCCCTCGGCGGCAGC
GGGGCGCTCCTGCTGTACCA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MPHILVVDDEPGLVKGLRLSLEQEGFQVTTASDGREALSKFRAGDFDLIVLDLMLPGVDGLTICREVRAAGMTPIIMLTA
KADDIDKILGLELGADDYITKPFNTRELIARIRAVLRRAEAASRQDRAGRLVVGDLVLHPRQRRAEVAGRPLELTAREYD
LLELLARHPGVVYTRQELLDLVWGYDFAGDERTVDVHVRRIREKLEEDPSRPRYLRTKWGVGYYLEAEP

Sequences:

>Translated_229_residues
MPHILVVDDEPGLVKGLRLSLEQEGFQVTTASDGREALSKFRAGDFDLIVLDLMLPGVDGLTICREVRAAGMTPIIMLTA
KADDIDKILGLELGADDYITKPFNTRELIARIRAVLRRAEAASRQDRAGRLVVGDLVLHPRQRRAEVAGRPLELTAREYD
LLELLARHPGVVYTRQELLDLVWGYDFAGDERTVDVHVRRIREKLEEDPSRPRYLRTKWGVGYYLEAEP
>Mature_228_residues
PHILVVDDEPGLVKGLRLSLEQEGFQVTTASDGREALSKFRAGDFDLIVLDLMLPGVDGLTICREVRAAGMTPIIMLTAK
ADDIDKILGLELGADDYITKPFNTRELIARIRAVLRRAEAASRQDRAGRLVVGDLVLHPRQRRAEVAGRPLELTAREYDL
LELLARHPGVVYTRQELLDLVWGYDFAGDERTVDVHVRRIREKLEEDPSRPRYLRTKWGVGYYLEAEP

Specific function: Member of the two-component regulatory system walK/walR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=44.4444444444444, Blast_Score=181, Evalue=3e-47,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=40.4347826086956, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=40.8071748878924, Blast_Score=160, Evalue=6e-41,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=41.9213973799127, Blast_Score=153, Evalue=8e-39,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=39.8230088495575, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=37.219730941704, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=36.4035087719298, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=35.8744394618834, Blast_Score=138, Evalue=2e-34,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=36.322869955157, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1787229, Length=235, Percent_Identity=36.5957446808511, Blast_Score=134, Evalue=3e-33,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=37.0535714285714, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=37.6106194690265, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=32.034632034632, Blast_Score=110, Evalue=5e-26,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=32.1428571428571, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=35.8490566037736, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=32.5, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790299, Length=110, Percent_Identity=30.9090909090909, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=32.4561403508772, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI145693157, Length=100, Percent_Identity=37, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25883; Mature: 25752

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHILVVDDEPGLVKGLRLSLEQEGFQVTTASDGREALSKFRAGDFDLIVLDLMLPGVDG
CCEEEEEECCCCHHHHHHHEECCCCEEEEECCCHHHHHHHHCCCCCCEEEEEHHHCCCCH
LTICREVRAAGMTPIIMLTAKADDIDKILGLELGADDYITKPFNTRELIARIRAVLRRAE
HHHHHHHHHCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AASRQDRAGRLVVGDLVLHPRQRRAEVAGRPLELTAREYDLLELLARHPGVVYTRQELLD
HHHHHCCCCCEEEEHHHCCCCHHHHHHCCCCEEECHHHHHHHHHHHHCCCEEEEHHHHHH
LVWGYDFAGDERTVDVHVRRIREKLEEDPSRPRYLRTKWGVGYYLEAEP
HHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCC
>Mature Secondary Structure 
PHILVVDDEPGLVKGLRLSLEQEGFQVTTASDGREALSKFRAGDFDLIVLDLMLPGVDG
CEEEEEECCCCHHHHHHHEECCCCEEEEECCCHHHHHHHHCCCCCCEEEEEHHHCCCCH
LTICREVRAAGMTPIIMLTAKADDIDKILGLELGADDYITKPFNTRELIARIRAVLRRAE
HHHHHHHHHCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AASRQDRAGRLVVGDLVLHPRQRRAEVAGRPLELTAREYDLLELLARHPGVVYTRQELLD
HHHHHCCCCCEEEEHHHCCCCHHHHHHCCCCEEECHHHHHHHHHHHHCCCEEEEHHHHHH
LVWGYDFAGDERTVDVHVRRIREKLEEDPSRPRYLRTKWGVGYYLEAEP
HHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA