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The map label for this gene is aroE

Identifier: 51893090

GI number: 51893090

Start: 2092730

End: 2093614

Strand: Reverse

Name: aroE

Synonym: STH1952

Alternate gene names: 51893090

Gene position: 2093614-2092730 (Counterclockwise)

Preceding gene: 51893091

Following gene: 51893089

Centisome position: 58.71

GC content: 73.22

Gene sequence:

>885_bases
ATGACCAAGCGTCGGAGCACATCGCGGGGTCCGGGGCGGATCCTGGGGATCCTGGGCCATCCGGTGGCGCACTCCGCCTC
GCCCGCCATGCACAACGCCGCATTCGCCGCGCAGGGGATGCACGCCATGTACGGGGCCTTTGACGTCCCGCCTTCCCAGC
TGGAGAAGGCGATCGCCGGGATTCGCGCGCTGGGGCTCCTGGGCGTCAACGTCACCATTCCCCACAAGGAGGCGGTCATG
GCCTACCTGGACGACGTGGCCCCCACCGCCCGGCAGGTGGGTGCGGTGAACACCATCGTCAACCGGGGCGGCCGGCTGAT
CGGGTACAATACCGACGGCTGGGGCTTCCTGCTCAGCCTGGAGGAGCGGGGCGTGCGGGTCGCCGGCCGGAACGCCGTGG
TGCTGGGTGCGGGTGGCGCCGCCCGGGCGGTGGCCCTGCACCTGGGCATGGCCGGGGTGGCGCGCCTGACGATCATCAAC
CGTTCCCGCCAGCGGGCCGAGTTCCTGGCGGCCGATCTCGCCCGGGCCAAGACCCCGGTGCGGGCGGAGGTGGCCGATCC
GGGGTCGGAGGAGGCCCGGGCCGCGCTCGCGGAGGCCGGCCTGGTCGTCAACTGCACCCCTCTGGGCATGGAGCCCGACA
CCGAGTCGACGCCGCTGGAGGACGTCGGGCTGCTCCCGGCCCACTGCGTGGTCTACGACACCGTGTACCGGCCGCTGGAG
ACCCGCCTCCTGCGGGAGGCGCGGCAGCACGGGCTCATCACCGTCAACGGCCTGGCGATGCTGGTGCACCAGGGCGCCTG
CGCCTGGGAGTACTGGTTCGGCCGGCGGGGCCCGGTGGACGTGATGCGGACGGCCGCGCTGGCGGCCCTGGAGGGACAGC
CATGA

Upstream 100 bases:

>100_bases
GGCCAGCCGGTCTGCCTATAGTTGGCAGGTTCCGCCGGGGGCACCGCCGAAAGGAGTAAGGTGAGAAGAGACCCGCTGTG
GCGCGGGAGGGGGGACTGGG

Downstream 100 bases:

>100_bases
GCGGGCAGGCGTGGCCCGCCGCCCTCCTGGGCGTGGCCCTGGGGGCGGCCCTGGGCTATCTGGGTGTGCGGTTCTCCCCC
CGCTGGCTGACCCGGCCGGC

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTKRRSTSRGPGRILGILGHPVAHSASPAMHNAAFAAQGMHAMYGAFDVPPSQLEKAIAGIRALGLLGVNVTIPHKEAVM
AYLDDVAPTARQVGAVNTIVNRGGRLIGYNTDGWGFLLSLEERGVRVAGRNAVVLGAGGAARAVALHLGMAGVARLTIIN
RSRQRAEFLAADLARAKTPVRAEVADPGSEEARAALAEAGLVVNCTPLGMEPDTESTPLEDVGLLPAHCVVYDTVYRPLE
TRLLREARQHGLITVNGLAMLVHQGACAWEYWFGRRGPVDVMRTAALAALEGQP

Sequences:

>Translated_294_residues
MTKRRSTSRGPGRILGILGHPVAHSASPAMHNAAFAAQGMHAMYGAFDVPPSQLEKAIAGIRALGLLGVNVTIPHKEAVM
AYLDDVAPTARQVGAVNTIVNRGGRLIGYNTDGWGFLLSLEERGVRVAGRNAVVLGAGGAARAVALHLGMAGVARLTIIN
RSRQRAEFLAADLARAKTPVRAEVADPGSEEARAALAEAGLVVNCTPLGMEPDTESTPLEDVGLLPAHCVVYDTVYRPLE
TRLLREARQHGLITVNGLAMLVHQGACAWEYWFGRRGPVDVMRTAALAALEGQP
>Mature_293_residues
TKRRSTSRGPGRILGILGHPVAHSASPAMHNAAFAAQGMHAMYGAFDVPPSQLEKAIAGIRALGLLGVNVTIPHKEAVMA
YLDDVAPTARQVGAVNTIVNRGGRLIGYNTDGWGFLLSLEERGVRVAGRNAVVLGAGGAARAVALHLGMAGVARLTIINR
SRQRAEFLAADLARAKTPVRAEVADPGSEEARAALAEAGLVVNCTPLGMEPDTESTPLEDVGLLPAHCVVYDTVYRPLET
RLLREARQHGLITVNGLAMLVHQGACAWEYWFGRRGPVDVMRTAALAALEGQP

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=277, Percent_Identity=36.4620938628159, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789675, Length=261, Percent_Identity=34.4827586206897, Blast_Score=106, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320332, Length=276, Percent_Identity=31.5217391304348, Blast_Score=112, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_SYMTH (Q67N06)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_075781.1
- HSSP:   Q9SQT8
- ProteinModelPortal:   Q67N06
- SMR:   Q67N06
- GeneID:   2980928
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH1952
- NMPDR:   fig|292459.1.peg.1882
- HOGENOM:   HBG553408
- OMA:   QKANING
- BioCyc:   STHE292459:STH1952-MONOMER
- BRENDA:   1.1.1.25
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 31067; Mature: 30936

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: ACT_SITE 76-76

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRRSTSRGPGRILGILGHPVAHSASPAMHNAAFAAQGMHAMYGAFDVPPSQLEKAIAG
CCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHH
IRALGLLGVNVTIPHKEAVMAYLDDVAPTARQVGAVNTIVNRGGRLIGYNTDGWGFLLSL
HHHHHEEEEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEE
EERGVRVAGRNAVVLGAGGAARAVALHLGMAGVARLTIINRSRQRAEFLAADLARAKTPV
CCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHCCCCC
RAEVADPGSEEARAALAEAGLVVNCTPLGMEPDTESTPLEDVGLLPAHCVVYDTVYRPLE
EEECCCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHH
TRLLREARQHGLITVNGLAMLVHQGACAWEYWFGRRGPVDVMRTAALAALEGQP
HHHHHHHHHCCCEEEHHHHEEHHCCCEEEHHHCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TKRRSTSRGPGRILGILGHPVAHSASPAMHNAAFAAQGMHAMYGAFDVPPSQLEKAIAG
CCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHH
IRALGLLGVNVTIPHKEAVMAYLDDVAPTARQVGAVNTIVNRGGRLIGYNTDGWGFLLSL
HHHHHEEEEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEE
EERGVRVAGRNAVVLGAGGAARAVALHLGMAGVARLTIINRSRQRAEFLAADLARAKTPV
CCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHCCCCC
RAEVADPGSEEARAALAEAGLVVNCTPLGMEPDTESTPLEDVGLLPAHCVVYDTVYRPLE
EEECCCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHH
TRLLREARQHGLITVNGLAMLVHQGACAWEYWFGRRGPVDVMRTAALAALEGQP
HHHHHHHHHCCCEEEHHHHEEHHCCCEEEHHHCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA