Click here to switch to the map view.

The map label for this gene is comC [H]

Identifier: 51893089

GI number: 51893089

Start: 2092089

End: 2092733

Strand: Reverse

Name: comC [H]

Synonym: STH1951

Alternate gene names: 51893089

Gene position: 2092733-2092089 (Counterclockwise)

Preceding gene: 51893090

Following gene: 51893088

Centisome position: 58.68

GC content: 70.54

Gene sequence:

>645_bases
ATGAGCGGGCAGGCGTGGCCCGCCGCCCTCCTGGGCGTGGCCCTGGGGGCGGCCCTGGGCTATCTGGGTGTGCGGTTCTC
CCCCCGCTGGCTGACCCGGCCGGCGCCGCGGTGGCTCTCGGCCTCGCTGGTCGCGGGTATCGCGCTGGCGGCGGGGCTGC
TCGGCTACTTCCACCGGCTCACGCCTTACTTCTGGCACCAGCTGGCGCTGGTGGCCATCCTCCTTGCAGCGGCCTTCATC
GACCTGCAGGACCACATTATCCCCAACGACCTGGTGCTGGTGGGCTTCGCGGTCTGGCTGCCGGCGATGCTGCTCTTCCC
GTACGACGGGAAGACGTGGCTCTCTGCGCTGGGGGGCGGCGCGGCCGCCTTTGCGTTCTTCTACCTGCTCGCGGTGCTCG
TGCCCGACGGCATGGGCATGGGAGATGTGAAGCTGGCCCTGGTGATGGGGCTGTTCCTGGGAGCGGGATGGGTAGCCATG
GCCCTCATCCTGGCGTTTCTCCTGGGCGGTCTGGCCTCGGCCGTGCTGCTGGCCACCCGGCGGGTCGGGCGCAGGGGGCA
CATCCCCTTCGGCCCGTTCCTCGCCGCGGGCGGCCTGATCACCATCCTGTGGGGAAGCCAGATCTGGAACTGGTACGCGG
GATGA

Upstream 100 bases:

>100_bases
TGGTGCACCAGGGCGCCTGCGCCTGGGAGTACTGGTTCGGCCGGCGGGGCCCGGTGGACGTGATGCGGACGGCCGCGCTG
GCGGCCCTGGAGGGACAGCC

Downstream 100 bases:

>100_bases
CGCATAGGAAGGGGGCGGTCCCGGAGTGTTGCGGTACCTGACAGCCGGCGAGTCGCACGGGCGGGCGCTGGTGACCATCG
TCGAGGGGCTGCCCGCCGGC

Product: type IV prepilin-like leader peptide processing enzyme

Products: NA

Alternate protein names: Late competence protein ComC; Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MSGQAWPAALLGVALGAALGYLGVRFSPRWLTRPAPRWLSASLVAGIALAAGLLGYFHRLTPYFWHQLALVAILLAAAFI
DLQDHIIPNDLVLVGFAVWLPAMLLFPYDGKTWLSALGGGAAAFAFFYLLAVLVPDGMGMGDVKLALVMGLFLGAGWVAM
ALILAFLLGGLASAVLLATRRVGRRGHIPFGPFLAAGGLITILWGSQIWNWYAG

Sequences:

>Translated_214_residues
MSGQAWPAALLGVALGAALGYLGVRFSPRWLTRPAPRWLSASLVAGIALAAGLLGYFHRLTPYFWHQLALVAILLAAAFI
DLQDHIIPNDLVLVGFAVWLPAMLLFPYDGKTWLSALGGGAAAFAFFYLLAVLVPDGMGMGDVKLALVMGLFLGAGWVAM
ALILAFLLGGLASAVLLATRRVGRRGHIPFGPFLAAGGLITILWGSQIWNWYAG
>Mature_213_residues
SGQAWPAALLGVALGAALGYLGVRFSPRWLTRPAPRWLSASLVAGIALAAGLLGYFHRLTPYFWHQLALVAILLAAAFID
LQDHIIPNDLVLVGFAVWLPAMLLFPYDGKTWLSALGGGAAAFAFFYLLAVLVPDGMGMGDVKLALVMGLFLGAGWVAMA
LILAFLLGGLASAVLLATRRVGRRGHIPFGPFLAAGGLITILWGSQIWNWYAG

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 22700; Mature: 22569

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGQAWPAALLGVALGAALGYLGVRFSPRWLTRPAPRWLSASLVAGIALAAGLLGYFHRL
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TPYFWHQLALVAILLAAAFIDLQDHIIPNDLVLVGFAVWLPAMLLFPYDGKTWLSALGGG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCH
AAAFAFFYLLAVLVPDGMGMGDVKLALVMGLFLGAGWVAMALILAFLLGGLASAVLLATR
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVGRRGHIPFGPFLAAGGLITILWGSQIWNWYAG
HHCCCCCCCCCHHHHHCCHHEEHHHHHHHHHCCC
>Mature Secondary Structure 
SGQAWPAALLGVALGAALGYLGVRFSPRWLTRPAPRWLSASLVAGIALAAGLLGYFHRL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TPYFWHQLALVAILLAAAFIDLQDHIIPNDLVLVGFAVWLPAMLLFPYDGKTWLSALGGG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCH
AAAFAFFYLLAVLVPDGMGMGDVKLALVMGLFLGAGWVAMALILAFLLGGLASAVLLATR
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVGRRGHIPFGPFLAAGGLITILWGSQIWNWYAG
HHCCCCCCCCCHHHHHCCHHEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2553669; 9384377; 8419299 [H]