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The map label for this gene is cobQ [H]

Identifier: 51893070

GI number: 51893070

Start: 2074526

End: 2075374

Strand: Reverse

Name: cobQ [H]

Synonym: STH1932

Alternate gene names: 51893070

Gene position: 2075374-2074526 (Counterclockwise)

Preceding gene: 51893071

Following gene: 51893069

Centisome position: 58.2

GC content: 71.85

Gene sequence:

>849_bases
ATGGCACGTTCGTTGATGTTCCTGGGCACCGCATCCAGCGTGGGCAAGTCGACCCTGGCCGCGGCCTTCTGCCGCATCCT
GCGCCAGGAGGGCTTCCGGGTGGCGCCGTTCAAGGCGCAGAACATGTCCTGCGCCGCGACGGAGATCGAGGGCGGGCTGC
GCATCAGCGTGGTGCAGGCCATGCAGGCGCAGGCGGCGGGGGTGGCCCCCCGGGTGGAGATGAACCCGGTGATGCTGCTG
CCCCGGACGGAGCTCCGCTCCGAGGTGATCGTCAACGGCCGGTCGCTGGGCGAGATGGCCTGGCAGCAGTACACGGCCGA
TCTGCACACTGTGGCCCTGCAGGCGGTGCGGGAGGCCATTGCCCGGCTGGAGGCAGAGTTCGAGGTGATTGTGGCCGAGG
GGGCCGGCTCGCCGGTGGAGGTGAACCTGCGGGACCGTGACCTGGCCAACATGAAGACCGCGGAACTGCTGGACGCCGAC
GTGCTGCTGGTGGCCGACATCGACCGGGGCGGGGTGTTCGCCTCGATCGTGGGCACCCTGGAGCTGCTGCCCCCGGCCGA
GCGGGCCCGGGTGAAGGGGCTGGTGATCAACCGCTTCCGGGGCGACGCCTCGCTCTTCGAGGACGGCGTGCGCTGGCTGG
AGGAGCGCACCGGCCTGCCGGTGATCGGCGTGATTCCCTACCTGGCCGACCTGGGCCTCGATGAGGAGGACTCGGCGGGC
CTGACCGATGTGAGCGCCCCGGCGCCGTCCGCTGCGGCGCGGGAGGGGGCCCTGGACCGGCTGGCCGACCACGTGCGCCG
GCACGCCCGGGTGGACCAGGTGCTGGAGCTGCTTGCCCGGCAACGGTGA

Upstream 100 bases:

>100_bases
CTGCTCTCGAGGGAGGTTGCGGCGCCGGCCCAGCCGCTGGAGCCGGTCAGCGCCGGCAGCGACTAGTCCCGGGAGATCTT
GCAGAAGAGGTGGCACCGTC

Downstream 100 bases:

>100_bases
CGGGCGGGCGCTCCGGTGCGGCGAGGTGCCGGACGAAGGGAACGACCCATGCGGGTTCTGGGCACAACAGCGTGCCGGTT
TGGGAGGGCAACTGCATAGA

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MARSLMFLGTASSVGKSTLAAAFCRILRQEGFRVAPFKAQNMSCAATEIEGGLRISVVQAMQAQAAGVAPRVEMNPVMLL
PRTELRSEVIVNGRSLGEMAWQQYTADLHTVALQAVREAIARLEAEFEVIVAEGAGSPVEVNLRDRDLANMKTAELLDAD
VLLVADIDRGGVFASIVGTLELLPPAERARVKGLVINRFRGDASLFEDGVRWLEERTGLPVIGVIPYLADLGLDEEDSAG
LTDVSAPAPSAAAREGALDRLADHVRRHARVDQVLELLARQR

Sequences:

>Translated_282_residues
MARSLMFLGTASSVGKSTLAAAFCRILRQEGFRVAPFKAQNMSCAATEIEGGLRISVVQAMQAQAAGVAPRVEMNPVMLL
PRTELRSEVIVNGRSLGEMAWQQYTADLHTVALQAVREAIARLEAEFEVIVAEGAGSPVEVNLRDRDLANMKTAELLDAD
VLLVADIDRGGVFASIVGTLELLPPAERARVKGLVINRFRGDASLFEDGVRWLEERTGLPVIGVIPYLADLGLDEEDSAG
LTDVSAPAPSAAAREGALDRLADHVRRHARVDQVLELLARQR
>Mature_281_residues
ARSLMFLGTASSVGKSTLAAAFCRILRQEGFRVAPFKAQNMSCAATEIEGGLRISVVQAMQAQAAGVAPRVEMNPVMLLP
RTELRSEVIVNGRSLGEMAWQQYTADLHTVALQAVREAIARLEAEFEVIVAEGAGSPVEVNLRDRDLANMKTAELLDADV
LLVADIDRGGVFASIVGTLELLPPAERARVKGLVINRFRGDASLFEDGVRWLEERTGLPVIGVIPYLADLGLDEEDSAGL
TDVSAPAPSAAAREGALDRLADHVRRHARVDQVLELLARQR

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 30418; Mature: 30287

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARSLMFLGTASSVGKSTLAAAFCRILRQEGFRVAPFKAQNMSCAATEIEGGLRISVVQA
CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEHHECCCCEEEHHHHH
MQAQAAGVAPRVEMNPVMLLPRTELRSEVIVNGRSLGEMAWQQYTADLHTVALQAVREAI
HHHHHCCCCCCCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLEAEFEVIVAEGAGSPVEVNLRDRDLANMKTAELLDADVLLVADIDRGGVFASIVGTL
HHHCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHH
ELLPPAERARVKGLVINRFRGDASLFEDGVRWLEERTGLPVIGVIPYLADLGLDEEDSAG
HCCCCHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCCC
LTDVSAPAPSAAAREGALDRLADHVRRHARVDQVLELLARQR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARSLMFLGTASSVGKSTLAAAFCRILRQEGFRVAPFKAQNMSCAATEIEGGLRISVVQA
CCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEHHECCCCEEEHHHHH
MQAQAAGVAPRVEMNPVMLLPRTELRSEVIVNGRSLGEMAWQQYTADLHTVALQAVREAI
HHHHHCCCCCCCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLEAEFEVIVAEGAGSPVEVNLRDRDLANMKTAELLDADVLLVADIDRGGVFASIVGTL
HHHCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHH
ELLPPAERARVKGLVINRFRGDASLFEDGVRWLEERTGLPVIGVIPYLADLGLDEEDSAG
HCCCCHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCCC
LTDVSAPAPSAAAREGALDRLADHVRRHARVDQVLELLARQR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]