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The map label for this gene is glyA

Identifier: 51893055

GI number: 51893055

Start: 2060109

End: 2061347

Strand: Reverse

Name: glyA

Synonym: STH1917

Alternate gene names: 51893055

Gene position: 2061347-2060109 (Counterclockwise)

Preceding gene: 51893056

Following gene: 51893051

Centisome position: 57.8

GC content: 68.04

Gene sequence:

>1239_bases
ATGGATGCACTGAAGCGGTATGATCCCGAGGTCTTCGCGGCCATTCAGCAGGAGGTCGAGCGGCAGCAGCGCAACATTGA
GCTGATCGCCTCGGAGAACTTCGTGCCCAAGGCGGTCCTCGAGGCGGCGGGCACGGTGCTCACCAACAAGTACGCCGAGG
GCTATCCCGGCCGGCGGTACTACGGCGGCTGCGAGTACGTGGACATCGTGGAGAACATCGCCCGGGAGCGGCTGAAGGCG
GCCTTCGGCGCGGAGCACGTCAACGTCCAGCCGCACTCGGGGGCCAACGCCAACACGGCGGTCTACTTCGCCTTCCTCCA
GCCCGGCGATACGGTGCTGGGCATGAACCTGGCCCAGGGCGGCCACCTGACCCACGGCTCGCCGGTCAACTTCAGCGGCA
GGACTTACAACTTCGTGCCCTACGGCCTGGACCCGGAGACCGAGCGGATCAACATGGACCAGGTGGCGGAGCTGGCCCGG
CAGCACCGGCCCAAGCTCATCGTCGCCGGCTACTCGGCCTACCCGCGGGTCCTGGACTTCAAGCGGTTCCGGGAGATCGC
CGAAGAGGTGGGCGCCATCCTGATGGTGGACATGGCCCACTTCGCCGGCCTGGCGGCCACGGGCTACTACCCGAACCCGG
TGGAGCACGCGCACGTGGTCACCACCACCACCCACAAGACGCTGCGCGGGCCGCGGGGCGGGGCGATCCTCTGCAAGAAG
GAGTTCGCCAAGGAGATCGACAAGGCGGTCTTCCCGGGCATGCAGGGCGGCCCCCTGATGCACATCATCGCCGCCAAGGC
GGTGGCCTTCAAGCAGCTCTCCGACCCGGACTACAGGGCATACTGCGGCCAGGTGGTGAAGAACGCCAAGGCCCTGGCCC
AGGCGCTGCTGGAGCGGGGCTACCGGCTGGTCACCGGCGGCACCGACAACCACCTGATGCTGGTGGACCTGCGGCCCAAG
GGCATCACCGGCCGGGACGCGGAGCACCTGCTGGACAGGGTCTCGATCACGGTCAACAAGAACGCCATCCCCAACGACCC
CGAGAAGCCGATGGTGACCAGCGGCATCCGCATCGGCACCCCGGCCATGACCACCCGGGGGATGAAGGAGGCCGAGATGG
TCCAGATCGCCGACCTCATCGACCGGGCCATCACCCACCGGAACGACGAGGCGGAGCTGGACCGGATCCGGGCGGAGGTG
CACGAGCTCACGGCCCGGTTCCCGCTCTACGCCGACTAG

Upstream 100 bases:

>100_bases
CTCACGGAGAGGGAGGAAAAAGAGGCGCAGACGCTTGTCGAGGCCAAGTACGGGTGTGATAATTGGAACATGAGAAAATA
AGCAGGGGGCGGCTCACTCC

Downstream 100 bases:

>100_bases
CGGCCAGGAGCAGCTGGCACCGGCGGGCGATCATCCGCACGCACACGGATGCAGCCAGGCGGATCCCCGTGGCGGGTCCG
CCTGGCTTGCGTGTCCCTGC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MDALKRYDPEVFAAIQQEVERQQRNIELIASENFVPKAVLEAAGTVLTNKYAEGYPGRRYYGGCEYVDIVENIARERLKA
AFGAEHVNVQPHSGANANTAVYFAFLQPGDTVLGMNLAQGGHLTHGSPVNFSGRTYNFVPYGLDPETERINMDQVAELAR
QHRPKLIVAGYSAYPRVLDFKRFREIAEEVGAILMVDMAHFAGLAATGYYPNPVEHAHVVTTTTHKTLRGPRGGAILCKK
EFAKEIDKAVFPGMQGGPLMHIIAAKAVAFKQLSDPDYRAYCGQVVKNAKALAQALLERGYRLVTGGTDNHLMLVDLRPK
GITGRDAEHLLDRVSITVNKNAIPNDPEKPMVTSGIRIGTPAMTTRGMKEAEMVQIADLIDRAITHRNDEAELDRIRAEV
HELTARFPLYAD

Sequences:

>Translated_412_residues
MDALKRYDPEVFAAIQQEVERQQRNIELIASENFVPKAVLEAAGTVLTNKYAEGYPGRRYYGGCEYVDIVENIARERLKA
AFGAEHVNVQPHSGANANTAVYFAFLQPGDTVLGMNLAQGGHLTHGSPVNFSGRTYNFVPYGLDPETERINMDQVAELAR
QHRPKLIVAGYSAYPRVLDFKRFREIAEEVGAILMVDMAHFAGLAATGYYPNPVEHAHVVTTTTHKTLRGPRGGAILCKK
EFAKEIDKAVFPGMQGGPLMHIIAAKAVAFKQLSDPDYRAYCGQVVKNAKALAQALLERGYRLVTGGTDNHLMLVDLRPK
GITGRDAEHLLDRVSITVNKNAIPNDPEKPMVTSGIRIGTPAMTTRGMKEAEMVQIADLIDRAITHRNDEAELDRIRAEV
HELTARFPLYAD
>Mature_412_residues
MDALKRYDPEVFAAIQQEVERQQRNIELIASENFVPKAVLEAAGTVLTNKYAEGYPGRRYYGGCEYVDIVENIARERLKA
AFGAEHVNVQPHSGANANTAVYFAFLQPGDTVLGMNLAQGGHLTHGSPVNFSGRTYNFVPYGLDPETERINMDQVAELAR
QHRPKLIVAGYSAYPRVLDFKRFREIAEEVGAILMVDMAHFAGLAATGYYPNPVEHAHVVTTTTHKTLRGPRGGAILCKK
EFAKEIDKAVFPGMQGGPLMHIIAAKAVAFKQLSDPDYRAYCGQVVKNAKALAQALLERGYRLVTGGTDNHLMLVDLRPK
GITGRDAEHLLDRVSITVNKNAIPNDPEKPMVTSGIRIGTPAMTTRGMKEAEMVQIADLIDRAITHRNDEAELDRIRAEV
HELTARFPLYAD

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI261862352, Length=407, Percent_Identity=49.1400491400491, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI261862350, Length=407, Percent_Identity=49.1400491400491, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI261862348, Length=407, Percent_Identity=49.1400491400491, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI19923315, Length=407, Percent_Identity=49.1400491400491, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI261862346, Length=407, Percent_Identity=48.1572481572482, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI22547186, Length=428, Percent_Identity=46.9626168224299, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI22547189, Length=413, Percent_Identity=45.0363196125908, Blast_Score=320, Evalue=2e-87,
Organism=Escherichia coli, GI1788902, Length=408, Percent_Identity=60.0490196078431, Blast_Score=494, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI25144732, Length=407, Percent_Identity=46.6830466830467, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI25144729, Length=407, Percent_Identity=46.6830466830467, Blast_Score=366, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319739, Length=401, Percent_Identity=46.3840399002494, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323087, Length=401, Percent_Identity=46.1346633416459, Blast_Score=355, Evalue=8e-99,
Organism=Drosophila melanogaster, GI24640005, Length=452, Percent_Identity=45.575221238938, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI221329721, Length=452, Percent_Identity=45.575221238938, Blast_Score=392, Evalue=1e-109,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_SYMTH (Q67N41)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_075746.1
- ProteinModelPortal:   Q67N41
- SMR:   Q67N41
- GeneID:   2980499
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH1917
- NMPDR:   fig|292459.1.peg.1850
- HOGENOM:   HBG301263
- OMA:   PETERIN
- BioCyc:   STHE292459:STH1917-MONOMER
- BRENDA:   2.1.2.1
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 45509; Mature: 45509

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDALKRYDPEVFAAIQQEVERQQRNIELIASENFVPKAVLEAAGTVLTNKYAEGYPGRRY
CCCHHHCCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
YGGCEYVDIVENIARERLKAAFGAEHVNVQPHSGANANTAVYFAFLQPGDTVLGMNLAQG
CCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEEECCCCEEEEEEECCC
GHLTHGSPVNFSGRTYNFVPYGLDPETERINMDQVAELARQHRPKLIVAGYSAYPRVLDF
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHH
KRFREIAEEVGAILMVDMAHFAGLAATGYYPNPVEHAHVVTTTTHKTLRGPRGGAILCKK
HHHHHHHHHHCCEEEHHHHHHHHHHCCCCCCCCCCCCEEEEEECHHHHCCCCCCEEEEHH
EFAKEIDKAVFPGMQGGPLMHIIAAKAVAFKQLSDPDYRAYCGQVVKNAKALAQALLERG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
YRLVTGGTDNHLMLVDLRPKGITGRDAEHLLDRVSITVNKNAIPNDPEKPMVTSGIRIGT
CEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHEEEEEECCCCCCCCCCCCEECCEEECC
PAMTTRGMKEAEMVQIADLIDRAITHRNDEAELDRIRAEVHELTARFPLYAD
CCHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDALKRYDPEVFAAIQQEVERQQRNIELIASENFVPKAVLEAAGTVLTNKYAEGYPGRRY
CCCHHHCCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
YGGCEYVDIVENIARERLKAAFGAEHVNVQPHSGANANTAVYFAFLQPGDTVLGMNLAQG
CCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEEECCCCEEEEEEECCC
GHLTHGSPVNFSGRTYNFVPYGLDPETERINMDQVAELARQHRPKLIVAGYSAYPRVLDF
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHH
KRFREIAEEVGAILMVDMAHFAGLAATGYYPNPVEHAHVVTTTTHKTLRGPRGGAILCKK
HHHHHHHHHHCCEEEHHHHHHHHHHCCCCCCCCCCCCEEEEEECHHHHCCCCCCEEEEHH
EFAKEIDKAVFPGMQGGPLMHIIAAKAVAFKQLSDPDYRAYCGQVVKNAKALAQALLERG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
YRLVTGGTDNHLMLVDLRPKGITGRDAEHLLDRVSITVNKNAIPNDPEKPMVTSGIRIGT
CEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHEEEEEECCCCCCCCCCCCEECCEEECC
PAMTTRGMKEAEMVQIADLIDRAITHRNDEAELDRIRAEVHELTARFPLYAD
CCHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA