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The map label for this gene is ldh [H]

Identifier: 51892965

GI number: 51892965

Start: 1971914

End: 1972981

Strand: Reverse

Name: ldh [H]

Synonym: STH1827

Alternate gene names: 51892965

Gene position: 1972981-1971914 (Counterclockwise)

Preceding gene: 51892966

Following gene: 51892964

Centisome position: 55.33

GC content: 66.29

Gene sequence:

>1068_bases
ATGGGGATCTTTGAGCAGATGGCGCAGTACGGACACGAGCAGCTGGTCTTCTGCTATGACAAGTCCACCGGGCTCCGCGC
GATCATCGCCATTCACGATACGACGCTGGGGCCGGCGCTGGGCGGGCTCCGCATGTGGCCGTATGAGCGGGAGGAGGATG
CCATCACCGACGTGCTCCGGCTGGCCCGGGGCATGACGTACAAGAACTCCGCCATGGGCCTCAACCTGGGCGGGGGCAAG
GCCGTGCTGTGGGGTGATCCGCACACCGACAAGAGCGAGGAGCTGTTCCGGGCGTTCGGCAAGTTCGTCGAGACGCTGGG
CGGCCGGTACATCACGGCGGAGGATGTCGGTACCACCGTCGAGGACATGAACTACGTCCTCATGGAGACTGACCACGCCT
GCGGCCGGGCTGAGGTGTCGGGCGACCCCTCCCCGGTGACGGCGTACGGCGTGTTCATGGGCATCAAGGCCTGTGTCAAG
CAGGTGTTCGGGACCGAGGAGTTGAAGGGGAAGAAGATCGCGGTCCAGGGGCTCGGCAAGGTGGGTTACCACCTGTGCCG
GTACCTGCACGAGGCCGGCGCCGAGCTGATCGTCACCGACATCGACCCGGAGGCCGTGGAGCGGGCGAAGCAGGAGTTCG
GGGCCAAGGCCGTCGCCCCCGACGAGATCTACACCGCTGAGTGCGACATCTTCGCCCCGTGCGCCCTGGGCGCCATCTTG
AACGACGACACCATCCCCGGCCTGAAGTGCAGGATCGTCGCCGGCGCGGCCAACAACCAGCTGAAGGAGCCGCGGCACGG
CAACATGCTGCGGGAGCGCGGCATCCTGTACGCGCCCGACTTCGTCATCAACGGCGGCGGCGTGATCAACGTGGCCGAGG
AGTACCATCCCCAGGGCTACAGCCGGGAGCGGGCCCTGAAGCGGGTGGAGACCATCTACGACAAGCTCCTGCGGGTCTTC
CAGATCGCCGAGCAGCGGAACATCAGCACCGCCGAGGCGGCGGACGTCATGGCCGAGGAGCGCATGCACAGGATCCATCA
GCTCAACCGGATCTACCTGGCCGAGTAA

Upstream 100 bases:

>100_bases
ACTCGATTGCACTGGCGGTCCTCGCCGCCTCTGCATAGCGGATCACCCCCGTATAGCCCACACGCATGGGTCAAGCACCA
TCACAAAAGGAGGTCATCGC

Downstream 100 bases:

>100_bases
ACGCAGGGGGCCGGAGGGGGAGCGGGCCTCCCTCTCCGGCCCCCGCACGGCGACCCTGAAGCAGCGAAAGGACGAGGAGC
GAACTTGCAGCAGCGCCTGC

Product: leucine dehydrogenase

Products: NA

Alternate protein names: LeuDH [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MGIFEQMAQYGHEQLVFCYDKSTGLRAIIAIHDTTLGPALGGLRMWPYEREEDAITDVLRLARGMTYKNSAMGLNLGGGK
AVLWGDPHTDKSEELFRAFGKFVETLGGRYITAEDVGTTVEDMNYVLMETDHACGRAEVSGDPSPVTAYGVFMGIKACVK
QVFGTEELKGKKIAVQGLGKVGYHLCRYLHEAGAELIVTDIDPEAVERAKQEFGAKAVAPDEIYTAECDIFAPCALGAIL
NDDTIPGLKCRIVAGAANNQLKEPRHGNMLRERGILYAPDFVINGGGVINVAEEYHPQGYSRERALKRVETIYDKLLRVF
QIAEQRNISTAEAADVMAEERMHRIHQLNRIYLAE

Sequences:

>Translated_355_residues
MGIFEQMAQYGHEQLVFCYDKSTGLRAIIAIHDTTLGPALGGLRMWPYEREEDAITDVLRLARGMTYKNSAMGLNLGGGK
AVLWGDPHTDKSEELFRAFGKFVETLGGRYITAEDVGTTVEDMNYVLMETDHACGRAEVSGDPSPVTAYGVFMGIKACVK
QVFGTEELKGKKIAVQGLGKVGYHLCRYLHEAGAELIVTDIDPEAVERAKQEFGAKAVAPDEIYTAECDIFAPCALGAIL
NDDTIPGLKCRIVAGAANNQLKEPRHGNMLRERGILYAPDFVINGGGVINVAEEYHPQGYSRERALKRVETIYDKLLRVF
QIAEQRNISTAEAADVMAEERMHRIHQLNRIYLAE
>Mature_354_residues
GIFEQMAQYGHEQLVFCYDKSTGLRAIIAIHDTTLGPALGGLRMWPYEREEDAITDVLRLARGMTYKNSAMGLNLGGGKA
VLWGDPHTDKSEELFRAFGKFVETLGGRYITAEDVGTTVEDMNYVLMETDHACGRAEVSGDPSPVTAYGVFMGIKACVKQ
VFGTEELKGKKIAVQGLGKVGYHLCRYLHEAGAELIVTDIDPEAVERAKQEFGAKAVAPDEIYTAECDIFAPCALGAILN
DDTIPGLKCRIVAGAANNQLKEPRHGNMLRERGILYAPDFVINGGGVINVAEEYHPQGYSRERALKRVETIYDKLLRVFQ
IAEQRNISTAEAADVMAEERMHRIHQLNRIYLAE

Specific function: Functions catabolically in the bacterial metabolism of branched-chain L-amino acids, and plays an important role in spore germination in cooperation with alanine dehydrogenase [H]

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=314, Percent_Identity=28.6624203821656, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI4885281, Length=314, Percent_Identity=28.6624203821656, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45553475, Length=364, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45549226, Length=321, Percent_Identity=29.9065420560748, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24649460, Length=274, Percent_Identity=29.5620437956204, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24649283, Length=303, Percent_Identity=24.4224422442244, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR016211
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.9 [H]

Molecular weight: Translated: 39205; Mature: 39074

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIFEQMAQYGHEQLVFCYDKSTGLRAIIAIHDTTLGPALGGLRMWPYEREEDAITDVLR
CCHHHHHHHCCCCEEEEEEECCCCCEEEEEEECCCCCHHHCCCCCCCCCCCHHHHHHHHH
LARGMTYKNSAMGLNLGGGKAVLWGDPHTDKSEELFRAFGKFVETLGGRYITAEDVGTTV
HHHCCCCCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHCCCH
EDMNYVLMETDHACGRAEVSGDPSPVTAYGVFMGIKACVKQVFGTEELKGKKIAVQGLGK
HHCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEHHHHH
VGYHLCRYLHEAGAELIVTDIDPEAVERAKQEFGAKAVAPDEIYTAECDIFAPCALGAIL
HHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCEEECCCCEECHHHHHHHC
NDDTIPGLKCRIVAGAANNQLKEPRHGNMLRERGILYAPDFVINGGGVINVAEEYHPQGY
CCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHCCCEECCCEEECCCCEEEEHHHHCCCCC
SRERALKRVETIYDKLLRVFQIAEQRNISTAEAADVMAEERMHRIHQLNRIYLAE
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHEECC
>Mature Secondary Structure 
GIFEQMAQYGHEQLVFCYDKSTGLRAIIAIHDTTLGPALGGLRMWPYEREEDAITDVLR
CHHHHHHHCCCCEEEEEEECCCCCEEEEEEECCCCCHHHCCCCCCCCCCCHHHHHHHHH
LARGMTYKNSAMGLNLGGGKAVLWGDPHTDKSEELFRAFGKFVETLGGRYITAEDVGTTV
HHHCCCCCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHCCCH
EDMNYVLMETDHACGRAEVSGDPSPVTAYGVFMGIKACVKQVFGTEELKGKKIAVQGLGK
HHCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEHHHHH
VGYHLCRYLHEAGAELIVTDIDPEAVERAKQEFGAKAVAPDEIYTAECDIFAPCALGAIL
HHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCEEECCCCEECHHHHHHHC
NDDTIPGLKCRIVAGAANNQLKEPRHGNMLRERGILYAPDFVINGGGVINVAEEYHPQGY
CCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHCCCEECCCEEECCCCEEEEHHHHCCCCC
SRERALKRVETIYDKLLRVFQIAEQRNISTAEAADVMAEERMHRIHQLNRIYLAE
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3069133; 1400267 [H]