Click here to switch to the map view.

The map label for this gene is mutL

Identifier: 51892886

GI number: 51892886

Start: 1893415

End: 1895322

Strand: Reverse

Name: mutL

Synonym: STH1748

Alternate gene names: 51892886

Gene position: 1895322-1893415 (Counterclockwise)

Preceding gene: 51892887

Following gene: 51892885

Centisome position: 53.15

GC content: 72.75

Gene sequence:

>1908_bases
TTGGCCCGGATTCGCCTGCTCGACGAGCGGACGGCCAACCAGATCGCCGCGGGCGAGGTGGTGGAGCGGCCGGCCAGCGT
GGTGAAGGAGCTGGTGGAGAACGCCCTGGACGCCCAGGCGAAGCGCATCGTGGTGGAGGTCAGCGGCGGTGGGCGGGAAC
TGGTGCGGGTGACGGACGACGGCATCGGCATGGTGCCCGAGGACGCCCGGCTGGCCCTGCAGCGGCATGCGACCTCCAAG
ATCCGCACCGCGGAGGACCTCAACGCCATCACCACCCTGGGGTTCCGCGGGGAGGCCCTGCCCTCCATCGCCGCGGTCTC
CCAGTTCGAGCTGATCACCCGTCCCCACGACCAGCTGGCCGGCTACCGCATCCTGGCGGAAGGCGGCCAGATCGTCGCCG
AAGGGGAGCACGGTTGCCCCGCCGGCACCCGGGTGACGGTGCGGGACCTGTTCTTTAACGTACCGGCGCGGCTGAAGTAC
CTGAAGACCAACGCGACGGAGCTGGCCCAGATCGGCGACATCCTGACCCGCCTGGCCCTGGCGAACCCCGAGGTGGCCTT
CCGGTTCCAGAGCGGTCAGGCCCAGGTGTTCGCCACGCCGGGAACCGGCGACCTGACGGCCGCCGTTGCGGCACTGCTGG
GCCGGGAGATGGCAAAGGAGCTGCTCCCGGTCGACTACCGCAACGATGCCGCCCGGGTGCACGGGTTCGTGGGCCGGCCT
ACCATCGCCCGGGCCGGGCGCAGCCATCAGTACTTCTTCGTCAACCGGCGGGCCGTGCGGACCATCGCCGCCCGGTATGC
CCTGGAGGAGGCATATGCCCACCTCCTGCCCAACGGGCGCTACCCTGTCTGCATCCTCTTCATTGAGGTGGAGCCCCACG
AGGTCGATGTAAACGTGCATCCCACCAAGGCCGAGGTCCGGTTCCAGCGGGACCGGGAGGTGCGGGCGGCCGTCTACCAG
GCGGCCCGGCACGCCCTCGGCGCCGCCCTGCTGATTCCGGGCACCGAGGTCACGGCCGACGGGGAGGTCCGGGTGCCGGA
CCGGGCGGAGGAGAAAGCGGCCCTGCAGCGGGGATGGGTTCCGCCTGGTGCCGGGCGGCCCGGCGAAGGGGGCGGGAGGG
CCGCACCGCCGCCGTGGCGGGTATCGGCCGGCGGCCCGGGCGGGCAGACTACCGCCCGGGAGCCGGTGCAGGCCTACCTG
CCCGCCGGCGGCCTGCAGGCGGCCCTGGCGCAGCGCGCGGCGGAGGAGGCCGCCGCCGCGGTGCCGGCAGTCGACCTGGC
CGAGGCGACCCTCGTGCCCCGTTCCGCCGAGCCTGGCGAGCTGATCCGGGCGCTCCGGCCGCTGGGCCAGGTTCACCGCT
CCTACATCGCCTGCGACGGGCCGGAGGGGCTCTACCTCATCGACCAGCATGCGGCCCACGAGCGCATCTTCTTCGAGCGG
TTGTATGCGGCCGCGCAGGAGCAGGCCACTGCGGTGCAGCGGCTCCTCTTTCCGCTCACGCTGGACCTCACGCCCGCGCA
GATGGCCATCTGGCAGGAGAACGCCGCCATCTTCGCCGAGAGCGGCTTCGAGGCGGAGCCCTTCGGCGGCAACACGCTGC
TGATCCACGGGGTCCCCGCCGGCCTGGGGACGGATCACGTGGCCCGGCTGGTGTGCGACTTCCTGGACCGGCTGCAGGAG
GACCAGGTGGCCCCCGGCACGCCGGTCACGGACCGGCGCCGGCGCGTCCTGGCCGCGATGGCGGCCTGCAAGGCGGCGAT
CAAGGCGCGGGACCCGCTGCAGCCCGAGGACATCGCCGCGCTGCTCAGCGACCTGGCGGCCTGCGCGTCGCCCGAGACCT
GTCCCCACGGGCGGCCGACCGTCATCTGCGTGTCCATATCCGAGCTGGAGAAGAGGTTCAAGCGGTGA

Upstream 100 bases:

>100_bases
GCCCAGGAAGTAGAGAGCCTGACGGGCGGCGCCTCCGGCTGGGAAGGCGCCGCCGCAGTGTCACCGGCGGCTTCCGGGGC
TCCGAGGCGGAGGTGAGAGC

Downstream 100 bases:

>100_bases
AGCTGCCACTCGTGGTGCTGGTGGGCCCCACCGCAGTGGGCAAGACCGCCCTGTCCGTGGCGGTGGCCCAGGCGGTGGGG
GCGGAGATCATATCCGGCGA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 635; Mature: 634

Protein sequence:

>635_residues
MARIRLLDERTANQIAAGEVVERPASVVKELVENALDAQAKRIVVEVSGGGRELVRVTDDGIGMVPEDARLALQRHATSK
IRTAEDLNAITTLGFRGEALPSIAAVSQFELITRPHDQLAGYRILAEGGQIVAEGEHGCPAGTRVTVRDLFFNVPARLKY
LKTNATELAQIGDILTRLALANPEVAFRFQSGQAQVFATPGTGDLTAAVAALLGREMAKELLPVDYRNDAARVHGFVGRP
TIARAGRSHQYFFVNRRAVRTIAARYALEEAYAHLLPNGRYPVCILFIEVEPHEVDVNVHPTKAEVRFQRDREVRAAVYQ
AARHALGAALLIPGTEVTADGEVRVPDRAEEKAALQRGWVPPGAGRPGEGGGRAAPPPWRVSAGGPGGQTTAREPVQAYL
PAGGLQAALAQRAAEEAAAAVPAVDLAEATLVPRSAEPGELIRALRPLGQVHRSYIACDGPEGLYLIDQHAAHERIFFER
LYAAAQEQATAVQRLLFPLTLDLTPAQMAIWQENAAIFAESGFEAEPFGGNTLLIHGVPAGLGTDHVARLVCDFLDRLQE
DQVAPGTPVTDRRRRVLAAMAACKAAIKARDPLQPEDIAALLSDLAACASPETCPHGRPTVICVSISELEKRFKR

Sequences:

>Translated_635_residues
MARIRLLDERTANQIAAGEVVERPASVVKELVENALDAQAKRIVVEVSGGGRELVRVTDDGIGMVPEDARLALQRHATSK
IRTAEDLNAITTLGFRGEALPSIAAVSQFELITRPHDQLAGYRILAEGGQIVAEGEHGCPAGTRVTVRDLFFNVPARLKY
LKTNATELAQIGDILTRLALANPEVAFRFQSGQAQVFATPGTGDLTAAVAALLGREMAKELLPVDYRNDAARVHGFVGRP
TIARAGRSHQYFFVNRRAVRTIAARYALEEAYAHLLPNGRYPVCILFIEVEPHEVDVNVHPTKAEVRFQRDREVRAAVYQ
AARHALGAALLIPGTEVTADGEVRVPDRAEEKAALQRGWVPPGAGRPGEGGGRAAPPPWRVSAGGPGGQTTAREPVQAYL
PAGGLQAALAQRAAEEAAAAVPAVDLAEATLVPRSAEPGELIRALRPLGQVHRSYIACDGPEGLYLIDQHAAHERIFFER
LYAAAQEQATAVQRLLFPLTLDLTPAQMAIWQENAAIFAESGFEAEPFGGNTLLIHGVPAGLGTDHVARLVCDFLDRLQE
DQVAPGTPVTDRRRRVLAAMAACKAAIKARDPLQPEDIAALLSDLAACASPETCPHGRPTVICVSISELEKRFKR
>Mature_634_residues
ARIRLLDERTANQIAAGEVVERPASVVKELVENALDAQAKRIVVEVSGGGRELVRVTDDGIGMVPEDARLALQRHATSKI
RTAEDLNAITTLGFRGEALPSIAAVSQFELITRPHDQLAGYRILAEGGQIVAEGEHGCPAGTRVTVRDLFFNVPARLKYL
KTNATELAQIGDILTRLALANPEVAFRFQSGQAQVFATPGTGDLTAAVAALLGREMAKELLPVDYRNDAARVHGFVGRPT
IARAGRSHQYFFVNRRAVRTIAARYALEEAYAHLLPNGRYPVCILFIEVEPHEVDVNVHPTKAEVRFQRDREVRAAVYQA
ARHALGAALLIPGTEVTADGEVRVPDRAEEKAALQRGWVPPGAGRPGEGGGRAAPPPWRVSAGGPGGQTTAREPVQAYLP
AGGLQAALAQRAAEEAAAAVPAVDLAEATLVPRSAEPGELIRALRPLGQVHRSYIACDGPEGLYLIDQHAAHERIFFERL
YAAAQEQATAVQRLLFPLTLDLTPAQMAIWQENAAIFAESGFEAEPFGGNTLLIHGVPAGLGTDHVARLVCDFLDRLQED
QVAPGTPVTDRRRRVLAAMAACKAAIKARDPLQPEDIAALLSDLAACASPETCPHGRPTVICVSISELEKRFKR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=34.5454545454545, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI4505913, Length=336, Percent_Identity=29.7619047619048, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI310128478, Length=336, Percent_Identity=29.7619047619048, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI4505911, Length=358, Percent_Identity=27.9329608938547, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI189458898, Length=331, Percent_Identity=29.0030211480363, Blast_Score=135, Evalue=2e-31,
Organism=Homo sapiens, GI189458896, Length=346, Percent_Identity=28.3236994219653, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI310128480, Length=289, Percent_Identity=28.0276816608997, Blast_Score=116, Evalue=8e-26,
Organism=Homo sapiens, GI263191589, Length=236, Percent_Identity=28.8135593220339, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI91992162, Length=339, Percent_Identity=24.7787610619469, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI91992160, Length=339, Percent_Identity=24.7787610619469, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI310128484, Length=219, Percent_Identity=25.1141552511416, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI310128482, Length=219, Percent_Identity=25.1141552511416, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI310128486, Length=215, Percent_Identity=24.6511627906977, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1790612, Length=335, Percent_Identity=41.1940298507463, Blast_Score=236, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=34.0625, Blast_Score=188, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17562796, Length=376, Percent_Identity=25.2659574468085, Blast_Score=128, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=320, Percent_Identity=33.125, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324247, Length=351, Percent_Identity=26.2108262108262, Blast_Score=121, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6325093, Length=173, Percent_Identity=31.2138728323699, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323063, Length=161, Percent_Identity=30.4347826086957, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17136968, Length=351, Percent_Identity=35.042735042735, Blast_Score=208, Evalue=1e-53,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=26.890756302521, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_SYMTH (Q67NL0)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_075577.1
- HSSP:   P23367
- ProteinModelPortal:   Q67NL0
- SMR:   Q67NL0
- GeneID:   2979721
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH1748
- NMPDR:   fig|292459.1.peg.1686
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- BioCyc:   STHE292459:STH1748-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR008207
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- Gene3D:   G3DSA:1.20.120.160
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 68300; Mature: 68168

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIRLLDERTANQIAAGEVVERPASVVKELVENALDAQAKRIVVEVSGGGRELVRVTDD
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECC
GIGMVPEDARLALQRHATSKIRTAEDLNAITTLGFRGEALPSIAAVSQFELITRPHDQLA
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHC
GYRILAEGGQIVAEGEHGCPAGTRVTVRDLFFNVPARLKYLKTNATELAQIGDILTRLAL
CEEEEECCCEEEEECCCCCCCCCEEEHHHHHHCCCHHEEEECCCHHHHHHHHHHHHHHHH
ANPEVAFRFQSGQAQVFATPGTGDLTAAVAALLGREMAKELLPVDYRNDAARVHGFVGRP
CCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCC
TIARAGRSHQYFFVNRRAVRTIAARYALEEAYAHLLPNGRYPVCILFIEVEPHEVDVNVH
HHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEC
PTKAEVRFQRDREVRAAVYQAARHALGAALLIPGTEVTADGEVRVPDRAEEKAALQRGWV
CCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCEECCCCCEECCCCHHHHHHHHHCCC
PPGAGRPGEGGGRAAPPPWRVSAGGPGGQTTAREPVQAYLPAGGLQAALAQRAAEEAAAA
CCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
VPAVDLAEATLVPRSAEPGELIRALRPLGQVHRSYIACDGPEGLYLIDQHAAHERIFFER
CCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCHHHHHHHHH
LYAAAQEQATAVQRLLFPLTLDLTPAQMAIWQENAAIFAESGFEAEPFGGNTLLIHGVPA
HHHHHHHHHHHHHHHHHHHEECCCHHHHHHEECCCEEEECCCCCCCCCCCCEEEEEECCC
GLGTDHVARLVCDFLDRLQEDQVAPGTPVTDRRRRVLAAMAACKAAIKARDPLQPEDIAA
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LLSDLAACASPETCPHGRPTVICVSISELEKRFKR
HHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHCC
>Mature Secondary Structure 
ARIRLLDERTANQIAAGEVVERPASVVKELVENALDAQAKRIVVEVSGGGRELVRVTDD
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECC
GIGMVPEDARLALQRHATSKIRTAEDLNAITTLGFRGEALPSIAAVSQFELITRPHDQLA
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHC
GYRILAEGGQIVAEGEHGCPAGTRVTVRDLFFNVPARLKYLKTNATELAQIGDILTRLAL
CEEEEECCCEEEEECCCCCCCCCEEEHHHHHHCCCHHEEEECCCHHHHHHHHHHHHHHHH
ANPEVAFRFQSGQAQVFATPGTGDLTAAVAALLGREMAKELLPVDYRNDAARVHGFVGRP
CCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCC
TIARAGRSHQYFFVNRRAVRTIAARYALEEAYAHLLPNGRYPVCILFIEVEPHEVDVNVH
HHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEC
PTKAEVRFQRDREVRAAVYQAARHALGAALLIPGTEVTADGEVRVPDRAEEKAALQRGWV
CCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCEECCCCCEECCCCHHHHHHHHHCCC
PPGAGRPGEGGGRAAPPPWRVSAGGPGGQTTAREPVQAYLPAGGLQAALAQRAAEEAAAA
CCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
VPAVDLAEATLVPRSAEPGELIRALRPLGQVHRSYIACDGPEGLYLIDQHAAHERIFFER
CCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCHHHHHHHHH
LYAAAQEQATAVQRLLFPLTLDLTPAQMAIWQENAAIFAESGFEAEPFGGNTLLIHGVPA
HHHHHHHHHHHHHHHHHHHEECCCHHHHHHEECCCEEEECCCCCCCCCCCCEEEEEECCC
GLGTDHVARLVCDFLDRLQEDQVAPGTPVTDRRRRVLAAMAACKAAIKARDPLQPEDIAA
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LLSDLAACASPETCPHGRPTVICVSISELEKRFKR
HHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA