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The map label for this gene is dapE [H]

Identifier: 51892376

GI number: 51892376

Start: 1375941

End: 1377314

Strand: Reverse

Name: dapE [H]

Synonym: STH1238

Alternate gene names: 51892376

Gene position: 1377314-1375941 (Counterclockwise)

Preceding gene: 51892385

Following gene: 51892374

Centisome position: 38.62

GC content: 71.18

Gene sequence:

>1374_bases
GTGCAGCAGGTCGAAGCGTACCTGAGAGAGCGCCGTGATGAGCACCTGCGGCAGTTGATGGACTTCCTGCGGATCCCGTC
GGTCTCCGCCCTCTCGGAGCACCGGTCGGATGTGCGCCGGGCGGCCGAGTGGCTGGCCGCCGAGCTGCGCCGGATCGGCC
TCAACAGGGTCGAGGTGATGGAAACCGGCGGCCATCCGGTCGTCTACGCCGAGCGGCTGGACAACCCCGGCGGCCCGACG
GCCCTGATCTACGGCCACTACGACGTGCAGCCCGTCGACCCCATTGAGCTCTGGACCACCCCGCCGTTCGAGCCCGACAT
CCGGGACGGCAAGCTGTACGCCCGGGGCGCCAGCGACGACAAGGGTCAGGTGTTCATGCACCTGAAGGTGATCGAGGCCC
TGCTGGCTGCGGAGGGCCGGCTGCCCGTCAACGTGAAGCTCCTGATCGAGGGCGAGGAGGAAGTCGGCTCCGAAAACCTG
GAGCGGTTCATCGCGGCCCACCGGGACCTGCTGAAGGCGGATGTGGTCGTCATCTCCGACACGGCGCTGTACGCCCGGGG
CGTCCCGTCCCTCACCTACGCGCTGCGCGGCCTGGCGGCGCTGGAGGTCCACGTCATCGGCGCGAAGGGCGACCTGCACT
CCGGCGCCTTCGGCGGCGCCGCGCCCAACGCGGCCCAGGCCCTGGTTCAGCTCCTGGCCACCCTGCACAGGCCGGAGGGC
GGCGTCGCGGTGGCGGGCTTCTACGACCAGGTCCGGCCACTGACCCCGGAGGAGCGGGAGGGGTTCGCCGCCCTGGGCTT
CGACGAGGAGAAGCTGAAGGCCGACCTGGGCGTCGACGCCCTGCCCGGCGAGCCGGGGTACACGGCTCTGGAGCGGCTCT
GGGCCCGGCCGACCCTGGAGATCAACGGGATTTTCGGCGGGTTCCAGGGCGAGGGCACGAAGACCGTCATTCCCGCCCGG
GCCGGCGCCAAGATCACCTGCCGCCTGGTGCCCGACCAGGACCCGGAACGGGTGCTGGACGCCATCGAGGCGCACCTGAA
GGCCCACTGCCCCGCCGGCGTCAGGCTCGAGATCCGGCGCATGGGCGGCACCCCGGCGGCGATCACGCCCATCGACCACC
CGGCCATCCGCGCCGCGATGCAGGCGCTCTCCGACGCCTACGGCGCCGAGGCCCGGTTCATCCGCACCGGCGGGTCGATC
CCGGTGGTGGGCACCTTCGGGGCCGTCCTGGGCACGCCGTGCGTGCTGATGGGCTTCAGCCTGGAAGAGGAGAACTTCCA
CGCCCCGGACGAGCACTTCCACCTGGAGAACTTCGACCTGGGCATGCGGGCCCTGTCCCGGTTCTGGCACTACCTGGCCG
AGGGCATGAAGTAG

Upstream 100 bases:

>100_bases
TCTCGCACATCGCGTGTTGGCAAGGGGAGGAAAGAGGAATGACAGGTACAGGCCGTGGAAGAATCTCCGGTCAGGATGTG
CAGACAGGAGCGTGATGCGT

Downstream 100 bases:

>100_bases
GGGCGCCGCCTTTTTCGTCACGACTCGTGCGCGATGACCCCGCCGACCATGGTCAGCGTCGACCGGACGTCCTTCAACTC
GGCCGGGTCGCAGGCGAAGG

Product: hypothetical protein

Products: NA

Alternate protein names: SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MQQVEAYLRERRDEHLRQLMDFLRIPSVSALSEHRSDVRRAAEWLAAELRRIGLNRVEVMETGGHPVVYAERLDNPGGPT
ALIYGHYDVQPVDPIELWTTPPFEPDIRDGKLYARGASDDKGQVFMHLKVIEALLAAEGRLPVNVKLLIEGEEEVGSENL
ERFIAAHRDLLKADVVVISDTALYARGVPSLTYALRGLAALEVHVIGAKGDLHSGAFGGAAPNAAQALVQLLATLHRPEG
GVAVAGFYDQVRPLTPEEREGFAALGFDEEKLKADLGVDALPGEPGYTALERLWARPTLEINGIFGGFQGEGTKTVIPAR
AGAKITCRLVPDQDPERVLDAIEAHLKAHCPAGVRLEIRRMGGTPAAITPIDHPAIRAAMQALSDAYGAEARFIRTGGSI
PVVGTFGAVLGTPCVLMGFSLEEENFHAPDEHFHLENFDLGMRALSRFWHYLAEGMK

Sequences:

>Translated_457_residues
MQQVEAYLRERRDEHLRQLMDFLRIPSVSALSEHRSDVRRAAEWLAAELRRIGLNRVEVMETGGHPVVYAERLDNPGGPT
ALIYGHYDVQPVDPIELWTTPPFEPDIRDGKLYARGASDDKGQVFMHLKVIEALLAAEGRLPVNVKLLIEGEEEVGSENL
ERFIAAHRDLLKADVVVISDTALYARGVPSLTYALRGLAALEVHVIGAKGDLHSGAFGGAAPNAAQALVQLLATLHRPEG
GVAVAGFYDQVRPLTPEEREGFAALGFDEEKLKADLGVDALPGEPGYTALERLWARPTLEINGIFGGFQGEGTKTVIPAR
AGAKITCRLVPDQDPERVLDAIEAHLKAHCPAGVRLEIRRMGGTPAAITPIDHPAIRAAMQALSDAYGAEARFIRTGGSI
PVVGTFGAVLGTPCVLMGFSLEEENFHAPDEHFHLENFDLGMRALSRFWHYLAEGMK
>Mature_457_residues
MQQVEAYLRERRDEHLRQLMDFLRIPSVSALSEHRSDVRRAAEWLAAELRRIGLNRVEVMETGGHPVVYAERLDNPGGPT
ALIYGHYDVQPVDPIELWTTPPFEPDIRDGKLYARGASDDKGQVFMHLKVIEALLAAEGRLPVNVKLLIEGEEEVGSENL
ERFIAAHRDLLKADVVVISDTALYARGVPSLTYALRGLAALEVHVIGAKGDLHSGAFGGAAPNAAQALVQLLATLHRPEG
GVAVAGFYDQVRPLTPEEREGFAALGFDEEKLKADLGVDALPGEPGYTALERLWARPTLEINGIFGGFQGEGTKTVIPAR
AGAKITCRLVPDQDPERVLDAIEAHLKAHCPAGVRLEIRRMGGTPAAITPIDHPAIRAAMQALSDAYGAEARFIRTGGSI
PVVGTFGAVLGTPCVLMGFSLEEENFHAPDEHFHLENFDLGMRALSRFWHYLAEGMK

Specific function: Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bact

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. DapE subfamily [H]

Homologues:

Organism=Homo sapiens, GI271398239, Length=464, Percent_Identity=31.8965517241379, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI21071039, Length=472, Percent_Identity=32.2033898305085, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI271398277, Length=327, Percent_Identity=30.8868501529052, Blast_Score=168, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI193211059, Length=474, Percent_Identity=32.0675105485232, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17563146, Length=448, Percent_Identity=33.0357142857143, Blast_Score=228, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6321159, Length=464, Percent_Identity=30.3879310344828, Blast_Score=222, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6319758, Length=457, Percent_Identity=26.6958424507659, Blast_Score=163, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24585880, Length=469, Percent_Identity=33.6886993603412, Blast_Score=246, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR005941
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 49822; Mature: 49822

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQVEAYLRERRDEHLRQLMDFLRIPSVSALSEHRSDVRRAAEWLAAELRRIGLNRVEVM
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
ETGGHPVVYAERLDNPGGPTALIYGHYDVQPVDPIELWTTPPFEPDIRDGKLYARGASDD
ECCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCHHCCCCCCCCCCCCCCEEEEECCCCC
KGQVFMHLKVIEALLAAEGRLPVNVKLLIEGEEEVGSENLERFIAAHRDLLKADVVVISD
CCCEEEHHHHHHHHHHCCCCCCEEEEEEEECCHHHCHHHHHHHHHHHHHHHHHCEEEEEC
TALYARGVPSLTYALRGLAALEVHVIGAKGDLHSGAFGGAAPNAAQALVQLLATLHRPEG
CHHHHCCCCHHHHHHHCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
GVAVAGFYDQVRPLTPEEREGFAALGFDEEKLKADLGVDALPGEPGYTALERLWARPTLE
CEEEEEHHHHCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEE
INGIFGGFQGEGTKTVIPARAGAKITCRLVPDQDPERVLDAIEAHLKAHCPAGVRLEIRR
EEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
MGGTPAAITPIDHPAIRAAMQALSDAYGAEARFIRTGGSIPVVGTFGAVLGTPCVLMGFS
CCCCCCEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEECC
LEEENFHAPDEHFHLENFDLGMRALSRFWHYLAEGMK
CCCCCCCCCCHHEECCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQQVEAYLRERRDEHLRQLMDFLRIPSVSALSEHRSDVRRAAEWLAAELRRIGLNRVEVM
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
ETGGHPVVYAERLDNPGGPTALIYGHYDVQPVDPIELWTTPPFEPDIRDGKLYARGASDD
ECCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCHHCCCCCCCCCCCCCCEEEEECCCCC
KGQVFMHLKVIEALLAAEGRLPVNVKLLIEGEEEVGSENLERFIAAHRDLLKADVVVISD
CCCEEEHHHHHHHHHHCCCCCCEEEEEEEECCHHHCHHHHHHHHHHHHHHHHHCEEEEEC
TALYARGVPSLTYALRGLAALEVHVIGAKGDLHSGAFGGAAPNAAQALVQLLATLHRPEG
CHHHHCCCCHHHHHHHCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
GVAVAGFYDQVRPLTPEEREGFAALGFDEEKLKADLGVDALPGEPGYTALERLWARPTLE
CEEEEEHHHHCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEE
INGIFGGFQGEGTKTVIPARAGAKITCRLVPDQDPERVLDAIEAHLKAHCPAGVRLEIRR
EEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
MGGTPAAITPIDHPAIRAAMQALSDAYGAEARFIRTGGSIPVVGTFGAVLGTPCVLMGFS
CCCCCCEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEECC
LEEENFHAPDEHFHLENFDLGMRALSRFWHYLAEGMK
CCCCCCCCCCHHEECCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA