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The map label for this gene is algC [H]

Identifier: 51892256

GI number: 51892256

Start: 1243462

End: 1244895

Strand: Reverse

Name: algC [H]

Synonym: STH1118

Alternate gene names: 51892256

Gene position: 1244895-1243462 (Counterclockwise)

Preceding gene: 51892257

Following gene: 51892255

Centisome position: 34.91

GC content: 71.83

Gene sequence:

>1434_bases
ATGACCCAGACAATTTCCCCGCTGCCGGAGGTCATCTTCCGGGAGTACGACATCCGCGGCGTGTACGGCAGGACGATCAC
CGATGAGACGGCCCGCCTGGTCGGGCGGGCCTTCGCCCGGCTCGCCCGGGAGCGGGGCTTCCGCGAGGTGCTGGTGGGGC
GGGACAACCGGCTCTCGTCCCCCGCCCTCGCCCGGGCCCTTACGGAGGGCATCACCCGCGAGGGGCTGGACGTGCTGGAC
ATCGGGCAGGTGGTCACCCCCGTGCTCTACTGGGCTCGGGAGTTCTACGGCATCGACCCGGCGGTCATGATCACCGCCAG
CCACAACCCCGGCGACGAGAACGGTTTTAAGCTCTGCCTCGGCCCCGGCACGCTTTACGGGGAAGCGATCCAGGATCTCC
GCCGCAGGGCCGGGGCCCTGGCAGACGCCTCCCCCGAGGCGGAGATGGATCCGCGAGGCGGGACTGGCCCCGCGGCAGGA
GCGGGCCGGGTGCGCACCCGAGACCCGATCCCCAGCTACTGCGAGATGATCGCCGGCCGGGTGGCACTCCACCGCCCCCT
GAAAGTAGTGGTGGACGCCGGCAACGGCACCGCCGGCCCCATCGCACCCGGGCTCTTCCAAGCGCTGGGCTGTGAGGTCA
TCCCCCTCTACTGCGAGTCGGACCCCACCTTCCCGAACCATCATCCGGATCCGGTGCGGCCCGAGAACCTGCAGGACCTG
ATCCGCACGGTCCGGGAGACCGGGGCGGACCTGGGGCTGGCCTTCGACGGCGACGGCGATCGGCTGGGCGTCGTGGACGA
CCAGGGCCAGATCCTCTGGGGCGACCAGCTCATGATCCTCTTCTGGCGGGAGATCCTCCCCCGCTACCCCGGCGCCACCG
CCCTGGTGGAGGTCAAGTGCTCCCAGGCCCTGGTGGAGGAGATCGAGCGGCTGGGCGGCCGGCCGCAGTTCCACCGGACG
GGCCATTCCTACGTGAAGAAGAGCCTGCGGGAGCTGGGCGGCCCCTTCGCCGGCGAGATGTCGGGCCACCTCTTCTTCGC
CGACGGCTACTACGGCTTCGACGATGCCCTCTACGCCGGGGCCCGGCTCTGCCGGCTGGTGGCGGAGAGCGGCCGGCCGC
TGTCGGCGCTGTGGGCGGACGTGCCCCGGTACCCGTCCACCCCCGAGATCCGGGTGGACTGCCCGGAGGAGCGCAAGGCC
GCGGTGGTCGAGGGCGTGGTGCGGCACTTCCGGGACCGGTACGAGGTGCTGACGGTGGACGGCGCGCGGGTCCTCTTCCC
CGGCGGCTGGGGGCTGGTCCGGGCGTCCAACACCCAGCCGGTGCTGGTGCTCCGGTGCGAGGGGCGCTCGACCGAGGACC
TGGAGCGGGTGAAGGCGGAGATGGCCGAAGCCCTGGCCCGCTTCCCGGAGCTGGGCCCCGTAAGTTGGGAGTAG

Upstream 100 bases:

>100_bases
TGAACCGCAACCAGGGCGCGGAGTCCACCCTGGCATGGCTGATGGCGGCTTACGGTCTGGAGCAGCGCTCGGCGCTCAGC
ACGGCTGTGAGGTGATGGAC

Downstream 100 bases:

>100_bases
GGCGAGTCCGCGATGCAGGTATTCCATGGGCACGAGGTTCAGGCCGGGCAAGGGGGAGCCCCGCTCCCTGCCCGGCCCTG
GCTTGCCGGAACAGCGGGGG

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MTQTISPLPEVIFREYDIRGVYGRTITDETARLVGRAFARLARERGFREVLVGRDNRLSSPALARALTEGITREGLDVLD
IGQVVTPVLYWAREFYGIDPAVMITASHNPGDENGFKLCLGPGTLYGEAIQDLRRRAGALADASPEAEMDPRGGTGPAAG
AGRVRTRDPIPSYCEMIAGRVALHRPLKVVVDAGNGTAGPIAPGLFQALGCEVIPLYCESDPTFPNHHPDPVRPENLQDL
IRTVRETGADLGLAFDGDGDRLGVVDDQGQILWGDQLMILFWREILPRYPGATALVEVKCSQALVEEIERLGGRPQFHRT
GHSYVKKSLRELGGPFAGEMSGHLFFADGYYGFDDALYAGARLCRLVAESGRPLSALWADVPRYPSTPEIRVDCPEERKA
AVVEGVVRHFRDRYEVLTVDGARVLFPGGWGLVRASNTQPVLVLRCEGRSTEDLERVKAEMAEALARFPELGPVSWE

Sequences:

>Translated_477_residues
MTQTISPLPEVIFREYDIRGVYGRTITDETARLVGRAFARLARERGFREVLVGRDNRLSSPALARALTEGITREGLDVLD
IGQVVTPVLYWAREFYGIDPAVMITASHNPGDENGFKLCLGPGTLYGEAIQDLRRRAGALADASPEAEMDPRGGTGPAAG
AGRVRTRDPIPSYCEMIAGRVALHRPLKVVVDAGNGTAGPIAPGLFQALGCEVIPLYCESDPTFPNHHPDPVRPENLQDL
IRTVRETGADLGLAFDGDGDRLGVVDDQGQILWGDQLMILFWREILPRYPGATALVEVKCSQALVEEIERLGGRPQFHRT
GHSYVKKSLRELGGPFAGEMSGHLFFADGYYGFDDALYAGARLCRLVAESGRPLSALWADVPRYPSTPEIRVDCPEERKA
AVVEGVVRHFRDRYEVLTVDGARVLFPGGWGLVRASNTQPVLVLRCEGRSTEDLERVKAEMAEALARFPELGPVSWE
>Mature_476_residues
TQTISPLPEVIFREYDIRGVYGRTITDETARLVGRAFARLARERGFREVLVGRDNRLSSPALARALTEGITREGLDVLDI
GQVVTPVLYWAREFYGIDPAVMITASHNPGDENGFKLCLGPGTLYGEAIQDLRRRAGALADASPEAEMDPRGGTGPAAGA
GRVRTRDPIPSYCEMIAGRVALHRPLKVVVDAGNGTAGPIAPGLFQALGCEVIPLYCESDPTFPNHHPDPVRPENLQDLI
RTVRETGADLGLAFDGDGDRLGVVDDQGQILWGDQLMILFWREILPRYPGATALVEVKCSQALVEEIERLGGRPQFHRTG
HSYVKKSLRELGGPFAGEMSGHLFFADGYYGFDDALYAGARLCRLVAESGRPLSALWADVPRYPSTPEIRVDCPEERKAA
VVEGVVRHFRDRYEVLTVDGARVLFPGGWGLVRASNTQPVLVLRCEGRSTEDLERVKAEMAEALARFPELGPVSWE

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=448, Percent_Identity=32.8125, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI1789566, Length=455, Percent_Identity=28.1318681318681, Blast_Score=116, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 52286; Mature: 52155

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTISPLPEVIFREYDIRGVYGRTITDETARLVGRAFARLARERGFREVLVGRDNRLSS
CCCCCCHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
PALARALTEGITREGLDVLDIGQVVTPVLYWAREFYGIDPAVMITASHNPGDENGFKLCL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEE
GPGTLYGEAIQDLRRRAGALADASPEAEMDPRGGTGPAAGAGRVRTRDPIPSYCEMIAGR
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
VALHRPLKVVVDAGNGTAGPIAPGLFQALGCEVIPLYCESDPTFPNHHPDPVRPENLQDL
HHHCCCEEEEEECCCCCCCCCCHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHH
IRTVRETGADLGLAFDGDGDRLGVVDDQGQILWGDQLMILFWREILPRYPGATALVEVKC
HHHHHHCCCCEEEEECCCCCEEEEECCCCCEEECCHHHHHHHHHHHCCCCCCCEEEEEHH
SQALVEEIERLGGRPQFHRTGHSYVKKSLRELGGPFAGEMSGHLFFADGYYGFDDALYAG
HHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHH
ARLCRLVAESGRPLSALWADVPRYPSTPEIRVDCPEERKAAVVEGVVRHFRDRYEVLTVD
HHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCEEEEEEC
GARVLFPGGWGLVRASNTQPVLVLRCEGRSTEDLERVKAEMAEALARFPELGPVSWE
CCEEEECCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TQTISPLPEVIFREYDIRGVYGRTITDETARLVGRAFARLARERGFREVLVGRDNRLSS
CCCCCHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
PALARALTEGITREGLDVLDIGQVVTPVLYWAREFYGIDPAVMITASHNPGDENGFKLCL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEE
GPGTLYGEAIQDLRRRAGALADASPEAEMDPRGGTGPAAGAGRVRTRDPIPSYCEMIAGR
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
VALHRPLKVVVDAGNGTAGPIAPGLFQALGCEVIPLYCESDPTFPNHHPDPVRPENLQDL
HHHCCCEEEEEECCCCCCCCCCHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHH
IRTVRETGADLGLAFDGDGDRLGVVDDQGQILWGDQLMILFWREILPRYPGATALVEVKC
HHHHHHCCCCEEEEECCCCCEEEEECCCCCEEECCHHHHHHHHHHHCCCCCCCEEEEEHH
SQALVEEIERLGGRPQFHRTGHSYVKKSLRELGGPFAGEMSGHLFFADGYYGFDDALYAG
HHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHH
ARLCRLVAESGRPLSALWADVPRYPSTPEIRVDCPEERKAAVVEGVVRHFRDRYEVLTVD
HHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCEEEEEEC
GARVLFPGGWGLVRASNTQPVLVLRCEGRSTEDLERVKAEMAEALARFPELGPVSWE
CCEEEECCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]