Click here to switch to the map view.

The map label for this gene is menA [H]

Identifier: 51892209

GI number: 51892209

Start: 1183742

End: 1184641

Strand: Reverse

Name: menA [H]

Synonym: STH1071

Alternate gene names: 51892209

Gene position: 1184641-1183742 (Counterclockwise)

Preceding gene: 51892215

Following gene: 51892206

Centisome position: 33.22

GC content: 70.22

Gene sequence:

>900_bases
ATGGCTGTACGGGCAAGATTCGGCGTCTGGTGGCGCATGCTCCGCCCCTTCACCCTCGTGGCCAGCGTGGCGCCCGTGCT
GGGCGGCACCGCCCTGGCCTACGCGCACGGCGGTTTCCACACGGGCCGCTTCCTGGCCTTCCTGTTGGCGGCGGTGCTGA
TTCAGTCGGCCACCAATATGTTCAACGAATACTTCGATTATGTGCGCGGGCTGGACACCCGGGACCACGTGGGCATCGCG
GGGACCATCGTGCGCGACGGCGTATCGCCCCGGGTGGTCATCACGCTGGCCTGGATGTTCCTGGCCACCGCCGTGGCCCT
GGGGCTCTACATCTCCGCCACCAGCTCGTGGTGGGTCTTCGCCGTCGGCCTGGCCTGCCTCGGCGTTGCGTTCCTGTACT
CGGGCGGTCCGCTGCCGCTGTCGTCGACCCCCTTCGGGGAGCTGGCGGCCGGTTTCACGATGGGCCCGGTCATGATTCTG
CTGGTCTACTACACCCAGACGCTGCGGGTGACCGCGACGGCGCTGTGGGTCGCCGTGCCCATCGGCATCCTCATCGGCGC
GATCCTGCTGGCCAACAACATCCGGGACATCGAGGCCGATCGCGCGGGCGGGAGGCACACCCTGCCCATCGTGCTGGGCC
GCGGCGCCGCGGTGGGCGTCCTCGCCGGCAGCTTCGTGCTGGCTTACGCCATCGCCGTGGGCCTGGTGGCGACGGGCCGG
CTCACCCCGTGGGCCCTGCTGATCCTGCTGTCGCTGCCCAAGGCGTGGCCCCCGGTCCGGCTGTTTCTGCGGGAGCGGGA
GCCGGTGCGGCTGCATCCGGCGGTCAAGGGCGTGGCGCAGCTGCTGGCCGGCTTCGGCGGCCTGATGACGCTCGGTCTCC
TGCTCTCGGTCTGGGTATGA

Upstream 100 bases:

>100_bases
GCGTCCGAATGGGGACAACCGCATCGGGGGCTGTGCCGCCCTCACATGGGTCTGATAGTATAATAGGCGATGAATACAGA
TCGCTAAGAAGGAGCGTCGT

Downstream 100 bases:

>100_bases
CGGCCGGCTCGGCGGTTCCGGACAGGCGGCGCCGGGGATCTCCCCGGCGCCGCTTGCGCGTCCTCGGCGTGTCGCTATAC
CAGCCTGCGCCGCATGGCCA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MAVRARFGVWWRMLRPFTLVASVAPVLGGTALAYAHGGFHTGRFLAFLLAAVLIQSATNMFNEYFDYVRGLDTRDHVGIA
GTIVRDGVSPRVVITLAWMFLATAVALGLYISATSSWWVFAVGLACLGVAFLYSGGPLPLSSTPFGELAAGFTMGPVMIL
LVYYTQTLRVTATALWVAVPIGILIGAILLANNIRDIEADRAGGRHTLPIVLGRGAAVGVLAGSFVLAYAIAVGLVATGR
LTPWALLILLSLPKAWPPVRLFLREREPVRLHPAVKGVAQLLAGFGGLMTLGLLLSVWV

Sequences:

>Translated_299_residues
MAVRARFGVWWRMLRPFTLVASVAPVLGGTALAYAHGGFHTGRFLAFLLAAVLIQSATNMFNEYFDYVRGLDTRDHVGIA
GTIVRDGVSPRVVITLAWMFLATAVALGLYISATSSWWVFAVGLACLGVAFLYSGGPLPLSSTPFGELAAGFTMGPVMIL
LVYYTQTLRVTATALWVAVPIGILIGAILLANNIRDIEADRAGGRHTLPIVLGRGAAVGVLAGSFVLAYAIAVGLVATGR
LTPWALLILLSLPKAWPPVRLFLREREPVRLHPAVKGVAQLLAGFGGLMTLGLLLSVWV
>Mature_298_residues
AVRARFGVWWRMLRPFTLVASVAPVLGGTALAYAHGGFHTGRFLAFLLAAVLIQSATNMFNEYFDYVRGLDTRDHVGIAG
TIVRDGVSPRVVITLAWMFLATAVALGLYISATSSWWVFAVGLACLGVAFLYSGGPLPLSSTPFGELAAGFTMGPVMILL
VYYTQTLRVTATALWVAVPIGILIGAILLANNIRDIEADRAGGRHTLPIVLGRGAAVGVLAGSFVLAYAIAVGLVATGRL
TPWALLILLSLPKAWPPVRLFLREREPVRLHPAVKGVAQLLAGFGGLMTLGLLLSVWV

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=215, Percent_Identity=31.1627906976744, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1790365, Length=308, Percent_Identity=29.2207792207792, Blast_Score=91, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17737429, Length=281, Percent_Identity=29.5373665480427, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 31822; Mature: 31691

Theoretical pI: Translated: 10.79; Mature: 10.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVRARFGVWWRMLRPFTLVASVAPVLGGTALAYAHGGFHTGRFLAFLLAAVLIQSATNM
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
FNEYFDYVRGLDTRDHVGIAGTIVRDGVSPRVVITLAWMFLATAVALGLYISATSSWWVF
HHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
AVGLACLGVAFLYSGGPLPLSSTPFGELAAGFTMGPVMILLVYYTQTLRVTATALWVAVP
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGILIGAILLANNIRDIEADRAGGRHTLPIVLGRGAAVGVLAGSFVLAYAIAVGLVATGR
HHHHHHHHHHHCCCCCCHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
LTPWALLILLSLPKAWPPVRLFLREREPVRLHPAVKGVAQLLAGFGGLMTLGLLLSVWV
CHHHHHHHHHHCCCCCCHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AVRARFGVWWRMLRPFTLVASVAPVLGGTALAYAHGGFHTGRFLAFLLAAVLIQSATNM
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
FNEYFDYVRGLDTRDHVGIAGTIVRDGVSPRVVITLAWMFLATAVALGLYISATSSWWVF
HHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
AVGLACLGVAFLYSGGPLPLSSTPFGELAAGFTMGPVMILLVYYTQTLRVTATALWVAVP
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGILIGAILLANNIRDIEADRAGGRHTLPIVLGRGAAVGVLAGSFVLAYAIAVGLVATGR
HHHHHHHHHHHCCCCCCHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
LTPWALLILLSLPKAWPPVRLFLREREPVRLHPAVKGVAQLLAGFGGLMTLGLLLSVWV
CHHHHHHHHHHCCCCCCHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]