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The map label for this gene is glcD [H]

Identifier: 51892131

GI number: 51892131

Start: 1111592

End: 1113061

Strand: Reverse

Name: glcD [H]

Synonym: STH993

Alternate gene names: 51892131

Gene position: 1113061-1111592 (Counterclockwise)

Preceding gene: 51892132

Following gene: 51892130

Centisome position: 31.21

GC content: 68.84

Gene sequence:

>1470_bases
GTGAAGGGGTCCGACCATCAGACCACTCGCAGGACCTCGCGAAAGGAAGGCGAAAGCATGCTCACGCCGGAAATCCTCGC
CGCGCTCCGGGCGGCGGTCGGCGAAGAGTGGTGCCTGACCAGCAAGGCTGATCTCATGGCCTACTCCTATGACGCCACGC
CGCTTTACCAGCGGCTCCCCGACGCCGTCGTTCTGCCCCGGACCACCGAGGAGGTGGCCGCGGTGCTGCAGATCGCGCAC
GCGCATCGCATCCCGGTATTTACCCGGGGCGCGGGCACGAACCTGGCCGCCGGCACGGTGCCCGCAGGCGGCGGCATCGT
CCTGTCCCTGAACCGCATGAACCGGATCCTGGAGATCGACCAGGAGAACCTGACGGCCACCGCAGAGGCCGGGGTCATCA
CCGCCGAGCTGCACAAGGCCGTCGAGGCCGTGGGCCTGTTCTACCCGCCCGACCCCGGCTCCATGACCTCCTCGACCCTC
GGGGGCAACGTCATGGAGTCCGCCGGCGGCCTGCGCGGCCTGAAGTACGGCGTGACCAAGGACTACGTCATGGGCCTCAC
GGCCGTGACGGCCGACGGCCGCATCTTCCGGGCCGGCGGCAAGAACGTGAAGGACGTTGCCGGCTACGACCTGGTGAAGC
TGATCTGCGGGTCCGAGGGGACCCTCTGCGTGGTCACCGAGGTCATCCTGAAGCTGCTGCCGATGCCCGAGGCCAAGCGC
ACGGCCCTGGCGGTGTTCCACGACATGGAGGCGGCCGCGCGGACCGTCAGCCGGATCATCGCGGCCCGCATCATCCCGTG
CACCCTCGAGTTCATGGACAACGGCACCATCCGCGCCGTGGAGGACTACGTCCACCTGGGCCTGCCCACAGACGCCGCGG
CCCTGCTGCTCATCCAGCAGGACGGCCCGGCGTCGGTCTGCGACGCCGACATTCAGCGGATCGCCCAGATCTGCCGGGAA
GAGGGCGCCACGCGGGTGGAACACGCCAGCGATCCCGCCGAGCAGGACCGGCTGATGCAGGCGAGGCGCTTTGCGCTCTC
GGCCCTGGCCCGGCGCAGGCCCACCACGATCCTGGAGGACGCGACGGTGCCCCGCAGCCAGATCGCCCCGATGGTGGCGG
AGATTCAGCGCATCGCGCAGAAGTACGACCTGGACATCTGCACCTTCGGCCACGCCGGCGACGGCAACCTCCACCCCACC
TGCATGACCGACGAGCGGAACAAGGAGGAGATCCAGCGGGTCGAGCAGGCCTTTGCAGAGATCTTCGCCGCCGCCCTGGA
GCTGGGCGGCACCATCACCGGCGAGCACGGGGTGGGCGAGGCCAAGTCGCCGTACCTGGAGTGGAAGGTCGGACCCGTCG
GCATCGAGCTCATGAAGAACATCAAGAAAGCCTTCGATCCCCACGGCATCCTGAACCCGGGCAAGCTCTTCGCGGGCGAG
ACCCGGAAGCGGGTGGTGGTCCGCCAGTGA

Upstream 100 bases:

>100_bases
CCCTGGGCCAGACCGAATAGCCCGCGCAAGACGAGGAGCCTGCGCTCCTCGCCAGTCTTTTTTGTGGGGACAAGACCATG
TTTCATGCGTTATGATAGCG

Downstream 100 bases:

>100_bases
AGGTGCAGATCTCCGAGGATATGATCCTCAACTGCATGCGCTGCGGGTTCTGCCTGCCCGCCTGTCCCACCTACCGGTAC
AAGCAGGTGGAGTCGGCGAG

Product: glycolate oxidase subunit

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MKGSDHQTTRRTSRKEGESMLTPEILAALRAAVGEEWCLTSKADLMAYSYDATPLYQRLPDAVVLPRTTEEVAAVLQIAH
AHRIPVFTRGAGTNLAAGTVPAGGGIVLSLNRMNRILEIDQENLTATAEAGVITAELHKAVEAVGLFYPPDPGSMTSSTL
GGNVMESAGGLRGLKYGVTKDYVMGLTAVTADGRIFRAGGKNVKDVAGYDLVKLICGSEGTLCVVTEVILKLLPMPEAKR
TALAVFHDMEAAARTVSRIIAARIIPCTLEFMDNGTIRAVEDYVHLGLPTDAAALLLIQQDGPASVCDADIQRIAQICRE
EGATRVEHASDPAEQDRLMQARRFALSALARRRPTTILEDATVPRSQIAPMVAEIQRIAQKYDLDICTFGHAGDGNLHPT
CMTDERNKEEIQRVEQAFAEIFAAALELGGTITGEHGVGEAKSPYLEWKVGPVGIELMKNIKKAFDPHGILNPGKLFAGE
TRKRVVVRQ

Sequences:

>Translated_489_residues
MKGSDHQTTRRTSRKEGESMLTPEILAALRAAVGEEWCLTSKADLMAYSYDATPLYQRLPDAVVLPRTTEEVAAVLQIAH
AHRIPVFTRGAGTNLAAGTVPAGGGIVLSLNRMNRILEIDQENLTATAEAGVITAELHKAVEAVGLFYPPDPGSMTSSTL
GGNVMESAGGLRGLKYGVTKDYVMGLTAVTADGRIFRAGGKNVKDVAGYDLVKLICGSEGTLCVVTEVILKLLPMPEAKR
TALAVFHDMEAAARTVSRIIAARIIPCTLEFMDNGTIRAVEDYVHLGLPTDAAALLLIQQDGPASVCDADIQRIAQICRE
EGATRVEHASDPAEQDRLMQARRFALSALARRRPTTILEDATVPRSQIAPMVAEIQRIAQKYDLDICTFGHAGDGNLHPT
CMTDERNKEEIQRVEQAFAEIFAAALELGGTITGEHGVGEAKSPYLEWKVGPVGIELMKNIKKAFDPHGILNPGKLFAGE
TRKRVVVRQ
>Mature_489_residues
MKGSDHQTTRRTSRKEGESMLTPEILAALRAAVGEEWCLTSKADLMAYSYDATPLYQRLPDAVVLPRTTEEVAAVLQIAH
AHRIPVFTRGAGTNLAAGTVPAGGGIVLSLNRMNRILEIDQENLTATAEAGVITAELHKAVEAVGLFYPPDPGSMTSSTL
GGNVMESAGGLRGLKYGVTKDYVMGLTAVTADGRIFRAGGKNVKDVAGYDLVKLICGSEGTLCVVTEVILKLLPMPEAKR
TALAVFHDMEAAARTVSRIIAARIIPCTLEFMDNGTIRAVEDYVHLGLPTDAAALLLIQQDGPASVCDADIQRIAQICRE
EGATRVEHASDPAEQDRLMQARRFALSALARRRPTTILEDATVPRSQIAPMVAEIQRIAQKYDLDICTFGHAGDGNLHPT
CMTDERNKEEIQRVEQAFAEIFAAALELGGTITGEHGVGEAKSPYLEWKVGPVGIELMKNIKKAFDPHGILNPGKLFAGE
TRKRVVVRQ

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=472, Percent_Identity=32.8389830508475, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI37595754, Length=495, Percent_Identity=31.3131313131313, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI119964728, Length=421, Percent_Identity=29.9287410926366, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI4501993, Length=224, Percent_Identity=32.1428571428571, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1789351, Length=451, Percent_Identity=39.9113082039911, Blast_Score=320, Evalue=2e-88,
Organism=Escherichia coli, GI1787977, Length=513, Percent_Identity=27.2904483430799, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI48994907, Length=486, Percent_Identity=26.7489711934156, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI48994914, Length=125, Percent_Identity=36.8, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71992373, Length=457, Percent_Identity=29.7592997811816, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI71992381, Length=457, Percent_Identity=29.1028446389497, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17534361, Length=470, Percent_Identity=26.5957446808511, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71992392, Length=379, Percent_Identity=30.6068601583113, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17556096, Length=466, Percent_Identity=26.8240343347639, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320027, Length=453, Percent_Identity=30.9050772626932, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6320764, Length=488, Percent_Identity=28.0737704918033, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6320023, Length=478, Percent_Identity=29.0794979079498, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI18921117, Length=468, Percent_Identity=30.7692307692308, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24639277, Length=468, Percent_Identity=30.7692307692308, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24639275, Length=468, Percent_Identity=30.7692307692308, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24653753, Length=473, Percent_Identity=26.6384778012685, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 52729; Mature: 52729

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGSDHQTTRRTSRKEGESMLTPEILAALRAAVGEEWCLTSKADLMAYSYDATPLYQRLP
CCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHCCCCCCCCEEEECCCCHHHHHCC
DAVVLPRTTEEVAAVLQIAHAHRIPVFTRGAGTNLAAGTVPAGGGIVLSLNRMNRILEID
CCEECCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCEEEEHHHHHHHHHCC
QENLTATAEAGVITAELHKAVEAVGLFYPPDPGSMTSSTLGGNVMESAGGLRGLKYGVTK
CCCCEEHHHCCCHHHHHHHHHHHHCCEECCCCCCCCCHHCCCHHHHHCCCCCCCCCCCCH
DYVMGLTAVTADGRIFRAGGKNVKDVAGYDLVKLICGSEGTLCVVTEVILKLLPMPEAKR
HHHHHEEEEECCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHH
TALAVFHDMEAAARTVSRIIAARIIPCTLEFMDNGTIRAVEDYVHLGLPTDAAALLLIQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEHHHHHCCCCCCCEEEEEEEC
DGPASVCDADIQRIAQICREEGATRVEHASDPAEQDRLMQARRFALSALARRRPTTILED
CCCCHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEECC
ATVPRSQIAPMVAEIQRIAQKYDLDICTFGHAGDGNLHPTCMTDERNKEEIQRVEQAFAE
CCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHHHH
IFAAALELGGTITGEHGVGEAKSPYLEWKVGPVGIELMKNIKKAFDPHGILNPGKLFAGE
HHHHHHHHCCEEECCCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
TRKRVVVRQ
CCCEEEECC
>Mature Secondary Structure
MKGSDHQTTRRTSRKEGESMLTPEILAALRAAVGEEWCLTSKADLMAYSYDATPLYQRLP
CCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHCCCCCCCCEEEECCCCHHHHHCC
DAVVLPRTTEEVAAVLQIAHAHRIPVFTRGAGTNLAAGTVPAGGGIVLSLNRMNRILEID
CCEECCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCEEEEHHHHHHHHHCC
QENLTATAEAGVITAELHKAVEAVGLFYPPDPGSMTSSTLGGNVMESAGGLRGLKYGVTK
CCCCEEHHHCCCHHHHHHHHHHHHCCEECCCCCCCCCHHCCCHHHHHCCCCCCCCCCCCH
DYVMGLTAVTADGRIFRAGGKNVKDVAGYDLVKLICGSEGTLCVVTEVILKLLPMPEAKR
HHHHHEEEEECCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHH
TALAVFHDMEAAARTVSRIIAARIIPCTLEFMDNGTIRAVEDYVHLGLPTDAAALLLIQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEHHHHHCCCCCCCEEEEEEEC
DGPASVCDADIQRIAQICREEGATRVEHASDPAEQDRLMQARRFALSALARRRPTTILED
CCCCHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEECC
ATVPRSQIAPMVAEIQRIAQKYDLDICTFGHAGDGNLHPTCMTDERNKEEIQRVEQAFAE
CCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHHHH
IFAAALELGGTITGEHGVGEAKSPYLEWKVGPVGIELMKNIKKAFDPHGILNPGKLFAGE
HHHHHHHHCCEEECCCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
TRKRVVVRQ
CCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]