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The map label for this gene is dmsA2 [H]

Identifier: 51891851

GI number: 51891851

Start: 784868

End: 787444

Strand: Reverse

Name: dmsA2 [H]

Synonym: STH713

Alternate gene names: 51891851

Gene position: 787444-784868 (Counterclockwise)

Preceding gene: 51891852

Following gene: 51891850

Centisome position: 22.08

GC content: 66.63

Gene sequence:

>2577_bases
ATGGCCAAACTCATCCGATCAGCAGGCCAGTATAAGCTCGATCGGCGTCGGTTCCTGGGCTGGAGCGCCGCAACCGCAGG
CGCAGCGCTGCTGCTCGGCAACCAGACGGGGCTGCTCAAACTGGACCCGGCAAAGGCCAAGGCAGCTCCCGCTGCCGAAG
AGGGCAAGTGGGTCACCGCGGCCTGCTGGCACAACTGTGGCGGCCGGTGCCTGAACAAGGCCCTGGTCAGGGACGGCGTC
GTCATCCGACAGAAGACCGACGACACCCACGAAGACTCGCCCGACTTCCCGCAGCAGCGCGGCTGCGCCCGCGGCCGGTC
GCAGCGGAAGCAGGTCTTCGCGGTGGACCGGCTCCGGTACCCGATGAAGCGCAAGCACTGGGAACCCGGCGGCGGCCGGA
AGGACCTCCGGGGTCGCGACGAGTGGGTCCGCATCTCGTGGGACGAGGCGCTGGACATCGTCGCCAGCGAGATCAAGCGG
ATCGTGGAGAAGTACGGCAACCGCGCCATCCTCTCCACCGGCGGCAGCGAGATCGGCCGCACCCTGGCGCTCTACGGCGG
GTATGTGGGCACCTGGGGCACGACGTCGTGGGGAAGCTGGCGCTGGGGGCCGGCCAAGTTCGGCATGGCGGAAGGGTACA
ACGATACCAGCATCAACGACCGGCTCGACCTGCGTAATTCCAACCTGATCGTGATCTGGGGCGGGAACCCGGCGTGGAGC
GCGGGCGGCAGCCCGACCTACCACTACCTGCAGGCCAAGAAGGCCGGGGCCAAGTTCATCTTCATCGACCCGATCTACCA
CCAGTCGGCGGAGCTGCTGGCCGATGAGTGGATCCCCATCCGGCCCGGCACCGACCACGCGATGATGCTGGGCATGGCCT
ACACCCTGATCACCGAAGACGATCCCGTCAACAACCCGCTGATCGACTGGGACTTCCTGAACCGCTGCACGGTCGGCTTC
GACGCGGACCACATGCCGGAGGGCGCCGACCCGAAGGAGAACTTCAAGGACTACGTCCTGGGCACCTACGACGGCCAGCC
CAAGACGCCGGAGTGGGCCTCCGAGATCTGCGGCGTCGATCCGCACACCATCCGCCGGCTGGCCCGGGAGATCGCGACCA
CCCCGCGCGTCGCCCTGCTCACCGCCTGGGCGCCCGCCCGCACGCGCAACTCCGACAGCTGGCCCCAGATGTTCATGACC
TTCGGCGCGATGACCGGCCACATGGGCCAGCCGGGCCGCATGACGGGCGTGAGCTGCCACCGGCATACCGCCAACGGCGG
CCCCAACCTGGTGACGAGCGGCGGCGCCGGCCTGCCGGGCATCAAGAACCCGATCAACGAATCGATCAACGACAGCGAGC
TCTGGAACGCGGTCCTCACCGGCAAGTACACCGCAGGCTACAACGACGTCCGGGACATCAACATCCAGATGATCTACCAC
GGCGGCGGCGCCATCCTGCAGACCCGGGACGGCATGACCAAGGGCATCGAGGCGCACCGCCACGTCGAGTTCGTGGTCTC
CCACAGCCAGTTCCTCACCACCAACTCGAAGTACGCGGACATCGTGCTGCCCGTGACCACGCCCTGGGAGCGGCTGGGCG
GCCTGCTGACCGGCAACCGCGAGATCCTCATCTACTACACCAACGTCACGCAGCCGCTGTTCGAGGCCAAGGACGACGCC
TGGATCGCCACCGAGATCGCCAAGCGGCTGGGCTTCAAGGAAGAGGACATCTACCCGATCTCCGAGAAGCAGCAGCTCTT
CAACCAGCTGGCCGGGTCGAAGGTGATGAAGGAAGACGGTTCGGGGTACGAACCGCTGCTCACCATCACCGAGGAAGACA
TCGCCGAATGGGGCGTGGAAGGCAAGCCGCAGCAGGGGCGCATCACCCTGAAGGAGTTCGAGGAGCGCGGCATCTACCAG
GTGCCCCGCCGTCCGGGCGACAAGCTTGGCTTCATCGCCTACGAGGCCTTCCGGAAGGATCCCGAGAACAACCCGCTCAA
CACCGCCAGCGGCAAGCTGGAGATCCACTGCCAGGCTCTCGCGGACCTGATCAAGGGCTACGGCTTCACCGAGATTGATC
CGATCCCCACCTACCAGCCGCGCAAGGAAGGCTATGAGGACACCTTCGCGGACTGGGAGAAGAAGATCAAGGGCGAGTAC
CCGCTCCAGGTCATCAACCCGCACTACCCGCGGCGCTCCCACAGCGTCTTCGACAACGTGACCTGGCTCCGCGAGGCCTT
CCCCAGCATGGTGATGCTGAACAGCCAGGACGCCGCCGCCCGGGGCATCAAGGACGGCGACACCGTGCTCATCACCAGCC
GTCACGGCAAGGTCCTGCGCCGGGCGCACGTCACCGACCTGATCATGCCCGGCGTCGTGGGACTGCCCCACGGGGCCTGG
GTGGAGATGGACGAGGAGAAGCAGATCGACAAGGCCGGCGCCGACAACATCCTCTGCGGCGGAATCCCCTCCGGCCAGGG
CATCTCGGCGTGGAACTCCTGTATCGTCGAGGTCACGCGTTACGACGAGCCGCTGGCACCCGACCACACCTGGGAGCCGC
GGATCCCCCTGAAGTAA

Upstream 100 bases:

>100_bases
AAAACTGGACGTAGTTGCCTGCGTCCCCGTGCCCGTGGCCACCCTGCGGACGAAGTCCCGGGCACGGGGAATGGTGAATA
ACCCGTGGAGGTGGACGCAC

Downstream 100 bases:

>100_bases
GGAGGCGGCGTCACCGTGGCACAGAAAGGCTTTTACTATGACATGACCGCCTGCGTCGGGTGCAAGGCTTGCTACATCGC
GTGCAAGGATAAGAACGACC

Product: anaerobic dimethyl sulfoxide reductase subunit A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 858; Mature: 857

Protein sequence:

>858_residues
MAKLIRSAGQYKLDRRRFLGWSAATAGAALLLGNQTGLLKLDPAKAKAAPAAEEGKWVTAACWHNCGGRCLNKALVRDGV
VIRQKTDDTHEDSPDFPQQRGCARGRSQRKQVFAVDRLRYPMKRKHWEPGGGRKDLRGRDEWVRISWDEALDIVASEIKR
IVEKYGNRAILSTGGSEIGRTLALYGGYVGTWGTTSWGSWRWGPAKFGMAEGYNDTSINDRLDLRNSNLIVIWGGNPAWS
AGGSPTYHYLQAKKAGAKFIFIDPIYHQSAELLADEWIPIRPGTDHAMMLGMAYTLITEDDPVNNPLIDWDFLNRCTVGF
DADHMPEGADPKENFKDYVLGTYDGQPKTPEWASEICGVDPHTIRRLAREIATTPRVALLTAWAPARTRNSDSWPQMFMT
FGAMTGHMGQPGRMTGVSCHRHTANGGPNLVTSGGAGLPGIKNPINESINDSELWNAVLTGKYTAGYNDVRDINIQMIYH
GGGAILQTRDGMTKGIEAHRHVEFVVSHSQFLTTNSKYADIVLPVTTPWERLGGLLTGNREILIYYTNVTQPLFEAKDDA
WIATEIAKRLGFKEEDIYPISEKQQLFNQLAGSKVMKEDGSGYEPLLTITEEDIAEWGVEGKPQQGRITLKEFEERGIYQ
VPRRPGDKLGFIAYEAFRKDPENNPLNTASGKLEIHCQALADLIKGYGFTEIDPIPTYQPRKEGYEDTFADWEKKIKGEY
PLQVINPHYPRRSHSVFDNVTWLREAFPSMVMLNSQDAAARGIKDGDTVLITSRHGKVLRRAHVTDLIMPGVVGLPHGAW
VEMDEEKQIDKAGADNILCGGIPSGQGISAWNSCIVEVTRYDEPLAPDHTWEPRIPLK

Sequences:

>Translated_858_residues
MAKLIRSAGQYKLDRRRFLGWSAATAGAALLLGNQTGLLKLDPAKAKAAPAAEEGKWVTAACWHNCGGRCLNKALVRDGV
VIRQKTDDTHEDSPDFPQQRGCARGRSQRKQVFAVDRLRYPMKRKHWEPGGGRKDLRGRDEWVRISWDEALDIVASEIKR
IVEKYGNRAILSTGGSEIGRTLALYGGYVGTWGTTSWGSWRWGPAKFGMAEGYNDTSINDRLDLRNSNLIVIWGGNPAWS
AGGSPTYHYLQAKKAGAKFIFIDPIYHQSAELLADEWIPIRPGTDHAMMLGMAYTLITEDDPVNNPLIDWDFLNRCTVGF
DADHMPEGADPKENFKDYVLGTYDGQPKTPEWASEICGVDPHTIRRLAREIATTPRVALLTAWAPARTRNSDSWPQMFMT
FGAMTGHMGQPGRMTGVSCHRHTANGGPNLVTSGGAGLPGIKNPINESINDSELWNAVLTGKYTAGYNDVRDINIQMIYH
GGGAILQTRDGMTKGIEAHRHVEFVVSHSQFLTTNSKYADIVLPVTTPWERLGGLLTGNREILIYYTNVTQPLFEAKDDA
WIATEIAKRLGFKEEDIYPISEKQQLFNQLAGSKVMKEDGSGYEPLLTITEEDIAEWGVEGKPQQGRITLKEFEERGIYQ
VPRRPGDKLGFIAYEAFRKDPENNPLNTASGKLEIHCQALADLIKGYGFTEIDPIPTYQPRKEGYEDTFADWEKKIKGEY
PLQVINPHYPRRSHSVFDNVTWLREAFPSMVMLNSQDAAARGIKDGDTVLITSRHGKVLRRAHVTDLIMPGVVGLPHGAW
VEMDEEKQIDKAGADNILCGGIPSGQGISAWNSCIVEVTRYDEPLAPDHTWEPRIPLK
>Mature_857_residues
AKLIRSAGQYKLDRRRFLGWSAATAGAALLLGNQTGLLKLDPAKAKAAPAAEEGKWVTAACWHNCGGRCLNKALVRDGVV
IRQKTDDTHEDSPDFPQQRGCARGRSQRKQVFAVDRLRYPMKRKHWEPGGGRKDLRGRDEWVRISWDEALDIVASEIKRI
VEKYGNRAILSTGGSEIGRTLALYGGYVGTWGTTSWGSWRWGPAKFGMAEGYNDTSINDRLDLRNSNLIVIWGGNPAWSA
GGSPTYHYLQAKKAGAKFIFIDPIYHQSAELLADEWIPIRPGTDHAMMLGMAYTLITEDDPVNNPLIDWDFLNRCTVGFD
ADHMPEGADPKENFKDYVLGTYDGQPKTPEWASEICGVDPHTIRRLAREIATTPRVALLTAWAPARTRNSDSWPQMFMTF
GAMTGHMGQPGRMTGVSCHRHTANGGPNLVTSGGAGLPGIKNPINESINDSELWNAVLTGKYTAGYNDVRDINIQMIYHG
GGAILQTRDGMTKGIEAHRHVEFVVSHSQFLTTNSKYADIVLPVTTPWERLGGLLTGNREILIYYTNVTQPLFEAKDDAW
IATEIAKRLGFKEEDIYPISEKQQLFNQLAGSKVMKEDGSGYEPLLTITEEDIAEWGVEGKPQQGRITLKEFEERGIYQV
PRRPGDKLGFIAYEAFRKDPENNPLNTASGKLEIHCQALADLIKGYGFTEIDPIPTYQPRKEGYEDTFADWEKKIKGEYP
LQVINPHYPRRSHSVFDNVTWLREAFPSMVMLNSQDAAARGIKDGDTVLITSRHGKVLRRAHVTDLIMPGVVGLPHGAWV
EMDEEKQIDKAGADNILCGGIPSGQGISAWNSCIVEVTRYDEPLAPDHTWEPRIPLK

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=852, Percent_Identity=33.8028169014084, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1787870, Length=845, Percent_Identity=33.0177514792899, Blast_Score=373, Evalue=1e-104,
Organism=Escherichia coli, GI171474008, Length=845, Percent_Identity=31.2426035502959, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI145693196, Length=790, Percent_Identity=31.3924050632911, Blast_Score=279, Evalue=7e-76,
Organism=Escherichia coli, GI87081994, Length=885, Percent_Identity=28.8135593220339, Blast_Score=243, Evalue=3e-65,
Organism=Escherichia coli, GI1787231, Length=791, Percent_Identity=28.8242730720607, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI3868721, Length=475, Percent_Identity=25.0526315789474, Blast_Score=115, Evalue=2e-26,
Organism=Escherichia coli, GI1787477, Length=293, Percent_Identity=26.962457337884, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI3868720, Length=346, Percent_Identity=25.1445086705202, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI3868719, Length=346, Percent_Identity=24.5664739884393, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 95586; Mature: 95455

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLIRSAGQYKLDRRRFLGWSAATAGAALLLGNQTGLLKLDPAKAKAAPAAEEGKWVTA
CCHHHHHCCCCCHHHHHHCCCCHHHCCEEEEEECCCCEEEECCCCCCCCCCCCCCCEEEE
ACWHNCGGRCLNKALVRDGVVIRQKTDDTHEDSPDFPQQRGCARGRSQRKQVFAVDRLRY
HHHHCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PMKRKHWEPGGGRKDLRGRDEWVRISWDEALDIVASEIKRIVEKYGNRAILSTGGSEIGR
CHHHCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHH
TLALYGGYVGTWGTTSWGSWRWGPAKFGMAEGYNDTSINDRLDLRNSNLIVIWGGNPAWS
HHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCC
AGGSPTYHYLQAKKAGAKFIFIDPIYHQSAELLADEWIPIRPGTDHAMMLGMAYTLITED
CCCCCCEEEEEHHCCCCEEEEECCHHHCHHHHHHHCCEECCCCCCHHHHHHEEEEEEECC
DPVNNPLIDWDFLNRCTVGFDADHMPEGADPKENFKDYVLGTYDGQPKTPEWASEICGVD
CCCCCCEECHHHHCCEECCCCCCCCCCCCCHHHHHHHCEEEECCCCCCCHHHHHHHCCCC
PHTIRRLAREIATTPRVALLTAWAPARTRNSDSWPQMFMTFGAMTGHMGQPGRMTGVSCH
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEE
RHTANGGPNLVTSGGAGLPGIKNPINESINDSELWNAVLTGKYTAGYNDVRDINIQMIYH
CCCCCCCCCEEECCCCCCCCCCCHHHCCCCHHHHHHHHHCCCEECCCCCEEEEEEEEEEE
GGGAILQTRDGMTKGIEAHRHVEFVVSHSQFLTTNSKYADIVLPVTTPWERLGGLLTGNR
CCCEEEEECCCCHHHHHHHHEEEEEEECCCEEECCCCCEEEEEECCCCHHHHCCEEECCC
EILIYYTNVTQPLFEAKDDAWIATEIAKRLGFKEEDIYPISEKQQLFNQLAGSKVMKEDG
EEEEEEECCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCC
SGYEPLLTITEEDIAEWGVEGKPQQGRITLKEFEERGIYQVPRRPGDKLGFIAYEAFRKD
CCCCCEEEECHHHHHHCCCCCCCCCCCEEHHHHHHCCCEECCCCCCCCEEHEEHHHHHCC
PENNPLNTASGKLEIHCQALADLIKGYGFTEIDPIPTYQPRKEGYEDTFADWEKKIKGEY
CCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
PLQVINPHYPRRSHSVFDNVTWLREAFPSMVMLNSQDAAARGIKDGDTVLITSRHGKVLR
CEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHCCCCCCCEEEEECCCCHHHH
RAHVTDLIMPGVVGLPHGAWVEMDEEKQIDKAGADNILCGGIPSGQGISAWNSCIVEVTR
HHHHHHHHHCCCCCCCCCCEEEECHHHHHHHCCCCCEEECCCCCCCCCHHHHHHEEEHHH
YDEPLAPDHTWEPRIPLK
CCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKLIRSAGQYKLDRRRFLGWSAATAGAALLLGNQTGLLKLDPAKAKAAPAAEEGKWVTA
CHHHHHCCCCCHHHHHHCCCCHHHCCEEEEEECCCCEEEECCCCCCCCCCCCCCCEEEE
ACWHNCGGRCLNKALVRDGVVIRQKTDDTHEDSPDFPQQRGCARGRSQRKQVFAVDRLRY
HHHHCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PMKRKHWEPGGGRKDLRGRDEWVRISWDEALDIVASEIKRIVEKYGNRAILSTGGSEIGR
CHHHCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHH
TLALYGGYVGTWGTTSWGSWRWGPAKFGMAEGYNDTSINDRLDLRNSNLIVIWGGNPAWS
HHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCC
AGGSPTYHYLQAKKAGAKFIFIDPIYHQSAELLADEWIPIRPGTDHAMMLGMAYTLITED
CCCCCCEEEEEHHCCCCEEEEECCHHHCHHHHHHHCCEECCCCCCHHHHHHEEEEEEECC
DPVNNPLIDWDFLNRCTVGFDADHMPEGADPKENFKDYVLGTYDGQPKTPEWASEICGVD
CCCCCCEECHHHHCCEECCCCCCCCCCCCCHHHHHHHCEEEECCCCCCCHHHHHHHCCCC
PHTIRRLAREIATTPRVALLTAWAPARTRNSDSWPQMFMTFGAMTGHMGQPGRMTGVSCH
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEE
RHTANGGPNLVTSGGAGLPGIKNPINESINDSELWNAVLTGKYTAGYNDVRDINIQMIYH
CCCCCCCCCEEECCCCCCCCCCCHHHCCCCHHHHHHHHHCCCEECCCCCEEEEEEEEEEE
GGGAILQTRDGMTKGIEAHRHVEFVVSHSQFLTTNSKYADIVLPVTTPWERLGGLLTGNR
CCCEEEEECCCCHHHHHHHHEEEEEEECCCEEECCCCCEEEEEECCCCHHHHCCEEECCC
EILIYYTNVTQPLFEAKDDAWIATEIAKRLGFKEEDIYPISEKQQLFNQLAGSKVMKEDG
EEEEEEECCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCC
SGYEPLLTITEEDIAEWGVEGKPQQGRITLKEFEERGIYQVPRRPGDKLGFIAYEAFRKD
CCCCCEEEECHHHHHHCCCCCCCCCCCEEHHHHHHCCCEECCCCCCCCEEHEEHHHHHCC
PENNPLNTASGKLEIHCQALADLIKGYGFTEIDPIPTYQPRKEGYEDTFADWEKKIKGEY
CCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
PLQVINPHYPRRSHSVFDNVTWLREAFPSMVMLNSQDAAARGIKDGDTVLITSRHGKVLR
CEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHCCCCCCCEEEEECCCCHHHH
RAHVTDLIMPGVVGLPHGAWVEMDEEKQIDKAGADNILCGGIPSGQGISAWNSCIVEVTR
HHHHHHHHHCCCCCCCCCCEEEECHHHHHHHCCCCCEEECCCCCCCCCHHHHHHEEEHHH
YDEPLAPDHTWEPRIPLK
CCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]