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The map label for this gene is glpK [H]

Identifier: 51598502

GI number: 51598502

Start: 245534

End: 247039

Strand: Direct

Name: glpK [H]

Synonym: BG0244

Alternate gene names: 51598502

Gene position: 245534-247039 (Clockwise)

Preceding gene: 51598501

Following gene: 51598503

Centisome position: 27.15

GC content: 34.59

Gene sequence:

>1506_bases
ATGAAATATATTTTATCTATTGATCAAGGTACTACTAGCTCAAGAGCAATAGTATTTGATAAACATGCAAACATAAAAGG
GCTTGCTCAAAAAGAATTTACTCAAATTTATCCACAACCAAGCTGGGTGGAGCATGATCCTACTGAAATATGGGGATCGC
AACTTGGAGTTATAACAGAAGCTCTTGCAAATTCAAGAATTTTACCAAATGAAGTTGATGCTATTGGAATAACTAATCAA
AGAGAAACTACAGTTATATGGGAAAAAAGTACAGGAAAACCCATTTATAATGCAATAGTATGGCAAGATAGAAGAACTGC
AAAAATTTGTGACCAATTAACAAAAGAGGGAAAAGATAAAATTATTTTGGAAAAAACAGGTTTAGTACTAGATTCTTATT
TTAGTGGTACAAAAATACTGTGGATCTTGGATAATGTAGAGGGCGCTAGACAAAAAGCTGAAAATGGTGAATTGTGTTTT
GGAACAATAGATACATGGCTATTATGGAATCTGACTCAAAAAAAAGTACATGCAACCGACTATTCTAATGCTTCAAGAAC
ATTATTGTTAAACATTAAAACATTAGAATGGGATGATGAACTTTTAAAGATATTAAATATTCCAAAAGCAATTTTGCCTG
AACTTAAAGAAAGCTCTACAATATATGGCGAAACAGACAAATCGATATTTGGAGCAGAAATTCCTATTGCAGGAATTGCC
GGAGATCAATTTGCAGCAACATTTGGACAAGCCTGCCTTAAAAAAGGTATGGCTAAAAACACATATGGAACTGGTTGCTT
TTTAACGGTAAATATAGGTAAAGAACCAATTATTAACCATGAAAGACTTTTAACTTCAATCGCCTGGGGAAGAAAAAAAA
CCGTAACTTATGTTCTTGAAGGAAGCGTTTTTATTGGTGGAGCCGTAATCCAATGGCTAAGAGACGGTCTTGAATTTTTC
AGAAAAAGTTCAGATGCAGAATCATTGGCAAGCTCTGCTTCAGATAATGGAGGGGTTTATTTTGTACCAGCATTTGTTGG
GCTCGGTGCACCTCATTGGGATTCTTATGCAAGAGGAACAATCATTGGAATAACAAGGGGATCGACAAAAGCGCACATTA
CAAGAGCTGCTCTTGAAAGCATCGCATTTCAAAGTTTTGATATACTAAATACTATGAAAAAATCCATTCCCAACTTTGAA
ATTAAAGAATTAAGAGTAGACGGAGGAGCAAGTCAAAACAATCTATTAATGCAATTTCAAGCTGATCTTTTAGAATGTAA
AGTTGTAAGACCAAAAATAACAGAAACAACAGCACTTGGGGCTGCTTATCTTGCAGGACTTGCATCGGGTTATTGGCAAA
GCGCCGAGGAAATCATAAGCCTTTGGCAAGTAGATAAAATATTTGAACCTTCAATGCCAAAAAATCAAAAAGAAAAGCTT
CTTGAAAATTGGAACAGAGCAATTGAAAGATCAAAATCCTGGATACAGAATTCCAATAGTCTATAA

Upstream 100 bases:

>100_bases
TAATTGGAGCAATTTTAGGCGCTACAATTTACGAATTTACACTAAAAAACAATAAAGGCTAAAAGATATTCAGCTTTATT
AAAACTAAAAGGGAAAAATT

Downstream 100 bases:

>100_bases
AAGTTTAAAACAAGACTTTAAAGATTATAACAAAAATATACCGGAGACAAAATTATGCACAATTTATTTGATTTTTTTAA
AACTAGAACAACATATGATA

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MKYILSIDQGTTSSRAIVFDKHANIKGLAQKEFTQIYPQPSWVEHDPTEIWGSQLGVITEALANSRILPNEVDAIGITNQ
RETTVIWEKSTGKPIYNAIVWQDRRTAKICDQLTKEGKDKIILEKTGLVLDSYFSGTKILWILDNVEGARQKAENGELCF
GTIDTWLLWNLTQKKVHATDYSNASRTLLLNIKTLEWDDELLKILNIPKAILPELKESSTIYGETDKSIFGAEIPIAGIA
GDQFAATFGQACLKKGMAKNTYGTGCFLTVNIGKEPIINHERLLTSIAWGRKKTVTYVLEGSVFIGGAVIQWLRDGLEFF
RKSSDAESLASSASDNGGVYFVPAFVGLGAPHWDSYARGTIIGITRGSTKAHITRAALESIAFQSFDILNTMKKSIPNFE
IKELRVDGGASQNNLLMQFQADLLECKVVRPKITETTALGAAYLAGLASGYWQSAEEIISLWQVDKIFEPSMPKNQKEKL
LENWNRAIERSKSWIQNSNSL

Sequences:

>Translated_501_residues
MKYILSIDQGTTSSRAIVFDKHANIKGLAQKEFTQIYPQPSWVEHDPTEIWGSQLGVITEALANSRILPNEVDAIGITNQ
RETTVIWEKSTGKPIYNAIVWQDRRTAKICDQLTKEGKDKIILEKTGLVLDSYFSGTKILWILDNVEGARQKAENGELCF
GTIDTWLLWNLTQKKVHATDYSNASRTLLLNIKTLEWDDELLKILNIPKAILPELKESSTIYGETDKSIFGAEIPIAGIA
GDQFAATFGQACLKKGMAKNTYGTGCFLTVNIGKEPIINHERLLTSIAWGRKKTVTYVLEGSVFIGGAVIQWLRDGLEFF
RKSSDAESLASSASDNGGVYFVPAFVGLGAPHWDSYARGTIIGITRGSTKAHITRAALESIAFQSFDILNTMKKSIPNFE
IKELRVDGGASQNNLLMQFQADLLECKVVRPKITETTALGAAYLAGLASGYWQSAEEIISLWQVDKIFEPSMPKNQKEKL
LENWNRAIERSKSWIQNSNSL
>Mature_501_residues
MKYILSIDQGTTSSRAIVFDKHANIKGLAQKEFTQIYPQPSWVEHDPTEIWGSQLGVITEALANSRILPNEVDAIGITNQ
RETTVIWEKSTGKPIYNAIVWQDRRTAKICDQLTKEGKDKIILEKTGLVLDSYFSGTKILWILDNVEGARQKAENGELCF
GTIDTWLLWNLTQKKVHATDYSNASRTLLLNIKTLEWDDELLKILNIPKAILPELKESSTIYGETDKSIFGAEIPIAGIA
GDQFAATFGQACLKKGMAKNTYGTGCFLTVNIGKEPIINHERLLTSIAWGRKKTVTYVLEGSVFIGGAVIQWLRDGLEFF
RKSSDAESLASSASDNGGVYFVPAFVGLGAPHWDSYARGTIIGITRGSTKAHITRAALESIAFQSFDILNTMKKSIPNFE
IKELRVDGGASQNNLLMQFQADLLECKVVRPKITETTALGAAYLAGLASGYWQSAEEIISLWQVDKIFEPSMPKNQKEKL
LENWNRAIERSKSWIQNSNSL

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=503, Percent_Identity=43.7375745526839, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI4504007, Length=503, Percent_Identity=43.7375745526839, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI41393575, Length=507, Percent_Identity=43.7869822485207, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI42794763, Length=508, Percent_Identity=43.503937007874, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI88196792, Length=508, Percent_Identity=34.4488188976378, Blast_Score=330, Evalue=2e-90,
Organism=Escherichia coli, GI1790361, Length=494, Percent_Identity=54.6558704453441, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI1790005, Length=504, Percent_Identity=25, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1787789, Length=483, Percent_Identity=25.0517598343685, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789138, Length=493, Percent_Identity=23.9350912778905, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789168, Length=505, Percent_Identity=23.5643564356436, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17535599, Length=506, Percent_Identity=40.3162055335968, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71986140, Length=516, Percent_Identity=27.7131782945736, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71986147, Length=296, Percent_Identity=31.0810810810811, Blast_Score=137, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321755, Length=558, Percent_Identity=36.3799283154122, Blast_Score=310, Evalue=3e-85,
Organism=Drosophila melanogaster, GI17864214, Length=506, Percent_Identity=42.2924901185771, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24654573, Length=434, Percent_Identity=44.4700460829493, Blast_Score=359, Evalue=3e-99,
Organism=Drosophila melanogaster, GI24655555, Length=503, Percent_Identity=38.9662027833002, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24655560, Length=503, Percent_Identity=38.9662027833002, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24655570, Length=503, Percent_Identity=38.9662027833002, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24655574, Length=503, Percent_Identity=38.9662027833002, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24655565, Length=503, Percent_Identity=38.9662027833002, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI19922058, Length=527, Percent_Identity=32.8273244781784, Blast_Score=292, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24652871, Length=494, Percent_Identity=33.8056680161943, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24656367, Length=515, Percent_Identity=31.0679611650485, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI21357867, Length=531, Percent_Identity=30.1318267419962, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24656372, Length=351, Percent_Identity=31.9088319088319, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI45552909, Length=291, Percent_Identity=29.2096219931272, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55707; Mature: 55707

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYILSIDQGTTSSRAIVFDKHANIKGLAQKEFTQIYPQPSWVEHDPTEIWGSQLGVITE
CCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
ALANSRILPNEVDAIGITNQRETTVIWEKSTGKPIYNAIVWQDRRTAKICDQLTKEGKDK
HHHCCCCCCCCCCEEECCCCCCEEEEEECCCCCCHHHHEEECCCCHHHHHHHHHHCCCCE
IILEKTGLVLDSYFSGTKILWILDNVEGARQKAENGELCFGTIDTWLLWNLTQKKVHATD
EEEEECCCEEECCCCCCEEEEEEECCCHHHHHCCCCCEEEEEHHHHHHCCCHHHEEEECC
YSNASRTLLLNIKTLEWDDELLKILNIPKAILPELKESSTIYGETDKSIFGAEIPIAGIA
CCCCCCEEEEEEEEECCHHHHHHHHCCCHHHHHHHHCCCEEECCCCCCCCCCCCCEEECC
GDQFAATFGQACLKKGMAKNTYGTGCFLTVNIGKEPIINHERLLTSIAWGRKKTVTYVLE
CCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEEE
GSVFIGGAVIQWLRDGLEFFRKSSDAESLASSASDNGGVYFVPAFVGLGAPHWDSYARGT
CCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEHHHCCCCCCCCCCCCCE
IIGITRGSTKAHITRAALESIAFQSFDILNTMKKSIPNFEIKELRVDGGASQNNLLMQFQ
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEE
ADLLECKVVRPKITETTALGAAYLAGLASGYWQSAEEIISLWQVDKIFEPSMPKNQKEKL
HHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LENWNRAIERSKSWIQNSNSL
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKYILSIDQGTTSSRAIVFDKHANIKGLAQKEFTQIYPQPSWVEHDPTEIWGSQLGVITE
CCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
ALANSRILPNEVDAIGITNQRETTVIWEKSTGKPIYNAIVWQDRRTAKICDQLTKEGKDK
HHHCCCCCCCCCCEEECCCCCCEEEEEECCCCCCHHHHEEECCCCHHHHHHHHHHCCCCE
IILEKTGLVLDSYFSGTKILWILDNVEGARQKAENGELCFGTIDTWLLWNLTQKKVHATD
EEEEECCCEEECCCCCCEEEEEEECCCHHHHHCCCCCEEEEEHHHHHHCCCHHHEEEECC
YSNASRTLLLNIKTLEWDDELLKILNIPKAILPELKESSTIYGETDKSIFGAEIPIAGIA
CCCCCCEEEEEEEEECCHHHHHHHHCCCHHHHHHHHCCCEEECCCCCCCCCCCCCEEECC
GDQFAATFGQACLKKGMAKNTYGTGCFLTVNIGKEPIINHERLLTSIAWGRKKTVTYVLE
CCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEEE
GSVFIGGAVIQWLRDGLEFFRKSSDAESLASSASDNGGVYFVPAFVGLGAPHWDSYARGT
CCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEHHHCCCCCCCCCCCCCE
IIGITRGSTKAHITRAALESIAFQSFDILNTMKKSIPNFEIKELRVDGGASQNNLLMQFQ
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEE
ADLLECKVVRPKITETTALGAAYLAGLASGYWQSAEEIISLWQVDKIFEPSMPKNQKEKL
HHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LENWNRAIERSKSWIQNSNSL
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA