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The map label for this gene is mutL [H]

Identifier: 51598472

GI number: 51598472

Start: 214377

End: 216212

Strand: Direct

Name: mutL [H]

Synonym: BG0213

Alternate gene names: 51598472

Gene position: 214377-216212 (Clockwise)

Preceding gene: 51598471

Following gene: 51598473

Centisome position: 23.71

GC content: 25.82

Gene sequence:

>1836_bases
ATGAACAAAATAAGATTCTTAGATAAATACTTGGTTCAAAAAATAGCAGCGGGAGAATCAATAGATAGACCATGTTCAAT
ATTAAGAGAATTGCTAGACAATTCAATAGATTCTGGAGCTACTAAAATTGAAGTCTTTCTTGAAGAAGGGGGAATTCATA
AAATCTTAATAATAGACAATGGAATCGGAATAGGTAAAGAAGATTTAAAAATATGCTATTTACCACACACTACTTCAAAG
ATCTCCTCAGAAGAAGATTTGAGAAAAATAGAAACTCTAGGATTTAGAGGAGAAGCTCTCTCTAGTATTGCAATTTGCTC
CAACATTTCAATAACAAGCTCAACAACTGGTAATGAAAGCTATCAAATAGAAGTAGAAAATGGAATTGAAAAATGCTTTA
AAAAACAACCTGCCATAAACGGAACAATAGTTAATGTTACAAAAATATTTCACAACTTTCCGGCAAGAAAAAGATTTTTA
AAGCAAGAACCAATTGAAACAAAAATGTGTCTAAAAGTTTTAGAAGAAAAAATAATAACCCATCCCGAAATCAATTTCGA
AATTAATTTGAATCAAAAACTAAGAAAAATTTACTTTAAAGAATCGTTAATTGATAGAGTGCAAAATGTATATGGAAATG
TAATAGAAAATAATAAATTTAAGGTCTTAAAAAAAGAACATGAAAATATAAAAATAGAATTATTTTTAGCACCAGCTAAT
TTTTCTAAAAAAAGTAAAAGACATATTAAAACATTTGTTAACAGAAGACCTATTGATCAAAAAGATCTCTTAGAAGCAAT
AACTAATGGACACAGTAGAATAATTTCTCCTGGCAACTTCCCAATATGTTATTTATTTTTAGAAATAAACCCTGAATATA
TTGACTTTAATGTCCATCCTCAAAAAAAAGAAGTAAGATTTTTTAATCTTCCATTTTTATTTAAGTTAATCTCTGACAAT
ATTAATAATTTTTTTGATAAAGACATAAATAGCTACAACGAAATAGTAATAAAAAGACAATTAACAGATGATGATAATTT
AATAGAAATGATAAACCAACCAAAAAACCTTAATAAAACTAACACATATGATATAATACAAAACAAAAATTTAGAAACAG
AACATACTGTAAACGATCTAAGCAAAAACATAATACAAAACGATATTGGCCTTAGAAGATATAATTCAATTATACAAAAC
AGACCATCATTTAAGGAAAATATTACAAACATTTTCTCTGACAAATTTTTAGAATTTGAAGAACCACCAAACAAAAATGA
AAAAGAAGAAATAAAATTTAACTATATCGGGCAAATATTCTCTGAATTTTTGATCGTTGAAAAAGTAAATGAAATTTACT
TCATAGACCAACACGCAGTTCATGAAAAAATAATATATGAAAAACTTAGAAATTCAAAAAAAACTGTTCAAAAGCTTCTA
ATACCAATTGAATTCACAATAGTTGATAAAAACATAGAAGAAATTATAGATAGTGAAATCGAAGAATACAAAAAAATGGA
CATTATAATCTCTAAAATAGGCCCTAAAAAATATCAACTTGAATCTATTCCTAATATTTGCAATCAATATGAAAATACTC
TTATTAATTTTTTTCAATCAAGAAAAAGTAGAACAATAAATTCTCTTGAATCTGATTTATATGCAAATATTGCCTGTAGA
AAGGCTGTTAAAACAAATGACATATTAAGCCTTGAATTTAGCAAATTTTTAATAGATGAGTTTTTCAAACTAGAAATAAA
ACATTGTCCTCACGGACGAAAAATTTATTACAAAATATCTAAATTTGAGCTTGAAAAAAAAGTTGCCAGAGCATAA

Upstream 100 bases:

>100_bases
TGAAAATAATAATGATCAAATATTAAGAGAACTTGTCAAAAAATTTCCAAATTACAAAAAAAATGAAAATATTAGAAAAA
TAATAGGAATATAAACTTCA

Downstream 100 bases:

>100_bases
AATGAAATCAGAGTTCCCATGATAAAAAAAATCAAATCCGAAATCAGCTTGATAAAGGTAGAAAAAGAAAAAAGTTTAAT
TGAACTTGGAAAAATATTAA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 611; Mature: 611

Protein sequence:

>611_residues
MNKIRFLDKYLVQKIAAGESIDRPCSILRELLDNSIDSGATKIEVFLEEGGIHKILIIDNGIGIGKEDLKICYLPHTTSK
ISSEEDLRKIETLGFRGEALSSIAICSNISITSSTTGNESYQIEVENGIEKCFKKQPAINGTIVNVTKIFHNFPARKRFL
KQEPIETKMCLKVLEEKIITHPEINFEINLNQKLRKIYFKESLIDRVQNVYGNVIENNKFKVLKKEHENIKIELFLAPAN
FSKKSKRHIKTFVNRRPIDQKDLLEAITNGHSRIISPGNFPICYLFLEINPEYIDFNVHPQKKEVRFFNLPFLFKLISDN
INNFFDKDINSYNEIVIKRQLTDDDNLIEMINQPKNLNKTNTYDIIQNKNLETEHTVNDLSKNIIQNDIGLRRYNSIIQN
RPSFKENITNIFSDKFLEFEEPPNKNEKEEIKFNYIGQIFSEFLIVEKVNEIYFIDQHAVHEKIIYEKLRNSKKTVQKLL
IPIEFTIVDKNIEEIIDSEIEEYKKMDIIISKIGPKKYQLESIPNICNQYENTLINFFQSRKSRTINSLESDLYANIACR
KAVKTNDILSLEFSKFLIDEFFKLEIKHCPHGRKIYYKISKFELEKKVARA

Sequences:

>Translated_611_residues
MNKIRFLDKYLVQKIAAGESIDRPCSILRELLDNSIDSGATKIEVFLEEGGIHKILIIDNGIGIGKEDLKICYLPHTTSK
ISSEEDLRKIETLGFRGEALSSIAICSNISITSSTTGNESYQIEVENGIEKCFKKQPAINGTIVNVTKIFHNFPARKRFL
KQEPIETKMCLKVLEEKIITHPEINFEINLNQKLRKIYFKESLIDRVQNVYGNVIENNKFKVLKKEHENIKIELFLAPAN
FSKKSKRHIKTFVNRRPIDQKDLLEAITNGHSRIISPGNFPICYLFLEINPEYIDFNVHPQKKEVRFFNLPFLFKLISDN
INNFFDKDINSYNEIVIKRQLTDDDNLIEMINQPKNLNKTNTYDIIQNKNLETEHTVNDLSKNIIQNDIGLRRYNSIIQN
RPSFKENITNIFSDKFLEFEEPPNKNEKEEIKFNYIGQIFSEFLIVEKVNEIYFIDQHAVHEKIIYEKLRNSKKTVQKLL
IPIEFTIVDKNIEEIIDSEIEEYKKMDIIISKIGPKKYQLESIPNICNQYENTLINFFQSRKSRTINSLESDLYANIACR
KAVKTNDILSLEFSKFLIDEFFKLEIKHCPHGRKIYYKISKFELEKKVARA
>Mature_611_residues
MNKIRFLDKYLVQKIAAGESIDRPCSILRELLDNSIDSGATKIEVFLEEGGIHKILIIDNGIGIGKEDLKICYLPHTTSK
ISSEEDLRKIETLGFRGEALSSIAICSNISITSSTTGNESYQIEVENGIEKCFKKQPAINGTIVNVTKIFHNFPARKRFL
KQEPIETKMCLKVLEEKIITHPEINFEINLNQKLRKIYFKESLIDRVQNVYGNVIENNKFKVLKKEHENIKIELFLAPAN
FSKKSKRHIKTFVNRRPIDQKDLLEAITNGHSRIISPGNFPICYLFLEINPEYIDFNVHPQKKEVRFFNLPFLFKLISDN
INNFFDKDINSYNEIVIKRQLTDDDNLIEMINQPKNLNKTNTYDIIQNKNLETEHTVNDLSKNIIQNDIGLRRYNSIIQN
RPSFKENITNIFSDKFLEFEEPPNKNEKEEIKFNYIGQIFSEFLIVEKVNEIYFIDQHAVHEKIIYEKLRNSKKTVQKLL
IPIEFTIVDKNIEEIIDSEIEEYKKMDIIISKIGPKKYQLESIPNICNQYENTLINFFQSRKSRTINSLESDLYANIACR
KAVKTNDILSLEFSKFLIDEFFKLEIKHCPHGRKIYYKISKFELEKKVARA

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=312, Percent_Identity=34.6153846153846, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI4505911, Length=325, Percent_Identity=29.8461538461538, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI189458898, Length=325, Percent_Identity=29.8461538461538, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI4505913, Length=461, Percent_Identity=25.8134490238612, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI310128478, Length=461, Percent_Identity=25.8134490238612, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI189458896, Length=317, Percent_Identity=29.0220820189274, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI263191589, Length=218, Percent_Identity=27.5229357798165, Blast_Score=80, Evalue=8e-15,
Organism=Escherichia coli, GI1790612, Length=339, Percent_Identity=31.2684365781711, Blast_Score=164, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71991825, Length=324, Percent_Identity=30.2469135802469, Blast_Score=132, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17562796, Length=391, Percent_Identity=24.5524296675192, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323819, Length=319, Percent_Identity=34.7962382445141, Blast_Score=161, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324247, Length=359, Percent_Identity=27.8551532033426, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=728, Percent_Identity=22.5274725274725, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323063, Length=165, Percent_Identity=35.1515151515151, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17136968, Length=314, Percent_Identity=33.1210191082803, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI17136970, Length=176, Percent_Identity=34.6590909090909, Blast_Score=89, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 71443; Mature: 71443

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIRFLDKYLVQKIAAGESIDRPCSILRELLDNSIDSGATKIEVFLEEGGIHKILIIDN
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEEEC
GIGIGKEDLKICYLPHTTSKISSEEDLRKIETLGFRGEALSSIAICSNISITSSTTGNES
CCCCCCCCCEEEECCCCCHHCCCHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCCCCE
YQIEVENGIEKCFKKQPAINGTIVNVTKIFHNFPARKRFLKQEPIETKMCLKVLEEKIIT
EEEEHHHHHHHHHHCCCCCCCEEEHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHCC
HPEINFEINLNQKLRKIYFKESLIDRVQNVYGNVIENNKFKVLKKEHENIKIELFLAPAN
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEECCCCEEEEEEEECCC
FSKKSKRHIKTFVNRRPIDQKDLLEAITNGHSRIISPGNFPICYLFLEINPEYIDFNVHP
CCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEECCCCCCEEEEEEEECCCEEEEECCC
QKKEVRFFNLPFLFKLISDNINNFFDKDINSYNEIVIKRQLTDDDNLIEMINQPKNLNKT
CCCCCEEECCHHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCHHHHHHHCCCCCCCCC
NTYDIIQNKNLETEHTVNDLSKNIIQNDIGLRRYNSIIQNRPSFKENITNIFSDKFLEFE
CCEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
EPPNKNEKEEIKFNYIGQIFSEFLIVEKVNEIYFIDQHAVHEKIIYEKLRNSKKTVQKLL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHCHHHHHHHHH
IPIEFTIVDKNIEEIIDSEIEEYKKMDIIISKIGPKKYQLESIPNICNQYENTLINFFQS
HEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
RKSRTINSLESDLYANIACRKAVKTNDILSLEFSKFLIDEFFKLEIKHCPHGRKIYYKIS
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEH
KFELEKKVARA
HHHHHHHHHCC
>Mature Secondary Structure
MNKIRFLDKYLVQKIAAGESIDRPCSILRELLDNSIDSGATKIEVFLEEGGIHKILIIDN
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEEEC
GIGIGKEDLKICYLPHTTSKISSEEDLRKIETLGFRGEALSSIAICSNISITSSTTGNES
CCCCCCCCCEEEECCCCCHHCCCHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCCCCE
YQIEVENGIEKCFKKQPAINGTIVNVTKIFHNFPARKRFLKQEPIETKMCLKVLEEKIIT
EEEEHHHHHHHHHHCCCCCCCEEEHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHCC
HPEINFEINLNQKLRKIYFKESLIDRVQNVYGNVIENNKFKVLKKEHENIKIELFLAPAN
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEECCCCEEEEEEEECCC
FSKKSKRHIKTFVNRRPIDQKDLLEAITNGHSRIISPGNFPICYLFLEINPEYIDFNVHP
CCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEECCCCCCEEEEEEEECCCEEEEECCC
QKKEVRFFNLPFLFKLISDNINNFFDKDINSYNEIVIKRQLTDDDNLIEMINQPKNLNKT
CCCCCEEECCHHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCHHHHHHHCCCCCCCCC
NTYDIIQNKNLETEHTVNDLSKNIIQNDIGLRRYNSIIQNRPSFKENITNIFSDKFLEFE
CCEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
EPPNKNEKEEIKFNYIGQIFSEFLIVEKVNEIYFIDQHAVHEKIIYEKLRNSKKTVQKLL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHCHHHHHHHHH
IPIEFTIVDKNIEEIIDSEIEEYKKMDIIISKIGPKKYQLESIPNICNQYENTLINFFQS
HEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
RKSRTINSLESDLYANIACRKAVKTNDILSLEFSKFLIDEFFKLEIKHCPHGRKIYYKIS
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEH
KFELEKKVARA
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA