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The map label for this gene is degQ

Identifier: 51597803

GI number: 51597803

Start: 4180382

End: 4181755

Strand: Direct

Name: degQ

Synonym: YPTB3511

Alternate gene names: 51597803

Gene position: 4180382-4181755 (Clockwise)

Preceding gene: 51597802

Following gene: 51597804

Centisome position: 88.11

GC content: 48.76

Gene sequence:

>1374_bases
ATGAAGAAAACATCATTACTTCTTAGTGCGCTAGCAATAAGCGTCGGCTTAGGTCTCGCTTCTGTTCCTATGGTGAGTGC
AGCAGCACTGCCTGCGGCGGTCGCCGGACAAACGTTACCTAGCCTGGCACCAATGCTGGAAAAAGTATTACCCGCCGTTG
TCAGTGTTCATGTCTCTGGGAGCCAGGCACAGCAACAACGCTTGCCAGAAGAGTTTAAATTCTTCTTTGGCCCGAATGCA
CCATCAGGAAAAGAGAGCAGCCGGCCATTCGAAGGCTTAGGATCAGGCGTTATTATTAACGCTGAGAAGGGCTACATCCT
GACCAACAATCACGTCATCAATAATGCCGATAAAATTCGTGTTCAGTTGAATGATGGTCGTGAATACGATGCAAAATTGT
TGGGTCGTGATGAACAAACCGACATCGCTTTACTGCAATTAACGGATGCTAAAAATCTGACTGCGATCAAAATTGCAGAT
TCCGATAACCTGCGGGTGGGGGATTTTGCTGTCGCCGTAGGTAACCCGTTTGGTCTAGGGCAAACCGCGACGTCAGGTAT
TATTTCAGCACTGGGTCGTAGTGGCTTGAATCTGGAAGGGCTGGAAAACTTTATCCAGACCGATGCCTCAATCAACCGTG
GTAATTCTGGCGGTGCTCTGGTGAATCTGGATGGGGAACTGATCGGAATTAATACCGCCATCCTTGCGCCAGGTGGCGGT
AATATCGGTATCGGCTTCGCTATCCCAAGTAACATGGCACAAAACCTCAGCCAGCAGTTGATCGAGTTTGGCGAAGTGAA
ACGTGGGCTGCTCGGTATCCGTGGTAGTGAGATGACGGCTGACATTGCGAAAGCCTTTAATATTGATGCTCAGCGTGGGG
CTTTTGTCAGTGAAGTGCTGCCAAAATCAGCGGCAGCGAAAGCCGGGATCAAACCAGGTGATGTGTTGATTTCCGTTGAT
GGGAAAAAGATTAGCAGCTTTGCTGAATTGCGCGCCAAAGTCGGGACAACGGGGCCAGGCAAAACCATTAAAATTGGTTT
ACTGCGCGAAGGGAAACCACTGGAAGTATCGGTGACGCTGGATAACAGTAGCTCAACATCCACCAGCGCTGAAAATCTAT
CGCCATCATTACAGGGCGCATCCCTGAGCAACGGTGAGCTCAAAGACGGTAGTAAGGGGATCAAAGTTGATAGCGTCACT
AAAGGTTCGCCAGCCGCACAATCTGGCTTACAAAAAGATGATGTGATTATTGCCGTAAACCGCGAACGGGTTAAGGATAT
TGCTGAGTTGCGTAAAGCCATCGAAGCCAAACCTGCCGTGATTGCACTGAATATCGTGCGTGGTGAAGATAATATTTACT
TATTAATCCGCTAA

Upstream 100 bases:

>100_bases
GAGCGAATTTTTTTGCTATTTACGGGTCTGAATTTATACAGACTTGTGAGCGTCATCCACCCTATTCATTCACCGTTAGG
TATTGAGAGAGTTTAAATCA

Downstream 100 bases:

>100_bases
TTTGCAGAAAAATCGGACACAGCACGATGCTGTGTCCGCCTAACTCATGCTATTCTCCTTTTCACCCATTCATTTATGCC
TTAAACCTCATGTTTCTTAA

Product: protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MKKTSLLLSALAISVGLGLASVPMVSAAALPAAVAGQTLPSLAPMLEKVLPAVVSVHVSGSQAQQQRLPEEFKFFFGPNA
PSGKESSRPFEGLGSGVIINAEKGYILTNNHVINNADKIRVQLNDGREYDAKLLGRDEQTDIALLQLTDAKNLTAIKIAD
SDNLRVGDFAVAVGNPFGLGQTATSGIISALGRSGLNLEGLENFIQTDASINRGNSGGALVNLDGELIGINTAILAPGGG
NIGIGFAIPSNMAQNLSQQLIEFGEVKRGLLGIRGSEMTADIAKAFNIDAQRGAFVSEVLPKSAAAKAGIKPGDVLISVD
GKKISSFAELRAKVGTTGPGKTIKIGLLREGKPLEVSVTLDNSSSTSTSAENLSPSLQGASLSNGELKDGSKGIKVDSVT
KGSPAAQSGLQKDDVIIAVNRERVKDIAELRKAIEAKPAVIALNIVRGEDNIYLLIR

Sequences:

>Translated_457_residues
MKKTSLLLSALAISVGLGLASVPMVSAAALPAAVAGQTLPSLAPMLEKVLPAVVSVHVSGSQAQQQRLPEEFKFFFGPNA
PSGKESSRPFEGLGSGVIINAEKGYILTNNHVINNADKIRVQLNDGREYDAKLLGRDEQTDIALLQLTDAKNLTAIKIAD
SDNLRVGDFAVAVGNPFGLGQTATSGIISALGRSGLNLEGLENFIQTDASINRGNSGGALVNLDGELIGINTAILAPGGG
NIGIGFAIPSNMAQNLSQQLIEFGEVKRGLLGIRGSEMTADIAKAFNIDAQRGAFVSEVLPKSAAAKAGIKPGDVLISVD
GKKISSFAELRAKVGTTGPGKTIKIGLLREGKPLEVSVTLDNSSSTSTSAENLSPSLQGASLSNGELKDGSKGIKVDSVT
KGSPAAQSGLQKDDVIIAVNRERVKDIAELRKAIEAKPAVIALNIVRGEDNIYLLIR
>Mature_457_residues
MKKTSLLLSALAISVGLGLASVPMVSAAALPAAVAGQTLPSLAPMLEKVLPAVVSVHVSGSQAQQQRLPEEFKFFFGPNA
PSGKESSRPFEGLGSGVIINAEKGYILTNNHVINNADKIRVQLNDGREYDAKLLGRDEQTDIALLQLTDAKNLTAIKIAD
SDNLRVGDFAVAVGNPFGLGQTATSGIISALGRSGLNLEGLENFIQTDASINRGNSGGALVNLDGELIGINTAILAPGGG
NIGIGFAIPSNMAQNLSQQLIEFGEVKRGLLGIRGSEMTADIAKAFNIDAQRGAFVSEVLPKSAAAKAGIKPGDVLISVD
GKKISSFAELRAKVGTTGPGKTIKIGLLREGKPLEVSVTLDNSSSTSTSAENLSPSLQGASLSNGELKDGSKGIKVDSVT
KGSPAAQSGLQKDDVIIAVNRERVKDIAELRKAIEAKPAVIALNIVRGEDNIYLLIR

Specific function: Protease with a shared specificity with degP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=301, Percent_Identity=37.5415282392027, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI22129776, Length=319, Percent_Identity=36.9905956112853, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI24308541, Length=307, Percent_Identity=32.2475570032573, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI7019477, Length=308, Percent_Identity=34.4155844155844, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1789629, Length=458, Percent_Identity=72.0524017467249, Blast_Score=648, Evalue=0.0,
Organism=Escherichia coli, GI1786356, Length=454, Percent_Identity=57.7092511013216, Blast_Score=516, Evalue=1e-147,
Organism=Escherichia coli, GI1789630, Length=278, Percent_Identity=47.1223021582734, Blast_Score=218, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24646839, Length=289, Percent_Identity=34.2560553633218, Blast_Score=135, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 47400; Mature: 47400

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTSLLLSALAISVGLGLASVPMVSAAALPAAVAGQTLPSLAPMLEKVLPAVVSVHVSG
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHEEEEECC
SQAQQQRLPEEFKFFFGPNAPSGKESSRPFEGLGSGVIINAEKGYILTNNHVINNADKIR
CHHHHHHCCHHHHEEECCCCCCCCCCCCCHHHCCCCEEEECCCCEEEECCEEECCCEEEE
VQLNDGREYDAKLLGRDEQTDIALLQLTDAKNLTAIKIADSDNLRVGDFAVAVGNPFGLG
EEECCCCCCCHHHCCCCCCCCEEEEEEECCCCEEEEEEECCCCEEECEEEEEECCCCCCC
QTATSGIISALGRSGLNLEGLENFIQTDASINRGNSGGALVNLDGELIGINTAILAPGGG
HHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEEEEEEEECCCC
NIGIGFAIPSNMAQNLSQQLIEFGEVKRGLLGIRGSEMTADIAKAFNIDAQRGAFVSEVL
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHCCCCCCCCHHHHHC
PKSAAAKAGIKPGDVLISVDGKKISSFAELRAKVGTTGPGKTIKIGLLREGKPLEVSVTL
CCHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEEEEE
DNSSSTSTSAENLSPSLQGASLSNGELKDGSKGIKVDSVTKGSPAAQSGLQKDDVIIAVN
CCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHCCCCCCCEEEEEC
RERVKDIAELRKAIEAKPAVIALNIVRGEDNIYLLIR
HHHHHHHHHHHHHHCCCCEEEEEEEEECCCCEEEEEC
>Mature Secondary Structure
MKKTSLLLSALAISVGLGLASVPMVSAAALPAAVAGQTLPSLAPMLEKVLPAVVSVHVSG
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHEEEEECC
SQAQQQRLPEEFKFFFGPNAPSGKESSRPFEGLGSGVIINAEKGYILTNNHVINNADKIR
CHHHHHHCCHHHHEEECCCCCCCCCCCCCHHHCCCCEEEECCCCEEEECCEEECCCEEEE
VQLNDGREYDAKLLGRDEQTDIALLQLTDAKNLTAIKIADSDNLRVGDFAVAVGNPFGLG
EEECCCCCCCHHHCCCCCCCCEEEEEEECCCCEEEEEEECCCCEEECEEEEEECCCCCCC
QTATSGIISALGRSGLNLEGLENFIQTDASINRGNSGGALVNLDGELIGINTAILAPGGG
HHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEEEEEEEECCCC
NIGIGFAIPSNMAQNLSQQLIEFGEVKRGLLGIRGSEMTADIAKAFNIDAQRGAFVSEVL
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHCCCCCCCCHHHHHC
PKSAAAKAGIKPGDVLISVDGKKISSFAELRAKVGTTGPGKTIKIGLLREGKPLEVSVTL
CCHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEEEEE
DNSSSTSTSAENLSPSLQGASLSNGELKDGSKGIKVDSVTKGSPAAQSGLQKDDVIIAVN
CCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHCCCCCCCEEEEEC
RERVKDIAELRKAIEAKPAVIALNIVRGEDNIYLLIR
HHHHHHHHHHHHHHCCCCEEEEEEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8576051; 9278503 [H]