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The map label for this gene is mdtO [H]

Identifier: 51597734

GI number: 51597734

Start: 4077291

End: 4079192

Strand: Direct

Name: mdtO [H]

Synonym: YPTB3437

Alternate gene names: 51597734

Gene position: 4077291-4079192 (Clockwise)

Preceding gene: 51597733

Following gene: 51597735

Centisome position: 85.93

GC content: 53.26

Gene sequence:

>1902_bases
ATGACGACGGTTGCTGACGGTACGCTTGGCGGCATAATCCGTCAGGCGAAAGCTGACTTAGCCTTTTTCCCAGGGCGGGT
GGCGATGGCGTGGCGTGTTGCCGTGCTATGTGCATTGATGGCGATGATCGCCATGATATACGGCATCCCTGAATCTGCGA
TTAGTTGCTATCTCATTATTTTTGTTATGAAGCCGGATGGTGTAGAGAGCATGGTGATGGCCGTGGCGATAACGATCCTG
GTGTCGTTGGTCGTCGGGTTGGTATTTCTGCTTATCCATTTCACCCTAGAGGCCGCACCACTGCGCATGGCGGCCTTGAT
TGTCAGCTCGTTTCTCTTTCTCTATCTCGGATCGGCCAGTAAGCTCGGCCCGGTAGGGAGTATTATTGCGCTGGTTATCG
CTTATGTGATGACGTTACTGAGCAATATCCCAATGGGAGATGTGGCCACGCGGGGGCTGTTGTATGCCTGGTTGATGGCT
GTTTCACCGATGTTGCTGATTATTGGGTTTAACCTTTTCTTTGGCCGAGCACCACAGACGTTATTGCGGGCCAGCTTAGC
GGAGCGGTTATCCACGGTCGCCGAGACATTACGGCACCCCAATGCCGCCAATATGGCGCGGGTTGGAGAACAGCTACAGG
AAGGGCAACATGAGCATCAACAGCGGGCGCTTTTTGTTCGTATCTTTCATCTACGGCCCTCGGCTGAAGCGGCCTGGCTT
GAAAGTGCCGTAAAAAGCAGTTACCGGCTACTCTTGGTAACCTCGGCGTTACCTCCTACCTCACCAGAGGCCGTGCGCCT
TGAGCTTGCGGCCTACTGTAGTGATGCGGCTCAGGCGATTGCCAGCGGTGATCTCGCGGCCCCCCCTCACTTCGCGATTG
AGGATACCAGCGATGAAATCAATGAAATCAGAAACGCGCTGATCGCACTGGCAAATGCGGATAATGGGCAAGACCTGGAC
GCCCCGAAATCCTCATTCTTTGCAGCAGACGCATTGACTAACCCTGTTCATCAGCAGTTTGCCCTGAAAACCACCGCCGC
GGCTCTGATTTGCTACCTGATCTACACCGCACTGGATTGGCAGGACATTCATACTGCCATGATCACTTGCTATGTTGCCG
CACTCGGTACAACAGGTGAGACGGTTCATAAACTGGTCTTGCGGATTATAGGGTGTCTGATCGGGGCATTGATGGGGGTA
CTGTCGATTATTTTCATTATTCCCCACATGAGTGATATCGGGCAATTAATGGCGCTGGTATTTGGCTGCATTCTAGTGGC
CGCTTGGGTGTCATGTGGCAGCGAACGTATCGCGTATGCTGGCGTACAGGTTGGGTTGGCCTTCCTGCTTACCGTGCTGC
AAGGTTTTGGGCCAAGTACCGATATGGGTGTCGCACTCGATAGGGTGCTGGGTATCTTGCTGGGTAATCTGGTGGTGTAC
TTGATTTTTAGCCGGCTGTGGCCAGTCGCGATTACCGATGCGGTGCATGTACATATTAGTCGCGCCTTGAAGGGGCTGAC
AAATTTAGCCGCGCTCTCGCCGGATGCCCGGCCTGCAGCGCTCAGAGAGGCCACAACTGTCGAGGCGGAGATTACCAAGG
CGCAGGAAGAGTTGGCGCTAATTCCCTTTGAGCCAGTACAATTTCGCCCCTCACGGAAAGAGTGCGCACGCCTACAGGCC
ATCTTGGCAGAAATGGGCAAATTGTGCCCTGTTCTGTTTCTACCCACGGAAAAGTCAGCGTCTGATGTGGAACAACTGCG
CCAGCTCTCGGCTGGGAGCGATGCCATGACATTATCGGATGAGCAAGGACAGAATAGCGGGTCTTTACGGCAAGAGTTAT
CACCTATTAATCTTATAATTCAACAACGTATAAAGCGGCTTGAGGAACTTCTGGGAATTTAA

Upstream 100 bases:

>100_bases
TGGGTGCGTGTTGTTCAGCGTTTCCCGGTGAGGATCAGCCTGGAAAAACCGCCGGAGGACCTGATGCGTATCGGGGCGAC
TGCTGTGGTTATCGTGCGAA

Downstream 100 bases:

>100_bases
TGACATGATGACGCACGCAGTATTGACTGCCCGGATAGCCAAAATAAGCCTGACTTGCTCGATATTGAGTTGGAGCCTGT
TGATCGTAGGTTGTGCTACA

Product: PET family efflux transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 633; Mature: 632

Protein sequence:

>633_residues
MTTVADGTLGGIIRQAKADLAFFPGRVAMAWRVAVLCALMAMIAMIYGIPESAISCYLIIFVMKPDGVESMVMAVAITIL
VSLVVGLVFLLIHFTLEAAPLRMAALIVSSFLFLYLGSASKLGPVGSIIALVIAYVMTLLSNIPMGDVATRGLLYAWLMA
VSPMLLIIGFNLFFGRAPQTLLRASLAERLSTVAETLRHPNAANMARVGEQLQEGQHEHQQRALFVRIFHLRPSAEAAWL
ESAVKSSYRLLLVTSALPPTSPEAVRLELAAYCSDAAQAIASGDLAAPPHFAIEDTSDEINEIRNALIALANADNGQDLD
APKSSFFAADALTNPVHQQFALKTTAAALICYLIYTALDWQDIHTAMITCYVAALGTTGETVHKLVLRIIGCLIGALMGV
LSIIFIIPHMSDIGQLMALVFGCILVAAWVSCGSERIAYAGVQVGLAFLLTVLQGFGPSTDMGVALDRVLGILLGNLVVY
LIFSRLWPVAITDAVHVHISRALKGLTNLAALSPDARPAALREATTVEAEITKAQEELALIPFEPVQFRPSRKECARLQA
ILAEMGKLCPVLFLPTEKSASDVEQLRQLSAGSDAMTLSDEQGQNSGSLRQELSPINLIIQQRIKRLEELLGI

Sequences:

>Translated_633_residues
MTTVADGTLGGIIRQAKADLAFFPGRVAMAWRVAVLCALMAMIAMIYGIPESAISCYLIIFVMKPDGVESMVMAVAITIL
VSLVVGLVFLLIHFTLEAAPLRMAALIVSSFLFLYLGSASKLGPVGSIIALVIAYVMTLLSNIPMGDVATRGLLYAWLMA
VSPMLLIIGFNLFFGRAPQTLLRASLAERLSTVAETLRHPNAANMARVGEQLQEGQHEHQQRALFVRIFHLRPSAEAAWL
ESAVKSSYRLLLVTSALPPTSPEAVRLELAAYCSDAAQAIASGDLAAPPHFAIEDTSDEINEIRNALIALANADNGQDLD
APKSSFFAADALTNPVHQQFALKTTAAALICYLIYTALDWQDIHTAMITCYVAALGTTGETVHKLVLRIIGCLIGALMGV
LSIIFIIPHMSDIGQLMALVFGCILVAAWVSCGSERIAYAGVQVGLAFLLTVLQGFGPSTDMGVALDRVLGILLGNLVVY
LIFSRLWPVAITDAVHVHISRALKGLTNLAALSPDARPAALREATTVEAEITKAQEELALIPFEPVQFRPSRKECARLQA
ILAEMGKLCPVLFLPTEKSASDVEQLRQLSAGSDAMTLSDEQGQNSGSLRQELSPINLIIQQRIKRLEELLGI
>Mature_632_residues
TTVADGTLGGIIRQAKADLAFFPGRVAMAWRVAVLCALMAMIAMIYGIPESAISCYLIIFVMKPDGVESMVMAVAITILV
SLVVGLVFLLIHFTLEAAPLRMAALIVSSFLFLYLGSASKLGPVGSIIALVIAYVMTLLSNIPMGDVATRGLLYAWLMAV
SPMLLIIGFNLFFGRAPQTLLRASLAERLSTVAETLRHPNAANMARVGEQLQEGQHEHQQRALFVRIFHLRPSAEAAWLE
SAVKSSYRLLLVTSALPPTSPEAVRLELAAYCSDAAQAIASGDLAAPPHFAIEDTSDEINEIRNALIALANADNGQDLDA
PKSSFFAADALTNPVHQQFALKTTAAALICYLIYTALDWQDIHTAMITCYVAALGTTGETVHKLVLRIIGCLIGALMGVL
SIIFIIPHMSDIGQLMALVFGCILVAAWVSCGSERIAYAGVQVGLAFLLTVLQGFGPSTDMGVALDRVLGILLGNLVVYL
IFSRLWPVAITDAVHVHISRALKGLTNLAALSPDARPAALREATTVEAEITKAQEELALIPFEPVQFRPSRKECARLQAI
LAEMGKLCPVLFLPTEKSASDVEQLRQLSAGSDAMTLSDEQGQNSGSLRQELSPINLIIQQRIKRLEELLGI

Specific function: Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride [H]

COG id: COG1289

COG function: function code S; Predicted membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MdtO family [H]

Homologues:

Organism=Escherichia coli, GI87082367, Length=499, Percent_Identity=28.8577154308617, Blast_Score=168, Evalue=9e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006726 [H]

Pfam domain/function: PF04632 FUSC [H]

EC number: NA

Molecular weight: Translated: 68051; Mature: 67920

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVADGTLGGIIRQAKADLAFFPGRVAMAWRVAVLCALMAMIAMIYGIPESAISCYLII
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEHEE
FVMKPDGVESMVMAVAITILVSLVVGLVFLLIHFTLEAAPLRMAALIVSSFLFLYLGSAS
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KLGPVGSIIALVIAYVMTLLSNIPMGDVATRGLLYAWLMAVSPMLLIIGFNLFFGRAPQT
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LLRASLAERLSTVAETLRHPNAANMARVGEQLQEGQHEHQQRALFVRIFHLRPSAEAAWL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHH
ESAVKSSYRLLLVTSALPPTSPEAVRLELAAYCSDAAQAIASGDLAAPPHFAIEDTSDEI
HHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHH
NEIRNALIALANADNGQDLDAPKSSFFAADALTNPVHQQFALKTTAAALICYLIYTALDW
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCH
QDIHTAMITCYVAALGTTGETVHKLVLRIIGCLIGALMGVLSIIFIIPHMSDIGQLMALV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
FGCILVAAWVSCGSERIAYAGVQVGLAFLLTVLQGFGPSTDMGVALDRVLGILLGNLVVY
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
LIFSRLWPVAITDAVHVHISRALKGLTNLAALSPDARPAALREATTVEAEITKAQEELAL
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEE
IPFEPVQFRPSRKECARLQAILAEMGKLCPVLFLPTEKSASDVEQLRQLSAGSDAMTLSD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCCCEEECC
EQGQNSGSLRQELSPINLIIQQRIKRLEELLGI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTVADGTLGGIIRQAKADLAFFPGRVAMAWRVAVLCALMAMIAMIYGIPESAISCYLII
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEHEE
FVMKPDGVESMVMAVAITILVSLVVGLVFLLIHFTLEAAPLRMAALIVSSFLFLYLGSAS
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KLGPVGSIIALVIAYVMTLLSNIPMGDVATRGLLYAWLMAVSPMLLIIGFNLFFGRAPQT
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LLRASLAERLSTVAETLRHPNAANMARVGEQLQEGQHEHQQRALFVRIFHLRPSAEAAWL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHH
ESAVKSSYRLLLVTSALPPTSPEAVRLELAAYCSDAAQAIASGDLAAPPHFAIEDTSDEI
HHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHH
NEIRNALIALANADNGQDLDAPKSSFFAADALTNPVHQQFALKTTAAALICYLIYTALDW
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCH
QDIHTAMITCYVAALGTTGETVHKLVLRIIGCLIGALMGVLSIIFIIPHMSDIGQLMALV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
FGCILVAAWVSCGSERIAYAGVQVGLAFLLTVLQGFGPSTDMGVALDRVLGILLGNLVVY
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
LIFSRLWPVAITDAVHVHISRALKGLTNLAALSPDARPAALREATTVEAEITKAQEELAL
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEE
IPFEPVQFRPSRKECARLQAILAEMGKLCPVLFLPTEKSASDVEQLRQLSAGSDAMTLSD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCCCEEECC
EQGQNSGSLRQELSPINLIIQQRIKRLEELLGI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]