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The map label for this gene is lysR

Identifier: 51597360

GI number: 51597360

Start: 3597598

End: 3598539

Strand: Direct

Name: lysR

Synonym: YPTB3046

Alternate gene names: 51597360

Gene position: 3597598-3598539 (Clockwise)

Preceding gene: 51597358

Following gene: 51597363

Centisome position: 75.82

GC content: 51.38

Gene sequence:

>942_bases
ATGCCTGCAATTTCCTTACGACAAATCGAGATTTTTCATGGCGTCATGACCACGGGCAACCTGACTGAAGCGGCGTTGTT
ACTGCAAACATCACAACCGACTGTCAGCCGCGAATTGGCCCGCTTTGAGCAATTGGTGCAACTCACGCTTTTTGAACGGG
TACGTGGCCGCCTTTATCCTACCGTGCAAGGGCTACGGCTATTCGAAGAGGTTCAGCGTTCATATTATGGTTTGGATCGT
ATCAAACAGGCGGCTGAAGGTATCCGCCAATTTCAACATGCCCAACTCTCCATTGCCTGCCTGCCCGTCTTTTCTCAATC
GTTGCTACCCGCGGTATGTAAACCCTTTATTGACCGCTATCCAGAGGTCAGCCTAAATGTCATTCCGCAGGAGTCACCTT
TATTGGAGGAGTGGCTTTCAGCCCAGCGTCATGACTTAGGATTCACAGAAAATACCCAAACACCGGCGGGCACCCAGCGC
CATACCCTGATGACGGTCAATGAAGTTTGCGTATTACCTGCCGATCATCCGTTGCGGGAGAAATCGGTGCTGACACCACA
GGATTTTAACGGGGAAAATTTTGTCAGCCTGTCAGTCACCGACAGTTACCGTCAGCTATTGGATAACCTGTTTGCGGAGG
AAAAAGTCACCCGCCGATTAGTCATGGAGACCCACAGTGCGGCATCGGTTTGCGCCATGGTGCGTGAAGGGGTGGGGGTA
TCGATAGTCAACCCCCTTACCGCACTGGATTACCTGAGTAAAGGCCGTGGTTCGGGGGTTTGTGTACGGCCATTCAGTGT
CGACATTCCTTTTACGGTTAGCTTAATTCAGCCATTACATCGCCCATCATCCACCTTGGTCGATACGTTTGTCGGGCACT
TAAAACAGCAGACAACGCTTTTCCAACAGCGTCTGGCAACAGTCATTGCCCCTGCGTGCTAA

Upstream 100 bases:

>100_bases
TTAACGTTGTGGATTTGTTAGGAAAATATCTATTTACCCTTAGTCTATTCATTTATGATATGGGTTAAATTGATCAGTTC
GCGTTTCAGGAGTGCTGAGA

Downstream 100 bases:

>100_bases
GCCATTTTATTCCCAATAGTACGCGCGCGGGAAAACGTAAACAGACACAGCAACAACCCCATGACCGCCAGTGCCGCGGC
GGCCAGCGGCACCGCCGTCA

Product: DNA-binding transcriptional regulator LysR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MPAISLRQIEIFHGVMTTGNLTEAALLLQTSQPTVSRELARFEQLVQLTLFERVRGRLYPTVQGLRLFEEVQRSYYGLDR
IKQAAEGIRQFQHAQLSIACLPVFSQSLLPAVCKPFIDRYPEVSLNVIPQESPLLEEWLSAQRHDLGFTENTQTPAGTQR
HTLMTVNEVCVLPADHPLREKSVLTPQDFNGENFVSLSVTDSYRQLLDNLFAEEKVTRRLVMETHSAASVCAMVREGVGV
SIVNPLTALDYLSKGRGSGVCVRPFSVDIPFTVSLIQPLHRPSSTLVDTFVGHLKQQTTLFQQRLATVIAPAC

Sequences:

>Translated_313_residues
MPAISLRQIEIFHGVMTTGNLTEAALLLQTSQPTVSRELARFEQLVQLTLFERVRGRLYPTVQGLRLFEEVQRSYYGLDR
IKQAAEGIRQFQHAQLSIACLPVFSQSLLPAVCKPFIDRYPEVSLNVIPQESPLLEEWLSAQRHDLGFTENTQTPAGTQR
HTLMTVNEVCVLPADHPLREKSVLTPQDFNGENFVSLSVTDSYRQLLDNLFAEEKVTRRLVMETHSAASVCAMVREGVGV
SIVNPLTALDYLSKGRGSGVCVRPFSVDIPFTVSLIQPLHRPSSTLVDTFVGHLKQQTTLFQQRLATVIAPAC
>Mature_312_residues
PAISLRQIEIFHGVMTTGNLTEAALLLQTSQPTVSRELARFEQLVQLTLFERVRGRLYPTVQGLRLFEEVQRSYYGLDRI
KQAAEGIRQFQHAQLSIACLPVFSQSLLPAVCKPFIDRYPEVSLNVIPQESPLLEEWLSAQRHDLGFTENTQTPAGTQRH
TLMTVNEVCVLPADHPLREKSVLTPQDFNGENFVSLSVTDSYRQLLDNLFAEEKVTRRLVMETHSAASVCAMVREGVGVS
IVNPLTALDYLSKGRGSGVCVRPFSVDIPFTVSLIQPLHRPSSTLVDTFVGHLKQQTTLFQQRLATVIAPAC

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=295, Percent_Identity=71.1864406779661, Blast_Score=440, Evalue=1e-125,
Organism=Escherichia coli, GI145693105, Length=238, Percent_Identity=23.109243697479, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788887, Length=309, Percent_Identity=24.5954692556634, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI157672245, Length=229, Percent_Identity=23.5807860262009, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787530, Length=227, Percent_Identity=27.3127753303965, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788481, Length=261, Percent_Identity=24.1379310344828, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34972; Mature: 34841

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAISLRQIEIFHGVMTTGNLTEAALLLQTSQPTVSRELARFEQLVQLTLFERVRGRLYP
CCCCCHHHHHHHHHHHCCCCHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
TVQGLRLFEEVQRSYYGLDRIKQAAEGIRQFQHAQLSIACLPVFSQSLLPAVCKPFIDRY
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHCC
PEVSLNVIPQESPLLEEWLSAQRHDLGFTENTQTPAGTQRHTLMTVNEVCVLPADHPLRE
CCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCEEEECCCCCCCC
KSVLTPQDFNGENFVSLSVTDSYRQLLDNLFAEEKVTRRLVMETHSAASVCAMVREGVGV
CCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
SIVNPLTALDYLSKGRGSGVCVRPFSVDIPFTVSLIQPLHRPSSTLVDTFVGHLKQQTTL
EHHHHHHHHHHHHCCCCCCEEEECEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
FQQRLATVIAPAC
HHHHHHHHHCCCC
>Mature Secondary Structure 
PAISLRQIEIFHGVMTTGNLTEAALLLQTSQPTVSRELARFEQLVQLTLFERVRGRLYP
CCCCHHHHHHHHHHHCCCCHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
TVQGLRLFEEVQRSYYGLDRIKQAAEGIRQFQHAQLSIACLPVFSQSLLPAVCKPFIDRY
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHCC
PEVSLNVIPQESPLLEEWLSAQRHDLGFTENTQTPAGTQRHTLMTVNEVCVLPADHPLRE
CCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCEEEECCCCCCCC
KSVLTPQDFNGENFVSLSVTDSYRQLLDNLFAEEKVTRRLVMETHSAASVCAMVREGVGV
CCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
SIVNPLTALDYLSKGRGSGVCVRPFSVDIPFTVSLIQPLHRPSSTLVDTFVGHLKQQTTL
EHHHHHHHHHHHHCCCCCCEEEECEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
FQQRLATVIAPAC
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]