| Definition | Yersinia pseudotuberculosis IP 32953, complete genome. |
|---|---|
| Accession | NC_006155 |
| Length | 4,744,671 |
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The map label for this gene is dkgB
Identifier: 51597286
GI number: 51597286
Start: 3504095
End: 3504898
Strand: Reverse
Name: dkgB
Synonym: YPTB2971
Alternate gene names: 51597286
Gene position: 3504898-3504095 (Counterclockwise)
Preceding gene: 51597287
Following gene: 51597285
Centisome position: 73.87
GC content: 40.8
Gene sequence:
>804_bases ATGAGCATACCTGTATTCGGATTAGGAACTTTTCGCCTTCAAGATCAAATTGTTATTGATTCAGTGTGCCAAGCTCTGAC GTTGGGCTATCGGGCGATTGATACAGCACAAATATATGAAAATGAAGCGGCTGTTGGTCAGGCAATCCAAGAAAGTGGTA TTAATCGTGATGAACTATTTATTACTACTAAGATCTGGATTGCTAATTTATCAAAAGACAAATTAATTCCCAGCCTGCGA GAAAGCATACAGAAACTGAAAACTGACTATGTAGATTTAACACTGATTCATTGGCCATCACCTAATGATGAAGTTTCTGT TGCTGAATTTATGTCCGAGTTATTAAAAGCAAAAGGGCTAGGCTTAACTCGTCAAATTGGTATTTCTAACTTTACTATTG ATTTAATGAAGCAGGCGATTGCTGCCGTTGGTGCAGAAGAGATTGCAACTAATCAAATCGAGCTTTCTCCATTATTACAA AACCGTAATGTTGTTGATTTTGCCAAACAAAATGGCATTGCAGTGACTTCCTATATGACACTGGCTTATGGCAAGGCACT TGCAGAGCCAGTGATTAAAACGATTGCTGAGCAACATGGTGCGACCCCCGCACAAGTTATTTTGAGTTGGGCGATGCAAT TGGGTTATGGCGTTATTCCGTCATCGACTAAAGCTGCTAACTTGGCCAGCAACTTACTAGCACAGAAATTATGCCTGAAT GCAGCAGATATGGCGTTGATCGCCACATTGGATCGCAATGAGAGGTTGGTCAGCCCTGATGGTTTAGCACCTAAATGGGA TTAA
Upstream 100 bases:
>100_bases AGTTTTTCATCTGGTAGTTATTTAGAACATTCCACTGCCGATAAAAATTCGTTATGACTCGCAAGATAAAATGATTGTTA GCAAAAAATGAGGAACTATT
Downstream 100 bases:
>100_bases TAGCAGCCTAAGACACTGGACGAGCCACCTTACATTGAGGTGGTTTTTTATTTTGGTGCATCCTGACGGGGCTGAAACAG GCTCGGTGAAAAGTGTGCGG
Product: 2,5-diketo-D-gluconate reductase B
Products: NA
Alternate protein names: 2,5-DKG reductase B; 2,5-DKGR B; 25DKGR-B; AKR5D [H]
Number of amino acids: Translated: 267; Mature: 266
Protein sequence:
>267_residues MSIPVFGLGTFRLQDQIVIDSVCQALTLGYRAIDTAQIYENEAAVGQAIQESGINRDELFITTKIWIANLSKDKLIPSLR ESIQKLKTDYVDLTLIHWPSPNDEVSVAEFMSELLKAKGLGLTRQIGISNFTIDLMKQAIAAVGAEEIATNQIELSPLLQ NRNVVDFAKQNGIAVTSYMTLAYGKALAEPVIKTIAEQHGATPAQVILSWAMQLGYGVIPSSTKAANLASNLLAQKLCLN AADMALIATLDRNERLVSPDGLAPKWD
Sequences:
>Translated_267_residues MSIPVFGLGTFRLQDQIVIDSVCQALTLGYRAIDTAQIYENEAAVGQAIQESGINRDELFITTKIWIANLSKDKLIPSLR ESIQKLKTDYVDLTLIHWPSPNDEVSVAEFMSELLKAKGLGLTRQIGISNFTIDLMKQAIAAVGAEEIATNQIELSPLLQ NRNVVDFAKQNGIAVTSYMTLAYGKALAEPVIKTIAEQHGATPAQVILSWAMQLGYGVIPSSTKAANLASNLLAQKLCLN AADMALIATLDRNERLVSPDGLAPKWD >Mature_266_residues SIPVFGLGTFRLQDQIVIDSVCQALTLGYRAIDTAQIYENEAAVGQAIQESGINRDELFITTKIWIANLSKDKLIPSLRE SIQKLKTDYVDLTLIHWPSPNDEVSVAEFMSELLKAKGLGLTRQIGISNFTIDLMKQAIAAVGAEEIATNQIELSPLLQN RNVVDFAKQNGIAVTSYMTLAYGKALAEPVIKTIAEQHGATPAQVILSWAMQLGYGVIPSSTKAANLASNLLAQKLCLNA ADMALIATLDRNERLVSPDGLAPKWD
Specific function: Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI93277124, Length=300, Percent_Identity=30.6666666666667, Blast_Score=141, Evalue=8e-34, Organism=Homo sapiens, GI223468663, Length=289, Percent_Identity=31.1418685121107, Blast_Score=138, Evalue=6e-33, Organism=Homo sapiens, GI310109922, Length=280, Percent_Identity=30, Blast_Score=135, Evalue=3e-32, Organism=Homo sapiens, GI24497577, Length=289, Percent_Identity=29.0657439446367, Blast_Score=135, Evalue=4e-32, Organism=Homo sapiens, GI5174391, Length=289, Percent_Identity=29.0657439446367, Blast_Score=135, Evalue=4e-32, Organism=Homo sapiens, GI310109920, Length=297, Percent_Identity=28.6195286195286, Blast_Score=134, Evalue=1e-31, Organism=Homo sapiens, GI45446745, Length=297, Percent_Identity=28.6195286195286, Blast_Score=134, Evalue=1e-31, Organism=Homo sapiens, GI4503285, Length=297, Percent_Identity=28.6195286195286, Blast_Score=134, Evalue=1e-31, Organism=Homo sapiens, GI5453543, Length=297, Percent_Identity=28.2828282828283, Blast_Score=132, Evalue=3e-31, Organism=Homo sapiens, GI24497585, Length=296, Percent_Identity=28.3783783783784, Blast_Score=130, Evalue=1e-30, Organism=Homo sapiens, GI24497583, Length=297, Percent_Identity=28.956228956229, Blast_Score=129, Evalue=2e-30, Organism=Homo sapiens, GI291291012, Length=273, Percent_Identity=30.4029304029304, Blast_Score=125, Evalue=4e-29, Organism=Homo sapiens, GI4502049, Length=291, Percent_Identity=32.9896907216495, Blast_Score=125, Evalue=5e-29, Organism=Homo sapiens, GI5174695, Length=293, Percent_Identity=27.6450511945392, Blast_Score=119, Evalue=2e-27, Organism=Homo sapiens, GI300116273, Length=268, Percent_Identity=27.6119402985075, Blast_Score=110, Evalue=9e-25, Organism=Homo sapiens, GI300116271, Length=278, Percent_Identity=27.3381294964029, Blast_Score=104, Evalue=8e-23, Organism=Homo sapiens, GI310109926, Length=114, Percent_Identity=35.0877192982456, Blast_Score=75, Evalue=6e-14, Organism=Homo sapiens, GI207028673, Length=114, Percent_Identity=35.0877192982456, Blast_Score=75, Evalue=7e-14, Organism=Homo sapiens, GI310109924, Length=160, Percent_Identity=28.125, Blast_Score=74, Evalue=1e-13, Organism=Escherichia coli, GI1786400, Length=267, Percent_Identity=75.6554307116105, Blast_Score=406, Evalue=1e-115, Organism=Escherichia coli, GI87082198, Length=262, Percent_Identity=37.4045801526718, Blast_Score=173, Evalue=9e-45, Organism=Escherichia coli, GI1788081, Length=263, Percent_Identity=26.9961977186312, Blast_Score=92, Evalue=3e-20, Organism=Escherichia coli, GI48994888, Length=250, Percent_Identity=26, Blast_Score=71, Evalue=7e-14, Organism=Escherichia coli, GI1787674, Length=273, Percent_Identity=27.8388278388278, Blast_Score=69, Evalue=4e-13, Organism=Escherichia coli, GI1788070, Length=216, Percent_Identity=26.8518518518519, Blast_Score=63, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17550248, Length=290, Percent_Identity=33.7931034482759, Blast_Score=149, Evalue=1e-36, Organism=Caenorhabditis elegans, GI17537077, Length=288, Percent_Identity=31.9444444444444, Blast_Score=135, Evalue=2e-32, Organism=Caenorhabditis elegans, GI17537075, Length=290, Percent_Identity=32.0689655172414, Blast_Score=135, Evalue=3e-32, Organism=Caenorhabditis elegans, GI17561298, Length=275, Percent_Identity=28.3636363636364, Blast_Score=132, Evalue=2e-31, Organism=Caenorhabditis elegans, GI17552492, Length=268, Percent_Identity=30.2238805970149, Blast_Score=130, Evalue=8e-31, Organism=Caenorhabditis elegans, GI17566692, Length=288, Percent_Identity=30.5555555555556, Blast_Score=123, Evalue=8e-29, Organism=Caenorhabditis elegans, GI71998625, Length=263, Percent_Identity=29.277566539924, Blast_Score=122, Evalue=1e-28, Organism=Caenorhabditis elegans, GI17561300, Length=273, Percent_Identity=29.3040293040293, Blast_Score=122, Evalue=1e-28, Organism=Caenorhabditis elegans, GI17537079, Length=295, Percent_Identity=27.1186440677966, Blast_Score=121, Evalue=5e-28, Organism=Caenorhabditis elegans, GI17564128, Length=297, Percent_Identity=28.2828282828283, Blast_Score=112, Evalue=2e-25, Organism=Caenorhabditis elegans, GI17562292, Length=269, Percent_Identity=29.368029739777, Blast_Score=111, Evalue=4e-25, Organism=Caenorhabditis elegans, GI17538386, Length=265, Percent_Identity=28.6792452830189, Blast_Score=110, Evalue=7e-25, Organism=Saccharomyces cerevisiae, GI6324694, Length=292, Percent_Identity=34.5890410958904, Blast_Score=166, Evalue=4e-42, Organism=Saccharomyces cerevisiae, GI6320576, Length=282, Percent_Identity=36.8794326241135, Blast_Score=164, Evalue=9e-42, Organism=Saccharomyces cerevisiae, GI6321896, Length=315, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=1e-29, Organism=Saccharomyces cerevisiae, GI6322556, Length=262, Percent_Identity=26.7175572519084, Blast_Score=116, Evalue=4e-27, Organism=Saccharomyces cerevisiae, GI6319625, Length=269, Percent_Identity=31.2267657992565, Blast_Score=110, Evalue=2e-25, Organism=Saccharomyces cerevisiae, GI6320079, Length=242, Percent_Identity=29.3388429752066, Blast_Score=89, Evalue=8e-19, Organism=Drosophila melanogaster, GI24644950, Length=297, Percent_Identity=33.6700336700337, Blast_Score=152, Evalue=2e-37, Organism=Drosophila melanogaster, GI221378297, Length=314, Percent_Identity=31.5286624203822, Blast_Score=143, Evalue=1e-34, Organism=Drosophila melanogaster, GI24657054, Length=280, Percent_Identity=31.4285714285714, Blast_Score=136, Evalue=2e-32, Organism=Drosophila melanogaster, GI24663317, Length=289, Percent_Identity=30.1038062283737, Blast_Score=136, Evalue=2e-32, Organism=Drosophila melanogaster, GI24662789, Length=294, Percent_Identity=31.9727891156463, Blast_Score=135, Evalue=4e-32, Organism=Drosophila melanogaster, GI20129731, Length=286, Percent_Identity=31.1188811188811, Blast_Score=131, Evalue=5e-31, Organism=Drosophila melanogaster, GI21356425, Length=281, Percent_Identity=29.1814946619217, Blast_Score=128, Evalue=3e-30, Organism=Drosophila melanogaster, GI45553081, Length=284, Percent_Identity=27.4647887323944, Blast_Score=118, Evalue=3e-27, Organism=Drosophila melanogaster, GI24662785, Length=290, Percent_Identity=32.4137931034483, Blast_Score=113, Evalue=2e-25, Organism=Drosophila melanogaster, GI24662781, Length=290, Percent_Identity=31.3793103448276, Blast_Score=108, Evalue=3e-24, Organism=Drosophila melanogaster, GI281366140, Length=258, Percent_Identity=26.3565891472868, Blast_Score=97, Evalue=1e-20,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.274 [H]
Molecular weight: Translated: 29026; Mature: 28895
Theoretical pI: Translated: 4.79; Mature: 4.79
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 3.0 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSIPVFGLGTFRLQDQIVIDSVCQALTLGYRAIDTAQIYENEAAVGQAIQESGINRDELF CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEE ITTKIWIANLSKDKLIPSLRESIQKLKTDYVDLTLIHWPSPNDEVSVAEFMSELLKAKGL EEEEEEEEECCHHHCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCC GLTRQIGISNFTIDLMKQAIAAVGAEEIATNQIELSPLLQNRNVVDFAKQNGIAVTSYMT CCEEECCCCHHHHHHHHHHHHHHCHHHHHCCCEEEHHHHCCCCCHHHHHCCCEEEHHHHH LAYGKALAEPVIKTIAEQHGATPAQVILSWAMQLGYGVIPSSTKAANLASNLLAQKLCLN HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHC AADMALIATLDRNERLVSPDGLAPKWD HHHHHEEEEECCCCCEECCCCCCCCCC >Mature Secondary Structure SIPVFGLGTFRLQDQIVIDSVCQALTLGYRAIDTAQIYENEAAVGQAIQESGINRDELF CCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEE ITTKIWIANLSKDKLIPSLRESIQKLKTDYVDLTLIHWPSPNDEVSVAEFMSELLKAKGL EEEEEEEEECCHHHCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCC GLTRQIGISNFTIDLMKQAIAAVGAEEIATNQIELSPLLQNRNVVDFAKQNGIAVTSYMT CCEEECCCCHHHHHHHHHHHHHHCHHHHHCCCEEEHHHHCCCCCHHHHHCCCEEEHHHHH LAYGKALAEPVIKTIAEQHGATPAQVILSWAMQLGYGVIPSSTKAANLASNLLAQKLCLN HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHC AADMALIATLDRNERLVSPDGLAPKWD HHHHHEEEEECCCCCEECCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11586360; 12142430 [H]