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The map label for this gene is guaB

Identifier: 51597149

GI number: 51597149

Start: 3346768

End: 3348315

Strand: Reverse

Name: guaB

Synonym: YPTB2833

Alternate gene names: 51597149

Gene position: 3348315-3346768 (Counterclockwise)

Preceding gene: 51597151

Following gene: 51597148

Centisome position: 70.57

GC content: 51.29

Gene sequence:

>1548_bases
GTGCTGGAGGCAATCGATTACGCTCTGTATAATGCCACGGCAATATTTTATCTTTTTCACATTCACCTTGGTGAGATATT
GCCCATGCTACGTATCGCGAAAGAAGCACTAACATTTGATGACGTTCTCCTGGTTCCAGCCCACTCCACAGTCTTGCCTA
ACACGGCAGAACTTGGCACTCAACTGACCGCAACTATCCGCCTGAATATTCCTATGCTGTCCGCAGCCATGGATACCGTT
ACCGAATCTCGTCTGGCCATTGCGCTGGCACAAGAAGGCGGTTTGGGTTTCATTCACAAAAATATGTCCATTGAGCGCCA
GGCTGAAGAAGTCAGCCGCGTGAAAAAACATGAAAGTGGCGTTGTTACTGAGCCACAGACTGTTACCCCAACAACGACCC
TCCGTCAGGTTAAAGAATTGACCGCCCGTAACGGTTTTGCCGGGTATCCGGTGGTGACCGAAGATTACGAATTGGTTGGG
ATCATCACTGGCCGTGATGTTCGCTTTGTGACTGATTTGGATCAACCGGTGACCGCGGTGATGACACCGAAAGAACGCTT
GGTGACGGTCAAGGAAGGCGAAACCCGCGAAGTTGTGCTGCAAAAAATGCACGAAAAACGTGTAGAGAAAGTGTTGGTCG
TTGATGACAGCTTTCATTTGCGCGGCATGATAACCGTAAAAGATTTCCAAAAAGCAGAACGTAAGCCAAATGCCTGTAAA
GACGAGCATGGCCGTTTGCGTGTTGGTGCCGCTGTTGGTGCCGGTGCTGGCAATGAAGAGCGTATCGACGCGCTGGTCGC
CGCTGGTGTTGATGTATTACTGATAGACTCCTCTCATGGTCATTCTGAAGGTGTTCTGCAACGTATCCGTGAAACTCGCG
CTAAATATCCTAACTTGCAAATTGTGGGCGGTAACGTCGCAACCGGTGCTGGGGCGAAAGCGTTGGCAGATGCCGGTGTG
AGTGCGGTTAAGGTGGGTATCGGCCCAGGTTCAATCTGTACGACGCGCATTGTTACCGGTGTTGGTGTTCCACAGATTAC
CGCGATTGCCGATGCTGTTGAAGCACTGGAAGGTACCGGTATTCCGGTTATCGCCGATGGGGGTATCCGTTTCTCCGGCG
ATATTGCCAAAGCGATTGCTGCAGGGGCTTCTTGCGTCATGGTCGGTTCTATGTTGGCCGGTACTGAAGAGTCTCCGGGC
GAAATCGAACTGTATCAAGGTCGCTCCTTCAAATCTTACCGTGGTATGGGGTCGCTGGGCGCGATGTCCAAAGGCTCTTC
CGACCGTTACTTCCAAACCGATAATGCGGCCGATAAATTGGTTCCTGAAGGTATCGAAGGGCGCGTAGCCTACAAAGGCC
TGCTGAAAGAGATCGTGCACCAACAAATGGGCGGCCTGCGTTCTTGCATGGGGCTGACCGGTTGCGGCACTATCAATGAA
TTGCGCACTAAAGCGGAGTTCGTCCGCATCAGTGGTGCCGGCATTCAAGAAAGCCATGTGCATGATGTGACGATTACTAA
AGAGTCACCTAATTATCGTATGATGTAA

Upstream 100 bases:

>100_bases
GGAAGATTGCGACATGTGACCTGGATCAAATTTTAAAACAAGGACTTAATTAACCGATATTACCTGCCTCAAACTGGTTG
GCAAGAAATATTATGAGAAA

Downstream 100 bases:

>100_bases
CAATTAGTTAAATAATCATCTGGTGCTGGCCATCAGATGGTTATTTTTTATTTTAAAATCAATACCCAAAGTCATTGGCG
TTGCAGTAAGGCAGCAAATA

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MLEAIDYALYNATAIFYLFHIHLGEILPMLRIAKEALTFDDVLLVPAHSTVLPNTAELGTQLTATIRLNIPMLSAAMDTV
TESRLAIALAQEGGLGFIHKNMSIERQAEEVSRVKKHESGVVTEPQTVTPTTTLRQVKELTARNGFAGYPVVTEDYELVG
IITGRDVRFVTDLDQPVTAVMTPKERLVTVKEGETREVVLQKMHEKRVEKVLVVDDSFHLRGMITVKDFQKAERKPNACK
DEHGRLRVGAAVGAGAGNEERIDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPNLQIVGGNVATGAGAKALADAGV
SAVKVGIGPGSICTTRIVTGVGVPQITAIADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASCVMVGSMLAGTEESPG
EIELYQGRSFKSYRGMGSLGAMSKGSSDRYFQTDNAADKLVPEGIEGRVAYKGLLKEIVHQQMGGLRSCMGLTGCGTINE
LRTKAEFVRISGAGIQESHVHDVTITKESPNYRMM

Sequences:

>Translated_515_residues
MLEAIDYALYNATAIFYLFHIHLGEILPMLRIAKEALTFDDVLLVPAHSTVLPNTAELGTQLTATIRLNIPMLSAAMDTV
TESRLAIALAQEGGLGFIHKNMSIERQAEEVSRVKKHESGVVTEPQTVTPTTTLRQVKELTARNGFAGYPVVTEDYELVG
IITGRDVRFVTDLDQPVTAVMTPKERLVTVKEGETREVVLQKMHEKRVEKVLVVDDSFHLRGMITVKDFQKAERKPNACK
DEHGRLRVGAAVGAGAGNEERIDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPNLQIVGGNVATGAGAKALADAGV
SAVKVGIGPGSICTTRIVTGVGVPQITAIADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASCVMVGSMLAGTEESPG
EIELYQGRSFKSYRGMGSLGAMSKGSSDRYFQTDNAADKLVPEGIEGRVAYKGLLKEIVHQQMGGLRSCMGLTGCGTINE
LRTKAEFVRISGAGIQESHVHDVTITKESPNYRMM
>Mature_515_residues
MLEAIDYALYNATAIFYLFHIHLGEILPMLRIAKEALTFDDVLLVPAHSTVLPNTAELGTQLTATIRLNIPMLSAAMDTV
TESRLAIALAQEGGLGFIHKNMSIERQAEEVSRVKKHESGVVTEPQTVTPTTTLRQVKELTARNGFAGYPVVTEDYELVG
IITGRDVRFVTDLDQPVTAVMTPKERLVTVKEGETREVVLQKMHEKRVEKVLVVDDSFHLRGMITVKDFQKAERKPNACK
DEHGRLRVGAAVGAGAGNEERIDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPNLQIVGGNVATGAGAKALADAGV
SAVKVGIGPGSICTTRIVTGVGVPQITAIADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASCVMVGSMLAGTEESPG
EIELYQGRSFKSYRGMGSLGAMSKGSSDRYFQTDNAADKLVPEGIEGRVAYKGLLKEIVHQQMGGLRSCMGLTGCGTINE
LRTKAEFVRISGAGIQESHVHDVTITKESPNYRMM

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=456, Percent_Identity=41.4473684210526, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI217035146, Length=462, Percent_Identity=40.2597402597403, Blast_Score=322, Evalue=6e-88,
Organism=Homo sapiens, GI156616279, Length=462, Percent_Identity=40.2597402597403, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI34328928, Length=462, Percent_Identity=40.2597402597403, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI34328930, Length=462, Percent_Identity=40.2597402597403, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI217035152, Length=451, Percent_Identity=40.5764966740577, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI217035148, Length=462, Percent_Identity=39.6103896103896, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI217035150, Length=462, Percent_Identity=37.2294372294372, Blast_Score=281, Evalue=7e-76,
Organism=Homo sapiens, GI156104880, Length=247, Percent_Identity=35.6275303643725, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=35.2226720647773, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=35.2226720647773, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=35.2226720647773, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=35.3658536585366, Blast_Score=154, Evalue=3e-37,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=92.1810699588477, Blast_Score=851, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=37.10407239819, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=510, Percent_Identity=34.9019607843137, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71994389, Length=433, Percent_Identity=37.6443418013857, Blast_Score=261, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=219, Percent_Identity=37.8995433789954, Blast_Score=151, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322012, Length=487, Percent_Identity=38.6036960985626, Blast_Score=312, Evalue=9e-86,
Organism=Saccharomyces cerevisiae, GI6323585, Length=466, Percent_Identity=38.8412017167382, Blast_Score=308, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6323464, Length=445, Percent_Identity=41.3483146067416, Blast_Score=301, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=38.3040935672515, Blast_Score=231, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=41.1764705882353, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=40.1656314699793, Blast_Score=321, Evalue=8e-88,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=40.1656314699793, Blast_Score=321, Evalue=8e-88,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=41.2698412698413, Blast_Score=293, Evalue=1e-79,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 55060; Mature: 55060

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEAIDYALYNATAIFYLFHIHLGEILPMLRIAKEALTFDDVLLVPAHSTVLPNTAELGT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHCC
QLTATIRLNIPMLSAAMDTVTESRLAIALAQEGGLGFIHKNMSIERQAEEVSRVKKHESG
EEEEEEEECCCHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCC
VVTEPQTVTPTTTLRQVKELTARNGFAGYPVVTEDYELVGIITGRDVRFVTDLDQPVTAV
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCEEEEEEECCCEEEEECCCCCEEEE
MTPKERLVTVKEGETREVVLQKMHEKRVEKVLVVDDSFHLRGMITVKDFQKAERKPNACK
ECCHHHEEEECCCCHHHHHHHHHHHHHHCEEEEEECCEEEEEEEEHHHHHHHHCCCCCCC
DEHGRLRVGAAVGAGAGNEERIDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPNLQ
CCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEE
IVGGNVATGAGAKALADAGVSAVKVGIGPGSICTTRIVTGVGVPQITAIADAVEALEGTG
EECCCCCCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
IPVIADGGIRFSGDIAKAIAAGASCVMVGSMLAGTEESPGEIELYQGRSFKSYRGMGSLG
CEEEECCCEEECCHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEECCCCHHHCCCCCCC
AMSKGSSDRYFQTDNAADKLVPEGIEGRVAYKGLLKEIVHQQMGGLRSCMGLTGCGTINE
CCCCCCCCCEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHH
LRTKAEFVRISGAGIQESHVHDVTITKESPNYRMM
HHHHHHEEEEECCCCCCCCEEEEEEEECCCCCCCC
>Mature Secondary Structure
MLEAIDYALYNATAIFYLFHIHLGEILPMLRIAKEALTFDDVLLVPAHSTVLPNTAELGT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHCC
QLTATIRLNIPMLSAAMDTVTESRLAIALAQEGGLGFIHKNMSIERQAEEVSRVKKHESG
EEEEEEEECCCHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCC
VVTEPQTVTPTTTLRQVKELTARNGFAGYPVVTEDYELVGIITGRDVRFVTDLDQPVTAV
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCEEEEEEECCCEEEEECCCCCEEEE
MTPKERLVTVKEGETREVVLQKMHEKRVEKVLVVDDSFHLRGMITVKDFQKAERKPNACK
ECCHHHEEEECCCCHHHHHHHHHHHHHHCEEEEEECCEEEEEEEEHHHHHHHHCCCCCCC
DEHGRLRVGAAVGAGAGNEERIDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPNLQ
CCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEE
IVGGNVATGAGAKALADAGVSAVKVGIGPGSICTTRIVTGVGVPQITAIADAVEALEGTG
EECCCCCCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
IPVIADGGIRFSGDIAKAIAAGASCVMVGSMLAGTEESPGEIELYQGRSFKSYRGMGSLG
CEEEECCCEEECCHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEECCCCHHHCCCCCCC
AMSKGSSDRYFQTDNAADKLVPEGIEGRVAYKGLLKEIVHQQMGGLRSCMGLTGCGTINE
CCCCCCCCCEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHH
LRTKAEFVRISGAGIQESHVHDVTITKESPNYRMM
HHHHHHEEEEECCCCCCCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]