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The map label for this gene is purI

Identifier: 51597111

GI number: 51597111

Start: 3298322

End: 3299365

Strand: Direct

Name: purI

Synonym: YPTB2795

Alternate gene names: 51597111

Gene position: 3298322-3299365 (Clockwise)

Preceding gene: 51597107

Following gene: 51597112

Centisome position: 69.52

GC content: 51.72

Gene sequence:

>1044_bases
GTGACCAACAAAACCTCTCTCAGTTATAAAGACGCAGGTGTAGATATTGATGCCGGCAATGACCTTGTTGATCGCATAAA
AGGTGTGGTTAAACAAACCCGTCGACCAGAAGTCATGGGCGGATTAGGAGGGTTCGGTGCCCTGTGCGCGTTGCCGCAAA
AATACCGTGAACCTATTCTGGTTTCAGGCACGGATGGCGTCGGCACCAAGCTGCGTCTGGCGATGGACCTGAAACGTCAC
GATACTATCGGTATCGATTTAGTCGCGATGTGTGTCAACGATCTGGTGGTTCAGGGCGCAGAGCCGCTGTTCTTCCTCGA
CTACTTTGCGACCGGTAAACTGGATGTGGATACTGCCGCCAGTGTGATTACCGGGATTGCCGAAGGCTGTAAACAATCAG
GTTGTGCGTTGGTTGGCGGTGAAACCGCAGAAATGCCGGGCATGTACCACGGCGATGATTATGACGTTGCTGGCTTCTGT
GTGGGTGTCGTAGAGAAATCTGAAATCATCGATGGCAGTAAAGTTACACCAGGTGATGTCTTGGTCGCCTTAGGTGCTAG
CGGCCCACACTCCAATGGTTATTCATTGGTGCGCAAAATTCTGGACGTCAGCAACACCAATCCAGAACAGACCTCGTTGG
AAGGCAAATCTCTGGCCGATCATTTGCTAGAACCGACCAAAATCTATGTGAAATCCATTCTCAGCCTGATTGAACAGTTA
GATATCCACGCCATTGCGCATCTGACCGGTGGTGGCTTCTGGGAAAATATCCCGCGCGTACTACCGCAAGGCATGCAAGC
CGTTATCGACGAAGCCAGTTGGCAGTGGCCAGCGGTATTCAGTTGGCTGCAACACGCTGGCAATGTCAGCCGCCATGAGA
TGTACCGCACCTTTAACTGTGGCGTCGGTATGGTTGTTGCCTTGCCTGCAGAACTGGCAGATAAAGCGGTTGAGTTGCTG
ACAGCTTCTGGCGAAAAAGCCTGGAAAATCGGTGTCATTGCCGCGGCAACTGAGGGTGCTGAGCAAGTCATCATTAATCC
GTAA

Upstream 100 bases:

>100_bases
GCCAGTAAGTGATTCGGGTGATTGCGCATAGCCAATGCACATGTAGCTTGACGTATTACGGGTATAAGCTCAAACAGACA
ACCGCCGTGGGGACCTCGCA

Downstream 100 bases:

>100_bases
TATTGCTGATTAATCATATTGTTCGGCAAGGCGGCCTCGCCTCTGCGAGGCCCACCGATGGATCGGGTAAGTGAACATAG
CTAACCACCCTGCAGCTTCA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTNKTSLSYKDAGVDIDAGNDLVDRIKGVVKQTRRPEVMGGLGGFGALCALPQKYREPILVSGTDGVGTKLRLAMDLKRH
DTIGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDVDTAASVITGIAEGCKQSGCALVGGETAEMPGMYHGDDYDVAGFC
VGVVEKSEIIDGSKVTPGDVLVALGASGPHSNGYSLVRKILDVSNTNPEQTSLEGKSLADHLLEPTKIYVKSILSLIEQL
DIHAIAHLTGGGFWENIPRVLPQGMQAVIDEASWQWPAVFSWLQHAGNVSRHEMYRTFNCGVGMVVALPAELADKAVELL
TASGEKAWKIGVIAAATEGAEQVIINP

Sequences:

>Translated_347_residues
MTNKTSLSYKDAGVDIDAGNDLVDRIKGVVKQTRRPEVMGGLGGFGALCALPQKYREPILVSGTDGVGTKLRLAMDLKRH
DTIGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDVDTAASVITGIAEGCKQSGCALVGGETAEMPGMYHGDDYDVAGFC
VGVVEKSEIIDGSKVTPGDVLVALGASGPHSNGYSLVRKILDVSNTNPEQTSLEGKSLADHLLEPTKIYVKSILSLIEQL
DIHAIAHLTGGGFWENIPRVLPQGMQAVIDEASWQWPAVFSWLQHAGNVSRHEMYRTFNCGVGMVVALPAELADKAVELL
TASGEKAWKIGVIAAATEGAEQVIINP
>Mature_346_residues
TNKTSLSYKDAGVDIDAGNDLVDRIKGVVKQTRRPEVMGGLGGFGALCALPQKYREPILVSGTDGVGTKLRLAMDLKRHD
TIGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDVDTAASVITGIAEGCKQSGCALVGGETAEMPGMYHGDDYDVAGFCV
GVVEKSEIIDGSKVTPGDVLVALGASGPHSNGYSLVRKILDVSNTNPEQTSLEGKSLADHLLEPTKIYVKSILSLIEQLD
IHAIAHLTGGGFWENIPRVLPQGMQAVIDEASWQWPAVFSWLQHAGNVSRHEMYRTFNCGVGMVVALPAELADKAVELLT
ASGEKAWKIGVIAAATEGAEQVIINP

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=351, Percent_Identity=48.1481481481481, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI209869995, Length=351, Percent_Identity=48.1481481481481, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI209869993, Length=351, Percent_Identity=48.1481481481481, Blast_Score=336, Evalue=2e-92,
Organism=Escherichia coli, GI1788845, Length=345, Percent_Identity=82.3188405797101, Blast_Score=595, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI17567511, Length=349, Percent_Identity=40.974212034384, Blast_Score=246, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6321203, Length=358, Percent_Identity=47.7653631284916, Blast_Score=323, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24582400, Length=305, Percent_Identity=42.2950819672131, Blast_Score=237, Evalue=7e-63,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36864; Mature: 36732

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKTSLSYKDAGVDIDAGNDLVDRIKGVVKQTRRPEVMGGLGGFGALCALPQKYREPIL
CCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCHHHCCCCCHHHHHCCCHHHCCCEE
VSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDVDTAA
EECCCCCCCEEEEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHH
SVITGIAEGCKQSGCALVGGETAEMPGMYHGDDYDVAGFCVGVVEKSEIIDGSKVTPGDV
HHHHHHHHHHHHCCCEEECCCCHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCE
LVALGASGPHSNGYSLVRKILDVSNTNPEQTSLEGKSLADHLLEPTKIYVKSILSLIEQL
EEEECCCCCCCCCHHHHHHHHHCCCCCCCHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
DIHAIAHLTGGGFWENIPRVLPQGMQAVIDEASWQWPAVFSWLQHAGNVSRHEMYRTFNC
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCC
GVGMVVALPAELADKAVELLTASGEKAWKIGVIAAATEGAEQVIINP
CCCEEEECCHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCEEEECC
>Mature Secondary Structure 
TNKTSLSYKDAGVDIDAGNDLVDRIKGVVKQTRRPEVMGGLGGFGALCALPQKYREPIL
CCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCHHHCCCCCHHHHHCCCHHHCCCEE
VSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDVDTAA
EECCCCCCCEEEEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHH
SVITGIAEGCKQSGCALVGGETAEMPGMYHGDDYDVAGFCVGVVEKSEIIDGSKVTPGDV
HHHHHHHHHHHHCCCEEECCCCHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCE
LVALGASGPHSNGYSLVRKILDVSNTNPEQTSLEGKSLADHLLEPTKIYVKSILSLIEQL
EEEECCCCCCCCCHHHHHHHHHCCCCCCCHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
DIHAIAHLTGGGFWENIPRVLPQGMQAVIDEASWQWPAVFSWLQHAGNVSRHEMYRTFNC
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCC
GVGMVVALPAELADKAVELLTASGEKAWKIGVIAAATEGAEQVIINP
CCCEEEECCHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA