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The map label for this gene is edd

Identifier: 51596884

GI number: 51596884

Start: 3033544

End: 3035460

Strand: Reverse

Name: edd

Synonym: YPTB2565

Alternate gene names: 51596884

Gene position: 3035460-3033544 (Counterclockwise)

Preceding gene: 51596885

Following gene: 51596883

Centisome position: 63.98

GC content: 52.79

Gene sequence:

>1917_bases
ATGAACCCCATTATCACCCGTGTCACGCAGCGTATCATTGCGCGCTCAGCGGCCACACGCACGGCATATCTGCAACGTAT
CAGTGCAGCAAAAGAGCATACCGTTCACCGTTCACAACTGGCTTGCGGTAACCTGGCGCACGGCTTTGCGGCTTGTCAGC
CAGAGGATAAAGCGGCCCTAAAAAATAGGGTGCGTAGCGATATCGCCATCATTACGTCCTATAACGATATGCTGTCTGCT
CATCAACCTTATGAACATTACCCACAACAACTGAAAGACGCATTGCATGAGGTTGGGGCCATTGGGCAGGTTGCCGGTGG
GGTTCCTGCCATGTGTGATGGGGTGACGCAAGGGCAGGATGGGATGGAGTTGTCGCTAATGAGCCGCGATGTGATTGCTA
TGTCAGCGGCTATTGGCCTGTCACACAATATGTTTGATGGTGCTCTCTACCTCGGTGTGTGCGATAAAATCGTTCCCGGT
TTGTTAATGGCAGCGCTGTCATTTGGCCATTTACCGGCTATTTTTGTCCCCGCCGGGCCTATGGCCAGCGGTTTGCCTAA
CAAAGAGAAAGTCCGGATCCGCCAACTTTACGCTGAGGGGAAAGTGGATAGGCAAGCCTTGTTGGAGGCTGAAGCCGCTT
CGTATCACAGTGCCGGGACCTGTACTTTTTACGGTACAGCCAATTCTAATCAGATGGTGATGGAAGTGATGGGGCTGCAT
TTGCCGGGAGCCTCTTTTATCCAACCGAATACGCCACTGCGTGATGCGCTGACTGCAGCGGCTGCACGTCAAATCACCCG
TCTGACCGAAACTGGCATCAATTGTATTGATAGCAATCATATTGATGGCAATCATATTAATGTTAACCACATTGAAAGTA
ACCATATCAACAGTAACCATATCAGCAGTAACCATATCAACAGCAGCTATTTGCCTGTTGGCCAATTGGTGGATGAAAAA
GTGGTCGTCAATGGGATTGTCGCGCTGTTGGCAACCGGCGGTTCGACTAATCACACCTTACATTTGGTCGCGATGGCGCG
GGCGGCGGGCATCATCATTAATTGGGATGATTTCTCTGAACTGTCGGAAGCGGTGCCGCAGCTATGCCGTATTTACCCTA
ATGGCCCCGCGGACATCAACTATTTTCAGGCATCGGGTGGTGTGGCACTGCTGGTTAATATGCTATTGCAAGGCGGTTTA
CTGCACGAAGAGGTGCATACCGTCGCTGGATTTGGTTTGCAGCGTTATACGCAAGAGCCTTATCTGGCGGCGGGTAAATT
ACAATGGCGTCCTGGGCCGCAACAGTCACTGGATGCGACGGTGATCGCCAGTCTGGAACAGCCTTTTTCTGCTCAGGGGG
GGACGAAAGTATTAAACGGCAATCTGGGGCGGGCGGTAATGAAAACCTCGGCAGTGCCACGGGAGCATCAGGTTATTGAA
GGGCCAGCGCGGGTATTTGAGAGTCAGCATGATGTGGAAGCCGCCTTTGAATCCGGTGATTTGGATCGCGATTGTGTGGT
GGTGGTGCGCTATCAGGGGCCGCAGGCCATTGGTATGCCGGAGTTACATAAGCTGATGCCGCCGCTAGGAGTATTACTTG
ATCGTGGCTTTAAGGTGGCGTTGGTGACGGATGGCCGATTATCCGGCGCATCAGGCAAGGTGCCGTCTGCCATTCACGTG
ACGCCAGAAGCCTATTGCGGTGGTTTACTGGCCAACGTCCGCAATGGTGACCGGATTCGGGTCGATGGGGTCAGTGGCGA
GCTGTCATTACTGGTGGATGAGGCTGAATTGGCCACTCGCGATAGTCCGTTACCGGCTATCTCTGCTTTCCATGTGGGAT
GTGGCCGTGAGTTGTTTGGGGCATTACGTGAACAGCTTTCTGGTGCAGAGCAGGGGGCGTGTTGTATTCGTTTCTAA

Upstream 100 bases:

>100_bases
CAATTTACTGTTACAGGTACTGGCCGACTTTATCGGCCTGCCCACTGGCAGCATTGAACTTTTGACCCCATTAACCCCAT
TGAGCGTATAAGGAATGGAG

Downstream 100 bases:

>100_bases
ATGCTATTTAGGTGGTTTTATTCAGAGCACTGTGCGCCATTTCCGCGCAGGATTTCAATATATGAATGAGTTTCAAGTCA
ATAAATAAAAACGCAGATTT

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAALKNRVRSDIAIITSYNDMLSA
HQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQDGMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPG
LLMAALSFGHLPAIFVPAGPMASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMGLH
LPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDSNHIDGNHINVNHIESNHINSNHISSNHINSSYLPVGQLVDEK
VVVNGIVALLATGGSTNHTLHLVAMARAAGIIINWDDFSELSEAVPQLCRIYPNGPADINYFQASGGVALLVNMLLQGGL
LHEEVHTVAGFGLQRYTQEPYLAAGKLQWRPGPQQSLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIE
GPARVFESQHDVEAAFESGDLDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGKVPSAIHV
TPEAYCGGLLANVRNGDRIRVDGVSGELSLLVDEAELATRDSPLPAISAFHVGCGRELFGALREQLSGAEQGACCIRF

Sequences:

>Translated_638_residues
MNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAALKNRVRSDIAIITSYNDMLSA
HQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQDGMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPG
LLMAALSFGHLPAIFVPAGPMASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMGLH
LPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDSNHIDGNHINVNHIESNHINSNHISSNHINSSYLPVGQLVDEK
VVVNGIVALLATGGSTNHTLHLVAMARAAGIIINWDDFSELSEAVPQLCRIYPNGPADINYFQASGGVALLVNMLLQGGL
LHEEVHTVAGFGLQRYTQEPYLAAGKLQWRPGPQQSLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIE
GPARVFESQHDVEAAFESGDLDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGKVPSAIHV
TPEAYCGGLLANVRNGDRIRVDGVSGELSLLVDEAELATRDSPLPAISAFHVGCGRELFGALREQLSGAEQGACCIRF
>Mature_638_residues
MNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAALKNRVRSDIAIITSYNDMLSA
HQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQDGMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPG
LLMAALSFGHLPAIFVPAGPMASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMGLH
LPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDSNHIDGNHINVNHIESNHINSNHISSNHINSSYLPVGQLVDEK
VVVNGIVALLATGGSTNHTLHLVAMARAAGIIINWDDFSELSEAVPQLCRIYPNGPADINYFQASGGVALLVNMLLQGGL
LHEEVHTVAGFGLQRYTQEPYLAAGKLQWRPGPQQSLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIE
GPARVFESQHDVEAAFESGDLDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGKVPSAIHV
TPEAYCGGLLANVRNGDRIRVDGVSGELSLLVDEAELATRDSPLPAISAFHVGCGRELFGALREQLSGAEQGACCIRF

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=638, Percent_Identity=73.9811912225705, Blast_Score=966, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=570, Percent_Identity=30.3508771929825, Blast_Score=195, Evalue=8e-51,
Organism=Escherichia coli, GI2367371, Length=493, Percent_Identity=28.1947261663286, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1786464, Length=553, Percent_Identity=26.7631103074141, Blast_Score=118, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6322476, Length=510, Percent_Identity=30.7843137254902, Blast_Score=176, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 68110; Mature: 68110

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHCCCCCHHHHH
KNRVRSDIAIITSYNDMLSAHQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQD
HHHHHCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCCCCCC
GMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPGLLMAALSFGHLPAIFVPAGP
CCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMGLH
HHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCC
LPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDSNHIDGNHINVNHIESNHINSNH
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCC
ISSNHINSSYLPVGQLVDEKVVVNGIVALLATGGSTNHTLHLVAMARAAGIIINWDDFSE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCEEEECCCHHH
LSEAVPQLCRIYPNGPADINYFQASGGVALLVNMLLQGGLLHEEVHTVAGFGLQRYTQEP
HHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCCC
YLAAGKLQWRPGPQQSLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIE
CEECCEEECCCCCCCCCCHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHCCCCCHHHHHC
GPARVFESQHDVEAAFESGDLDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVA
CHHHHHCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHCCHHHHHHCCCCEEE
LVTDGRLSGASGKVPSAIHVTPEAYCGGLLANVRNGDRIRVDGVSGELSLLVDEAELATR
EEECCCCCCCCCCCCCEEEECHHHHHCHHHHHCCCCCEEEEECCCCCEEEEEECHHHHCC
DSPLPAISAFHVGCGRELFGALREQLSGAEQGACCIRF
CCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCCEEECC
>Mature Secondary Structure
MNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHCCCCCHHHHH
KNRVRSDIAIITSYNDMLSAHQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQD
HHHHHCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCCCCCC
GMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPGLLMAALSFGHLPAIFVPAGP
CCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMGLH
HHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCC
LPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDSNHIDGNHINVNHIESNHINSNH
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCC
ISSNHINSSYLPVGQLVDEKVVVNGIVALLATGGSTNHTLHLVAMARAAGIIINWDDFSE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCEEEECCCHHH
LSEAVPQLCRIYPNGPADINYFQASGGVALLVNMLLQGGLLHEEVHTVAGFGLQRYTQEP
HHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCCC
YLAAGKLQWRPGPQQSLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIE
CEECCEEECCCCCCCCCCHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHCCCCCHHHHHC
GPARVFESQHDVEAAFESGDLDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVA
CHHHHHCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHCCHHHHHHCCCCEEE
LVTDGRLSGASGKVPSAIHVTPEAYCGGLLANVRNGDRIRVDGVSGELSLLVDEAELATR
EEECCCCCCCCCCCCCEEEECHHHHHCHHHHHCCCCCEEEEECCCCCEEEEEECHHHHCC
DSPLPAISAFHVGCGRELFGALREQLSGAEQGACCIRF
CCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]