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The map label for this gene is alsR [H]

Identifier: 51596253

GI number: 51596253

Start: 2264657

End: 2265541

Strand: Direct

Name: alsR [H]

Synonym: YPTB1927

Alternate gene names: 51596253

Gene position: 2264657-2265541 (Clockwise)

Preceding gene: 51596242

Following gene: 51596258

Centisome position: 47.73

GC content: 50.85

Gene sequence:

>885_bases
ATGAAGATGGAGTTACGTCATATACGCTATTTTCTGGCTGTTGCTGAAGAACGACATTTCACACGCGCTGCCGCCCGGCT
AGGAATAGGACAGCCTCCTCTCAGTCAGCAAATTAAGGATCTGGAGAGGGAACTCGGTGCGTTGTTGTTCCGGCGGGTTT
CTTATGGCGCAGAATTAACTGAGGCAGGTATTGCATTTCTGGATGTTGTCAAAGAGATACCTGTGATGGCAGAAAGAGCG
ACCCAAGCTGCGCAGCGGGCTGTCAGGGGAGAACTCGGCGTACTCAGAGTTGGCTTTACTGCGTCATCAGCATTTAACAG
CGTAGTGCCTACGGCGATCCGTGCCTTTAGACGTGCATATCCTGATGTACGATTACAGCTAGAGGAAGATAACACGACTC
GACTGGCTGATGGATTGAATGAAGGCTCGCTCGATGTCGCTTTCCTGAGGCCAGGCTTTGCTGGCAGCGAACGTTTCCAC
CTCAGAATGCTATCTGAAGAGCCGATGATGATTGTCATGGCGGAAAATCACCCGGCGGCATCGTATGAAGAAATTTCGCT
TAGCGCATTCAGGGATGAAACTTTCCTGCTATTTCCACGAGAGATTGGTCTGACGCTTTACGATTCAGTGATTGAGTCAT
GCCGTACTGCGGGTTTTGAGCCGACTATTGGCCAACTGGCACCACAAATCGCTTCGGTCATTAATCTCGTTGCGGCAGAA
ATGGGCGTTTCAATCGTTCCGGCTTCCATGAGCCAAGTGAAAGTTATTGGGGTTGTATATCGACACATTGCTGACCAGAC
GCCGACAGCAAAGCTCGCGTTGGCGTACCGGCGAGGGGATACCTCGCCGGTATTAAGAAACTTTGTCCTGACCGTGTTTC
CTTGA

Upstream 100 bases:

>100_bases
AAGATTAGACATGATGTTCCTCCTCCAACTTCGCTTAGTCTATGGTCGCCGTTATCATTTATCCAATATATGATACCGGT
GTGTTTAATTGCTTTTGGAT

Downstream 100 bases:

>100_bases
GTTCTCTCCGTCGGTTAAGGCGACTCTATAGGTTAAAACGATCCAATCGGTTAAAAAACGCCCCAAGAGCAAAATTATTG
GCTATCAATATCCGGCCTGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MKMELRHIRYFLAVAEERHFTRAAARLGIGQPPLSQQIKDLERELGALLFRRVSYGAELTEAGIAFLDVVKEIPVMAERA
TQAAQRAVRGELGVLRVGFTASSAFNSVVPTAIRAFRRAYPDVRLQLEEDNTTRLADGLNEGSLDVAFLRPGFAGSERFH
LRMLSEEPMMIVMAENHPAASYEEISLSAFRDETFLLFPREIGLTLYDSVIESCRTAGFEPTIGQLAPQIASVINLVAAE
MGVSIVPASMSQVKVIGVVYRHIADQTPTAKLALAYRRGDTSPVLRNFVLTVFP

Sequences:

>Translated_294_residues
MKMELRHIRYFLAVAEERHFTRAAARLGIGQPPLSQQIKDLERELGALLFRRVSYGAELTEAGIAFLDVVKEIPVMAERA
TQAAQRAVRGELGVLRVGFTASSAFNSVVPTAIRAFRRAYPDVRLQLEEDNTTRLADGLNEGSLDVAFLRPGFAGSERFH
LRMLSEEPMMIVMAENHPAASYEEISLSAFRDETFLLFPREIGLTLYDSVIESCRTAGFEPTIGQLAPQIASVINLVAAE
MGVSIVPASMSQVKVIGVVYRHIADQTPTAKLALAYRRGDTSPVLRNFVLTVFP
>Mature_294_residues
MKMELRHIRYFLAVAEERHFTRAAARLGIGQPPLSQQIKDLERELGALLFRRVSYGAELTEAGIAFLDVVKEIPVMAERA
TQAAQRAVRGELGVLRVGFTASSAFNSVVPTAIRAFRRAYPDVRLQLEEDNTTRLADGLNEGSLDVAFLRPGFAGSERFH
LRMLSEEPMMIVMAENHPAASYEEISLSAFRDETFLLFPREIGLTLYDSVIESCRTAGFEPTIGQLAPQIASVINLVAAE
MGVSIVPASMSQVKVIGVVYRHIADQTPTAKLALAYRRGDTSPVLRNFVLTVFP

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=289, Percent_Identity=40.4844290657439, Blast_Score=204, Evalue=6e-54,
Organism=Escherichia coli, GI1788887, Length=290, Percent_Identity=34.1379310344828, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI2367136, Length=284, Percent_Identity=30.9859154929577, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1790399, Length=283, Percent_Identity=31.8021201413428, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI157672245, Length=250, Percent_Identity=32.4, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787601, Length=301, Percent_Identity=26.9102990033223, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790262, Length=245, Percent_Identity=25.7142857142857, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081904, Length=190, Percent_Identity=30, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788748, Length=250, Percent_Identity=23.6, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788297, Length=252, Percent_Identity=26.5873015873016, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789173, Length=138, Percent_Identity=38.4057971014493, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787530, Length=251, Percent_Identity=24.3027888446215, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87082132, Length=298, Percent_Identity=25.1677852348993, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI145693105, Length=191, Percent_Identity=25.6544502617801, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787589, Length=174, Percent_Identity=29.8850574712644, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32482; Mature: 32482

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMELRHIRYFLAVAEERHFTRAAARLGIGQPPLSQQIKDLERELGALLFRRVSYGAELT
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
EAGIAFLDVVKEIPVMAERATQAAQRAVRGELGVLRVGFTASSAFNSVVPTAIRAFRRAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCC
PDVRLQLEEDNTTRLADGLNEGSLDVAFLRPGFAGSERFHLRMLSEEPMMIVMAENHPAA
CCEEEEECCCCCHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCEEEEEECCCCCC
SYEEISLSAFRDETFLLFPREIGLTLYDSVIESCRTAGFEPTIGQLAPQIASVINLVAAE
CHHHHHHHHCCCCEEEEEHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
MGVSIVPASMSQVKVIGVVYRHIADQTPTAKLALAYRRGDTSPVLRNFVLTVFP
HCCEEECCCHHHHHHHHHHHHHHCCCCCCHHEEEEEECCCCCHHHHHHHHEECC
>Mature Secondary Structure
MKMELRHIRYFLAVAEERHFTRAAARLGIGQPPLSQQIKDLERELGALLFRRVSYGAELT
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
EAGIAFLDVVKEIPVMAERATQAAQRAVRGELGVLRVGFTASSAFNSVVPTAIRAFRRAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCC
PDVRLQLEEDNTTRLADGLNEGSLDVAFLRPGFAGSERFHLRMLSEEPMMIVMAENHPAA
CCEEEEECCCCCHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCEEEEEECCCCCC
SYEEISLSAFRDETFLLFPREIGLTLYDSVIESCRTAGFEPTIGQLAPQIASVINLVAAE
CHHHHHHHHCCCCEEEEEHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
MGVSIVPASMSQVKVIGVVYRHIADQTPTAKLALAYRRGDTSPVLRNFVLTVFP
HCCEEECCCHHHHHHHHHHHHHHCCCCCCHHEEEEEECCCCCHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]