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The map label for this gene is yoaE

Identifier: 51595971

GI number: 51595971

Start: 1986391

End: 1987935

Strand: Direct

Name: yoaE

Synonym: YPTB1635

Alternate gene names: 51595971

Gene position: 1986391-1987935 (Clockwise)

Preceding gene: 51595965

Following gene: 51595973

Centisome position: 41.87

GC content: 51.07

Gene sequence:

>1545_bases
ATGGAACTTTTAATGGACCCCTCAATTTGGGCAGGGTTGCTTACACTGGTGGTATTAGAGATTGTTCTGGGCATTGATAA
CCTGGTATTTATTGCCATTTTGGCAGATAAACTGCCGCCTAAACAAAGGGATAAAGCCCGCATTATCGGTTTATCTCTGG
CATTGATCATGCGTTTGGGGCTGTTGTCGGTCATTTCATGGATGGTCACGCTTACGACACCGCTGTTCAGCGTCGGTGCG
TTTAATTTCGCTGGGCGAGATTTGATTTTGCTGGTGGGGGGGTTGTTCCTGCTGTTTAAAGCCACCACCGAGCTACATGA
ACGGTTAGAAGGTAATCAGCACAATGATGGGGCGAACCGGGGCTATGCCAGCTTCTGGGCGGTCGTGGTCCAAATTGTCA
TCCTGGATGCGGTCTTCTCCCTGGATGCAGTGATTACGGCGGTAGGGATGGTCAACGACTTGCCTATCATGATGACAGCC
GTGGTGATTGCCATGGGGGTCATGTTACTGGCCTCGAAATCCCTGACCCGATTTGTGAACGAGCACCCAACGGTGGTCGT
GCTATGTCTGAGCTTCCTGTTGATGATCGGCTTGAGTTTGATTGCCGAAGGTTTTGGCTTCCACATTCCGAAAGGTTACC
TGTATGCCGCGATTGGCTTCTCAATCTTGATTGAGTTGTTTAACCAGATTGCGCGTCGTAACTTCATCAAACATGAATCG
CGTTTACCAAGACGTCAACGTACAGCAGAAGCGATCATCCGTCTGATGGGTGGGCGTCAGCAGCAGGAACAACAGAGTGG
TGACCCTCAACAGGCAGTACCAACAGAAGCCTTTGCTGAAGAAGAACGCTATATGATCAGCGGGGTATTAACGCTGGCCT
CGCGATCATTACGCAGCGTAATGACGCCGCGTACCGAAATTTCTTGGGTTGATTGCAACCGTTCACAAGCCGAAATTCGC
GAGCAGTTGTTAGATACCCCACACAGTTTGTTCCCTGTTTGCCGCGACTCTTTGGATCAAATCATTGGTGTGGTTCGCGC
TAAAGACCTGCTGGTGGCGATTGAGCGGGGTGAGTCTATTTGTGATTTTGCCGCGACAACCCCGCCAATCGTGGTGCCTG
ATACCATGGATGTGATTAATCTGTTGGGGGTATTGCGCAAAGCCAAGGGCCGCCTGGTGGTGGTGAATGACGAGTTCGGC
GTGGTGCAGGGTCTGGTAACACCGCTGGATGTCCTGGAAGCGATTGCCGGTGAATTCCCTGATGAAGATGAAACGCCAGA
TATTATTGCCGATGGTGATGGTTGGTTGGTGAAAGGGGGGGCAGATCTGCACTCGTTGGAACAGGCGCTGGATTGCCAGA
CACTGGTTAGCCCAACCGCTGATTATGCCTCGTTAGCCGGTTTACTGTTGTCTCATTCGGGCCATATGCCAACGGCAGGG
GATGTGATTGAGCTGCATAACCTGCGCTTCCAGATTATGGACGTCTCAGATTACCGTATTGAGCTGGTGCGCATTACCAA
GCTGAGTAATGAGTTGGAAGAGTAA

Upstream 100 bases:

>100_bases
CTTTCTGTGTATCAGTGCTGACAACCGTGCAGCGGCGTTTTGCCGTCTCTGTTGCAGGGCGCGCATCATCTGGATCATGT
TCTTATTTTCGGAGTCTGAC

Downstream 100 bases:

>100_bases
GCAGAGAGTGGAACCTCAGGGGCGCTTCGGCTCCCCTGAGGTTATTGACAACGTACCCGCGACGGAGGTAACAGACAGAA
CGCAAAGACGCCGTAAACCC

Product: CorC/HlyC family Mg+2/Co+2/heavy metal efflux pumps

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MELLMDPSIWAGLLTLVVLEIVLGIDNLVFIAILADKLPPKQRDKARIIGLSLALIMRLGLLSVISWMVTLTTPLFSVGA
FNFAGRDLILLVGGLFLLFKATTELHERLEGNQHNDGANRGYASFWAVVVQIVILDAVFSLDAVITAVGMVNDLPIMMTA
VVIAMGVMLLASKSLTRFVNEHPTVVVLCLSFLLMIGLSLIAEGFGFHIPKGYLYAAIGFSILIELFNQIARRNFIKHES
RLPRRQRTAEAIIRLMGGRQQQEQQSGDPQQAVPTEAFAEEERYMISGVLTLASRSLRSVMTPRTEISWVDCNRSQAEIR
EQLLDTPHSLFPVCRDSLDQIIGVVRAKDLLVAIERGESICDFAATTPPIVVPDTMDVINLLGVLRKAKGRLVVVNDEFG
VVQGLVTPLDVLEAIAGEFPDEDETPDIIADGDGWLVKGGADLHSLEQALDCQTLVSPTADYASLAGLLLSHSGHMPTAG
DVIELHNLRFQIMDVSDYRIELVRITKLSNELEE

Sequences:

>Translated_514_residues
MELLMDPSIWAGLLTLVVLEIVLGIDNLVFIAILADKLPPKQRDKARIIGLSLALIMRLGLLSVISWMVTLTTPLFSVGA
FNFAGRDLILLVGGLFLLFKATTELHERLEGNQHNDGANRGYASFWAVVVQIVILDAVFSLDAVITAVGMVNDLPIMMTA
VVIAMGVMLLASKSLTRFVNEHPTVVVLCLSFLLMIGLSLIAEGFGFHIPKGYLYAAIGFSILIELFNQIARRNFIKHES
RLPRRQRTAEAIIRLMGGRQQQEQQSGDPQQAVPTEAFAEEERYMISGVLTLASRSLRSVMTPRTEISWVDCNRSQAEIR
EQLLDTPHSLFPVCRDSLDQIIGVVRAKDLLVAIERGESICDFAATTPPIVVPDTMDVINLLGVLRKAKGRLVVVNDEFG
VVQGLVTPLDVLEAIAGEFPDEDETPDIIADGDGWLVKGGADLHSLEQALDCQTLVSPTADYASLAGLLLSHSGHMPTAG
DVIELHNLRFQIMDVSDYRIELVRITKLSNELEE
>Mature_514_residues
MELLMDPSIWAGLLTLVVLEIVLGIDNLVFIAILADKLPPKQRDKARIIGLSLALIMRLGLLSVISWMVTLTTPLFSVGA
FNFAGRDLILLVGGLFLLFKATTELHERLEGNQHNDGANRGYASFWAVVVQIVILDAVFSLDAVITAVGMVNDLPIMMTA
VVIAMGVMLLASKSLTRFVNEHPTVVVLCLSFLLMIGLSLIAEGFGFHIPKGYLYAAIGFSILIELFNQIARRNFIKHES
RLPRRQRTAEAIIRLMGGRQQQEQQSGDPQQAVPTEAFAEEERYMISGVLTLASRSLRSVMTPRTEISWVDCNRSQAEIR
EQLLDTPHSLFPVCRDSLDQIIGVVRAKDLLVAIERGESICDFAATTPPIVVPDTMDVINLLGVLRKAKGRLVVVNDEFG
VVQGLVTPLDVLEAIAGEFPDEDETPDIIADGDGWLVKGGADLHSLEQALDCQTLVSPTADYASLAGLLLSHSGHMPTAG
DVIELHNLRFQIMDVSDYRIELVRITKLSNELEE

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Escherichia coli, GI1788119, Length=510, Percent_Identity=73.921568627451, Blast_Score=747, Evalue=0.0,
Organism=Escherichia coli, GI87082033, Length=528, Percent_Identity=49.2424242424242, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI1789197, Length=229, Percent_Identity=50.6550218340611, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1790664, Length=235, Percent_Identity=26.3829787234043, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1786879, Length=226, Percent_Identity=29.2035398230088, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI145693175, Length=231, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005496
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF03741 TerC [H]

EC number: NA

Molecular weight: Translated: 56454; Mature: 56454

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHCCCEEEEEECCCCEEEEHHHHHHHHHHCC
>Mature Secondary Structure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CHHHHCCCEEEEEECCCCEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]