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The map label for this gene is metG

Identifier: 51595871

GI number: 51595871

Start: 1844535

End: 1846562

Strand: Reverse

Name: metG

Synonym: YPTB1534

Alternate gene names: 51595871

Gene position: 1846562-1844535 (Counterclockwise)

Preceding gene: 51595876

Following gene: 51595869

Centisome position: 38.92

GC content: 48.32

Gene sequence:

>2028_bases
ATGGCTCAAGTCGCGAAAAAAATATTGGTGACGTGCGCGCTACCATACGCTAACGGTTCTATTCATCTCGGCCACATGCT
CGAGCATATCCAGGCAGACATCTGGGTCCGTTTCCAGCGAATGCGCGGCAACCAGGTTCATTTTATCTGTGCAGATGATG
CCCACGGGACTCCTATCATGCTGAAAGCTCAGCAAATGGGTATTGAACCAGAGCAGATGATTGCCGAAATGAGCCAGGAG
CACCAACAGGATTTCGCCGGTTTTGCTATCAGTTATGATAACTATCACTCCACCCACAGTGATGAAAACCGTGAACTGTC
GAGCCTGATCTATGGCCGTCTGAAAGCCAACGGTTATATAAAGAACCGTACTATTTCTCAGCTCTATGATCCTGAGAAAG
GCATGTTTCTGCCCGATCGTTTCGTGAAAGGCACTTGCCCAAAATGCAAAGCCCCGGAACAGTACGGCGATAACTGTGAA
GTCTGTGGCGCAACCTACAGCCCAACTGAACTTATCGACCCCAAATCCGCCGTTTCTGGTGCGACACCAGTGATGCGTGA
ATCTGAACACTTCTTCTTCGATTTACCGGCTTTCAGTGACATGTTGCAAGCCTGGACACGCTCAGGTGCGCTGCAAGAAC
AAGTCGCAAACAAAATGCAGGAATGGTTTGATTCCGGCCTGCAACAGTGGGATATCACGCGTGATGCCCCTTATTTCGGT
TTCGAAGTACCGGATGCACCGGGTAAATATTTTTACGTCTGGTTAGATGCCCCAATCGGTTACATGGGGGCGTTTAAAAA
CCTATGTGATAAACGTGGTGACCTGGATTTTGATGAATTCTGGGGTAAAGACGCCAAAACTGACCTCTATCACTTCATCG
GTAAAGATATTGTTTACTTCCACAGTCTGTTCTGGCCAGCCATGTTGGAAGGCAGTAACTTCCGCAAGCCGACAAACCTG
TTTGTCCATGGCTATGTCACGGTAAACGGCGCGAAAATGTCTAAATCTCGCGGTACGTTTATTAAGGCGGGGACTTACCT
GAAATATCTGGATGCGGATTGCCTGCGTTACTACTACGCGGCGAAACTCTCTTCGCGTATTGATGATATCGATTTAAATC
TGGAAGATTTCGTCCAACGCGTTAACGCCGATATCGTTAATAAAGTGGTGAATCTGGCCTCACGTAATGCTGGTTTTATC
AATAAACGCTTTGCAGGCCAGTTAGCTGACCAATTGGCTGACCCGGTGTTGTATAAAACATTCACCGATGCCGCAACCAG
TATTGCTGATGCTTATAACAACCGTGAGTCAGGTAAAGCCATTCGTGAAATTATGGCGCTAGCTGATGTGGCTAATCGCT
ATGTTGATGAACAGGCTCCATGGGTGGTCGCTAAACAAGAAGGCCACGATGCCGATCTACACGCTATCTGCTCGATGGGG
ATCAACCTATTCCGTGTCCTGATGACCTATCTGAAACCGGTATTACCCTCTCTGACAGAGCGTACCGAGGCCTTCCTCAA
TACCGAGCTAACTTGGGATAGCATTGAACAACCTCTGCTGGGCCACTCTATCACCGCTTTCAAGGCACTGTTTAATCGTA
TTGATTTAGACAAAGTAAACGAAATGGTCGCCTCGTCTAAAGAAGATATGGCACCTGCAACCAGGGTTACAGGCCCGTTA
GCCGATGATCCAATTCAGGAAACCATCAGTTTTGATGACTTTGCCAAAGTTGATATGCGAATTGCGTTGATTCAACAAGC
CGAATTTGTTGAAGGCTCAGATAAGTTATTAAAACTAACACTTGAACTTGGAGGGGAGACCCGCCAGATATTCTCGGGTA
TCCGTTCAGCTTACCCTGACCCAAAAGCCTTGGAAGGCCGCATGACCGTGATGGTCGCTAACCTTGCCCCGAGAAAAATG
CGCTTTGGGGTTTCAGAAGGCATGGTGATGACCGCAGGCCCCGGAGGTAGCGATATCTTCCTGCTTAGCCCTGACAGTGG
TGCGCAGCCAGGCATGCAAGTGAAGTGA

Upstream 100 bases:

>100_bases
ACTTAAGGTGCAGTACCCGCTCCCTTGCCCTAGCGGCAAACTCGCTTATCGGTTAACATCAAAGGCCCTTTAATCAACAT
AAAGAAAGCAATTTCCCACT

Downstream 100 bases:

>100_bases
TTTTCTTCTGGCGACTAAGCGAAGATACAATAGATAACTGAAAGATCCTTAAAGAACAAAATGCCGGTCTGGGGTAACCC
TACCGGCATTTTTATGATTG

Product: methionyl-tRNA synthetase

Products: NA

Alternate protein names: Methionine--tRNA ligase; MetRS [H]

Number of amino acids: Translated: 675; Mature: 674

Protein sequence:

>675_residues
MAQVAKKILVTCALPYANGSIHLGHMLEHIQADIWVRFQRMRGNQVHFICADDAHGTPIMLKAQQMGIEPEQMIAEMSQE
HQQDFAGFAISYDNYHSTHSDENRELSSLIYGRLKANGYIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKAPEQYGDNCE
VCGATYSPTELIDPKSAVSGATPVMRESEHFFFDLPAFSDMLQAWTRSGALQEQVANKMQEWFDSGLQQWDITRDAPYFG
FEVPDAPGKYFYVWLDAPIGYMGAFKNLCDKRGDLDFDEFWGKDAKTDLYHFIGKDIVYFHSLFWPAMLEGSNFRKPTNL
FVHGYVTVNGAKMSKSRGTFIKAGTYLKYLDADCLRYYYAAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFI
NKRFAGQLADQLADPVLYKTFTDAATSIADAYNNRESGKAIREIMALADVANRYVDEQAPWVVAKQEGHDADLHAICSMG
INLFRVLMTYLKPVLPSLTERTEAFLNTELTWDSIEQPLLGHSITAFKALFNRIDLDKVNEMVASSKEDMAPATRVTGPL
ADDPIQETISFDDFAKVDMRIALIQQAEFVEGSDKLLKLTLELGGETRQIFSGIRSAYPDPKALEGRMTVMVANLAPRKM
RFGVSEGMVMTAGPGGSDIFLLSPDSGAQPGMQVK

Sequences:

>Translated_675_residues
MAQVAKKILVTCALPYANGSIHLGHMLEHIQADIWVRFQRMRGNQVHFICADDAHGTPIMLKAQQMGIEPEQMIAEMSQE
HQQDFAGFAISYDNYHSTHSDENRELSSLIYGRLKANGYIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKAPEQYGDNCE
VCGATYSPTELIDPKSAVSGATPVMRESEHFFFDLPAFSDMLQAWTRSGALQEQVANKMQEWFDSGLQQWDITRDAPYFG
FEVPDAPGKYFYVWLDAPIGYMGAFKNLCDKRGDLDFDEFWGKDAKTDLYHFIGKDIVYFHSLFWPAMLEGSNFRKPTNL
FVHGYVTVNGAKMSKSRGTFIKAGTYLKYLDADCLRYYYAAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFI
NKRFAGQLADQLADPVLYKTFTDAATSIADAYNNRESGKAIREIMALADVANRYVDEQAPWVVAKQEGHDADLHAICSMG
INLFRVLMTYLKPVLPSLTERTEAFLNTELTWDSIEQPLLGHSITAFKALFNRIDLDKVNEMVASSKEDMAPATRVTGPL
ADDPIQETISFDDFAKVDMRIALIQQAEFVEGSDKLLKLTLELGGETRQIFSGIRSAYPDPKALEGRMTVMVANLAPRKM
RFGVSEGMVMTAGPGGSDIFLLSPDSGAQPGMQVK
>Mature_674_residues
AQVAKKILVTCALPYANGSIHLGHMLEHIQADIWVRFQRMRGNQVHFICADDAHGTPIMLKAQQMGIEPEQMIAEMSQEH
QQDFAGFAISYDNYHSTHSDENRELSSLIYGRLKANGYIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKAPEQYGDNCEV
CGATYSPTELIDPKSAVSGATPVMRESEHFFFDLPAFSDMLQAWTRSGALQEQVANKMQEWFDSGLQQWDITRDAPYFGF
EVPDAPGKYFYVWLDAPIGYMGAFKNLCDKRGDLDFDEFWGKDAKTDLYHFIGKDIVYFHSLFWPAMLEGSNFRKPTNLF
VHGYVTVNGAKMSKSRGTFIKAGTYLKYLDADCLRYYYAAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFIN
KRFAGQLADQLADPVLYKTFTDAATSIADAYNNRESGKAIREIMALADVANRYVDEQAPWVVAKQEGHDADLHAICSMGI
NLFRVLMTYLKPVLPSLTERTEAFLNTELTWDSIEQPLLGHSITAFKALFNRIDLDKVNEMVASSKEDMAPATRVTGPLA
DDPIQETISFDDFAKVDMRIALIQQAEFVEGSDKLLKLTLELGGETRQIFSGIRSAYPDPKALEGRMTVMVANLAPRKMR
FGVSEGMVMTAGPGGSDIFLLSPDSGAQPGMQVK

Specific function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation [H]

COG id: COG0143

COG function: function code J; Methionyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 tRNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI14043022, Length=566, Percent_Identity=27.5618374558304, Blast_Score=236, Evalue=7e-62,
Organism=Homo sapiens, GI24308436, Length=513, Percent_Identity=25.9259259259259, Blast_Score=167, Evalue=3e-41,
Organism=Escherichia coli, GI1788432, Length=677, Percent_Identity=84.3426883308715, Blast_Score=1222, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17540794, Length=571, Percent_Identity=28.7215411558669, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI212645096, Length=511, Percent_Identity=23.8747553816047, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71992781, Length=405, Percent_Identity=23.4567901234568, Blast_Score=109, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6321704, Length=559, Percent_Identity=28.8014311270125, Blast_Score=245, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6321610, Length=537, Percent_Identity=22.5325884543762, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24655311, Length=567, Percent_Identity=28.3950617283951, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI21358483, Length=513, Percent_Identity=24.5614035087719, Blast_Score=135, Evalue=8e-32,

Paralogues:

None

Copy number: 871 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR015413
- InterPro:   IPR004495
- InterPro:   IPR014758
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR014729
- InterPro:   IPR002547
- InterPro:   IPR009080 [H]

Pfam domain/function: PF09334 tRNA-synt_1g; PF01588 tRNA_bind [H]

EC number: =6.1.1.10 [H]

Molecular weight: Translated: 75662; Mature: 75531

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS50886 TRBD ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQVAKKILVTCALPYANGSIHLGHMLEHIQADIWVRFQRMRGNQVHFICADDAHGTPIM
CHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEE
LKAQQMGIEPEQMIAEMSQEHQQDFAGFAISYDNYHSTHSDENRELSSLIYGRLKANGYI
EEHHHHCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEE
KNRTISQLYDPEKGMFLPDRFVKGTCPKCKAPEQYGDNCEVCGATYSPTELIDPKSAVSG
ECCCHHHHCCCCCCCCCCHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCHHHCCCHHHCCC
ATPVMRESEHFFFDLPAFSDMLQAWTRSGALQEQVANKMQEWFDSGLQQWDITRDAPYFG
CCCCCCCCCCEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCC
FEVPDAPGKYFYVWLDAPIGYMGAFKNLCDKRGDLDFDEFWGKDAKTDLYHFIGKDIVYF
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHH
HSLFWPAMLEGSNFRKPTNLFVHGYVTVNGAKMSKSRGTFIKAGTYLKYLDADCLRYYYA
HHHHHHHHHCCCCCCCCCEEEEEEEEEEECCEECCCCCCEEECCCHHHHHHHHHHHHHHH
AKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFAGQLADQLADPVLYKT
HHHHCCCCCCCCCHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHH
FTDAATSIADAYNNRESGKAIREIMALADVANRYVDEQAPWVVAKQEGHDADLHAICSMG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHH
INLFRVLMTYLKPVLPSLTERTEAFLNTELTWDSIEQPLLGHSITAFKALFNRIDLDKVN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHCCHHHHHHHHHHHCCHHHHH
EMVASSKEDMAPATRVTGPLADDPIQETISFDDFAKVDMRIALIQQAEFVEGSDKLLKLT
HHHHCCHHHCCCHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEE
LELGGETRQIFSGIRSAYPDPKALEGRMTVMVANLAPRKMRFGVSEGMVMTAGPGGSDIF
ECCCCCHHHHHHHHHHCCCCCHHCCCEEEEEEECCCCHHHHCCCCCCEEEEECCCCCEEE
LLSPDSGAQPGMQVK
EECCCCCCCCCCCCC
>Mature Secondary Structure 
AQVAKKILVTCALPYANGSIHLGHMLEHIQADIWVRFQRMRGNQVHFICADDAHGTPIM
HHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEE
LKAQQMGIEPEQMIAEMSQEHQQDFAGFAISYDNYHSTHSDENRELSSLIYGRLKANGYI
EEHHHHCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEE
KNRTISQLYDPEKGMFLPDRFVKGTCPKCKAPEQYGDNCEVCGATYSPTELIDPKSAVSG
ECCCHHHHCCCCCCCCCCHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCHHHCCCHHHCCC
ATPVMRESEHFFFDLPAFSDMLQAWTRSGALQEQVANKMQEWFDSGLQQWDITRDAPYFG
CCCCCCCCCCEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCC
FEVPDAPGKYFYVWLDAPIGYMGAFKNLCDKRGDLDFDEFWGKDAKTDLYHFIGKDIVYF
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHH
HSLFWPAMLEGSNFRKPTNLFVHGYVTVNGAKMSKSRGTFIKAGTYLKYLDADCLRYYYA
HHHHHHHHHCCCCCCCCCEEEEEEEEEEECCEECCCCCCEEECCCHHHHHHHHHHHHHHH
AKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFAGQLADQLADPVLYKT
HHHHCCCCCCCCCHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHH
FTDAATSIADAYNNRESGKAIREIMALADVANRYVDEQAPWVVAKQEGHDADLHAICSMG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHH
INLFRVLMTYLKPVLPSLTERTEAFLNTELTWDSIEQPLLGHSITAFKALFNRIDLDKVN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHCCHHHHHHHHHHHCCHHHHH
EMVASSKEDMAPATRVTGPLADDPIQETISFDDFAKVDMRIALIQQAEFVEGSDKLLKLT
HHHHCCHHHCCCHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEE
LELGGETRQIFSGIRSAYPDPKALEGRMTVMVANLAPRKMRFGVSEGMVMTAGPGGSDIF
ECCCCCHHHHHHHHHHCCCCCHHCCCEEEEEEECCCCHHHHCCCCCCEEEEECCCCCEEE
LLSPDSGAQPGMQVK
EECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA