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The map label for this gene is dacC

Identifier: 51595692

GI number: 51595692

Start: 1610450

End: 1611655

Strand: Direct

Name: dacC

Synonym: YPTB1351

Alternate gene names: 51595692

Gene position: 1610450-1611655 (Clockwise)

Preceding gene: 51595691

Following gene: 51595700

Centisome position: 33.94

GC content: 48.01

Gene sequence:

>1206_bases
ATGATGAAATATATCCTCCCTTTCAAGATTAAAAATTTTACGTTCAGTGCAGGTTTATTGCTTCTGGCACTGCCTGCTGC
TTATGCAGTCGATGACCCTGCCGCTCCCCAGATTGATGCTAAAGCTTATGTGCTGATGGATTTTAATAGCGGAAAAGTGC
TGGCAGAAGGCAATCCTGATCTGCGCCTTGATCCGGCCAGTTTGACAAAAATCATGTCCAGCTATGTGATCGGGCAGTCG
ATTAAAGCGGGCAAAATACAGCCTGATGATCTGGTCACCGTGGGGAAAGACGCCTGGGCGACCGGTAACCCAGCTCTGCG
CGGCTCGTCGCTGATGTTTTTGAAGCCGGGCGATCGGGTAAAAGTGTCTGATCTCAACAAAGGCATTGTGATCCAATCAG
GTAATGATGCCAGTATTGCATTGGCTGATTATGTCGCGGGTAGTCAGGACAGTTTTGTTGGCCTGATGAATAACTACGCT
AAAGCACTTGGCCTGAGTAATACTCACTTTATGACGGTACACGGCCTGGATTCACCGGGGCAGTACAGTACTGCGCGTGA
TATGGCTTTACTGGGGCAGGCATTGATCCGCGATGTGCCAGAAGAATATGCGCTGCATAAAGAGAAAGAATTTACCTTTA
ATAAAATTCGCCAAACCAACCGTAACCGGCTGTTATGGAACAGTAGTTTAAACGTTGATGGGATGAAAACCGGTTATACC
AACGGGGCGGGGTATAATTTGGTCGCATCGGCGACAGATGGGCCGATGCGTTTGATTTCCGTGGTGCTGGGTGCACCAAG
TGACAAAGTACGCTTTAGTGAAAGTGAAAAATTGCTGACTTGGGGTTTCCGCTTCTATGAAACCGTGGTGCCAATTAAAT
CAACAAAGCCATTTGTGACAGAGAAAGTGTGGCTTGGCGATAACAGCCAGGTTGAACTTGGGGTGGCGGAGGATGCGGCG
ATCACCATTCCTAAAGGGCAGATGAAAAATCTGAAAGCCAGTTATACCCTGAACCAAACCGAGCTACGCGCGCCGCTAGC
GAAACATCAAGTGGTTGGAACCATCGATTTTCAACTCAATGGCAAAACCATTGAACAGCGCCCACTCGTGGTGTTGAATG
AGGTCAAAGAGGGGGGCATCTTTAGCCGTTTCTGGGATTACGTAATGATGAAACTTAACCAATGGTTTGGTGGGATATTC
GGCTAA

Upstream 100 bases:

>100_bases
AGTCTCAGTGGAAAGACGTTATTTTTCGCTAATTGGACAGTGGCGATCTCTGGGAATACCACTAATTTCCGATTATTTGC
AAGGATACTCTGGCGACCTC

Downstream 100 bases:

>100_bases
TTTAGCCAGTATTAGCCAGCAGAAACCCGTATTAGTCCGTAGAAATCAATAGTCCGTAGAAATCAATAGTCCGTAGAAAT
CAATAGACCGTAGAAACCAA

Product: D-alanyl-D-alanine carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MMKYILPFKIKNFTFSAGLLLLALPAAYAVDDPAAPQIDAKAYVLMDFNSGKVLAEGNPDLRLDPASLTKIMSSYVIGQS
IKAGKIQPDDLVTVGKDAWATGNPALRGSSLMFLKPGDRVKVSDLNKGIVIQSGNDASIALADYVAGSQDSFVGLMNNYA
KALGLSNTHFMTVHGLDSPGQYSTARDMALLGQALIRDVPEEYALHKEKEFTFNKIRQTNRNRLLWNSSLNVDGMKTGYT
NGAGYNLVASATDGPMRLISVVLGAPSDKVRFSESEKLLTWGFRFYETVVPIKSTKPFVTEKVWLGDNSQVELGVAEDAA
ITIPKGQMKNLKASYTLNQTELRAPLAKHQVVGTIDFQLNGKTIEQRPLVVLNEVKEGGIFSRFWDYVMMKLNQWFGGIF
G

Sequences:

>Translated_401_residues
MMKYILPFKIKNFTFSAGLLLLALPAAYAVDDPAAPQIDAKAYVLMDFNSGKVLAEGNPDLRLDPASLTKIMSSYVIGQS
IKAGKIQPDDLVTVGKDAWATGNPALRGSSLMFLKPGDRVKVSDLNKGIVIQSGNDASIALADYVAGSQDSFVGLMNNYA
KALGLSNTHFMTVHGLDSPGQYSTARDMALLGQALIRDVPEEYALHKEKEFTFNKIRQTNRNRLLWNSSLNVDGMKTGYT
NGAGYNLVASATDGPMRLISVVLGAPSDKVRFSESEKLLTWGFRFYETVVPIKSTKPFVTEKVWLGDNSQVELGVAEDAA
ITIPKGQMKNLKASYTLNQTELRAPLAKHQVVGTIDFQLNGKTIEQRPLVVLNEVKEGGIFSRFWDYVMMKLNQWFGGIF
G
>Mature_401_residues
MMKYILPFKIKNFTFSAGLLLLALPAAYAVDDPAAPQIDAKAYVLMDFNSGKVLAEGNPDLRLDPASLTKIMSSYVIGQS
IKAGKIQPDDLVTVGKDAWATGNPALRGSSLMFLKPGDRVKVSDLNKGIVIQSGNDASIALADYVAGSQDSFVGLMNNYA
KALGLSNTHFMTVHGLDSPGQYSTARDMALLGQALIRDVPEEYALHKEKEFTFNKIRQTNRNRLLWNSSLNVDGMKTGYT
NGAGYNLVASATDGPMRLISVVLGAPSDKVRFSESEKLLTWGFRFYETVVPIKSTKPFVTEKVWLGDNSQVELGVAEDAA
ITIPKGQMKNLKASYTLNQTELRAPLAKHQVVGTIDFQLNGKTIEQRPLVVLNEVKEGGIFSRFWDYVMMKLNQWFGGIF
G

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=392, Percent_Identity=71.4285714285714, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI1786851, Length=394, Percent_Identity=63.9593908629442, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI87082022, Length=385, Percent_Identity=48.3116883116883, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI87082054, Length=286, Percent_Identity=26.9230769230769, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 43948; Mature: 43948

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKYILPFKIKNFTFSAGLLLLALPAAYAVDDPAAPQIDAKAYVLMDFNSGKVLAEGNPD
CCCEEEEEEECCEEEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCEEEECCCCC
LRLDPASLTKIMSSYVIGQSIKAGKIQPDDLVTVGKDAWATGNPALRGSSLMFLKPGDRV
CEECHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEECCCCEE
KVSDLNKGIVIQSGNDASIALADYVAGSQDSFVGLMNNYAKALGLSNTHFMTVHGLDSPG
EEEECCCCEEEECCCCCEEEEEEHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCC
QYSTARDMALLGQALIRDVPEEYALHKEKEFTFNKIRQTNRNRLLWNSSLNVDGMKTGYT
CCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCC
NGAGYNLVASATDGPMRLISVVLGAPSDKVRFSESEKLLTWGFRFYETVVPIKSTKPFVT
CCCCCEEEEECCCCHHHHHHHHHCCCCCCEEECCCCCEEEEHHHHHHEEECCCCCCCCEE
EKVWLGDNSQVELGVAEDAAITIPKGQMKNLKASYTLNQTELRAPLAKHQVVGTIDFQLN
EEEEECCCCEEEEEECCCCEEEECCCHHHCCEEEEEECHHHHHCCHHHCEEEEEEEEEEC
GKTIEQRPLVVLNEVKEGGIFSRFWDYVMMKLNQWFGGIFG
CCEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MMKYILPFKIKNFTFSAGLLLLALPAAYAVDDPAAPQIDAKAYVLMDFNSGKVLAEGNPD
CCCEEEEEEECCEEEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCEEEECCCCC
LRLDPASLTKIMSSYVIGQSIKAGKIQPDDLVTVGKDAWATGNPALRGSSLMFLKPGDRV
CEECHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEECCCCEE
KVSDLNKGIVIQSGNDASIALADYVAGSQDSFVGLMNNYAKALGLSNTHFMTVHGLDSPG
EEEECCCCEEEECCCCCEEEEEEHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCC
QYSTARDMALLGQALIRDVPEEYALHKEKEFTFNKIRQTNRNRLLWNSSLNVDGMKTGYT
CCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCC
NGAGYNLVASATDGPMRLISVVLGAPSDKVRFSESEKLLTWGFRFYETVVPIKSTKPFVT
CCCCCEEEEECCCCHHHHHHHHHCCCCCCEEECCCCCEEEEHHHHHHEEECCCCCCCCEE
EKVWLGDNSQVELGVAEDAAITIPKGQMKNLKASYTLNQTELRAPLAKHQVVGTIDFQLN
EEEEECCCCEEEEEECCCCEEEECCCHHHCCEEEEEECHHHHHCCHHHCEEEEEEEEEEC
GKTIEQRPLVVLNEVKEGGIFSRFWDYVMMKLNQWFGGIFG
CCEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]