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The map label for this gene is pla2

Identifier: 51595610

GI number: 51595610

Start: 1517662

End: 1518597

Strand: Reverse

Name: pla2

Synonym: YPTB1266

Alternate gene names: 51595610

Gene position: 1518597-1517662 (Counterclockwise)

Preceding gene: 51595611

Following gene: 51595609

Centisome position: 32.01

GC content: 40.06

Gene sequence:

>936_bases
ATGAATAAAGAAGCACTAGCAAAAAAAGGGGCCGGCGCACTGGCATTACTTATTCTGAGTCATCCTGCCGTGGCCAACAA
TAATACGGATACAGCAGGCAACGTGACTGTCAGCACCTCGCTTGGATTATTGAATGCCGAGTCAATCGAATCTGTTTATC
AATCCAGTGAACCTAAACAAAAGCTCAGTCAGTTAAACTGGGAAGCCAACAATACACCCATCGTAAAAATGGATATCGCC
TGGGATGCGTTACCCCGACTAACCCTAACAGCCAAGGGCTGGAGCACGCTTTCATCAGGTCAGGGAGTGATGGATAATTA
TGATTGGCTTACCCCACAACAAACACAGTGGAGTGATTGGTCTCATCACGAAAAAACCAATTTGAATTATGCCAATGAAA
TAGACATAAATGCGAAGATTTGGTTTTTAAAACAATACAATTATCGGGTTGGGCCTATTTTAGGTTATCAGGAAAACAAT
CAAAGCTGGACAGCTTATGGTGGTAACTTTAATTATAATAATGACACAAATATCTTTACTGCTCCTGACGGCATTGTTGG
CGTTGGTTATAAACAAAAATTTGATATGCTTTATATTGGCTTAGCAGGAAGTTATCGCTATCAACAATTAGAATTTAATG
CCTTATTGAAATACAGCAATTGGGTTAATGCCAATGCATACGATAATCACTATAACCGCAAAGTTTCATTTAAAGACAGT
AGCAAGAATTCAAGTTACTACTCGGCCGTTATTGATGTTGGATATTACTTCACAGAAAATACTAAACTTTTCGTGGAAGC
CGCTTGGAACCAATATTCTGAAGGGCGAGGAGAGACACAAACGCTCAACTACGCCACCGGGAATGTTGGCAGTAGTAAAT
CAGGTATTGAGTATCAAAGCCAAACCCTTACCGTGGGTTTTCAGTACAAATTTTAA

Upstream 100 bases:

>100_bases
ATTAATTTTTTTAAAATTTTTTTAATCTTTAATTTAAAAAATTAAATCTTTATCGATGTTAGTTTTAATCATGATGATTT
AAGTGAATTAAAGGTTAAAA

Downstream 100 bases:

>100_bases
TCGCATAAAAACACAATAAGCGCCGGAAATCGAAAATCAGGGGTTGTGTACAATTGATCTGTACACAATCGATCTGTACA
CAATACATCTGCACACAGTA

Product: outer membrane protease

Products: NA

Alternate protein names: Plasminogen activator [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MNKEALAKKGAGALALLILSHPAVANNNTDTAGNVTVSTSLGLLNAESIESVYQSSEPKQKLSQLNWEANNTPIVKMDIA
WDALPRLTLTAKGWSTLSSGQGVMDNYDWLTPQQTQWSDWSHHEKTNLNYANEIDINAKIWFLKQYNYRVGPILGYQENN
QSWTAYGGNFNYNNDTNIFTAPDGIVGVGYKQKFDMLYIGLAGSYRYQQLEFNALLKYSNWVNANAYDNHYNRKVSFKDS
SKNSSYYSAVIDVGYYFTENTKLFVEAAWNQYSEGRGETQTLNYATGNVGSSKSGIEYQSQTLTVGFQYKF

Sequences:

>Translated_311_residues
MNKEALAKKGAGALALLILSHPAVANNNTDTAGNVTVSTSLGLLNAESIESVYQSSEPKQKLSQLNWEANNTPIVKMDIA
WDALPRLTLTAKGWSTLSSGQGVMDNYDWLTPQQTQWSDWSHHEKTNLNYANEIDINAKIWFLKQYNYRVGPILGYQENN
QSWTAYGGNFNYNNDTNIFTAPDGIVGVGYKQKFDMLYIGLAGSYRYQQLEFNALLKYSNWVNANAYDNHYNRKVSFKDS
SKNSSYYSAVIDVGYYFTENTKLFVEAAWNQYSEGRGETQTLNYATGNVGSSKSGIEYQSQTLTVGFQYKF
>Mature_311_residues
MNKEALAKKGAGALALLILSHPAVANNNTDTAGNVTVSTSLGLLNAESIESVYQSSEPKQKLSQLNWEANNTPIVKMDIA
WDALPRLTLTAKGWSTLSSGQGVMDNYDWLTPQQTQWSDWSHHEKTNLNYANEIDINAKIWFLKQYNYRVGPILGYQENN
QSWTAYGGNFNYNNDTNIFTAPDGIVGVGYKQKFDMLYIGLAGSYRYQQLEFNALLKYSNWVNANAYDNHYNRKVSFKDS
SKNSSYYSAVIDVGYYFTENTKLFVEAAWNQYSEGRGETQTLNYATGNVGSSKSGIEYQSQTLTVGFQYKF

Specific function: Seems to play an essential role in plague transmission by mediating flea blockage in a temperature-dependent fashion. Fibrinolytic activity prevails at 37 degrees Celsius whereas coagulase expression predominates at lower temperatures (<30 degrees Celsius

COG id: COG4571

COG function: function code M; Outer membrane protease

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A26 family [H]

Homologues:

Organism=Escherichia coli, GI1786777, Length=290, Percent_Identity=39.6551724137931, Blast_Score=222, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020080
- InterPro:   IPR000036
- InterPro:   IPR020079 [H]

Pfam domain/function: PF01278 Omptin [H]

EC number: =3.4.23.48 [H]

Molecular weight: Translated: 35013; Mature: 35013

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKEALAKKGAGALALLILSHPAVANNNTDTAGNVTVSTSLGLLNAESIESVYQSSEPKQ
CCHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHH
KLSQLNWEANNTPIVKMDIAWDALPRLTLTAKGWSTLSSGQGVMDNYDWLTPQQTQWSDW
HHHHCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SHHEKTNLNYANEIDINAKIWFLKQYNYRVGPILGYQENNQSWTAYGGNFNYNNDTNIFT
CCCCCCCCCCCEEEECCEEEEEEEECCCEECCEEEEECCCCEEEEECCCCCCCCCCEEEE
APDGIVGVGYKQKFDMLYIGLAGSYRYQQLEFNALLKYSNWVNANAYDNHYNRKVSFKDS
CCCCEEECCCCCCCEEEEEEECCCCEEEEEEEEEEEEECCCCCCCCCCCCCCEEEEECCC
SKNSSYYSAVIDVGYYFTENTKLFVEAAWNQYSEGRGETQTLNYATGNVGSSKSGIEYQS
CCCCCEEEEEEEEEEEEECCCEEEEEEECCHHCCCCCCCEEEEEEECCCCCCCCCCEEEC
QTLTVGFQYKF
EEEEEEEEECC
>Mature Secondary Structure
MNKEALAKKGAGALALLILSHPAVANNNTDTAGNVTVSTSLGLLNAESIESVYQSSEPKQ
CCHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHH
KLSQLNWEANNTPIVKMDIAWDALPRLTLTAKGWSTLSSGQGVMDNYDWLTPQQTQWSDW
HHHHCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SHHEKTNLNYANEIDINAKIWFLKQYNYRVGPILGYQENNQSWTAYGGNFNYNNDTNIFT
CCCCCCCCCCCEEEECCEEEEEEEECCCEECCEEEEECCCCEEEEECCCCCCCCCCEEEE
APDGIVGVGYKQKFDMLYIGLAGSYRYQQLEFNALLKYSNWVNANAYDNHYNRKVSFKDS
CCCCEEECCCCCCCEEEEEEECCCCEEEEEEEEEEEEECCCCCCCCCCCCCCEEEEECCC
SKNSSYYSAVIDVGYYFTENTKLFVEAAWNQYSEGRGETQTLNYATGNVGSSKSGIEYQS
CCCCCEEEEEEEEEEEEECCCEEEEEEECCHHCCCCCCCEEEEEEECCCCCCCCCCEEEC
QTLTVGFQYKF
EEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2526282; 2651310; 9748454; 11586360 [H]