Click here to switch to the map view.

The map label for this gene is zitB [H]

Identifier: 51595508

GI number: 51595508

Start: 1390197

End: 1391135

Strand: Reverse

Name: zitB [H]

Synonym: YPTB1164

Alternate gene names: 51595508

Gene position: 1391135-1390197 (Counterclockwise)

Preceding gene: 51595510

Following gene: 51595486

Centisome position: 29.32

GC content: 47.18

Gene sequence:

>939_bases
ATGGCTGTATCCGCAATTTTCTCGCAAGATAGCAACAGCAAACGCCTATTGATAGCCTTCGCCATCACCACATTATTTAT
GGTGACGGAAGCGATTGGCGGCTGGTTATCTGGTTCTCTGGCATTATTGGCTGATACCGGACACATGTTGACCGACTCTG
CAGCATTATTTATCGCGTTGATGGCAGTACACTTCTCCCAGAGAAAACCAGACCCCCGCCATACTTTTGGCTACCTACGG
CTGACGACACTCGCGGCCTTTGTTAACGCAGCGGCATTATTGCTGATTGTTATATTGATCGTCTGGGAGGCCGTTCATCG
CTTCTTTTCACCTCATGAGGTGATGGGTACCCCGATGTTAATCATCGCTATCGCCGGACTGTTGGCGAATATTTTTTGTT
TTTGGATCCTGCATAAGGGAGAAGAAGAGAAAAACATCAATGTACGGGCAGCAGCCTTGCATGTGCTAAGTGATTTATTA
GGTTCAGTGGGCGCGATGATTGCGGCTATCGTGATTTTAACCACGGGCTGGACACCAATAGACCCCATTCTCTCGGTATT
GGTGTCGGTACTGATTTTGCGTAACGCCTGGCGATTACTGAAAGAAAGTTTTCACGAATTATTGGAGGGTGCGCCGCAAG
AGATTGATATCAACAAGCTGCGTAAAGACCTATGTACCAATATTTATGAAGTCCGGAACATTCATCATGTTCACTTATGG
CAAGTGGGTGAACAACGGCTAATGACCCTTCATGCCCAAGTGATACCGCCACTGGATCATGATGCGTTATTACAACGCAT
CCAAGACTATTTACTGCATCACTACCGCATTAGTCATGCCACAGTTCAAATGGAGTATCAGCATTGTGGAACACCGGATT
GTGGTATCAATCAAGCGGCCCCTGCCGACGGACATCACCGTCATCATCACCACGAATAA

Upstream 100 bases:

>100_bases
GTAGATAAAATATAGCTTGTAGATAAAACATAGCCTGTAGAAAAAACATAGCTTGCGCCTATTTGCACAATAAAACCGTG
ATGGAAACAAAGGATAAATA

Downstream 100 bases:

>100_bases
CCGCTGACACAGTCATATACCCAAAGTTATTGTTGCTGCAGGCAGTAAACGAAACCGAATCAGGAACTGATTTGAACCGT
ATTTATGCTATCCCGCAGGT

Product: zinc transporter ZitB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MAVSAIFSQDSNSKRLLIAFAITTLFMVTEAIGGWLSGSLALLADTGHMLTDSAALFIALMAVHFSQRKPDPRHTFGYLR
LTTLAAFVNAAALLLIVILIVWEAVHRFFSPHEVMGTPMLIIAIAGLLANIFCFWILHKGEEEKNINVRAAALHVLSDLL
GSVGAMIAAIVILTTGWTPIDPILSVLVSVLILRNAWRLLKESFHELLEGAPQEIDINKLRKDLCTNIYEVRNIHHVHLW
QVGEQRLMTLHAQVIPPLDHDALLQRIQDYLLHHYRISHATVQMEYQHCGTPDCGINQAAPADGHHRHHHHE

Sequences:

>Translated_312_residues
MAVSAIFSQDSNSKRLLIAFAITTLFMVTEAIGGWLSGSLALLADTGHMLTDSAALFIALMAVHFSQRKPDPRHTFGYLR
LTTLAAFVNAAALLLIVILIVWEAVHRFFSPHEVMGTPMLIIAIAGLLANIFCFWILHKGEEEKNINVRAAALHVLSDLL
GSVGAMIAAIVILTTGWTPIDPILSVLVSVLILRNAWRLLKESFHELLEGAPQEIDINKLRKDLCTNIYEVRNIHHVHLW
QVGEQRLMTLHAQVIPPLDHDALLQRIQDYLLHHYRISHATVQMEYQHCGTPDCGINQAAPADGHHRHHHHE
>Mature_311_residues
AVSAIFSQDSNSKRLLIAFAITTLFMVTEAIGGWLSGSLALLADTGHMLTDSAALFIALMAVHFSQRKPDPRHTFGYLRL
TTLAAFVNAAALLLIVILIVWEAVHRFFSPHEVMGTPMLIIAIAGLLANIFCFWILHKGEEEKNINVRAAALHVLSDLLG
SVGAMIAAIVILTTGWTPIDPILSVLVSVLILRNAWRLLKESFHELLEGAPQEIDINKLRKDLCTNIYEVRNIHHVHLWQ
VGEQRLMTLHAQVIPPLDHDALLQRIQDYLLHHYRISHATVQMEYQHCGTPDCGINQAAPADGHHRHHHHE

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=303, Percent_Identity=30.03300330033, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI21359890, Length=325, Percent_Identity=27.3846153846154, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI64762489, Length=290, Percent_Identity=28.6206896551724, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI289803013, Length=290, Percent_Identity=28.6206896551724, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI289803009, Length=290, Percent_Identity=28.6206896551724, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI289803007, Length=290, Percent_Identity=28.6206896551724, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI289803003, Length=290, Percent_Identity=28.6206896551724, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI21361112, Length=314, Percent_Identity=28.0254777070064, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI20070323, Length=332, Percent_Identity=25, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI14210520, Length=233, Percent_Identity=27.4678111587983, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI52352803, Length=130, Percent_Identity=39.2307692307692, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI52351208, Length=160, Percent_Identity=29.375, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI222080086, Length=129, Percent_Identity=28.6821705426357, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI40255009, Length=129, Percent_Identity=28.6821705426357, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786966, Length=293, Percent_Identity=66.5529010238908, Blast_Score=363, Evalue=1e-102,
Organism=Escherichia coli, GI1790349, Length=246, Percent_Identity=25.609756097561, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI193210990, Length=312, Percent_Identity=31.0897435897436, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17555794, Length=284, Percent_Identity=30.6338028169014, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17555796, Length=287, Percent_Identity=30.6620209059233, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32564488, Length=311, Percent_Identity=28.9389067524116, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17550440, Length=126, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17550442, Length=126, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323899, Length=127, Percent_Identity=34.6456692913386, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320411, Length=187, Percent_Identity=32.620320855615, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=136, Percent_Identity=34.5588235294118, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24656728, Length=341, Percent_Identity=29.6187683284457, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24656724, Length=341, Percent_Identity=29.6187683284457, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24656720, Length=341, Percent_Identity=29.6187683284457, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24656715, Length=341, Percent_Identity=29.6187683284457, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI21357035, Length=341, Percent_Identity=29.6187683284457, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24583858, Length=327, Percent_Identity=24.7706422018349, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24585900, Length=140, Percent_Identity=31.4285714285714, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24585898, Length=140, Percent_Identity=31.4285714285714, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24585896, Length=140, Percent_Identity=31.4285714285714, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19921672, Length=140, Percent_Identity=31.4285714285714, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24645863, Length=126, Percent_Identity=34.1269841269841, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24584409, Length=119, Percent_Identity=34.453781512605, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574430, Length=119, Percent_Identity=34.453781512605, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34855; Mature: 34724

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00511 CRF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSAIFSQDSNSKRLLIAFAITTLFMVTEAIGGWLSGSLALLADTGHMLTDSAALFIAL
CCCHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHH
MAVHFSQRKPDPRHTFGYLRLTTLAAFVNAAALLLIVILIVWEAVHRFFSPHEVMGTPML
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHH
IIAIAGLLANIFCFWILHKGEEEKNINVRAAALHVLSDLLGSVGAMIAAIVILTTGWTPI
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DPILSVLVSVLILRNAWRLLKESFHELLEGAPQEIDINKLRKDLCTNIYEVRNIHHVHLW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEHHH
QVGEQRLMTLHAQVIPPLDHDALLQRIQDYLLHHYRISHATVQMEYQHCGTPDCGINQAA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCCCC
PADGHHRHHHHE
CCCCCCCCCCCC
>Mature Secondary Structure 
AVSAIFSQDSNSKRLLIAFAITTLFMVTEAIGGWLSGSLALLADTGHMLTDSAALFIAL
CCHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHH
MAVHFSQRKPDPRHTFGYLRLTTLAAFVNAAALLLIVILIVWEAVHRFFSPHEVMGTPML
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHH
IIAIAGLLANIFCFWILHKGEEEKNINVRAAALHVLSDLLGSVGAMIAAIVILTTGWTPI
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DPILSVLVSVLILRNAWRLLKESFHELLEGAPQEIDINKLRKDLCTNIYEVRNIHHVHLW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEHHH
QVGEQRLMTLHAQVIPPLDHDALLQRIQDYLLHHYRISHATVQMEYQHCGTPDCGINQAA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCCCC
PADGHHRHHHHE
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]