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The map label for this gene is tibA [H]

Identifier: 51595408

GI number: 51595408

Start: 1268552

End: 1270468

Strand: Reverse

Name: tibA [H]

Synonym: YPTB1061

Alternate gene names: 51595408

Gene position: 1270468-1268552 (Counterclockwise)

Preceding gene: 51595412

Following gene: 51595405

Centisome position: 26.78

GC content: 47.26

Gene sequence:

>1917_bases
ATGGACAAAACATTATTGGCCGGTGCTATCAGTCTATCTTTAGTTACATTACCTGTTCAGGTATTGGCTTTTACACCGAA
TGTGGTGGGAATAACTGTCAACGATGAAGTCGTCATTCATGGTATACAGAATGTGCGCGACGGCGGAGTCATTAATAATG
GGCTGGTTAGTGACAATGCCGCAATTACTGTCACCAACGGGAGCAGTGCTGGTACGGCAAATAATACTACCGTGGGTGAT
AAAGGCTGGTTACAGATTACCGGTGCTCTGGCGACGGGTACCATTGTTAATCAAGGCGGGCTGCTTGACACCAAAACGGC
GGGTACCGTAATAGATAGCCAAATTAATGATGGCGGCCATATGACTCTGGGACTTAATAGCCAGTCTAAAGGCTACCTCA
ATATAGCGGCTGGCGCAGAACTTTTTGTTACCAACAACGATCCATACACCTCCGATGTGACCACCCATAACCCCGCACTG
CCTGCCAATGTTATGATTGAGAATCTCAACGTCGCGGGTCTGGTCGAAATCGGCCCTTCCTGGAAGGGCACGAGTATCGT
GCCGCTTCCCCTCTCTGACGTTTTAGGGCCGGTGCTGGTTACCCGAATCAATAATGTGACTTTGCAAGGGGGGGATATCA
ATTTAATGGCCTATTCTGCTGGTGGGCAATTTAACCGGCTGGAGATAGAAAATTTGTCTGGTCAGGGTAATTTTGCGATG
ACAACCCAGCTTGCCAGCAATACCGGGGATTTCATTACGGTCTCACAGCAGGCGACCGGCCAATTTGGTATTACCGTTCA
GGACAGCGGTAAAGAGCCGCAATCTGCCGACAACCTGGCACTGGTACATATTAATCGTGGTGATGCTCAGTTCCGTTTAC
TCAATACAGGCGGAGTGGTGGATTTAGGTGTTTACCAATACGGGCTATATAGTCAGGAAAGCAATGGCAGCACTGACTGG
TATCTGGCAACTAGCACAGAAGAACTGCCAGGTACAACACCGAACGTAACCGCTCCAATGCTCAGTTCCGCAGCACAAGG
TGTGCTGAATATGGCAGCGGCACCGCGGCATATCCTGAATGCGGAATTGAGTACCTTGCGTCAGCGCCAAGGCGAGTTGA
AGGCAGATGCGGAAGGGACTGTTGGCGTTTGGGCGCGTTATCTTACGGATGACAGCCGGTTGTCTGATAATAAAAATATC
GCTTTCAAGAATACCTTAAGTGGCATGGAAATTGGGGCCGATAAACAACTTGGATTAAACCGGGGTAATATGTTGATCGG
AGCATTTACCTCCTACAGTTCATCTGATGTCAAATCCACCCACGGCGCTAATGGTGATATTCGCAGTTACGGTGGTGGCC
TCTATCTGACCTATTTGGATCAAAGCGGATTTTATGTTGATACGGTGCTAAAAGCTAACCGCTTTAATAATAAGATGAAT
ACACAGGAAACCCGTGGCGAATATAACCAGAATGCTCTTACCACCTCAGTAGAAAGTGGTTATCAATGGCCTGTTTATGC
CAATCTGGTGCTCGAACCCTATGGAAAGGTGAGTTATTCACGTATTGGTAGCGCAGATTATACTCTCAGTAACGGTATGG
TAGCGGAAGTGGCGAAAGCCGATAGCGTGCAAGGCGAGTTAGGCACGGTACTCGCCGCCTCTTACAGCATTAACCAAATG
ACGATAAAGCCTTATATTAAACTGGCTATTACCCGTGAATTTACCAAAAGTAATGCTGTAGCGATTAACAACATTGGTTT
CGATAATGATTTCTCCGGTAATGTCGGTAAATATGGCGTAGGCATAAATGCGACGGTAGCCAATAACACCGCCATTTTTG
CTGAAGTGGATTATCTCAATGGTTCAAAAATTGAAACACCGGTAACTGCCAATATCGGTTTCCGCCTTCGGTTCTAA

Upstream 100 bases:

>100_bases
CTGATAAACATAACGTTCAAACCGTCCCAAGGGCGGTGTGTCTCTTTTTACAATGAGTGATATAGCATCATCTCATTACA
TTTAATATTTTTGAGGTTTT

Downstream 100 bases:

>100_bases
TTGTTTCAGCCCCTCTTCTGAGGGGTTCAGACTGCTGACAAACCCCGATGACTCACTCTTGAACGGTGAGGATAGGCAGA
GGAGTAAAGCGTCCGCGCCA

Product: pertactin family virulence factor/autotransporter

Products: NA

Alternate protein names: Glycoprotein TibA [H]

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MDKTLLAGAISLSLVTLPVQVLAFTPNVVGITVNDEVVIHGIQNVRDGGVINNGLVSDNAAITVTNGSSAGTANNTTVGD
KGWLQITGALATGTIVNQGGLLDTKTAGTVIDSQINDGGHMTLGLNSQSKGYLNIAAGAELFVTNNDPYTSDVTTHNPAL
PANVMIENLNVAGLVEIGPSWKGTSIVPLPLSDVLGPVLVTRINNVTLQGGDINLMAYSAGGQFNRLEIENLSGQGNFAM
TTQLASNTGDFITVSQQATGQFGITVQDSGKEPQSADNLALVHINRGDAQFRLLNTGGVVDLGVYQYGLYSQESNGSTDW
YLATSTEELPGTTPNVTAPMLSSAAQGVLNMAAAPRHILNAELSTLRQRQGELKADAEGTVGVWARYLTDDSRLSDNKNI
AFKNTLSGMEIGADKQLGLNRGNMLIGAFTSYSSSDVKSTHGANGDIRSYGGGLYLTYLDQSGFYVDTVLKANRFNNKMN
TQETRGEYNQNALTTSVESGYQWPVYANLVLEPYGKVSYSRIGSADYTLSNGMVAEVAKADSVQGELGTVLAASYSINQM
TIKPYIKLAITREFTKSNAVAINNIGFDNDFSGNVGKYGVGINATVANNTAIFAEVDYLNGSKIETPVTANIGFRLRF

Sequences:

>Translated_638_residues
MDKTLLAGAISLSLVTLPVQVLAFTPNVVGITVNDEVVIHGIQNVRDGGVINNGLVSDNAAITVTNGSSAGTANNTTVGD
KGWLQITGALATGTIVNQGGLLDTKTAGTVIDSQINDGGHMTLGLNSQSKGYLNIAAGAELFVTNNDPYTSDVTTHNPAL
PANVMIENLNVAGLVEIGPSWKGTSIVPLPLSDVLGPVLVTRINNVTLQGGDINLMAYSAGGQFNRLEIENLSGQGNFAM
TTQLASNTGDFITVSQQATGQFGITVQDSGKEPQSADNLALVHINRGDAQFRLLNTGGVVDLGVYQYGLYSQESNGSTDW
YLATSTEELPGTTPNVTAPMLSSAAQGVLNMAAAPRHILNAELSTLRQRQGELKADAEGTVGVWARYLTDDSRLSDNKNI
AFKNTLSGMEIGADKQLGLNRGNMLIGAFTSYSSSDVKSTHGANGDIRSYGGGLYLTYLDQSGFYVDTVLKANRFNNKMN
TQETRGEYNQNALTTSVESGYQWPVYANLVLEPYGKVSYSRIGSADYTLSNGMVAEVAKADSVQGELGTVLAASYSINQM
TIKPYIKLAITREFTKSNAVAINNIGFDNDFSGNVGKYGVGINATVANNTAIFAEVDYLNGSKIETPVTANIGFRLRF
>Mature_638_residues
MDKTLLAGAISLSLVTLPVQVLAFTPNVVGITVNDEVVIHGIQNVRDGGVINNGLVSDNAAITVTNGSSAGTANNTTVGD
KGWLQITGALATGTIVNQGGLLDTKTAGTVIDSQINDGGHMTLGLNSQSKGYLNIAAGAELFVTNNDPYTSDVTTHNPAL
PANVMIENLNVAGLVEIGPSWKGTSIVPLPLSDVLGPVLVTRINNVTLQGGDINLMAYSAGGQFNRLEIENLSGQGNFAM
TTQLASNTGDFITVSQQATGQFGITVQDSGKEPQSADNLALVHINRGDAQFRLLNTGGVVDLGVYQYGLYSQESNGSTDW
YLATSTEELPGTTPNVTAPMLSSAAQGVLNMAAAPRHILNAELSTLRQRQGELKADAEGTVGVWARYLTDDSRLSDNKNI
AFKNTLSGMEIGADKQLGLNRGNMLIGAFTSYSSSDVKSTHGANGDIRSYGGGLYLTYLDQSGFYVDTVLKANRFNNKMN
TQETRGEYNQNALTTSVESGYQWPVYANLVLEPYGKVSYSRIGSADYTLSNGMVAEVAKADSVQGELGTVLAASYSINQM
TIKPYIKLAITREFTKSNAVAINNIGFDNDFSGNVGKYGVGINATVANNTAIFAEVDYLNGSKIETPVTANIGFRLRF

Specific function: Mediates both adhesion to and invasion of human intestine epithelial cells. Also mediates bacterial cell aggregation via intercellular TibA-TibA interaction. Enhances biofilm formation [H]

COG id: COG3468

COG function: function code MU; Type V secretory pathway, adhesin AidA

Gene ontology:

Cell location: Adhesin/invasin TibA translocator:Cell outer membrane; Multi-pass membrane protein (Potential). Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 autotransporter (TC 1.B.12) domain [H]

Homologues:

Organism=Escherichia coli, GI87082145, Length=476, Percent_Identity=32.3529411764706, Blast_Score=211, Evalue=2e-55,
Organism=Escherichia coli, GI1787452, Length=458, Percent_Identity=25.3275109170306, Blast_Score=104, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005546
- InterPro:   IPR006315
- InterPro:   IPR012332
- InterPro:   IPR011050
- InterPro:   IPR004899
- InterPro:   IPR003991 [H]

Pfam domain/function: PF03797 Autotransporter; PF03212 Pertactin [H]

EC number: NA

Molecular weight: Translated: 67431; Mature: 67431

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKTLLAGAISLSLVTLPVQVLAFTPNVVGITVNDEVVIHGIQNVRDGGVINNGLVSDNA
CCCCEEEHHHEEEEEEEEEEEEEECCCEEEEEECCCEEEEECCCCCCCCCEECCEECCCC
AITVTNGSSAGTANNTTVGDKGWLQITGALATGTIVNQGGLLDTKTAGTVIDSQINDGGH
EEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECEEEECCCCEECCCCCEEEECEECCCCE
MTLGLNSQSKGYLNIAAGAELFVTNNDPYTSDVTTHNPALPANVMIENLNVAGLVEIGPS
EEEEECCCCCCEEEEECCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCC
WKGTSIVPLPLSDVLGPVLVTRINNVTLQGGDINLMAYSAGGQFNRLEIENLSGQGNFAM
CCCCEEEECCHHHHHHHHHHEEECCEEEECCCEEEEEEECCCCEEEEEEECCCCCCCEEE
TTQLASNTGDFITVSQQATGQFGITVQDSGKEPQSADNLALVHINRGDAQFRLLNTGGVV
EEEECCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCEEEEEECCCEE
DLGVYQYGLYSQESNGSTDWYLATSTEELPGTTPNVTAPMLSSAAQGVLNMAAAPRHILN
EEEEEEEEEEECCCCCCCEEEEEECCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHH
AELSTLRQRQGELKADAEGTVGVWARYLTDDSRLSDNKNIAFKNTLSGMEIGADKQLGLN
HHHHHHHHHCCCCCCCCCCCHHHHEEECCCCCCCCCCCCEEEEECCCCCEECCCCCCCCC
RGNMLIGAFTSYSSSDVKSTHGANGDIRSYGGGLYLTYLDQSGFYVDTVLKANRFNNKMN
CCCEEEEEEECCCCCCCCCCCCCCCCHHHCCCEEEEEEECCCCCEEEEEEEHHHCCCCCC
TQETRGEYNQNALTTSVESGYQWPVYANLVLEPYGKVSYSRIGSADYTLSNGMVAEVAKA
CHHHCCCCCCCEEEEECCCCCCCCEEEEEEECCCCCEEHHHCCCCCEEECCCCEEEHHHC
DSVQGELGTVLAASYSINQMTIKPYIKLAITREFTKSNAVAINNIGFDNDFSGNVGKYGV
CCCCCCCCEEEEEEEECCEEEECEEEEEEEEEECCCCCCEEEECCCCCCCCCCCCCEEEC
GINATVANNTAIFAEVDYLNGSKIETPVTANIGFRLRF
EEEEEEECCEEEEEEEEECCCCEECCCEEECCEEEEEC
>Mature Secondary Structure
MDKTLLAGAISLSLVTLPVQVLAFTPNVVGITVNDEVVIHGIQNVRDGGVINNGLVSDNA
CCCCEEEHHHEEEEEEEEEEEEEECCCEEEEEECCCEEEEECCCCCCCCCEECCEECCCC
AITVTNGSSAGTANNTTVGDKGWLQITGALATGTIVNQGGLLDTKTAGTVIDSQINDGGH
EEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECEEEECCCCEECCCCCEEEECEECCCCE
MTLGLNSQSKGYLNIAAGAELFVTNNDPYTSDVTTHNPALPANVMIENLNVAGLVEIGPS
EEEEECCCCCCEEEEECCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCC
WKGTSIVPLPLSDVLGPVLVTRINNVTLQGGDINLMAYSAGGQFNRLEIENLSGQGNFAM
CCCCEEEECCHHHHHHHHHHEEECCEEEECCCEEEEEEECCCCEEEEEEECCCCCCCEEE
TTQLASNTGDFITVSQQATGQFGITVQDSGKEPQSADNLALVHINRGDAQFRLLNTGGVV
EEEECCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCEEEEEECCCEE
DLGVYQYGLYSQESNGSTDWYLATSTEELPGTTPNVTAPMLSSAAQGVLNMAAAPRHILN
EEEEEEEEEEECCCCCCCEEEEEECCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHH
AELSTLRQRQGELKADAEGTVGVWARYLTDDSRLSDNKNIAFKNTLSGMEIGADKQLGLN
HHHHHHHHHCCCCCCCCCCCHHHHEEECCCCCCCCCCCCEEEEECCCCCEECCCCCCCCC
RGNMLIGAFTSYSSSDVKSTHGANGDIRSYGGGLYLTYLDQSGFYVDTVLKANRFNNKMN
CCCEEEEEEECCCCCCCCCCCCCCCCHHHCCCEEEEEEECCCCCEEEEEEEHHHCCCCCC
TQETRGEYNQNALTTSVESGYQWPVYANLVLEPYGKVSYSRIGSADYTLSNGMVAEVAKA
CHHHCCCCCCCEEEEECCCCCCCCEEEEEEECCCCCEEHHHCCCCCEEECCCCEEEHHHC
DSVQGELGTVLAASYSINQMTIKPYIKLAITREFTKSNAVAINNIGFDNDFSGNVGKYGV
CCCCCCCCEEEEEEEECCEEEECEEEEEEEEEECCCCCCEEEECCCCCCCCCCCCCEEEC
GINATVANNTAIFAEVDYLNGSKIETPVTANIGFRLRF
EEEEEEECCEEEEEEEEECCCCEECCCEEECCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10417177 [H]