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The map label for this gene is glpK2 [H]

Identifier: 51595168

GI number: 51595168

Start: 981893

End: 983380

Strand: Direct

Name: glpK2 [H]

Synonym: YPTB0818

Alternate gene names: 51595168

Gene position: 981893-983380 (Clockwise)

Preceding gene: 51595167

Following gene: 51595169

Centisome position: 20.69

GC content: 56.38

Gene sequence:

>1488_bases
ATGTCAACGCCAATCATTCTGGCTATTGATGAAGGGACAACCAACGCCAAAGCCATTGCGGTAGATCGTGCCGGGCGAGT
TCTGGCGAAAGCCTCGGTACCATTACAACTGGAACATCCTCAGCCCGGTTGGGCAGAACAGGATCCGCTGGCGATTTGGC
TGGCGGTTTCTCAGGCGGTTGAGGGGTGCCTAAATCAATTGGCGGGCGCACAGGTGGCGGGGATTGCCATCAGTAATCAG
CGTGAATCGGTACTGATTTGGGAACGGGAAACCGGCACGCCGCTCACGCCAGTCGTAAGCTGGCAGTGCCGTCGTTCAGA
GGCTTTCTGTCTGGCTTTGCGCCAATTACCGGCTGCGGCGATGGTTGCGGAACGGACTGGATTGCAGATTGATCCCCTGT
TTCCTGCGGCCAAAATTCACGGCATGTTGGCGCAGATCCCTCATGGCGCTGAACGTGCCGCTCACGGTGAGCTGTGTGTT
GGCACGCTTGATTGCTGGCTGACCTGGCAGTTTAGCGAAGGGCAAAGTTTCTCGACTGACTTCTCTAATGCGGCCCGGAC
CCAGCTGTTTAATATCCATTCAGGTCAATGGGACCCCGATTTACTGGCGCTGTTTGGTATCCCAAGTCTTTGCCTGCCCG
CCGTCTTACCCTCGGCATCCATCCACGGACACACCGCGCGCACCGGGATTCTCGGCCTGGAGCAGGGCGTGCCTATCGTG
GCACACATTGGTGATTCGCACGCCGCGCTGTACGGGCAAGGCGGCGACCAGGCCGGTGAAATCAAAGCCACTTATGGCAC
CGGCTCCTCTCTGATGATGACCCTAAAACAGGCCTGTGCACCAAGCCACGGCCTAAGCACCACCATTGCCTGGCATGACG
GCGAATTACGCTATGCCCTTGAAGGTAACATCACCCATACCGGCTCAGGAGTGGCATGGGTCTCGCGCATGTTAGGGATC
AGTGATTTGTCACGTCTGACTGACATGGCAGAAAGCCAATCAGGTAATCAAGGCGTCTATTTTGTACCGGCATTATCAGG
ACTGGGTGCGCCTTATTGGGACAGTCAGGCGCGTGGTTTGTTCTGTGGTCTGACGGATGCCACGACACCGGCAGTACTGG
CGCGAGCGGCACTTGAATCAGTCGCTTATCAAATAGCCGATGTTTTCTTTGCGATGGAGAATGCGGCTCATCATCGCCTT
GAACGGCTGCGGGTTGATGGCGGTGCGACCAGTAATCGCTGGCTGATGCAGTTTCAGGCCGATTTATTACAGCGCACATT
GATACGTAATCACACGGCAGAAGTGTCAGCACTGGGTGCCGCGTATTTGGGCGGGAAAACCCTTGGTTGGTGGCAGGATA
GCCAACAACTGGCTGCGCTCCCCCGTGAAGTGGAATACATCGAACCGCGCATTCACAGTGCGGAGATGCAAGATAACTAT
AGCCTCTGGCAAACGGCCATCGCGCGTGCGCGTTTTCAGCCGAAATAA

Upstream 100 bases:

>100_bases
ATGCGATTGCCGCTGATCGGGCTGAGATGCGTGCCTATCATGGTTTTGATGCGGCAGGCATTGTGGCTCGTGCTCTGCGG
TTTTGCCGAGGGGAATAACG

Downstream 100 bases:

>100_bases
CCCACACTAGGAGTAAGCATATGTCAGCAATACCTCGCAAGTTAACTTTTGCGGTGATTATCGGCAATCGGGGTTTCTTC
CCAAACTATCTGGTGAGCGA

Product: glycerol kinase 2

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase 2; Glycerokinase 2; GK 2 [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MSTPIILAIDEGTTNAKAIAVDRAGRVLAKASVPLQLEHPQPGWAEQDPLAIWLAVSQAVEGCLNQLAGAQVAGIAISNQ
RESVLIWERETGTPLTPVVSWQCRRSEAFCLALRQLPAAAMVAERTGLQIDPLFPAAKIHGMLAQIPHGAERAAHGELCV
GTLDCWLTWQFSEGQSFSTDFSNAARTQLFNIHSGQWDPDLLALFGIPSLCLPAVLPSASIHGHTARTGILGLEQGVPIV
AHIGDSHAALYGQGGDQAGEIKATYGTGSSLMMTLKQACAPSHGLSTTIAWHDGELRYALEGNITHTGSGVAWVSRMLGI
SDLSRLTDMAESQSGNQGVYFVPALSGLGAPYWDSQARGLFCGLTDATTPAVLARAALESVAYQIADVFFAMENAAHHRL
ERLRVDGGATSNRWLMQFQADLLQRTLIRNHTAEVSALGAAYLGGKTLGWWQDSQQLAALPREVEYIEPRIHSAEMQDNY
SLWQTAIARARFQPK

Sequences:

>Translated_495_residues
MSTPIILAIDEGTTNAKAIAVDRAGRVLAKASVPLQLEHPQPGWAEQDPLAIWLAVSQAVEGCLNQLAGAQVAGIAISNQ
RESVLIWERETGTPLTPVVSWQCRRSEAFCLALRQLPAAAMVAERTGLQIDPLFPAAKIHGMLAQIPHGAERAAHGELCV
GTLDCWLTWQFSEGQSFSTDFSNAARTQLFNIHSGQWDPDLLALFGIPSLCLPAVLPSASIHGHTARTGILGLEQGVPIV
AHIGDSHAALYGQGGDQAGEIKATYGTGSSLMMTLKQACAPSHGLSTTIAWHDGELRYALEGNITHTGSGVAWVSRMLGI
SDLSRLTDMAESQSGNQGVYFVPALSGLGAPYWDSQARGLFCGLTDATTPAVLARAALESVAYQIADVFFAMENAAHHRL
ERLRVDGGATSNRWLMQFQADLLQRTLIRNHTAEVSALGAAYLGGKTLGWWQDSQQLAALPREVEYIEPRIHSAEMQDNY
SLWQTAIARARFQPK
>Mature_494_residues
STPIILAIDEGTTNAKAIAVDRAGRVLAKASVPLQLEHPQPGWAEQDPLAIWLAVSQAVEGCLNQLAGAQVAGIAISNQR
ESVLIWERETGTPLTPVVSWQCRRSEAFCLALRQLPAAAMVAERTGLQIDPLFPAAKIHGMLAQIPHGAERAAHGELCVG
TLDCWLTWQFSEGQSFSTDFSNAARTQLFNIHSGQWDPDLLALFGIPSLCLPAVLPSASIHGHTARTGILGLEQGVPIVA
HIGDSHAALYGQGGDQAGEIKATYGTGSSLMMTLKQACAPSHGLSTTIAWHDGELRYALEGNITHTGSGVAWVSRMLGIS
DLSRLTDMAESQSGNQGVYFVPALSGLGAPYWDSQARGLFCGLTDATTPAVLARAALESVAYQIADVFFAMENAAHHRLE
RLRVDGGATSNRWLMQFQADLLQRTLIRNHTAEVSALGAAYLGGKTLGWWQDSQQLAALPREVEYIEPRIHSAEMQDNYS
LWQTAIARARFQPK

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI42794763, Length=511, Percent_Identity=36.2035225048924, Blast_Score=295, Evalue=8e-80,
Organism=Homo sapiens, GI4504007, Length=506, Percent_Identity=36.3636363636364, Blast_Score=291, Evalue=7e-79,
Organism=Homo sapiens, GI189409120, Length=506, Percent_Identity=36.3636363636364, Blast_Score=291, Evalue=7e-79,
Organism=Homo sapiens, GI41393575, Length=506, Percent_Identity=36.5612648221344, Blast_Score=288, Evalue=1e-77,
Organism=Homo sapiens, GI88196792, Length=517, Percent_Identity=28.6266924564797, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1790361, Length=493, Percent_Identity=40.3651115618661, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1789168, Length=487, Percent_Identity=23.6139630390144, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1789987, Length=446, Percent_Identity=26.2331838565022, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790005, Length=499, Percent_Identity=25.4509018036072, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17535599, Length=448, Percent_Identity=30.8035714285714, Blast_Score=238, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI71986140, Length=515, Percent_Identity=23.6893203883495, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71986147, Length=257, Percent_Identity=29.5719844357977, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321755, Length=547, Percent_Identity=27.4223034734918, Blast_Score=180, Evalue=4e-46,
Organism=Drosophila melanogaster, GI17864214, Length=515, Percent_Identity=34.368932038835, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24654573, Length=464, Percent_Identity=33.8362068965517, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24655555, Length=510, Percent_Identity=31.1764705882353, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24655560, Length=510, Percent_Identity=31.1764705882353, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24655570, Length=510, Percent_Identity=31.1764705882353, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24655574, Length=510, Percent_Identity=31.1764705882353, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24655565, Length=510, Percent_Identity=31.1764705882353, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24656367, Length=516, Percent_Identity=28.8759689922481, Blast_Score=194, Evalue=9e-50,
Organism=Drosophila melanogaster, GI21357867, Length=535, Percent_Identity=28.2242990654206, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI19922058, Length=518, Percent_Identity=28.1853281853282, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24652871, Length=491, Percent_Identity=28.1059063136456, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24656372, Length=347, Percent_Identity=30.835734870317, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI45552909, Length=261, Percent_Identity=29.5019157088123, Blast_Score=105, Evalue=9e-23,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 53268; Mature: 53137

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPIILAIDEGTTNAKAIAVDRAGRVLAKASVPLQLEHPQPGWAEQDPLAIWLAVSQAV
CCCCEEEEECCCCCCCEEEEEECCCCEEEECCCCEEECCCCCCCCCCCCEEEEEHHHHHH
EGCLNQLAGAQVAGIAISNQRESVLIWERETGTPLTPVVSWQCRRSEAFCLALRQLPAAA
HHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCCCEEECEECCCHHHHHHHHHCCHHH
MVAERTGLQIDPLFPAAKIHGMLAQIPHGAERAAHGELCVGTLDCWLTWQFSEGQSFSTD
HHHHHCCCEECCCCCHHHHHHHHHHCCCCHHHCCCCCEEEEEEEEEEEEEECCCCCCCCC
FSNAARTQLFNIHSGQWDPDLLALFGIPSLCLPAVLPSASIHGHTARTGILGLEQGVPIV
CCHHHHHEEEECCCCCCCHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHCCEECCCCCEEE
AHIGDSHAALYGQGGDQAGEIKATYGTGSSLMMTLKQACAPSHGLSTTIAWHDGELRYAL
EEECCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEECCEEEEEE
EGNITHTGSGVAWVSRMLGISDLSRLTDMAESQSGNQGVYFVPALSGLGAPYWDSQARGL
ECCEEECCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCEE
FCGLTDATTPAVLARAALESVAYQIADVFFAMENAAHHRLERLRVDGGATSNRWLMQFQA
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHH
DLLQRTLIRNHTAEVSALGAAYLGGKTLGWWQDSQQLAALPREVEYIEPRIHSAEMQDNY
HHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCCHHHHHCCHHHHHHCCCCCCCCCCCCH
SLWQTAIARARFQPK
HHHHHHHHHHCCCCC
>Mature Secondary Structure 
STPIILAIDEGTTNAKAIAVDRAGRVLAKASVPLQLEHPQPGWAEQDPLAIWLAVSQAV
CCCEEEEECCCCCCCEEEEEECCCCEEEECCCCEEECCCCCCCCCCCCEEEEEHHHHHH
EGCLNQLAGAQVAGIAISNQRESVLIWERETGTPLTPVVSWQCRRSEAFCLALRQLPAAA
HHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCCCEEECEECCCHHHHHHHHHCCHHH
MVAERTGLQIDPLFPAAKIHGMLAQIPHGAERAAHGELCVGTLDCWLTWQFSEGQSFSTD
HHHHHCCCEECCCCCHHHHHHHHHHCCCCHHHCCCCCEEEEEEEEEEEEEECCCCCCCCC
FSNAARTQLFNIHSGQWDPDLLALFGIPSLCLPAVLPSASIHGHTARTGILGLEQGVPIV
CCHHHHHEEEECCCCCCCHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHCCEECCCCCEEE
AHIGDSHAALYGQGGDQAGEIKATYGTGSSLMMTLKQACAPSHGLSTTIAWHDGELRYAL
EEECCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEECCEEEEEE
EGNITHTGSGVAWVSRMLGISDLSRLTDMAESQSGNQGVYFVPALSGLGAPYWDSQARGL
ECCEEECCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCEE
FCGLTDATTPAVLARAALESVAYQIADVFFAMENAAHHRLERLRVDGGATSNRWLMQFQA
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHH
DLLQRTLIRNHTAEVSALGAAYLGGKTLGWWQDSQQLAALPREVEYIEPRIHSAEMQDNY
HHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCCHHHHHCCHHHHHHCCCCCCCCCCCCH
SLWQTAIARARFQPK
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]