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The map label for this gene is sgbK

Identifier: 51595147

GI number: 51595147

Start: 956538

End: 958034

Strand: Reverse

Name: sgbK

Synonym: YPTB0797

Alternate gene names: 51595147

Gene position: 958034-956538 (Counterclockwise)

Preceding gene: 51595148

Following gene: 51595146

Centisome position: 20.19

GC content: 51.7

Gene sequence:

>1497_bases
ATGAGCCACTATTTTCTCGGCATTGATCTGGGCGGTACCGTGACCAAAGCCGGTATTTATACCGCCGACGGCAGCGAAAT
TGCCGTTACTGAACAGGCACTCCCGGTACTTAGCCCACAAGCGGGATTCTGTGAGCGCGATATGGAGGCCCTGTGGATCG
CCACCTGTCAGGTGATCCGCCAAACGCTGAACAAGGCATGTGCTTTATCGGAATATCATATTTCGGCAGAGAACATCGGT
GGCATCAGTTTCTCTGCCCATGGCAAAGGGTTATATCTGGTGGATAAACAGGGGCTGCCGGTACGTAACGGAATTGTTTC
CTCCGATTCCCGTGCACAGAAACTGGTTAACCGTTGGCAGCAAGAAGGCAAAGATCACGCCGCCTATGAACGTAGCCTGC
AACAACTGTGGCCATCCCATCCCGCAGCCCTCTTGCGTTGGTTAAAGGAAAACGAGCCAGAAAACTATCAGCGCAGCGGT
TATGTGCTCATGGTCCATGACTATATCCGTTACCGTCTAACGGGTGAGTTTACTATTGAAGAAACCAATATTTCTGGCAG
CAATCTTTATAATCAATACAACGGCAGTTTTGATCCGCAACTAATGGCGATTTTTGCCATTGAGGAAGTCATGGAGAAAA
CCGCGCCGATTATCGGTTCAGCCGATTTAGCAGGTCATGTCAGTGAAGATGCGGCTAACGCCTGTGGGCTGAAAGCAGGA
ACACCGGTGTTCGGCGGCATGTTTGATGTGGTCGGTGCGGCACTGACTTCTGGTTTACACGACAGCCGCCAACTCAGTGC
GGTGGCGGGTACTTGGTCAATCGCCACCCGTATTTTTGAGGCGATCACCCCCTCCGAATACCCCTATGTTTGGGGGAAAT
ATTGCATCCCCGGCACCTACTTCGTACATGAAGGCAGCCCAACCTCGGCCAGTAACCTTGCCTGGTTCGTGAAACAATTT
CTCCCTGAACTGCCAAATAGCTACCAGACCCTGAATCAGTGGGCGGCTTTGGGCTATGAAAAATCTGAAGATATTCTGTT
TTTCCCTTGGCTATACGGCTCCAACCACAGTGCTAATCTTAGCGGAGGCCTGCTTGGGTTAAGTGGGCATCACAATATCG
AAGACATTGTGTACGCCATTTATCAGGGAGTGGTTTTTTCACATCTTCTGCATCAGGACAAGATTTTGGCGTTGGATGAC
ACCATCGACTGTATCCGCTTTACCGGTGGCCCGACACATTCCGCTATTTGGATGCAGATGTTCTGCGATGCCAGTAATTT
GCCACTGGAAATTGTCGATATTCAGCAATCCGGCTGCCGGGCAGCGGCGCTGTGTGCGGCGGTGGGGAGCCACTATTACC
ACGGGTTTGAAGAGGCGATCCGCGCCTGCCCGCCCCCTATCACCCGCCTGCTCCCCAATGCTGAAAAAAATCAGCGATTA
CGGGCGCGTTTTGACAAATTCAAACAGGTCGCTGAAGCGCTCAGCACGGTAATGTAA

Upstream 100 bases:

>100_bases
TTGCTGGAAATTATCCATGCCCGCCACTGGATCGAAGACAAAATGCGGTTGGCTGGCTGGGATAACGAATCCAGCCAGTT
AACCCGCTAAGGAGCCACAC

Downstream 100 bases:

>100_bases
GCCTCATACATCACATTCAGTGATCGATAAAACCATCATGTCACCAGGCCAGCACACGGTGAGATCGATGACCGTCGGTC
AGTGCCCCACTCCCCTACTG

Product: L-xylulose kinase

Products: NA

Alternate protein names: L-xylulokinase; 3-dehydro-L-gulonate kinase [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSHYFLGIDLGGTVTKAGIYTADGSEIAVTEQALPVLSPQAGFCERDMEALWIATCQVIRQTLNKACALSEYHISAENIG
GISFSAHGKGLYLVDKQGLPVRNGIVSSDSRAQKLVNRWQQEGKDHAAYERSLQQLWPSHPAALLRWLKENEPENYQRSG
YVLMVHDYIRYRLTGEFTIEETNISGSNLYNQYNGSFDPQLMAIFAIEEVMEKTAPIIGSADLAGHVSEDAANACGLKAG
TPVFGGMFDVVGAALTSGLHDSRQLSAVAGTWSIATRIFEAITPSEYPYVWGKYCIPGTYFVHEGSPTSASNLAWFVKQF
LPELPNSYQTLNQWAALGYEKSEDILFFPWLYGSNHSANLSGGLLGLSGHHNIEDIVYAIYQGVVFSHLLHQDKILALDD
TIDCIRFTGGPTHSAIWMQMFCDASNLPLEIVDIQQSGCRAAALCAAVGSHYYHGFEEAIRACPPPITRLLPNAEKNQRL
RARFDKFKQVAEALSTVM

Sequences:

>Translated_498_residues
MSHYFLGIDLGGTVTKAGIYTADGSEIAVTEQALPVLSPQAGFCERDMEALWIATCQVIRQTLNKACALSEYHISAENIG
GISFSAHGKGLYLVDKQGLPVRNGIVSSDSRAQKLVNRWQQEGKDHAAYERSLQQLWPSHPAALLRWLKENEPENYQRSG
YVLMVHDYIRYRLTGEFTIEETNISGSNLYNQYNGSFDPQLMAIFAIEEVMEKTAPIIGSADLAGHVSEDAANACGLKAG
TPVFGGMFDVVGAALTSGLHDSRQLSAVAGTWSIATRIFEAITPSEYPYVWGKYCIPGTYFVHEGSPTSASNLAWFVKQF
LPELPNSYQTLNQWAALGYEKSEDILFFPWLYGSNHSANLSGGLLGLSGHHNIEDIVYAIYQGVVFSHLLHQDKILALDD
TIDCIRFTGGPTHSAIWMQMFCDASNLPLEIVDIQQSGCRAAALCAAVGSHYYHGFEEAIRACPPPITRLLPNAEKNQRL
RARFDKFKQVAEALSTVM
>Mature_497_residues
SHYFLGIDLGGTVTKAGIYTADGSEIAVTEQALPVLSPQAGFCERDMEALWIATCQVIRQTLNKACALSEYHISAENIGG
ISFSAHGKGLYLVDKQGLPVRNGIVSSDSRAQKLVNRWQQEGKDHAAYERSLQQLWPSHPAALLRWLKENEPENYQRSGY
VLMVHDYIRYRLTGEFTIEETNISGSNLYNQYNGSFDPQLMAIFAIEEVMEKTAPIIGSADLAGHVSEDAANACGLKAGT
PVFGGMFDVVGAALTSGLHDSRQLSAVAGTWSIATRIFEAITPSEYPYVWGKYCIPGTYFVHEGSPTSASNLAWFVKQFL
PELPNSYQTLNQWAALGYEKSEDILFFPWLYGSNHSANLSGGLLGLSGHHNIEDIVYAIYQGVVFSHLLHQDKILALDDT
IDCIRFTGGPTHSAIWMQMFCDASNLPLEIVDIQQSGCRAAALCAAVGSHYYHGFEEAIRACPPPITRLLPNAEKNQRLR
ARFDKFKQVAEALSTVM

Specific function: Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI164663828, Length=544, Percent_Identity=22.6102941176471, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI164663830, Length=568, Percent_Identity=21.830985915493, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1790005, Length=495, Percent_Identity=42.8282828282828, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1787789, Length=515, Percent_Identity=23.1067961165049, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1789987, Length=502, Percent_Identity=23.5059760956175, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790338, Length=251, Percent_Identity=30.2788844621514, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24657106, Length=545, Percent_Identity=23.4862385321101, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24657102, Length=545, Percent_Identity=23.4862385321101, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.53 [H]

Molecular weight: Translated: 54876; Mature: 54744

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHYFLGIDLGGTVTKAGIYTADGSEIAVTEQALPVLSPQAGFCERDMEALWIATCQVIR
CCEEEEEEECCCCEEECEEEECCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
QTLNKACALSEYHISAENIGGISFSAHGKGLYLVDKQGLPVRNGIVSSDSRAQKLVNRWQ
HHHHHHHHHHHHEECCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
QEGKDHAAYERSLQQLWPSHPAALLRWLKENEPENYQRSGYVLMVHDYIRYRLTGEFTIE
HCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECEEEEEEEEEEEE
ETNISGSNLYNQYNGSFDPQLMAIFAIEEVMEKTAPIIGSADLAGHVSEDAANACGLKAG
ECCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHCCCCCC
TPVFGGMFDVVGAALTSGLHDSRQLSAVAGTWSIATRIFEAITPSEYPYVWGKYCIPGTY
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCEE
FVHEGSPTSASNLAWFVKQFLPELPNSYQTLNQWAALGYEKSEDILFFPWLYGSNHSANL
EEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCC
SGGLLGLSGHHNIEDIVYAIYQGVVFSHLLHQDKILALDDTIDCIRFTGGPTHSAIWMQM
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCCCHHHHHHHH
FCDASNLPLEIVDIQQSGCRAAALCAAVGSHYYHGFEEAIRACPPPITRLLPNAEKNQRL
HCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHCCCCCCHHHH
RARFDKFKQVAEALSTVM
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SHYFLGIDLGGTVTKAGIYTADGSEIAVTEQALPVLSPQAGFCERDMEALWIATCQVIR
CEEEEEEECCCCEEECEEEECCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
QTLNKACALSEYHISAENIGGISFSAHGKGLYLVDKQGLPVRNGIVSSDSRAQKLVNRWQ
HHHHHHHHHHHHEECCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
QEGKDHAAYERSLQQLWPSHPAALLRWLKENEPENYQRSGYVLMVHDYIRYRLTGEFTIE
HCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECEEEEEEEEEEEE
ETNISGSNLYNQYNGSFDPQLMAIFAIEEVMEKTAPIIGSADLAGHVSEDAANACGLKAG
ECCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHCCCCCC
TPVFGGMFDVVGAALTSGLHDSRQLSAVAGTWSIATRIFEAITPSEYPYVWGKYCIPGTY
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCEE
FVHEGSPTSASNLAWFVKQFLPELPNSYQTLNQWAALGYEKSEDILFFPWLYGSNHSANL
EEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCC
SGGLLGLSGHHNIEDIVYAIYQGVVFSHLLHQDKILALDDTIDCIRFTGGPTHSAIWMQM
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCCCHHHHHHHH
FCDASNLPLEIVDIQQSGCRAAALCAAVGSHYYHGFEEAIRACPPPITRLLPNAEKNQRL
HCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHCCCCCCHHHH
RARFDKFKQVAEALSTVM
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7961955; 11741871 [H]