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The map label for this gene is xanP [H]

Identifier: 51594389

GI number: 51594389

Start: 41738

End: 43123

Strand: Reverse

Name: xanP [H]

Synonym: YPTB0031

Alternate gene names: 51594389

Gene position: 43123-41738 (Counterclockwise)

Preceding gene: 51594391

Following gene: 51594388

Centisome position: 0.91

GC content: 50.72

Gene sequence:

>1386_bases
ATGTCTACGCAATCTGCCGAACTTGATACTGCACAGCCATCACCGGCTCGCCCCAGCGAATTGATCTACCACCTAGAAGA
CCGACCGCCACTCCCACAAACACTGTTTGCCGCTTGCCAGCATCTCTTGGCGATGTTTGTTGCGGTAATCACCCCCGGTT
TATTGATTTGTCAGGCTTTGGGGTTACCCGCAGAAGATACTCAACGCATTATTAGTATGTCGTTATTTGCTTCGGGCCTA
GCGTCTTTACTGCAGATTAAAACTTGGGGCCCCGTGGGTTCAGGCCTGTTATCCATTCAAGGCACCAGTTTTAACTTTGT
TTCTCCGTTGATTATGGGGGGGCTGGCGCTAAAAAACGGTGGGGCGGATATCCCAACGATGATGGCGGCGCTGTTCGGTA
CGTTAATGGTTGCGTCCTGCACCGAGATCTTACTCTCACGTGTGCTGCATCTGGCACGCCGTATTATCACCCCGCTGGTA
TCCGGTATTGTGGTGATGATTATCGGCCTGTCATTGATTCAAGTTGGGCTGACATCTATTGGTGGTGGTTATGGTGCGAT
GAGCGATAACACCTTTGGTGCACCGAAAAACTTATTATTAGCCGGTGCCGTATTGGGGGTGATCATTCTGCTTAACCGCC
AGCGTAACCCGTATTTACGTGTTGCCTCTTTGGTTATCGCTATGGCCGTGGGTTATCTGCTCGCCTGGGCATTGGGGATG
TTGCCTGAGAGCCGCCCAGTTGTAGATACCGCGCTGATTACTATTCCAACGCCGTTGTACTATGGGCTGTCCTTCGACTG
GAACTTACTGATTCCTCTGATGCTGATCTTTATGGTGACCTCACTGGAAACCATAGGCGATATTACCGCAACATCTGATG
TATCAGAGCAACCGGTTCGCGGCCCGTTATATATGAAACGCCTAAAAGGCGGTGTACTGGCCAATGGTTTGAACTCGATG
CTGTCCGCTATATTCAATACCTTCCCCAACTCCTGCTTCGGTCAGAATAATGGCGTGATCCAATTGACCGGCGTTGCCAG
CCGTTATGTCGGTTTTGTTGTGGCAATAATGCTCATCATTCTGGGCCTGTTCCCTGCTGTCGCTGGGTTTGTGCAGCATA
TTCCTGAGCCGGTACTGGGTGGAGCAACTCTCGTGATGTTCGGGACTATCGCAGCGTCTGGAGTGCGTATTGTGTCACGC
GAGACCCTGAATCGCCGGGCGATTATGATAATGGCCTTATCATTAGCGGTTGGTATGGGTGTCGCACAGCAGCCATTGAT
TTTGCAATTTGCGCCTGACTGGATCAAAACGCTGTTCTCTTCTGGGATTGCCGCTGGCGGTATTACTGCCATCGTACTTA
ACTTACTCTTCCCACAAGAAAAATAG

Upstream 100 bases:

>100_bases
AGCAAAAAAATAGAAATAATATAAAAACCCAGCGCAAACGATTGCTTTTGTGAGTTGGATCATTAAAATGCCCCCTTTGC
CGATCTGGAAATACCACGCC

Downstream 100 bases:

>100_bases
TCTTTACGCTAACACATCACTGAAATGGTCGGTCATTAATGATGCCGGCCATTTTTTTATGGTCCGATAGCTGATTATCT
ATTGAGCTAATGGAAAAATT

Product: NCS2 family xanthine/uracil:H+ symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSTQSAELDTAQPSPARPSELIYHLEDRPPLPQTLFAACQHLLAMFVAVITPGLLICQALGLPAEDTQRIISMSLFASGL
ASLLQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNGGADIPTMMAALFGTLMVASCTEILLSRVLHLARRIITPLV
SGIVVMIIGLSLIQVGLTSIGGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVASLVIAMAVGYLLAWALGM
LPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDITATSDVSEQPVRGPLYMKRLKGGVLANGLNSM
LSAIFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAIMLIILGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSR
ETLNRRAIMIMALSLAVGMGVAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK

Sequences:

>Translated_461_residues
MSTQSAELDTAQPSPARPSELIYHLEDRPPLPQTLFAACQHLLAMFVAVITPGLLICQALGLPAEDTQRIISMSLFASGL
ASLLQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNGGADIPTMMAALFGTLMVASCTEILLSRVLHLARRIITPLV
SGIVVMIIGLSLIQVGLTSIGGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVASLVIAMAVGYLLAWALGM
LPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDITATSDVSEQPVRGPLYMKRLKGGVLANGLNSM
LSAIFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAIMLIILGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSR
ETLNRRAIMIMALSLAVGMGVAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK
>Mature_460_residues
STQSAELDTAQPSPARPSELIYHLEDRPPLPQTLFAACQHLLAMFVAVITPGLLICQALGLPAEDTQRIISMSLFASGLA
SLLQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNGGADIPTMMAALFGTLMVASCTEILLSRVLHLARRIITPLVS
GIVVMIIGLSLIQVGLTSIGGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVASLVIAMAVGYLLAWALGML
PESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDITATSDVSEQPVRGPLYMKRLKGGVLANGLNSML
SAIFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAIMLIILGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSRE
TLNRRAIMIMALSLAVGMGVAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=511, Percent_Identity=22.3091976516634, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI40316845, Length=511, Percent_Identity=22.3091976516634, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1790087, Length=462, Percent_Identity=84.4155844155844, Blast_Score=769, Evalue=0.0,
Organism=Escherichia coli, GI87082178, Length=440, Percent_Identity=46.5909090909091, Blast_Score=357, Evalue=1e-99,
Organism=Escherichia coli, GI87082181, Length=460, Percent_Identity=31.0869565217391, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1788843, Length=399, Percent_Identity=27.0676691729323, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87081818, Length=414, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558856, Length=471, Percent_Identity=24.416135881104, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17541904, Length=269, Percent_Identity=26.7657992565056, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 48711; Mature: 48580

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQSAELDTAQPSPARPSELIYHLEDRPPLPQTLFAACQHLLAMFVAVITPGLLICQAL
CCCCCCCCCCCCCCCCCHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
GLPAEDTQRIISMSLFASGLASLLQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHCCHHCCCC
GADIPTMMAALFGTLMVASCTEILLSRVLHLARRIITPLVSGIVVMIIGLSLIQVGLTSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVASLVIAMAVGYLLAWALGM
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
LPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDITATSDVSEQPVR
CCCCCCCHHHHHEEECCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GPLYMKRLKGGVLANGLNSMLSAIFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAIMLII
CHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHH
LGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSRETLNRRAIMIMALSLAVGMG
HHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK
CCCCCEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STQSAELDTAQPSPARPSELIYHLEDRPPLPQTLFAACQHLLAMFVAVITPGLLICQAL
CCCCCCCCCCCCCCCCHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
GLPAEDTQRIISMSLFASGLASLLQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHCCHHCCCC
GADIPTMMAALFGTLMVASCTEILLSRVLHLARRIITPLVSGIVVMIIGLSLIQVGLTSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVASLVIAMAVGYLLAWALGM
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
LPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDITATSDVSEQPVR
CCCCCCCHHHHHEEECCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GPLYMKRLKGGVLANGLNSMLSAIFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAIMLII
CHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHH
LGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSRETLNRRAIMIMALSLAVGMG
HHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK
CCCCCEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]