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The map label for this gene is strD [H]

Identifier: 50843725

GI number: 50843725

Start: 2483853

End: 2484689

Strand: Reverse

Name: strD [H]

Synonym: PPA2288

Alternate gene names: 50843725

Gene position: 2484689-2483853 (Counterclockwise)

Preceding gene: 50843727

Following gene: 50843724

Centisome position: 97.05

GC content: 56.51

Gene sequence:

>837_bases
ATGACACACGATCCCGTGGCACAAACGGCTCCTCACAAGGTCGTCATCATGGCGCGTGGTTTGGGAACGCGGATGCGCAA
ATCTGTCGAGGGAGTCTCCCTTACAGCAGACCAAGCAGCTGCTGCTTCAGCCGGCGTCAAGGCAATGATCAGTCTTGATG
ATCGTCCATTTCTCGACTACGTCATCTCAGCGCTAGCCGACGCTGGCTTTGACGAATTTTGTCTGGTGATCGGCCCTGAA
CACAACGTAATCCGGGACTACTACGACGCATGCGAAAAATCGCGGTTATCGATTGTCTATGCGGTCCAGGAGCATCCTCT
GGGTACTGCGGACGCCGTCGCAGCCGCCGAGGAATTTGCCGGTGATGACCGTGTGCTGGTTGTGAACTCTGACAATTTTT
ACCCGGAGGACGCGGTCGCCAGACTTCGCGAGGTTCCCGCCTCAGGAACCCTAGGTTTCACGAAGCGCGCCATGATCGCG
CAGTCCAACATCGATCCTGAGCGCATTCGTGCCTTCGCCCTGCTGGATTCTGATGATTCAGGTCAACTTACGGATATCAT
CGAGAAGCCGGACCCCCACATCGTTGATGCTGCCGGAGAGACTGCGCTGGTATCGATGAACTGTTTCCTTCTTACCCCGA
GAATCTTCGAGGCGTGCCGCTCGATCGACAAGTCGGAGCGCGGGGAATACGAGATTGTCGATGCAGTGCGCTGGATGGTG
GAGCATGGCGAGCATTTTGATGTCGTTCCGGTCGAGTCGGGAGTTCTCGACATGTCGAACCGCGGCGACATTACGTCTGT
AGTGGAGGCTCTCAGCAGCCGTGAGGTGAAACTGTGA

Upstream 100 bases:

>100_bases
GTCCCCTGACGGACGGGTAGAAATGGAAAAGGATCATCTTAGGTGACCGGATGTTGCCCTATCTGCGCGCGGACTCGAAC
TGATTCCTAGGATTACCCAC

Downstream 100 bases:

>100_bases
CACGCTGGTTCGTTCCGGGACGGATAGAGGTTCTCGGCAAGCACACTGACTACGCTGGCGGGTCCACACTGGTGGCCGCC
GTGGATCGCGGGGTGACGAT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MTHDPVAQTAPHKVVIMARGLGTRMRKSVEGVSLTADQAAAASAGVKAMISLDDRPFLDYVISALADAGFDEFCLVIGPE
HNVIRDYYDACEKSRLSIVYAVQEHPLGTADAVAAAEEFAGDDRVLVVNSDNFYPEDAVARLREVPASGTLGFTKRAMIA
QSNIDPERIRAFALLDSDDSGQLTDIIEKPDPHIVDAAGETALVSMNCFLLTPRIFEACRSIDKSERGEYEIVDAVRWMV
EHGEHFDVVPVESGVLDMSNRGDITSVVEALSSREVKL

Sequences:

>Translated_278_residues
MTHDPVAQTAPHKVVIMARGLGTRMRKSVEGVSLTADQAAAASAGVKAMISLDDRPFLDYVISALADAGFDEFCLVIGPE
HNVIRDYYDACEKSRLSIVYAVQEHPLGTADAVAAAEEFAGDDRVLVVNSDNFYPEDAVARLREVPASGTLGFTKRAMIA
QSNIDPERIRAFALLDSDDSGQLTDIIEKPDPHIVDAAGETALVSMNCFLLTPRIFEACRSIDKSERGEYEIVDAVRWMV
EHGEHFDVVPVESGVLDMSNRGDITSVVEALSSREVKL
>Mature_277_residues
THDPVAQTAPHKVVIMARGLGTRMRKSVEGVSLTADQAAAASAGVKAMISLDDRPFLDYVISALADAGFDEFCLVIGPEH
NVIRDYYDACEKSRLSIVYAVQEHPLGTADAVAAAEEFAGDDRVLVVNSDNFYPEDAVARLREVPASGTLGFTKRAMIAQ
SNIDPERIRAFALLDSDDSGQLTDIIEKPDPHIVDAAGETALVSMNCFLLTPRIFEACRSIDKSERGEYEIVDAVRWMVE
HGEHFDVVPVESGVLDMSNRGDITSVVEALSSREVKL

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1790224, Length=237, Percent_Identity=27.4261603375527, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1788351, Length=234, Percent_Identity=26.4957264957265, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 30240; Mature: 30109

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHDPVAQTAPHKVVIMARGLGTRMRKSVEGVSLTADQAAAASAGVKAMISLDDRPFLDY
CCCCCCCCCCCCEEEEEECCCCHHHHHHCCCCEEEHHHHHHHHCCCEEEEEECCCHHHHH
VISALADAGFDEFCLVIGPEHNVIRDYYDACEKSRLSIVYAVQEHPLGTADAVAAAEEFA
HHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHC
GDDRVLVVNSDNFYPEDAVARLREVPASGTLGFTKRAMIAQSNIDPERIRAFALLDSDDS
CCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHEEEEEEECCCCC
GQLTDIIEKPDPHIVDAAGETALVSMNCFLLTPRIFEACRSIDKSERGEYEIVDAVRWMV
CCHHHHHCCCCCCEEECCCCEEEEEEEEEEECHHHHHHHHCCCCCCCCCCHHHHHHHHHH
EHGEHFDVVPVESGVLDMSNRGDITSVVEALSSREVKL
HCCCCCEEEECCCCEEECCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
THDPVAQTAPHKVVIMARGLGTRMRKSVEGVSLTADQAAAASAGVKAMISLDDRPFLDY
CCCCCCCCCCCEEEEEECCCCHHHHHHCCCCEEEHHHHHHHHCCCEEEEEECCCHHHHH
VISALADAGFDEFCLVIGPEHNVIRDYYDACEKSRLSIVYAVQEHPLGTADAVAAAEEFA
HHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHC
GDDRVLVVNSDNFYPEDAVARLREVPASGTLGFTKRAMIAQSNIDPERIRAFALLDSDDS
CCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHEEEEEEECCCCC
GQLTDIIEKPDPHIVDAAGETALVSMNCFLLTPRIFEACRSIDKSERGEYEIVDAVRWMV
CCHHHHHCCCCCCEEECCCCEEEEEEEEEEECHHHHHHHHCCCCCCCCCCHHHHHHHHHH
EHGEHFDVVPVESGVLDMSNRGDITSVVEALSSREVKL
HCCCCCEEEECCCCEEECCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]