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The map label for this gene is ald [H]

Identifier: 50843711

GI number: 50843711

Start: 2465524

End: 2466636

Strand: Reverse

Name: ald [H]

Synonym: PPA2274

Alternate gene names: 50843711

Gene position: 2466636-2465524 (Counterclockwise)

Preceding gene: 50843712

Following gene: 50843701

Centisome position: 96.34

GC content: 57.05

Gene sequence:

>1113_bases
ATGCGTGTTGGTGTTCCTACTGAGGTTAAGAATAGTGAGTTTCGTGTGGCTGTGACGCCGGCGGGTGTTCATGCGTTGGT
TGGTCGTGGTCATGAGGTGTTGGTTCAGGCTGGTGCTGGTGTGGGTTCGGGTATTCCGGATTCGGATTTTGTGGGTGCTG
GTGCGCGGGTTGTGGGTGATGTGGAGTCGGTGTGGGGTGATGCTGATTTGGTGTTGAAGGTGAAGGAGCCTGTTGCGGAG
GAGTATGGGCGGTTGCATGAGGGTTTGGTTCTTTTTACGTATCTTCATTTGGCTGCTGATGAGGCGTTGACTCGTGAGCT
TTTGGGGCGTGGGGTGACGTCGATTGCGTATGAGACGGTGGAGTTGGCTGATCATTCGTTGCCGTTGTTGTCTCCGATGT
CGGAGATTGCGGGTCGGTTGGCTGCTCAGGTGGGTGCGAATTGTTTGTTGCAGTCTGCTGGGGGTCGTGGTGTGTTGTTT
GGTGGTGGTTCGGGTGTGCGTCGTGGTCGGGTGAGTGTGCTTGGTGGTGGTGTGGCTGGGTTGTGTGCGGCTCGTGTGGC
TGCGGGTATGGGTGCTGATGTGACGGTGTTTGATGTGGATGTGGCGCGGATGCGTTATATCGATGAGGTGTGGGGTGGGC
GTATTGGTACGCGGTTTTCGAGTCCGTTGGCGGTTCGGGAGGCGTGTGGTGAGTCTGATGTGGTGATTGGGTCGGTGTTG
GTGCCTGGTGCTCGGACTCCGCATTTGGTGGATCATGAGATGGTGTTGGGGATGGTGCCGGGGTCGGTGTTGGTGGATGT
TGCGGTGGATCAGGGTGGGTGTTTTGAGGATTCTCATCCGACGACGCATGCGGATCCGACGTTTGTGGTGGGGGGTTCGG
TGTTTTATTGTGTGGCGAATATGCCGGGTGCGGTGCCGCATACGTCGACGTATGCGTTGACGAATGCGACGATGCGGTAT
GTGTTGTTGTTGGCTGATGAGGGTTGGAGGGGTGCGTGTGGGTCGCGTGATGATTTGCGGCGTGGTTTGGCGACTTGTGA
TGGGAAGTTGGTGAGTGCGCCGGTGGGTGAGGCGTTGGGTATTGAGTGTGTGCCTGTGTCTGAGGTGTTGTGA

Upstream 100 bases:

>100_bases
TGCCGTGGTATTGGGGCTGTATCGATGCTTATTCTCGTGGTAACTAGTCGCAGCCGGTCAACGTTGTTGTTGGCGGGTGT
TGTTGTAAGGAGTGTGTGTG

Downstream 100 bases:

>100_bases
GGTTGGTGGTGGGGGTGAAACCACACCACCCCCACCTACCGTGCGCTCAGACCAGCAGGGGAACGAGAGACTGCTTATCG
TCCTGGGAACAGAAGGCTGC

Product: alanine dehydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MRVGVPTEVKNSEFRVAVTPAGVHALVGRGHEVLVQAGAGVGSGIPDSDFVGAGARVVGDVESVWGDADLVLKVKEPVAE
EYGRLHEGLVLFTYLHLAADEALTRELLGRGVTSIAYETVELADHSLPLLSPMSEIAGRLAAQVGANCLLQSAGGRGVLF
GGGSGVRRGRVSVLGGGVAGLCAARVAAGMGADVTVFDVDVARMRYIDEVWGGRIGTRFSSPLAVREACGESDVVIGSVL
VPGARTPHLVDHEMVLGMVPGSVLVDVAVDQGGCFEDSHPTTHADPTFVVGGSVFYCVANMPGAVPHTSTYALTNATMRY
VLLLADEGWRGACGSRDDLRRGLATCDGKLVSAPVGEALGIECVPVSEVL

Sequences:

>Translated_370_residues
MRVGVPTEVKNSEFRVAVTPAGVHALVGRGHEVLVQAGAGVGSGIPDSDFVGAGARVVGDVESVWGDADLVLKVKEPVAE
EYGRLHEGLVLFTYLHLAADEALTRELLGRGVTSIAYETVELADHSLPLLSPMSEIAGRLAAQVGANCLLQSAGGRGVLF
GGGSGVRRGRVSVLGGGVAGLCAARVAAGMGADVTVFDVDVARMRYIDEVWGGRIGTRFSSPLAVREACGESDVVIGSVL
VPGARTPHLVDHEMVLGMVPGSVLVDVAVDQGGCFEDSHPTTHADPTFVVGGSVFYCVANMPGAVPHTSTYALTNATMRY
VLLLADEGWRGACGSRDDLRRGLATCDGKLVSAPVGEALGIECVPVSEVL
>Mature_370_residues
MRVGVPTEVKNSEFRVAVTPAGVHALVGRGHEVLVQAGAGVGSGIPDSDFVGAGARVVGDVESVWGDADLVLKVKEPVAE
EYGRLHEGLVLFTYLHLAADEALTRELLGRGVTSIAYETVELADHSLPLLSPMSEIAGRLAAQVGANCLLQSAGGRGVLF
GGGSGVRRGRVSVLGGGVAGLCAARVAAGMGADVTVFDVDVARMRYIDEVWGGRIGTRFSSPLAVREACGESDVVIGSVL
VPGARTPHLVDHEMVLGMVPGSVLVDVAVDQGGCFEDSHPTTHADPTFVVGGSVFYCVANMPGAVPHTSTYALTNATMRY
VLLLADEGWRGACGSRDDLRRGLATCDGKLVSAPVGEALGIECVPVSEVL

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=308, Percent_Identity=31.1688311688312, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI122939153, Length=308, Percent_Identity=31.1688311688312, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1787887, Length=356, Percent_Identity=30.3370786516854, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17550456, Length=373, Percent_Identity=29.4906166219839, Blast_Score=131, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 38193; Mature: 38193

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGVPTEVKNSEFRVAVTPAGVHALVGRGHEVLVQAGAGVGSGIPDSDFVGAGARVVGD
CCCCCCCCCCCCEEEEEECCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHEECC
VESVWGDADLVLKVKEPVAEEYGRLHEGLVLFTYLHLAADEALTRELLGRGVTSIAYETV
HHHHCCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ELADHSLPLLSPMSEIAGRLAAQVGANCLLQSAGGRGVLFGGGSGVRRGRVSVLGGGVAG
HHHCCCCCCCCHHHHHHHHHHHHHCCHHEEECCCCCEEEEECCCCCCCCEEEEECCCHHH
LCAARVAAGMGADVTVFDVDVARMRYIDEVWGGRIGTRFSSPLAVREACGESDVVIGSVL
HHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCEEEEEEE
VPGARTPHLVDHEMVLGMVPGSVLVDVAVDQGGCFEDSHPTTHADPTFVVGGSVFYCVAN
CCCCCCCCEECCHHHEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCEEECCEEEEEEEC
MPGAVPHTSTYALTNATMRYVLLLADEGWRGACGSRDDLRRGLATCDGKLVSAPVGEALG
CCCCCCCCCEEEEHHCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCCHHHC
IECVPVSEVL
CEEEEHHHCC
>Mature Secondary Structure
MRVGVPTEVKNSEFRVAVTPAGVHALVGRGHEVLVQAGAGVGSGIPDSDFVGAGARVVGD
CCCCCCCCCCCCEEEEEECCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHEECC
VESVWGDADLVLKVKEPVAEEYGRLHEGLVLFTYLHLAADEALTRELLGRGVTSIAYETV
HHHHCCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ELADHSLPLLSPMSEIAGRLAAQVGANCLLQSAGGRGVLFGGGSGVRRGRVSVLGGGVAG
HHHCCCCCCCCHHHHHHHHHHHHHCCHHEEECCCCCEEEEECCCCCCCCEEEEECCCHHH
LCAARVAAGMGADVTVFDVDVARMRYIDEVWGGRIGTRFSSPLAVREACGESDVVIGSVL
HHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCEEEEEEE
VPGARTPHLVDHEMVLGMVPGSVLVDVAVDQGGCFEDSHPTTHADPTFVVGGSVFYCVAN
CCCCCCCCEECCHHHEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCEEECCEEEEEEEC
MPGAVPHTSTYALTNATMRYVLLLADEGWRGACGSRDDLRRGLATCDGKLVSAPVGEALG
CCCCCCCCCEEEEHHCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCCHHHC
IECVPVSEVL
CEEEEHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]