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The map label for this gene is add2 [H]

Identifier: 50843710

GI number: 50843710

Start: 2464452

End: 2465477

Strand: Direct

Name: add2 [H]

Synonym: PPA2273

Alternate gene names: 50843710

Gene position: 2464452-2465477 (Clockwise)

Preceding gene: 50843709

Following gene: 50843713

Centisome position: 96.26

GC content: 60.62

Gene sequence:

>1026_bases
ATGGATTCGGCCGAAGCGATGAACCTCCCCAAAGTCGTGCTGCACGATCATCTGGATGGTGGGCTACGTCCGGCGACAGT
TTTAGAACTCGCCGCGCAGCGAGGCCGGCCCGTGCCTGCACAAACCCCCGAGGACCTCGCAACCTGGTTTTTTGAGTCAG
CCGATTCCGGCTCTTTGGCCCGTTATCTCGACGCCTTCACCGAAACTATCGCCCTCATGCAGGATGCTGATTCCCTCCGG
CGCGTCGCACGGGAATTCGTGGTAGATATGGCCACTGACGGCGTTATTTACGCCGAAGCTCGATGGGCTCCCCAACAGCA
TTTAACAGGTGGGTTGTCCGCTGCGGAGGCCGTCGAGGCAGTCCAGGTTGGCTTAGTAGACGGGATGGAATCTGCATCGC
TGTCGGGCACGACGATCATCGCCCGCCAAATTCTGTGCCTCATGAGGCATCTCGACGTCCCCGAGGACGTGGTAGATCTT
GCCGTCAACCATGCTCCGGGGGTCGTTGGCGTCGACGTTGCTGGGCCAGAGGATGGTTTTCCGCTAGCTCCGTTTACCAA
CGCGCTCACGCGCGTCCAAGCGGCCGGAATCCACCTCACCGTTCATGCCGGCGAAGCTGCTGGGCCGGAGTCTATTCTCG
ACGCCCTTAATCATGGGGCAGAGCGTCTCGGACATGGGGTGCGGATCATTGAAGACCGCGACGAATCCGGGTGGGGTCCG
ACAGCCCAGCAGGTGTTGTCGAATCAGGTGCCGTTGGAGGTCTGCCCAACGTCGAACACCCAGACCGGCATCTGCCGCAA
GGTTGCCGAGCATCCGCTATCGACGCTGTGGTCTACCGGATTTAACATCACGGTGAGCTGTGATAACCGCCTCATGAGCC
GTACGACGACGTCTCGAGAGATATCGCTGGTCTCCCAGGCACTCTGCTGGAACCGCGACGACGCCCTGGCTGCCCAGCGC
AATGCGCTGCAAGCAGCCTTCTGTTCCCAGGACGATAAGCAGTCTCTCGTTCCCCTGCTGGTCTGA

Upstream 100 bases:

>100_bases
CATCAGGGTGTCCCGACCACCCTTCGCTCGGGATTTTTGTTCACCAGACTTCGGGCTGCTCCGCGCTTCTCCCCGGTGCG
ACGCCGATAGACTCCGGCAC

Downstream 100 bases:

>100_bases
GCGCACGGTAGGTGGGGGTGGTGTGGTTTCACCCCCACCACCAACCTCACAACACCTCAGACACAGGCACACACTCAATA
CCCAACGCCTCACCCACCGG

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase 2 [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MDSAEAMNLPKVVLHDHLDGGLRPATVLELAAQRGRPVPAQTPEDLATWFFESADSGSLARYLDAFTETIALMQDADSLR
RVAREFVVDMATDGVIYAEARWAPQQHLTGGLSAAEAVEAVQVGLVDGMESASLSGTTIIARQILCLMRHLDVPEDVVDL
AVNHAPGVVGVDVAGPEDGFPLAPFTNALTRVQAAGIHLTVHAGEAAGPESILDALNHGAERLGHGVRIIEDRDESGWGP
TAQQVLSNQVPLEVCPTSNTQTGICRKVAEHPLSTLWSTGFNITVSCDNRLMSRTTTSREISLVSQALCWNRDDALAAQR
NALQAAFCSQDDKQSLVPLLV

Sequences:

>Translated_341_residues
MDSAEAMNLPKVVLHDHLDGGLRPATVLELAAQRGRPVPAQTPEDLATWFFESADSGSLARYLDAFTETIALMQDADSLR
RVAREFVVDMATDGVIYAEARWAPQQHLTGGLSAAEAVEAVQVGLVDGMESASLSGTTIIARQILCLMRHLDVPEDVVDL
AVNHAPGVVGVDVAGPEDGFPLAPFTNALTRVQAAGIHLTVHAGEAAGPESILDALNHGAERLGHGVRIIEDRDESGWGP
TAQQVLSNQVPLEVCPTSNTQTGICRKVAEHPLSTLWSTGFNITVSCDNRLMSRTTTSREISLVSQALCWNRDDALAAQR
NALQAAFCSQDDKQSLVPLLV
>Mature_341_residues
MDSAEAMNLPKVVLHDHLDGGLRPATVLELAAQRGRPVPAQTPEDLATWFFESADSGSLARYLDAFTETIALMQDADSLR
RVAREFVVDMATDGVIYAEARWAPQQHLTGGLSAAEAVEAVQVGLVDGMESASLSGTTIIARQILCLMRHLDVPEDVVDL
AVNHAPGVVGVDVAGPEDGFPLAPFTNALTRVQAAGIHLTVHAGEAAGPESILDALNHGAERLGHGVRIIEDRDESGWGP
TAQQVLSNQVPLEVCPTSNTQTGICRKVAEHPLSTLWSTGFNITVSCDNRLMSRTTTSREISLVSQALCWNRDDALAAQR
NALQAAFCSQDDKQSLVPLLV

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family [H]

Homologues:

Organism=Homo sapiens, GI47078295, Length=359, Percent_Identity=29.5264623955432, Blast_Score=135, Evalue=7e-32,
Organism=Escherichia coli, GI1787910, Length=331, Percent_Identity=33.5347432024169, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32565969, Length=347, Percent_Identity=34.0057636887608, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17538512, Length=347, Percent_Identity=34.0057636887608, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324188, Length=349, Percent_Identity=23.2091690544413, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24645260, Length=336, Percent_Identity=24.4047619047619, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001365
- InterPro:   IPR006330 [H]

Pfam domain/function: PF00962 A_deaminase [H]

EC number: =3.5.4.4 [H]

Molecular weight: Translated: 36439; Mature: 36439

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSAEAMNLPKVVLHDHLDGGLRPATVLELAAQRGRPVPAQTPEDLATWFFESADSGSLA
CCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHH
RYLDAFTETIALMQDADSLRRVAREFVVDMATDGVIYAEARWAPQQHLTGGLSAAEAVEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCHHHHHHHH
VQVGLVDGMESASLSGTTIIARQILCLMRHLDVPEDVVDLAVNHAPGVVGVDVAGPEDGF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCC
PLAPFTNALTRVQAAGIHLTVHAGEAAGPESILDALNHGAERLGHGVRIIEDRDESGWGP
CCCHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCH
TAQQVLSNQVPLEVCPTSNTQTGICRKVAEHPLSTLWSTGFNITVSCDNRLMSRTTTSRE
HHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHCCCHHH
ISLVSQALCWNRDDALAAQRNALQAAFCSQDDKQSLVPLLV
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCC
>Mature Secondary Structure
MDSAEAMNLPKVVLHDHLDGGLRPATVLELAAQRGRPVPAQTPEDLATWFFESADSGSLA
CCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHH
RYLDAFTETIALMQDADSLRRVAREFVVDMATDGVIYAEARWAPQQHLTGGLSAAEAVEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCHHHHHHHH
VQVGLVDGMESASLSGTTIIARQILCLMRHLDVPEDVVDLAVNHAPGVVGVDVAGPEDGF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCC
PLAPFTNALTRVQAAGIHLTVHAGEAAGPESILDALNHGAERLGHGVRIIEDRDESGWGP
CCCHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCH
TAQQVLSNQVPLEVCPTSNTQTGICRKVAEHPLSTLWSTGFNITVSCDNRLMSRTTTSRE
HHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHCCCHHH
ISLVSQALCWNRDDALAAQRNALQAAFCSQDDKQSLVPLLV
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]