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The map label for this gene is galK [H]

Identifier: 50843629

GI number: 50843629

Start: 2374475

End: 2375710

Strand: Reverse

Name: galK [H]

Synonym: PPA2192

Alternate gene names: 50843629

Gene position: 2375710-2374475 (Counterclockwise)

Preceding gene: 50843632

Following gene: 50843628

Centisome position: 92.79

GC content: 65.37

Gene sequence:

>1236_bases
ATGTCGCAGACACCCCACGCCATTGCGGCAGACCACCAGACCCCGACGATCGGCACAGCATGGTCGGTAGAGGAGGGTGC
CACTCGCGCCCGGCACCTCTTTGGCGGGCACATTGGTGGTAGCCCCGATGGCGTCTGGGCGGCCCCCGGACGTGTCAACA
TCATCGGCGAGCACACCGACTACAACAACGGTTTCTGCCTGCCAATCGCCCTTCCCCATCGCACCTACGTCGCTGCTCGA
CGCCGTGATGACGACAAGGTCATCCTCGTCTCCCAGCTTGACGACAGCGTTCTCACCTGGGAGGGAACCCTCGACGAGAT
CGCTCCTGGGTCGGTTGCTGGTTGGAAGGCCTATACCGGTGGTGTCGCGTGGGCGCTGCGTCAGGCCGGGCATGGCCTCG
GGGGATTCGAGGCTGCACTGGTCACGTGCGTCCCCCTGGGTGCGGGACTGTCGTCGTCGGCAGCCGTCGAGTGTGGCGTC
GGTCTGGCCCTCGCCGACCTCTACGACCTTGATCTCACCGACTCTGACTCCGGCCGTATTGGCCTCGTCAATGCTGCCCG
CGCTGCGGAGAACGAGGTTGCTGAGGCTCCCACTGGAGGGCTCGATCAAACCGCTTCGCTGCGCACTACCGAAGGTCACG
CCCTCCTCATCGACTGTGACGACTGGTCGGTTCGTCAAGTCCCCTTCAACCTGGCCACCGCCGACCTAGAACTGCTTGTC
ATCGACACCTGCGCTCCCCACCGGCTGGTCGACGGCCAGTATGAGGCACGACGGCGGGCCTGCGAGAATGCCGCACGCAT
CCTCGGAGTTGGTAGCCTGCGTGACGTCGGTGACTTGGGGGCCGCCGTGGCCGCCCTCGATGACGAAGGGATGGCTAGCC
GCGTCCGCCACGTCGTCACTGAGAACGACCGTGTTACCCAGTTCGTTAAGCTCCTCGATACCGGCCAAATCCGCGAAGTG
GGGCCGCTTATGAATGCCTCCCACGACTCCCTGCGTGACGACTACGAGGTCACCTGTCCCGAACTGGACACCGCTGTCGA
CGCGGCCCGCGCTGCTGGTGCTCTTGGCGCGCGGATGACTGGCGGCGGATTCGGCGGTTGCGCCATCGCTCTGGTCGATC
GCGACGTTCGTAACAAGGTTGCCACGCAGGTCGCGGACTCCTTCCGGGAGGCCGGTTTCGCCCACCCCGAGTTCTACGTC
GTTACCCCTGGCCCTGCTGCCCTGCGGGTGCAGTGA

Upstream 100 bases:

>100_bases
ACGTAAACATTTTGAGTGAGCGAAGTCGACGCAGCGCCACTGGCATCGTCGTACGCTCAGCCTCGTTGTCACGGGATTTT
GACCGGCAAAGGAGCCATTT

Downstream 100 bases:

>100_bases
TATGACCGAGCGGCAGCGTCGAGGACCGTCTCGCCCCTCAATGGGTGATGTCGCCGCGGCTGCCGGGGTATCCCAACAGA
CCGTCTCGCGGGTCGTCAAC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MSQTPHAIAADHQTPTIGTAWSVEEGATRARHLFGGHIGGSPDGVWAAPGRVNIIGEHTDYNNGFCLPIALPHRTYVAAR
RRDDDKVILVSQLDDSVLTWEGTLDEIAPGSVAGWKAYTGGVAWALRQAGHGLGGFEAALVTCVPLGAGLSSSAAVECGV
GLALADLYDLDLTDSDSGRIGLVNAARAAENEVAEAPTGGLDQTASLRTTEGHALLIDCDDWSVRQVPFNLATADLELLV
IDTCAPHRLVDGQYEARRRACENAARILGVGSLRDVGDLGAAVAALDDEGMASRVRHVVTENDRVTQFVKLLDTGQIREV
GPLMNASHDSLRDDYEVTCPELDTAVDAARAAGALGARMTGGGFGGCAIALVDRDVRNKVATQVADSFREAGFAHPEFYV
VTPGPAALRVQ

Sequences:

>Translated_411_residues
MSQTPHAIAADHQTPTIGTAWSVEEGATRARHLFGGHIGGSPDGVWAAPGRVNIIGEHTDYNNGFCLPIALPHRTYVAAR
RRDDDKVILVSQLDDSVLTWEGTLDEIAPGSVAGWKAYTGGVAWALRQAGHGLGGFEAALVTCVPLGAGLSSSAAVECGV
GLALADLYDLDLTDSDSGRIGLVNAARAAENEVAEAPTGGLDQTASLRTTEGHALLIDCDDWSVRQVPFNLATADLELLV
IDTCAPHRLVDGQYEARRRACENAARILGVGSLRDVGDLGAAVAALDDEGMASRVRHVVTENDRVTQFVKLLDTGQIREV
GPLMNASHDSLRDDYEVTCPELDTAVDAARAAGALGARMTGGGFGGCAIALVDRDVRNKVATQVADSFREAGFAHPEFYV
VTPGPAALRVQ
>Mature_410_residues
SQTPHAIAADHQTPTIGTAWSVEEGATRARHLFGGHIGGSPDGVWAAPGRVNIIGEHTDYNNGFCLPIALPHRTYVAARR
RDDDKVILVSQLDDSVLTWEGTLDEIAPGSVAGWKAYTGGVAWALRQAGHGLGGFEAALVTCVPLGAGLSSSAAVECGVG
LALADLYDLDLTDSDSGRIGLVNAARAAENEVAEAPTGGLDQTASLRTTEGHALLIDCDDWSVRQVPFNLATADLELLVI
DTCAPHRLVDGQYEARRRACENAARILGVGSLRDVGDLGAAVAALDDEGMASRVRHVVTENDRVTQFVKLLDTGQIREVG
PLMNASHDSLRDDYEVTCPELDTAVDAARAAGALGARMTGGGFGGCAIALVDRDVRNKVATQVADSFREAGFAHPEFYVV
TPGPAALRVQ

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=368, Percent_Identity=42.3913043478261, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI4503897, Length=445, Percent_Identity=26.5168539325843, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI48527957, Length=445, Percent_Identity=26.5168539325843, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1786972, Length=388, Percent_Identity=36.8556701030928, Blast_Score=225, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI71989053, Length=405, Percent_Identity=27.4074074074074, Blast_Score=108, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6319494, Length=89, Percent_Identity=38.2022471910112, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 43178; Mature: 43046

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTPHAIAADHQTPTIGTAWSVEEGATRARHLFGGHIGGSPDGVWAAPGRVNIIGEHTD
CCCCCCCEECCCCCCCCCCEECCHHHHHHHHHHHCCCCCCCCCCEEECCCEEEEEECCCC
YNNGFCLPIALPHRTYVAARRRDDDKVILVSQLDDSVLTWEGTLDEIAPGSVAGWKAYTG
CCCCEEEEEECCCCCEEHHHCCCCCCEEEEEECCCCEEEECCCHHHCCCCCCCCCCHHCC
GVAWALRQAGHGLGGFEAALVTCVPLGAGLSSSAAVECGVGLALADLYDLDLTDSDSGRI
HHHHHHHHHCCCCCHHHHHHHHHEECCCCCCCCCEEECCCCEEEHHEEECCCCCCCCCCE
GLVNAARAAENEVAEAPTGGLDQTASLRTTEGHALLIDCDDWSVRQVPFNLATADLELLV
EEEEHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEECCCCCEEECCCEEEECCEEEEE
IDTCAPHRLVDGQYEARRRACENAARILGVGSLRDVGDLGAAVAALDDEGMASRVRHVVT
EECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHEEEECCCCCHHHHHHHHHC
ENDRVTQFVKLLDTGQIREVGPLMNASHDSLRDDYEVTCPELDTAVDAARAAGALGARMT
CCHHHHHHHHHHCCCCCHHHHHHCCCCCHHCCCCCEEECCCHHHHHHHHHHHHHCCCEEC
GGGFGGCAIALVDRDVRNKVATQVADSFREAGFAHPEFYVVTPGPAALRVQ
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEC
>Mature Secondary Structure 
SQTPHAIAADHQTPTIGTAWSVEEGATRARHLFGGHIGGSPDGVWAAPGRVNIIGEHTD
CCCCCCEECCCCCCCCCCEECCHHHHHHHHHHHCCCCCCCCCCEEECCCEEEEEECCCC
YNNGFCLPIALPHRTYVAARRRDDDKVILVSQLDDSVLTWEGTLDEIAPGSVAGWKAYTG
CCCCEEEEEECCCCCEEHHHCCCCCCEEEEEECCCCEEEECCCHHHCCCCCCCCCCHHCC
GVAWALRQAGHGLGGFEAALVTCVPLGAGLSSSAAVECGVGLALADLYDLDLTDSDSGRI
HHHHHHHHHCCCCCHHHHHHHHHEECCCCCCCCCEEECCCCEEEHHEEECCCCCCCCCCE
GLVNAARAAENEVAEAPTGGLDQTASLRTTEGHALLIDCDDWSVRQVPFNLATADLELLV
EEEEHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEECCCCCEEECCCEEEECCEEEEE
IDTCAPHRLVDGQYEARRRACENAARILGVGSLRDVGDLGAAVAALDDEGMASRVRHVVT
EECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHEEEECCCCCHHHHHHHHHC
ENDRVTQFVKLLDTGQIREVGPLMNASHDSLRDDYEVTCPELDTAVDAARAAGALGARMT
CCHHHHHHHHHHCCCCCHHHHHHCCCCCHHCCCCCEEECCCHHHHHHHHHHHHHCCCEEC
GGGFGGCAIALVDRDVRNKVATQVADSFREAGFAHPEFYVVTPGPAALRVQ
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]