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The map label for this gene is guaA [C]

Identifier: 50843625

GI number: 50843625

Start: 2369851

End: 2370552

Strand: Reverse

Name: guaA [C]

Synonym: PPA2188

Alternate gene names: 50843625

Gene position: 2370552-2369851 (Counterclockwise)

Preceding gene: 50843628

Following gene: 50843623

Centisome position: 92.59

GC content: 62.39

Gene sequence:

>702_bases
TTGGTCATCGTTCACGAGCCCTCCTGCAGCTCAGGCAGACTCGGGCAACTTTGGCGCAACGCCGGGGCAGACGTCGTCGA
GATCAACGCCTGGAACCATCCGGTGCCGCCGATTGTGGACGCTGACGCACTCGTGGTGCTGGGCGGCTCTATGAGCTGCC
AGGACGATGCTGAGGCTCCGTGGCTCGCGCCTACCCGCCAGCTCATCTCCCGGACAGTGAGGGCAGGTACGCCCTTCCTC
GGCATCTGCCTGGGTCACCAACTCGCCACCGTCGCGCTGGGAGGACAGGTCTGCACCTCCGACCATTTCTGCCTTGGAGC
GGCCGAGATGCACCTCACCCCGGAGGGAAAGAAGGACCCGCTGCTGTCGGTCTACGACGGACATCGCGGTATTCATTTCA
ACAACGATGTTGCGGTCGTCCTGCCCGAGGACGCCGTTCTGCTGGCGCGCGATCCCACCGGTCAGATCGAGGCCGTCAGG
TTCGCTGAGCGTGCATGGGGGGTACAGTTTCATCCCGAGTGCACTCCCGAAATCTTCGATGCCTGGACTATCGGCCACGG
TGAGAAAGAATGGCAGCAGCGTCTTCCTTGGTCAGAGGCCGTCACGGTAGCAGAGACGGTGCGTCGCGACATCGACACCG
TCAATGCCGAAGAGGCTTTCGCGGCGCGATTCCAGGAACTTATAGACCCTGAGAAAAGGTGA

Upstream 100 bases:

>100_bases
GCAACTGGCGTCCGGTCGGGCGAAATCTGTACTCCGGTTGCAGCAGTTCTGGCATACGGCCGTGACAGAAAGCTCGTAGT
GTTTCCCCATGACGCGGATC

Downstream 100 bases:

>100_bases
TTCCCGAGGCTCAGTAGGCCTCGGGAATCAGTTGTGAGTATCAGCGACAGACCGTCACAAGGCGACGGCCTCACCCATAA
CCACCGCGCGAGTGCGCGGT

Product: glutamine amidotransferase / GMP synthase

Products: AMP; L-Glutamate; GMP; H+; Diphosphate [C]

Alternate protein names: Glutamine Amidotransferase; GMP Synthase; Amino Transferase; Glutamine Amidotransferase Class I; Class I Glutamine Amidotransferase; GMP Synthase Family Protein; Amidotransferase; Glutamine Amidotransferase Protein; Glutamine Amidotransferase Class-I Family Protein; Glutamine Amidotransferase Class-I Family; Class I Glutamine Amidotransferase Family Protein; Class I Glutamine Amidotransferase Domain Protein; Glutamine Amidotransferase Class-I/GMP Synthase; GMP Synthase Glutamine Amidotransferase Subunit; Class I Glutamine-Dependent Amidotransferase; Glutamine Amidotransferase Domain; Conserved Proteinconserved Protein; Glutamine Amidotransferase Class-I Protein; Trimethylamine-N-Oxide Reductase

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MVIVHEPSCSSGRLGQLWRNAGADVVEINAWNHPVPPIVDADALVVLGGSMSCQDDAEAPWLAPTRQLISRTVRAGTPFL
GICLGHQLATVALGGQVCTSDHFCLGAAEMHLTPEGKKDPLLSVYDGHRGIHFNNDVAVVLPEDAVLLARDPTGQIEAVR
FAERAWGVQFHPECTPEIFDAWTIGHGEKEWQQRLPWSEAVTVAETVRRDIDTVNAEEAFAARFQELIDPEKR

Sequences:

>Translated_233_residues
MVIVHEPSCSSGRLGQLWRNAGADVVEINAWNHPVPPIVDADALVVLGGSMSCQDDAEAPWLAPTRQLISRTVRAGTPFL
GICLGHQLATVALGGQVCTSDHFCLGAAEMHLTPEGKKDPLLSVYDGHRGIHFNNDVAVVLPEDAVLLARDPTGQIEAVR
FAERAWGVQFHPECTPEIFDAWTIGHGEKEWQQRLPWSEAVTVAETVRRDIDTVNAEEAFAARFQELIDPEKR
>Mature_233_residues
MVIVHEPSCSSGRLGQLWRNAGADVVEINAWNHPVPPIVDADALVVLGGSMSCQDDAEAPWLAPTRQLISRTVRAGTPFL
GICLGHQLATVALGGQVCTSDHFCLGAAEMHLTPEGKKDPLLSVYDGHRGIHFNNDVAVVLPEDAVLLARDPTGQIEAVR
FAERAWGVQFHPECTPEIFDAWTIGHGEKEWQQRLPWSEAVTVAETVRRDIDTVNAEEAFAARFQELIDPEKR

Specific function: Catalyzes The Synthesis Of Gmp From Xmp. [C]

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 6.3.5.2 [C]

Molecular weight: Translated: 25529; Mature: 25529

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIVHEPSCSSGRLGQLWRNAGADVVEINAWNHPVPPIVDADALVVLGGSMSCQDDAEAP
CEEEECCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCC
WLAPTRQLISRTVRAGTPFLGICLGHQLATVALGGQVCTSDHFCLGAAEMHLTPEGKKDP
CCCHHHHHHHHHHHCCCCEEEHHHHHHHEEHEECCEEECCCCEEEEEEEEEECCCCCCCC
LLSVYDGHRGIHFNNDVAVVLPEDAVLLARDPTGQIEAVRFAERAWGVQFHPECTPEIFD
EEEEECCCCCEEECCCEEEEECCCEEEEEECCCCCCHHHHHHHHHCCEEECCCCCHHHHH
AWTIGHGEKEWQQRLPWSEAVTVAETVRRDIDTVNAEEAFAARFQELIDPEKR
HEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVIVHEPSCSSGRLGQLWRNAGADVVEINAWNHPVPPIVDADALVVLGGSMSCQDDAEAP
CEEEECCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCC
WLAPTRQLISRTVRAGTPFLGICLGHQLATVALGGQVCTSDHFCLGAAEMHLTPEGKKDP
CCCHHHHHHHHHHHCCCCEEEHHHHHHHEEHEECCEEECCCCEEEEEEEEEECCCCCCCC
LLSVYDGHRGIHFNNDVAVVLPEDAVLLARDPTGQIEAVRFAERAWGVQFHPECTPEIFD
EEEEECCCCCEEECCCEEEEECCCEEEEEECCCCCCHHHHHHHHHCCEEECCCCCHHHHH
AWTIGHGEKEWQQRLPWSEAVTVAETVRRDIDTVNAEEAFAARFQELIDPEKR
HEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.35 {8-azaXMP}} 1 {NH4+}} 0.42 {6-thioXMP}} 0.53 {ATP}} 2 {1-ribosyl-4,6-dihydroxypyrazolo[3,4-d]-pyrimidine} 0.058 {XMP}} 0.029 {XMP}} [C]

Substrates: ATP; L-Glutamine; H2O; Xanthosine 5'-phosphate [C]

Specific reaction: ATP + L-Glutamine + H2O + Xanthosine 5'-phosphate --> AMP + L-Glutamate + GMP + (2) H+ + Diphosphate [C]

General reaction: Amination [C]

Inhibitor: 1, N6-Ethenoadenosine; 1-Methyl adenosine 5'-phosphate 5'-phosphate; 2', 3'-Dihydroadenosine; 2'-Deoxyadenosine; 2, 6-Diaminopurine ribonucleoside; 2-Amino-6-methyl thiopurine ribonucleoside; 2-Fluoroadenosine; 3'-Deoxyadenosine; 5'-Azido-5'-deoxyadenosin

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA