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The map label for this gene is upp

Identifier: 50843621

GI number: 50843621

Start: 2365576

End: 2366217

Strand: Direct

Name: upp

Synonym: PPA2184

Alternate gene names: 50843621

Gene position: 2365576-2366217 (Clockwise)

Preceding gene: 50843615

Following gene: 50843622

Centisome position: 92.4

GC content: 63.71

Gene sequence:

>642_bases
GTGGAACTCAACGTCATGGATCATCCGCTCGTCTCTCATAAGTTGACCTTGTTGCGCTCGGTAGACACCCCCAGCCCGGT
TTTCCGCCAGCTTGTCGAGGAACTTGTCACCCTCATGGCTTACGAGGGCACCCGCGAGGTGCGCATCGAGCCAACCACCG
TCACCACCCCACTCACCGCCACCGAGGGCGTCGCCCTGACCCGCCCTAAGCCCCTCGTGGTTCCGATTCTGCGCGCCGGC
CTGGGAATGCTCGAGGGCATGATGCGCCTCATCCCGTCAGCTGAGGTCGGCTTCGTGGGCATGGCCCGTGATGAGGAAAC
CCTCCAACCGATGACCTACGCTGAGCGTCTCCCCAAGGATCTCTCTGGCCGTCAGTGCTACGTCCTCGACCCGATGCTGG
CTACCGGCGGTTCCTTAGGCGGCACTGTCGAGTTCCTGGTCCGCCGCGGCGCCGACCACATCACCTGCCTGTGCATCCTG
GCTGCCCCTGAAGGCATTGAGAATTTCCGCAAGCTCGTCAGGGACCTTGACGTCCCCTGTCACCTCATCGTCGCCGGCCT
GGACGATCATCTCGACGAACACGGCTACATCGTCCCTGGCCTGGGTGACGCCGGCGACCGTCTGTACGGCCTGGCGGAAT
GA

Upstream 100 bases:

>100_bases
TACCCGGCCCCACTGTCCGTTCCTGCCAATACTTAAGGCCCACTCACCAGACGGGGAGCCGAATGCTACCAACGCGCCCC
CATGTGCCAAGGTTGGACTC

Downstream 100 bases:

>100_bases
CTATCCTGCGCCCAGCCGACCTGCGTGGCTTAGCGGCTTTACTCGGCTCCCAAGAACCCCGCGCAGTCGTCCCGCCGTGC
TGGCATTGGGTGCTCCTCCT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MELNVMDHPLVSHKLTLLRSVDTPSPVFRQLVEELVTLMAYEGTREVRIEPTTVTTPLTATEGVALTRPKPLVVPILRAG
LGMLEGMMRLIPSAEVGFVGMARDEETLQPMTYAERLPKDLSGRQCYVLDPMLATGGSLGGTVEFLVRRGADHITCLCIL
AAPEGIENFRKLVRDLDVPCHLIVAGLDDHLDEHGYIVPGLGDAGDRLYGLAE

Sequences:

>Translated_213_residues
MELNVMDHPLVSHKLTLLRSVDTPSPVFRQLVEELVTLMAYEGTREVRIEPTTVTTPLTATEGVALTRPKPLVVPILRAG
LGMLEGMMRLIPSAEVGFVGMARDEETLQPMTYAERLPKDLSGRQCYVLDPMLATGGSLGGTVEFLVRRGADHITCLCIL
AAPEGIENFRKLVRDLDVPCHLIVAGLDDHLDEHGYIVPGLGDAGDRLYGLAE
>Mature_213_residues
MELNVMDHPLVSHKLTLLRSVDTPSPVFRQLVEELVTLMAYEGTREVRIEPTTVTTPLTATEGVALTRPKPLVVPILRAG
LGMLEGMMRLIPSAEVGFVGMARDEETLQPMTYAERLPKDLSGRQCYVLDPMLATGGSLGGTVEFLVRRGADHITCLCIL
AAPEGIENFRKLVRDLDVPCHLIVAGLDDHLDEHGYIVPGLGDAGDRLYGLAE

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Escherichia coli, GI87082118, Length=210, Percent_Identity=42.8571428571429, Blast_Score=175, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321920, Length=197, Percent_Identity=36.0406091370558, Blast_Score=114, Evalue=8e-27,
Organism=Drosophila melanogaster, GI45550449, Length=198, Percent_Identity=25.2525252525253, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28573516, Length=198, Percent_Identity=25.2525252525253, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28573514, Length=198, Percent_Identity=25.2525252525253, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28573512, Length=198, Percent_Identity=25.2525252525253, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_PROAC (Q6A5S3)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056848.1
- ProteinModelPortal:   Q6A5S3
- SMR:   Q6A5S3
- GeneID:   2932235
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA2184
- NMPDR:   fig|267747.1.peg.2125
- HOGENOM:   HBG326432
- OMA:   NPLAKYY
- ProtClustDB:   PRK00129
- BioCyc:   PACN267747:PPA2184-MONOMER
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 23240; Mature: 23240

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 103-103 BINDING 197-197 BINDING 203-203

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELNVMDHPLVSHKLTLLRSVDTPSPVFRQLVEELVTLMAYEGTREVRIEPTTVTTPLTA
CCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCEEECCCCC
TEGVALTRPKPLVVPILRAGLGMLEGMMRLIPSAEVGFVGMARDEETLQPMTYAERLPKD
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHCCCC
LSGRQCYVLDPMLATGGSLGGTVEFLVRRGADHITCLCILAAPEGIENFRKLVRDLDVPC
CCCCEEEEECCHHHCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCC
HLIVAGLDDHLDEHGYIVPGLGDAGDRLYGLAE
EEEEECHHHHHCCCCEEECCCCCCCCCCEECCC
>Mature Secondary Structure
MELNVMDHPLVSHKLTLLRSVDTPSPVFRQLVEELVTLMAYEGTREVRIEPTTVTTPLTA
CCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCEEECCCCC
TEGVALTRPKPLVVPILRAGLGMLEGMMRLIPSAEVGFVGMARDEETLQPMTYAERLPKD
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHCCCC
LSGRQCYVLDPMLATGGSLGGTVEFLVRRGADHITCLCILAAPEGIENFRKLVRDLDVPC
CCCCEEEEECCHHHCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCC
HLIVAGLDDHLDEHGYIVPGLGDAGDRLYGLAE
EEEEECHHHHHCCCCEEECCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA