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The map label for this gene is cvrA [H]

Identifier: 50843616

GI number: 50843616

Start: 2360337

End: 2361851

Strand: Reverse

Name: cvrA [H]

Synonym: PPA2179

Alternate gene names: 50843616

Gene position: 2361851-2360337 (Counterclockwise)

Preceding gene: 50843617

Following gene: 50843613

Centisome position: 92.25

GC content: 61.45

Gene sequence:

>1515_bases
ATGGAAGTCATGCAGCCAGCCGATCTCGCTCTATTCCTCGGCGCTGTCGTCGTGTTGCTCGCCGCTTTCGCAGCCCGGAT
TGGCACTCGTCTGGGACTGCCGGCACTATTGCTGTTCTTGCTGGTTGGCATGCTGCTCGGCCCGATCGGGTTCGGTATTA
ACTTCAACGATTTAGCTGGCGCACACGCTATTGGTTTTGCTGCTCTCGTGCTCGTCCTTGCCGAGGGCGGACTCTCAACG
AACTGGAAGGACATCCGACCAGCCTTGGCCCCGGCTGCCCTGCTTGCAACCGTTGGCGTCGGGGTCTGTTTTGGTGTCAT
GACGCTGCTCGGCCACTATGTGCTCGGTTTGCATTGGAGCGTCGCCGCCTTGCTCGGTGCAGCCACTGCACCCACTGACT
CTGCCGCAGTCTTTTCGGTACTGCGCGGGGTCTCGTTGCCGAATCACTTGAGGTCTGTGTTGGAGGCCGAGTCGGGCCTC
AATGACGCCCCAACCGTTCTCGTCGTCATTGCCCTGACGGGAGTGGCCACCGGGGAGTCGAACGCCGGTGTCCTTCCGCT
ACTCGGATCGATCGCCGTCCAACTCATCGGCGGCATCCTCGTCGGTCTGCTCGTGGGGTGGGTAGCCGGCAAGGTCAGTC
GGCGTATCACCCTGCCATCGGGCAACCTGTACGCTATCGCCGCGATGGCATGGGCCGTCACTGCCTATGGCACAGGAGCG
TGGATTGGCGTCTCCGGGTTTTCGGCCGTCTACATCGCCGCCGTCGTCATCGGCAACGGCGATCTTCCCTACCAACACAC
CACCAGGTCCTTCTCAGAAGGCATCGCCTGGATCTGCCAGATCGGCCTATTCGTCATGCTCGGTCTGTTAGCCAACCCCG
ATCGCCTCACCTGGGGTTCGGTCGGGGTAGGCATCGCTGCCGGTCTGCTGCTCACCCTCGTTGCGCGCCCAGTGGCTGTG
GCCGCCTGCACGATATGGTTCGGGTTCGAACGCAACGAACGGCTCTTCATGTCGTGGGCTGGCCTGCGCGGCGCCGTGCC
CATTATTCTGGCAACCATCCCAATGGCGTCGAATATGGATCGTGCGGACAAGTTCTTCGACGTTATCCTGGTTCTCGTTG
TTGTCTTCACCTGCATCCAAGCCCCAACTCTGCCTGCCGCCGCGGATATTCTCGGCGTCGTCGATCCCCAGATGGCTAAA
GATGTCTCCATCGAGGTTGCGCCCCTCGACGAGATCGCTGCTGACTTACTGCAGGCCGACGTGCCCAAAGGGTCGCGTCT
GGCTGGGGTGACAATCCGCGAACTGAGACTTCCACGCAACTGCGTCGTTTCCCTTATCATTCGCGGTGACAGATCCTTTA
CCCCGCACGCCGGAACAGTGCTGGAACAAGGTGACGAGTTGCTAATCGTCGTGCCCCAGGGGAAGCGTCGGACCGTCGCT
GAGAGGCTTATCGAGATCAGTCGGGGCGGTCGTTTGGCACGCTGGCACGGCCTGCGGGTGCAGACTGCTGACTGA

Upstream 100 bases:

>100_bases
CAAATCAGAGCATCGCGGGACCGCCATCCCTATCATCACCTGGCTCCGATCACTGATCTGCGTCCTCAGCTGCGAAGAAC
CCGTTTGCTCGGTTGCAATA

Downstream 100 bases:

>100_bases
GGAGCCGCTGCGCAAGAGTTCCGGTAAGCCCTAGGAGGGCTGTTCCCCCGGCGACGCGAGTATGGATGGAGTCGGTGAGG
GAGATGGCAGACACACCGAC

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MEVMQPADLALFLGAVVVLLAAFAARIGTRLGLPALLLFLLVGMLLGPIGFGINFNDLAGAHAIGFAALVLVLAEGGLST
NWKDIRPALAPAALLATVGVGVCFGVMTLLGHYVLGLHWSVAALLGAATAPTDSAAVFSVLRGVSLPNHLRSVLEAESGL
NDAPTVLVVIALTGVATGESNAGVLPLLGSIAVQLIGGILVGLLVGWVAGKVSRRITLPSGNLYAIAAMAWAVTAYGTGA
WIGVSGFSAVYIAAVVIGNGDLPYQHTTRSFSEGIAWICQIGLFVMLGLLANPDRLTWGSVGVGIAAGLLLTLVARPVAV
AACTIWFGFERNERLFMSWAGLRGAVPIILATIPMASNMDRADKFFDVILVLVVVFTCIQAPTLPAAADILGVVDPQMAK
DVSIEVAPLDEIAADLLQADVPKGSRLAGVTIRELRLPRNCVVSLIIRGDRSFTPHAGTVLEQGDELLIVVPQGKRRTVA
ERLIEISRGGRLARWHGLRVQTAD

Sequences:

>Translated_504_residues
MEVMQPADLALFLGAVVVLLAAFAARIGTRLGLPALLLFLLVGMLLGPIGFGINFNDLAGAHAIGFAALVLVLAEGGLST
NWKDIRPALAPAALLATVGVGVCFGVMTLLGHYVLGLHWSVAALLGAATAPTDSAAVFSVLRGVSLPNHLRSVLEAESGL
NDAPTVLVVIALTGVATGESNAGVLPLLGSIAVQLIGGILVGLLVGWVAGKVSRRITLPSGNLYAIAAMAWAVTAYGTGA
WIGVSGFSAVYIAAVVIGNGDLPYQHTTRSFSEGIAWICQIGLFVMLGLLANPDRLTWGSVGVGIAAGLLLTLVARPVAV
AACTIWFGFERNERLFMSWAGLRGAVPIILATIPMASNMDRADKFFDVILVLVVVFTCIQAPTLPAAADILGVVDPQMAK
DVSIEVAPLDEIAADLLQADVPKGSRLAGVTIRELRLPRNCVVSLIIRGDRSFTPHAGTVLEQGDELLIVVPQGKRRTVA
ERLIEISRGGRLARWHGLRVQTAD
>Mature_504_residues
MEVMQPADLALFLGAVVVLLAAFAARIGTRLGLPALLLFLLVGMLLGPIGFGINFNDLAGAHAIGFAALVLVLAEGGLST
NWKDIRPALAPAALLATVGVGVCFGVMTLLGHYVLGLHWSVAALLGAATAPTDSAAVFSVLRGVSLPNHLRSVLEAESGL
NDAPTVLVVIALTGVATGESNAGVLPLLGSIAVQLIGGILVGLLVGWVAGKVSRRITLPSGNLYAIAAMAWAVTAYGTGA
WIGVSGFSAVYIAAVVIGNGDLPYQHTTRSFSEGIAWICQIGLFVMLGLLANPDRLTWGSVGVGIAAGLLLTLVARPVAV
AACTIWFGFERNERLFMSWAGLRGAVPIILATIPMASNMDRADKFFDVILVLVVVFTCIQAPTLPAAADILGVVDPQMAK
DVSIEVAPLDEIAADLLQADVPKGSRLAGVTIRELRLPRNCVVSLIIRGDRSFTPHAGTVLEQGDELLIVVPQGKRRTVA
ERLIEISRGGRLARWHGLRVQTAD

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=481, Percent_Identity=32.6403326403326, Blast_Score=189, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 52530; Mature: 52530

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVMQPADLALFLGAVVVLLAAFAARIGTRLGLPALLLFLLVGMLLGPIGFGINFNDLAG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHCC
AHAIGFAALVLVLAEGGLSTNWKDIRPALAPAALLATVGVGVCFGVMTLLGHYVLGLHWS
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAALLGAATAPTDSAAVFSVLRGVSLPNHLRSVLEAESGLNDAPTVLVVIALTGVATGES
HHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHEEEEEHHHCCCCCC
NAGVLPLLGSIAVQLIGGILVGLLVGWVAGKVSRRITLPSGNLYAIAAMAWAVTAYGTGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCHHHHHHHHHHHHCCCCC
WIGVSGFSAVYIAAVVIGNGDLPYQHTTRSFSEGIAWICQIGLFVMLGLLANPDRLTWGS
EEECCCHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VGVGIAAGLLLTLVARPVAVAACTIWFGFERNERLFMSWAGLRGAVPIILATIPMASNMD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHEECCCCCCCH
RADKFFDVILVLVVVFTCIQAPTLPAAADILGVVDPQMAKDVSIEVAPLDEIAADLLQAD
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHCCCEEEECCHHHHHHHHHHHC
VPKGSRLAGVTIRELRLPRNCVVSLIIRGDRSFTPHAGTVLEQGDELLIVVPQGKRRTVA
CCCCCCEECCCHHHHHCCHHHHEEEEEECCCCCCCCCCHHHHCCCCEEEEECCCCCHHHH
ERLIEISRGGRLARWHGLRVQTAD
HHHHHHHCCCCEEEEECCEEEECC
>Mature Secondary Structure
MEVMQPADLALFLGAVVVLLAAFAARIGTRLGLPALLLFLLVGMLLGPIGFGINFNDLAG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHCC
AHAIGFAALVLVLAEGGLSTNWKDIRPALAPAALLATVGVGVCFGVMTLLGHYVLGLHWS
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAALLGAATAPTDSAAVFSVLRGVSLPNHLRSVLEAESGLNDAPTVLVVIALTGVATGES
HHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHEEEEEHHHCCCCCC
NAGVLPLLGSIAVQLIGGILVGLLVGWVAGKVSRRITLPSGNLYAIAAMAWAVTAYGTGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCHHHHHHHHHHHHCCCCC
WIGVSGFSAVYIAAVVIGNGDLPYQHTTRSFSEGIAWICQIGLFVMLGLLANPDRLTWGS
EEECCCHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VGVGIAAGLLLTLVARPVAVAACTIWFGFERNERLFMSWAGLRGAVPIILATIPMASNMD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHEECCCCCCCH
RADKFFDVILVLVVVFTCIQAPTLPAAADILGVVDPQMAKDVSIEVAPLDEIAADLLQAD
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHCCCEEEECCHHHHHHHHHHHC
VPKGSRLAGVTIRELRLPRNCVVSLIIRGDRSFTPHAGTVLEQGDELLIVVPQGKRRTVA
CCCCCCEECCCHHHHHCCHHHHEEEEEECCCCCCCCCCHHHHCCCCEEEEECCCCCHHHH
ERLIEISRGGRLARWHGLRVQTAD
HHHHHHHCCCCEEEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]