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The map label for this gene is pip [H]

Identifier: 50843611

GI number: 50843611

Start: 2355632

End: 2356879

Strand: Reverse

Name: pip [H]

Synonym: PPA2174

Alternate gene names: 50843611

Gene position: 2356879-2355632 (Counterclockwise)

Preceding gene: 50843613

Following gene: 50843610

Centisome position: 92.06

GC content: 61.54

Gene sequence:

>1248_bases
ATGACGTGGAACCGCAACATTCCTGGCCTGCTGACCGATGACGTTCGTCTGAGGGTCCCGCTGAATCGCAGCAATCCTGA
CGATTTGCGCACTATTGAGGTGTACGCGCGTCTGGTGGCCACCCCCAACGGAACCGACAAGCCCTACCTGGTCTTCCTGC
AAGGCGGTCCGGGGTGTGAGTCTCCCCGCCCGACTTTGCGTGACCCCGGGTTTCCCGGTTGGCTGTCGCGCGCGTTGGAG
GACTACCAGCTTGTTTTGCTCGATCAGCGCGGCACGGGATTGTCGTCTCCGGTGAGTGAGCCAGTGGGGGATGCGCCTAG
TCAGGCCGAGTACCTCACCCATCTTCGTGCCGACGAGATCGTTGAGGACTGTGAGGATATTCGTCGACACCTCGGGATCC
AGAAGTGGGCGGCTCTGGGCCAGTCCTTCGGTGGATTCACGTTGCTCAGGTATTTGTCTACCTACCCGGAGTCGTTGTCT
GCTGGGTACTTCACTGGTGGTCTGTCGGCGGTCGGGCGATCCGCTGACGATATCTACGCAGCCTGCTACGAGCAGCTGCG
TGCCAAGTCGCTGGAGTATTACAAGCGCTTCCCCGGGGACAGGGTGCGGTTCGCTGAGTTGGCGGCGTTGGCGAAGAAAG
GCGAGATCGCCACCCCGAGCGGTGACGTCGTGTGTCCATCACGACTGCGGTCGCTGGGGCATGTGTTGGGCGCTTCGGGC
GGGGCAGAAAAGCTGCACTACCTGCTGGAGTACCCGCACACTTCGCGGGCGTTCCGTCATGACCTGGCCGAGCTGCTGCC
CTACGGCGGACGTAACCCGCTATATGCCGTCATTCATGAATCGTCCTATGCCGACGGTGTGGTCACCGATTGGTCGGCTG
CCCGGACGCTACCTGATGACTTCCGGGAGGACCCTACCCTCCTGACGGGTGAACACGTCATGCCGGAATGGTTTGACACT
GATCAGGAGTTGCGGCCTTGGAAGGAGGTAGCTGACCTCATTGCGAATCATCCGTGGCCAAAGTTGTACGACCCCGACGT
GCTCCGGACTGCTGAGGTGCCGTGTGCTGCGGCGGTGTACCACGACGATGCATATGTGCCGCGCAGGTTCTCTCTCGAGA
CGGCAGCCCTGCTGCCGCAGATGCACGCCTGGGTGACGACCGAATACGAGCATAACGGGTCGAACGCCTCAGGTGGGGCG
GTGCTTGACCGTCTCATTAAGCTCGCGAAGGGTGAGATCGTGAGGTGA

Upstream 100 bases:

>100_bases
CTCGCTCCTTCAACTCCGCGATAGTGACGACGATGGCCTTGGGAGAGGGAACGAACGCTAGAACCGACGTGAGGGCGTCG
GGACCTCATAGGCTGATCCC

Downstream 100 bases:

>100_bases
GATCGGGTTGGCTGGTGGGGTCGGCGGCGATCCGGCATACTCCATCAACCTCGGCCTACGACAGGAAAGATGAATGACCA
TGAACGACATTCCACAGGCT

Product: proline iminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MTWNRNIPGLLTDDVRLRVPLNRSNPDDLRTIEVYARLVATPNGTDKPYLVFLQGGPGCESPRPTLRDPGFPGWLSRALE
DYQLVLLDQRGTGLSSPVSEPVGDAPSQAEYLTHLRADEIVEDCEDIRRHLGIQKWAALGQSFGGFTLLRYLSTYPESLS
AGYFTGGLSAVGRSADDIYAACYEQLRAKSLEYYKRFPGDRVRFAELAALAKKGEIATPSGDVVCPSRLRSLGHVLGASG
GAEKLHYLLEYPHTSRAFRHDLAELLPYGGRNPLYAVIHESSYADGVVTDWSAARTLPDDFREDPTLLTGEHVMPEWFDT
DQELRPWKEVADLIANHPWPKLYDPDVLRTAEVPCAAAVYHDDAYVPRRFSLETAALLPQMHAWVTTEYEHNGSNASGGA
VLDRLIKLAKGEIVR

Sequences:

>Translated_415_residues
MTWNRNIPGLLTDDVRLRVPLNRSNPDDLRTIEVYARLVATPNGTDKPYLVFLQGGPGCESPRPTLRDPGFPGWLSRALE
DYQLVLLDQRGTGLSSPVSEPVGDAPSQAEYLTHLRADEIVEDCEDIRRHLGIQKWAALGQSFGGFTLLRYLSTYPESLS
AGYFTGGLSAVGRSADDIYAACYEQLRAKSLEYYKRFPGDRVRFAELAALAKKGEIATPSGDVVCPSRLRSLGHVLGASG
GAEKLHYLLEYPHTSRAFRHDLAELLPYGGRNPLYAVIHESSYADGVVTDWSAARTLPDDFREDPTLLTGEHVMPEWFDT
DQELRPWKEVADLIANHPWPKLYDPDVLRTAEVPCAAAVYHDDAYVPRRFSLETAALLPQMHAWVTTEYEHNGSNASGGA
VLDRLIKLAKGEIVR
>Mature_414_residues
TWNRNIPGLLTDDVRLRVPLNRSNPDDLRTIEVYARLVATPNGTDKPYLVFLQGGPGCESPRPTLRDPGFPGWLSRALED
YQLVLLDQRGTGLSSPVSEPVGDAPSQAEYLTHLRADEIVEDCEDIRRHLGIQKWAALGQSFGGFTLLRYLSTYPESLSA
GYFTGGLSAVGRSADDIYAACYEQLRAKSLEYYKRFPGDRVRFAELAALAKKGEIATPSGDVVCPSRLRSLGHVLGASGG
AEKLHYLLEYPHTSRAFRHDLAELLPYGGRNPLYAVIHESSYADGVVTDWSAARTLPDDFREDPTLLTGEHVMPEWFDTD
QELRPWKEVADLIANHPWPKLYDPDVLRTAEVPCAAAVYHDDAYVPRRFSLETAALLPQMHAWVTTEYEHNGSNASGGAV
LDRLIKLAKGEIVR

Specific function: Higher activity toward long peptides. Acts on hydroxyproline beta-naphthylamide with almost as high an activity as on proline beta-naphthylamide [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 46106; Mature: 45975

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWNRNIPGLLTDDVRLRVPLNRSNPDDLRTIEVYARLVATPNGTDKPYLVFLQGGPGCE
CCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCC
SPRPTLRDPGFPGWLSRALEDYQLVLLDQRGTGLSSPVSEPVGDAPSQAEYLTHLRADEI
CCCCCCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
VEDCEDIRRHLGIQKWAALGQSFGGFTLLRYLSTYPESLSAGYFTGGLSAVGRSADDIYA
HHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCHHCCHHHHCCCHHHHHH
ACYEQLRAKSLEYYKRFPGDRVRFAELAALAKKGEIATPSGDVVCPSRLRSLGHVLGASG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHCCCC
GAEKLHYLLEYPHTSRAFRHDLAELLPYGGRNPLYAVIHESSYADGVVTDWSAARTLPDD
CHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEECCHHHCCCCHH
FREDPTLLTGEHVMPEWFDTDQELRPWKEVADLIANHPWPKLYDPDVLRTAEVPCAAAVY
HCCCCCEEECCCCCCHHCCCCHHCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCCEEEEEE
HDDAYVPRRFSLETAALLPQMHAWVTTEYEHNGSNASGGAVLDRLIKLAKGEIVR
CCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TWNRNIPGLLTDDVRLRVPLNRSNPDDLRTIEVYARLVATPNGTDKPYLVFLQGGPGCE
CCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCC
SPRPTLRDPGFPGWLSRALEDYQLVLLDQRGTGLSSPVSEPVGDAPSQAEYLTHLRADEI
CCCCCCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
VEDCEDIRRHLGIQKWAALGQSFGGFTLLRYLSTYPESLSAGYFTGGLSAVGRSADDIYA
HHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCHHCCHHHHCCCHHHHHH
ACYEQLRAKSLEYYKRFPGDRVRFAELAALAKKGEIATPSGDVVCPSRLRSLGHVLGASG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHCCCC
GAEKLHYLLEYPHTSRAFRHDLAELLPYGGRNPLYAVIHESSYADGVVTDWSAARTLPDD
CHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEECCHHHCCCCHH
FREDPTLLTGEHVMPEWFDTDQELRPWKEVADLIANHPWPKLYDPDVLRTAEVPCAAAVY
HCCCCCEEECCCCCCHHCCCCHHCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCCEEEEEE
HDDAYVPRRFSLETAALLPQMHAWVTTEYEHNGSNASGGAVLDRLIKLAKGEIVR
CCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7883756 [H]