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The map label for this gene is pdhA [H]

Identifier: 50843533

GI number: 50843533

Start: 2268954

End: 2270099

Strand: Reverse

Name: pdhA [H]

Synonym: PPA2094

Alternate gene names: 50843533

Gene position: 2270099-2268954 (Counterclockwise)

Preceding gene: 50843537

Following gene: 50843532

Centisome position: 88.67

GC content: 63.7

Gene sequence:

>1146_bases
GTGACCGAGACCATTTGTGCCGACGAAGGCGGCACGGATCCGTTCGTCCTTCCGGCGCGGCAACACCCCGTTAATCGTCC
CGATCCTGCAATGGTGCGGATCCTCGACGAGCAGGGACGCCTCACCACACACCCCGACTTTCCTGTTGACCTGGTCGACG
ACGACCTCGTCAAGGCTCTCGAGATGATGGTCATGACGCGACGCCTCGACGTCGAGGCTACCGCCCTGCAGCGCCACGGC
GAATTGGGTTTGTGGCCGCCGCTATTGGGACAGGAGGCCACCCAGGCTGGCGCTTGGTTGGCACTGAGAGAGGGAGACCA
GGTGTTTCCCACCTACCGCGAGCAGGGCCTGGCCCACGCCATGGGCGTCAGTCTGGCTGACATCCTTGGAGCTTGGGACG
GGACCTCTCACTGCGGCTGGGATACCGTCGCGACCCACTTCAGCGCATATCCAGTGATGATCGGGTCGGGAACCCTGCAT
GCCGTCGGCTATGCCATGGGTGTCCAGCGTGACGTCGAGGCTGGAGGTGGTCCGGCTGCCGTGCTGGATTTCCACGGTGA
CGGCGCGATGAGCGAGGGGGACACGAACGAGGCTTATGTTTTTGCGGCTTCGATGAACGCCCCCGTGGTATTCGTATGCG
TCAATAACCAGTGGGCGATTTCAGAGCCGACCACGGTGCAGTCGCCCACGTCTCTTTTCCGCCGCGCTACCGGGTTCGGC
ATCCCTGCCGTGCAAGTCGACGGCAACGACGTCATCGCCATGATGGCCGTGCTGCGATCGGCCCTCGAATATGCCCGTAG
CGGAAAGGGGCCGGTGTTCGTCGAGGCGTGGACCTACCGGATGGGTGCTCACACCACCACCGACGACCCCACCCGCTACC
GCACCGCAGAAGAGGAGTCGACGTGGGGTAAGACCGACCCCATCGTCCGGCTGCGCACGTATTTGCAGAACCGCGGGATT
ATCAACCAGGTGTGGCTTGACGGCCTCGCTGAGCGCGAGGACGCCTTCGGTGCTGAGGTTCGCGCTGCTGTTCACGAGAA
TGCCACGCCTGTGATGGCTGACCTTATGGCGGACGTGTACGCCGAGCCGACCCCCGACGTCCTGGCTGACGCCGAGGAAA
TCGCGTCGTGGGAGGAGGATAAGTGA

Upstream 100 bases:

>100_bases
TCATCTTTGGTGTCTCTTTACGGAACGGTAGGTTTCGCTTGGAAACGGGACTTGTTGGCGTTCAGAATTGAGTTACGGAA
CACTTAACCAGGAGGAAGAT

Downstream 100 bases:

>100_bases
TGAGCGGGGAAGTATTGCACAGTGCGCGTCCGCAGGGGGAGACCACCCTTGCCAAGGCCCTTAACGCTGGCTTATCCGAT
GCTCTGGCAGCCGACGATCG

Product: pyruvate dehydrogenase E1 component, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MTETICADEGGTDPFVLPARQHPVNRPDPAMVRILDEQGRLTTHPDFPVDLVDDDLVKALEMMVMTRRLDVEATALQRHG
ELGLWPPLLGQEATQAGAWLALREGDQVFPTYREQGLAHAMGVSLADILGAWDGTSHCGWDTVATHFSAYPVMIGSGTLH
AVGYAMGVQRDVEAGGGPAAVLDFHGDGAMSEGDTNEAYVFAASMNAPVVFVCVNNQWAISEPTTVQSPTSLFRRATGFG
IPAVQVDGNDVIAMMAVLRSALEYARSGKGPVFVEAWTYRMGAHTTTDDPTRYRTAEEESTWGKTDPIVRLRTYLQNRGI
INQVWLDGLAEREDAFGAEVRAAVHENATPVMADLMADVYAEPTPDVLADAEEIASWEEDK

Sequences:

>Translated_381_residues
MTETICADEGGTDPFVLPARQHPVNRPDPAMVRILDEQGRLTTHPDFPVDLVDDDLVKALEMMVMTRRLDVEATALQRHG
ELGLWPPLLGQEATQAGAWLALREGDQVFPTYREQGLAHAMGVSLADILGAWDGTSHCGWDTVATHFSAYPVMIGSGTLH
AVGYAMGVQRDVEAGGGPAAVLDFHGDGAMSEGDTNEAYVFAASMNAPVVFVCVNNQWAISEPTTVQSPTSLFRRATGFG
IPAVQVDGNDVIAMMAVLRSALEYARSGKGPVFVEAWTYRMGAHTTTDDPTRYRTAEEESTWGKTDPIVRLRTYLQNRGI
INQVWLDGLAEREDAFGAEVRAAVHENATPVMADLMADVYAEPTPDVLADAEEIASWEEDK
>Mature_380_residues
TETICADEGGTDPFVLPARQHPVNRPDPAMVRILDEQGRLTTHPDFPVDLVDDDLVKALEMMVMTRRLDVEATALQRHGE
LGLWPPLLGQEATQAGAWLALREGDQVFPTYREQGLAHAMGVSLADILGAWDGTSHCGWDTVATHFSAYPVMIGSGTLHA
VGYAMGVQRDVEAGGGPAAVLDFHGDGAMSEGDTNEAYVFAASMNAPVVFVCVNNQWAISEPTTVQSPTSLFRRATGFGI
PAVQVDGNDVIAMMAVLRSALEYARSGKGPVFVEAWTYRMGAHTTTDDPTRYRTAEEESTWGKTDPIVRLRTYLQNRGII
NQVWLDGLAEREDAFGAEVRAAVHENATPVMADLMADVYAEPTPDVLADAEEIASWEEDK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI258645172, Length=365, Percent_Identity=30.958904109589, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI11386135, Length=366, Percent_Identity=30.8743169398907, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4885543, Length=303, Percent_Identity=29.7029702970297, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI4505685, Length=323, Percent_Identity=29.1021671826625, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI291084742, Length=323, Percent_Identity=29.4117647058824, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI291084744, Length=330, Percent_Identity=28.7878787878788, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI291084757, Length=322, Percent_Identity=27.3291925465839, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI86563357, Length=365, Percent_Identity=30.4109589041096, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI86563355, Length=365, Percent_Identity=30.4109589041096, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17536047, Length=339, Percent_Identity=29.4985250737463, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI32564172, Length=339, Percent_Identity=29.4985250737463, Blast_Score=111, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6321026, Length=291, Percent_Identity=30.5841924398625, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21355903, Length=364, Percent_Identity=28.8461538461538, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24639744, Length=335, Percent_Identity=30.4477611940298, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571106, Length=335, Percent_Identity=30.4477611940298, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24639740, Length=335, Percent_Identity=30.4477611940298, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24639748, Length=331, Percent_Identity=27.4924471299094, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24639746, Length=312, Percent_Identity=30.4487179487179, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 41389; Mature: 41258

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETICADEGGTDPFVLPARQHPVNRPDPAMVRILDEQGRLTTHPDFPVDLVDDDLVKAL
CCCCEECCCCCCCCEEECCCCCCCCCCCHHEEEEECCCCCEECCCCCCCCCCCHHHHHHH
EMMVMTRRLDVEATALQRHGELGLWPPLLGQEATQAGAWLALREGDQVFPTYREQGLAHA
HHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHCCCCEEEEECCCCCCCHHHHCCHHHH
MGVSLADILGAWDGTSHCGWDTVATHFSAYPVMIGSGTLHAVGYAMGVQRDVEAGGGPAA
HHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHCCCHHHCCCCCCEE
VLDFHGDGAMSEGDTNEAYVFAASMNAPVVFVCVNNQWAISEPTTVQSPTSLFRRATGFG
EEEECCCCCCCCCCCCCEEEEEEECCCCEEEEEECCEEECCCCCCCCCHHHHHHHHHCCC
IPAVQVDGNDVIAMMAVLRSALEYARSGKGPVFVEAWTYRMGAHTTTDDPTRYRTAEEES
CCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCHHCCCCCCCC
TWGKTDPIVRLRTYLQNRGIINQVWLDGLAEREDAFGAEVRAAVHENATPVMADLMADVY
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AEPTPDVLADAEEIASWEEDK
CCCCCHHHHCHHHHCCCCCCC
>Mature Secondary Structure 
TETICADEGGTDPFVLPARQHPVNRPDPAMVRILDEQGRLTTHPDFPVDLVDDDLVKAL
CCCEECCCCCCCCEEECCCCCCCCCCCHHEEEEECCCCCEECCCCCCCCCCCHHHHHHH
EMMVMTRRLDVEATALQRHGELGLWPPLLGQEATQAGAWLALREGDQVFPTYREQGLAHA
HHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHCCCCEEEEECCCCCCCHHHHCCHHHH
MGVSLADILGAWDGTSHCGWDTVATHFSAYPVMIGSGTLHAVGYAMGVQRDVEAGGGPAA
HHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHCCCHHHCCCCCCEE
VLDFHGDGAMSEGDTNEAYVFAASMNAPVVFVCVNNQWAISEPTTVQSPTSLFRRATGFG
EEEECCCCCCCCCCCCCEEEEEEECCCCEEEEEECCEEECCCCCCCCCHHHHHHHHHCCC
IPAVQVDGNDVIAMMAVLRSALEYARSGKGPVFVEAWTYRMGAHTTTDDPTRYRTAEEES
CCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCHHCCCCCCCC
TWGKTDPIVRLRTYLQNRGIINQVWLDGLAEREDAFGAEVRAAVHENATPVMADLMADVY
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AEPTPDVLADAEEIASWEEDK
CCCCCHHHHCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA