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The map label for this gene is pdhB [H]

Identifier: 50843532

GI number: 50843532

Start: 2267950

End: 2268954

Strand: Reverse

Name: pdhB [H]

Synonym: PPA2093

Alternate gene names: 50843532

Gene position: 2268954-2267950 (Counterclockwise)

Preceding gene: 50843533

Following gene: 50843531

Centisome position: 88.62

GC content: 63.08

Gene sequence:

>1005_bases
ATGAGCGGGGAAGTATTGCACAGTGCGCGTCCGCAGGGGGAGACCACCCTTGCCAAGGCCCTTAACGCTGGCTTATCCGA
TGCTCTGGCAGCCGACGATCGTGTTGTCCTCATGGGGGAGGACGTCGGGACCCTCGGTGGTGTCTTCCGCATCACGGACG
GCCTCAAAGCCCAGTTTGGTGGCCGTCGAGTCATCGATACGCCGTTGGCAGAGTCAGGCATCGTCGGAACAGCGATTGGT
ATGGCCATGCGCGGGTACCGCCCGTGTGTAGAAATCCAGTTTGACGGTTTCAGTGCCCCAGCCTTTGACCAGATCGTTTC
CCAGCTGGCCCGATACCGGGCTCGCGTCGGTGGCCGGTGGTCCTTGCCGGTGACGATCCGTATCCCCTTCGGGGGTGGTG
TCGGCTCGCCAGAACACCACTCCGAGTCGCCGGAAGGCTTCTATGCGAATACGCCTGGTCTCAAGGTGGTTACCTGCTCC
AACCCTGACGACGCCTACTGGATGCTGCGTCAGTCCATTGACAGCCCCGACCCGGTGATCTTCTTTGAGCCGAAACGTCG
GTACTACACCCGTGGCCACGTTGCGCAGACACCGACGCTGGGGTTGCACCAGGCCCGAATCGCGCGCTCTGGCGAGGAGG
CCACCCTGATCTGCTACGGTCCGATGGTCGATACCTGCGTGGAGGCGGCGAAGGAGGCGTCTCAGGAGGGGCGAAAACTC
GAGGTTATTGACTTGCGTAGCCTCTCCCCGCTCGACATGGCGACTGTCTACGAATCGGTGCGTCGTACGACAAGGGCCAT
CGTCGTCCAGGAGGCGCCACGCACCCAGGGTGTCGGCGCGGAGATCGCGGCTCGGCTGGGTGAGGAGCTTTATTACGTCA
TGGAGGCCCCGGTACTGCGAGTCACCGGCTGGTCGACCCCCTACCCGCCAGCCAAGGCTGAGGGGGAACACATCCCGGAC
GTCGACCGCATTCTCGACGCTGTAGACCGCTCTCTGGCCTTCTGA

Upstream 100 bases:

>100_bases
CGCCTGTGATGGCTGACCTTATGGCGGACGTGTACGCCGAGCCGACCCCCGACGTCCTGGCTGACGCCGAGGAAATCGCG
TCGTGGGAGGAGGATAAGTG

Downstream 100 bases:

>100_bases
TTCTGAGAGGCATTCACATGAAGAACTACTGCATGCCCGACCCGGGCGAAGGACTTACTGAGGGAGAAGTTGTCTCCTGG
CAGGTGTCTCCCGGCGACAC

Product: pyruvate dehydrogenase E1 component, beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MSGEVLHSARPQGETTLAKALNAGLSDALAADDRVVLMGEDVGTLGGVFRITDGLKAQFGGRRVIDTPLAESGIVGTAIG
MAMRGYRPCVEIQFDGFSAPAFDQIVSQLARYRARVGGRWSLPVTIRIPFGGGVGSPEHHSESPEGFYANTPGLKVVTCS
NPDDAYWMLRQSIDSPDPVIFFEPKRRYYTRGHVAQTPTLGLHQARIARSGEEATLICYGPMVDTCVEAAKEASQEGRKL
EVIDLRSLSPLDMATVYESVRRTTRAIVVQEAPRTQGVGAEIAARLGEELYYVMEAPVLRVTGWSTPYPPAKAEGEHIPD
VDRILDAVDRSLAF

Sequences:

>Translated_334_residues
MSGEVLHSARPQGETTLAKALNAGLSDALAADDRVVLMGEDVGTLGGVFRITDGLKAQFGGRRVIDTPLAESGIVGTAIG
MAMRGYRPCVEIQFDGFSAPAFDQIVSQLARYRARVGGRWSLPVTIRIPFGGGVGSPEHHSESPEGFYANTPGLKVVTCS
NPDDAYWMLRQSIDSPDPVIFFEPKRRYYTRGHVAQTPTLGLHQARIARSGEEATLICYGPMVDTCVEAAKEASQEGRKL
EVIDLRSLSPLDMATVYESVRRTTRAIVVQEAPRTQGVGAEIAARLGEELYYVMEAPVLRVTGWSTPYPPAKAEGEHIPD
VDRILDAVDRSLAF
>Mature_333_residues
SGEVLHSARPQGETTLAKALNAGLSDALAADDRVVLMGEDVGTLGGVFRITDGLKAQFGGRRVIDTPLAESGIVGTAIGM
AMRGYRPCVEIQFDGFSAPAFDQIVSQLARYRARVGGRWSLPVTIRIPFGGGVGSPEHHSESPEGFYANTPGLKVVTCSN
PDDAYWMLRQSIDSPDPVIFFEPKRRYYTRGHVAQTPTLGLHQARIARSGEEATLICYGPMVDTCVEAAKEASQEGRKLE
VIDLRSLSPLDMATVYESVRRTTRAIVVQEAPRTQGVGAEIAARLGEELYYVMEAPVLRVTGWSTPYPPAKAEGEHIPDV
DRILDAVDRSLAF

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=334, Percent_Identity=39.5209580838323, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI34101272, Length=334, Percent_Identity=39.5209580838323, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI156564403, Length=326, Percent_Identity=34.9693251533742, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI291084858, Length=326, Percent_Identity=33.4355828220859, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17506935, Length=325, Percent_Identity=39.0769230769231, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17538422, Length=332, Percent_Identity=34.9397590361446, Blast_Score=201, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6319698, Length=325, Percent_Identity=35.6923076923077, Blast_Score=196, Evalue=6e-51,
Organism=Drosophila melanogaster, GI160714828, Length=325, Percent_Identity=40.9230769230769, Blast_Score=227, Evalue=8e-60,
Organism=Drosophila melanogaster, GI160714832, Length=325, Percent_Identity=40.9230769230769, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI21358145, Length=326, Percent_Identity=37.1165644171779, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24650940, Length=326, Percent_Identity=37.1165644171779, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24650943, Length=91, Percent_Identity=43.956043956044, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24650945, Length=91, Percent_Identity=43.956043956044, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36206; Mature: 36074

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGEVLHSARPQGETTLAKALNAGLSDALAADDRVVLMGEDVGTLGGVFRITDGLKAQFG
CCCCCCCCCCCCCHHHHHHHHHCCHHHHHCCCCEEEEEECCCCHHCCEEEECCCCHHHCC
GRRVIDTPLAESGIVGTAIGMAMRGYRPCVEIQFDGFSAPAFDQIVSQLARYRARVGGRW
CCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEE
SLPVTIRIPFGGGVGSPEHHSESPEGFYANTPGLKVVTCSNPDDAYWMLRQSIDSPDPVI
CCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCCHHHHHHHHHCCCCCCEE
FFEPKRRYYTRGHVAQTPTLGLHQARIARSGEEATLICYGPMVDTCVEAAKEASQEGRKL
EECCCCCEEECCCCCCCCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEE
EVIDLRSLSPLDMATVYESVRRTTRAIVVQEAPRTQGVGAEIAARLGEELYYVMEAPVLR
EEEECCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
VTGWSTPYPPAKAEGEHIPDVDRILDAVDRSLAF
EECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGEVLHSARPQGETTLAKALNAGLSDALAADDRVVLMGEDVGTLGGVFRITDGLKAQFG
CCCCCCCCCCCCHHHHHHHHHCCHHHHHCCCCEEEEEECCCCHHCCEEEECCCCHHHCC
GRRVIDTPLAESGIVGTAIGMAMRGYRPCVEIQFDGFSAPAFDQIVSQLARYRARVGGRW
CCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEE
SLPVTIRIPFGGGVGSPEHHSESPEGFYANTPGLKVVTCSNPDDAYWMLRQSIDSPDPVI
CCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCCHHHHHHHHHCCCCCCEE
FFEPKRRYYTRGHVAQTPTLGLHQARIARSGEEATLICYGPMVDTCVEAAKEASQEGRKL
EECCCCCEEECCCCCCCCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEE
EVIDLRSLSPLDMATVYESVRRTTRAIVVQEAPRTQGVGAEIAARLGEELYYVMEAPVLR
EEEECCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
VTGWSTPYPPAKAEGEHIPDVDRILDAVDRSLAF
EECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA