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The map label for this gene is fba [H]

Identifier: 50843457

GI number: 50843457

Start: 2184062

End: 2185087

Strand: Reverse

Name: fba [H]

Synonym: PPA2011

Alternate gene names: 50843457

Gene position: 2185087-2184062 (Counterclockwise)

Preceding gene: 50843458

Following gene: 50843455

Centisome position: 85.35

GC content: 59.45

Gene sequence:

>1026_bases
ATGCCCATCGCAACACCTGAGGTCTACGGCGAGATGATTGACCGCGCGAAGGAACAAGGCTTCGCGTACCCGGCCATCAA
CGTGACCTCCTCCCAGACCCTCAATGCTGCTCTGCAGGGGTTCACTGAGGCCGGTTCCGACGGCATCGTCCAGATCTCCA
CCGGTGGCGCCGAGTACGCCTCCGGCCAGACGGTGAAGGACATGGTGACCGGTGCGGTTGCTCTCGCGGAGTACGCCCAC
GTCGTTGCTAAGAATTATCCGATCAACGTGGCCTTGCACACTGACCACTGCCAGAAGGAGAAGCTAGATAAGTACGTCAA
CCCGCTTATTGCCATCTCGCAGGAGCGCGTCGACAAGGGCCAGGACCCGCTATTCAACTCTCATATGTGGGACGGCTCGG
CCATCGAGGTTGAGGAGAACCTGCAGATTGCCGAGGAGCTACTGTCGCGCACCGCGAAGGCCAAGCTCATCCTCGAGATC
GAGGTCGGCGCTGTTGGTGGCGAGGAAGACGGTGTGACCGGCGAGATCAACGAGAAGTTGTACACCACCGTTGCTGACGG
CATGCGTACCCTCGAGGTGCTGGGCCTGGGTGAGAAGGGCCGCTACACCACCGCTCTGACCTTCGGGAACGTCCATGGTG
CGTACAAGCCTGGTTACGTCAAGCTGCGCCCGGGAATCCTCAAGGAGATCCAGGACGAGTGCGGCAAGAAGTACGGCAAG
GAGAAGCCGTTCGATCTGGTCTTCCATGGTGGGTCGGGATCGACTGCCCAGGAGATCGCCGACGCGGTGTCCTATGGCGT
TATCAAGATGAACATCGATACCGATACTCAGTACGCGTTCTCGCGTCCGGTTGTTGAGCACATGTTCAAGAACTACGACG
GCATGCTCAAGATTGACGGTGAGGTCGGCAACAAGAAGATGTACGACCCGCGTTCGTGGGGCAAGAAGGCTGAGGCTGGT
ATGGCCGCCCGGATTGTTGAGGCTTGTGAGCAGCTGGGTTCGAAGGGTACTTCGGTCAGCGCCTGA

Upstream 100 bases:

>100_bases
GCAGCACCTATGAGCGTGCCGGGTGCCGGAACTGACATCGGGAGGGTGCCTGCGGAAGAATAGCTCTTGTCAACGCGAGT
TCATATAGGAAAGGCCTAAC

Downstream 100 bases:

>100_bases
GTTGTTTTGTGAAGAATCCCGGCCAGTTCTGTTGTGAGGATTGGCTGGGATTTTTCACGTCATCGGTGTGATGGTAGTGG
TGGGAGCGGGGAATTGTTGG

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MPIATPEVYGEMIDRAKEQGFAYPAINVTSSQTLNAALQGFTEAGSDGIVQISTGGAEYASGQTVKDMVTGAVALAEYAH
VVAKNYPINVALHTDHCQKEKLDKYVNPLIAISQERVDKGQDPLFNSHMWDGSAIEVEENLQIAEELLSRTAKAKLILEI
EVGAVGGEEDGVTGEINEKLYTTVADGMRTLEVLGLGEKGRYTTALTFGNVHGAYKPGYVKLRPGILKEIQDECGKKYGK
EKPFDLVFHGGSGSTAQEIADAVSYGVIKMNIDTDTQYAFSRPVVEHMFKNYDGMLKIDGEVGNKKMYDPRSWGKKAEAG
MAARIVEACEQLGSKGTSVSA

Sequences:

>Translated_341_residues
MPIATPEVYGEMIDRAKEQGFAYPAINVTSSQTLNAALQGFTEAGSDGIVQISTGGAEYASGQTVKDMVTGAVALAEYAH
VVAKNYPINVALHTDHCQKEKLDKYVNPLIAISQERVDKGQDPLFNSHMWDGSAIEVEENLQIAEELLSRTAKAKLILEI
EVGAVGGEEDGVTGEINEKLYTTVADGMRTLEVLGLGEKGRYTTALTFGNVHGAYKPGYVKLRPGILKEIQDECGKKYGK
EKPFDLVFHGGSGSTAQEIADAVSYGVIKMNIDTDTQYAFSRPVVEHMFKNYDGMLKIDGEVGNKKMYDPRSWGKKAEAG
MAARIVEACEQLGSKGTSVSA
>Mature_340_residues
PIATPEVYGEMIDRAKEQGFAYPAINVTSSQTLNAALQGFTEAGSDGIVQISTGGAEYASGQTVKDMVTGAVALAEYAHV
VAKNYPINVALHTDHCQKEKLDKYVNPLIAISQERVDKGQDPLFNSHMWDGSAIEVEENLQIAEELLSRTAKAKLILEIE
VGAVGGEEDGVTGEINEKLYTTVADGMRTLEVLGLGEKGRYTTALTFGNVHGAYKPGYVKLRPGILKEIQDECGKKYGKE
KPFDLVFHGGSGSTAQEIADAVSYGVIKMNIDTDTQYAFSRPVVEHMFKNYDGMLKIDGEVGNKKMYDPRSWGKKAEAGM
AARIVEACEQLGSKGTSVSA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=336, Percent_Identity=40.7738095238095, Blast_Score=227, Evalue=7e-61,
Organism=Escherichia coli, GI87082041, Length=326, Percent_Identity=23.0061349693252, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1789526, Length=272, Percent_Identity=23.8970588235294, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322790, Length=343, Percent_Identity=38.1924198250729, Blast_Score=203, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 36843; Mature: 36712

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIATPEVYGEMIDRAKEQGFAYPAINVTSSQTLNAALQGFTEAGSDGIVQISTGGAEYA
CCCCCHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCC
SGQTVKDMVTGAVALAEYAHVVAKNYPINVALHTDHCQKEKLDKYVNPLIAISQERVDKG
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCHHHHCCC
QDPLFNSHMWDGSAIEVEENLQIAEELLSRTAKAKLILEIEVGAVGGEEDGVTGEINEKL
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCEEEEEEEEEECCCCCCCCCCCCHHHHH
YTTVADGMRTLEVLGLGEKGRYTTALTFGNVHGAYKPGYVKLRPGILKEIQDECGKKYGK
HHHHHHHHHEEHHEECCCCCCEEEEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHCC
EKPFDLVFHGGSGSTAQEIADAVSYGVIKMNIDTDTQYAFSRPVVEHMFKNYDGMLKIDG
CCCCEEEEECCCCCHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECC
EVGNKKMYDPRSWGKKAEAGMAARIVEACEQLGSKGTSVSA
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PIATPEVYGEMIDRAKEQGFAYPAINVTSSQTLNAALQGFTEAGSDGIVQISTGGAEYA
CCCCHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCC
SGQTVKDMVTGAVALAEYAHVVAKNYPINVALHTDHCQKEKLDKYVNPLIAISQERVDKG
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCHHHHCCC
QDPLFNSHMWDGSAIEVEENLQIAEELLSRTAKAKLILEIEVGAVGGEEDGVTGEINEKL
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCEEEEEEEEEECCCCCCCCCCCCHHHHH
YTTVADGMRTLEVLGLGEKGRYTTALTFGNVHGAYKPGYVKLRPGILKEIQDECGKKYGK
HHHHHHHHHEEHHEECCCCCCEEEEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHCC
EKPFDLVFHGGSGSTAQEIADAVSYGVIKMNIDTDTQYAFSRPVVEHMFKNYDGMLKIDG
CCCCEEEEECCCCCHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECC
EVGNKKMYDPRSWGKKAEAGMAARIVEACEQLGSKGTSVSA
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]