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The map label for this gene is ykgC [H]

Identifier: 50843428

GI number: 50843428

Start: 2150707

End: 2152113

Strand: Direct

Name: ykgC [H]

Synonym: PPA1981

Alternate gene names: 50843428

Gene position: 2150707-2152113 (Clockwise)

Preceding gene: 50843425

Following gene: 50843430

Centisome position: 84.0

GC content: 62.69

Gene sequence:

>1407_bases
ATGGGCCACCGACCACCAATCGCGTATACACGAAAGGGCGAACCATTGTTGAATAAAGAGTTCACGGTCGATGTTCTGGT
CATCGGATGGGGTAAGGCCGGCAAAACGATCGCCGGACGCCTGGCGGCGGAGGGACGCAAGGTCGCCCTCGTCGAGAGAT
CAGCACAGATGTACGGGGGCAGCTGCATCAACATCGCGTGCGTGCCTACCAAGGACCTCATCGACTCGGCATCCAAGCGG
GACGGTCGCGACCCCGCCTCCTACTTCACCTCAGCCGTCGCCGACCGAGACACCCTCATCGCCACATTGAACCGCACCAA
CCATGCCATGCTGGAGGGCAAAGTGCTCCTCCTCGACGGGGTAGCCAGCTTCACTGGGCCGCACACTGTCAAGGTGGTCG
CGGGAGACGATGAGATCACCGTGCGAGCGGAGACGATCATCGTCAACACCGGATCTCACCCAGCCAACCTTCCGGTTCCC
GGAGCCGATGGCCCGCGAGTCCATGACTCCACCACGATCCAGCACGTCGACCCCCTGCCGTCGCAGCTCGTCATCGTAGG
CGGCGGGTTCATCGGGCTGGAGTTCGCCCAGATGTTCGCCCGATTCGGCTCCCAGGTGACCCTGCTCGAGGCCGGCGAGA
CCTTCGTCCCCGCCCTTGACACCGACATCGCCGAGCGTGTGCGCAACATGCTTGAGGGTGAAGGGGTCACCGTCGTCACC
GGAGCGCAGGTGACCTCCTGCGATGAAACAGGTGACCATGTCGACGTCGTCACCGACGATCAGACATTCGCCGCCGACGC
GGTGTTGGTGGCAGCAGGCAGACGCCCAGCAACCGAGGATCTCGATCTGACCGCCGCCGGGGTGGCCACCGATGAGCGGG
GCTACATTACCGTCGACGATCAGCTGCGCACCAATATTGACGGAGTGTACGCAGTCGGTGACGTCAATGGTGGGCCGCAG
TTCACCTATATCTCCCTTGACGACAACCGGGTGTTGTGGGACACCTTGCACGACGGGCCACGTCGCCGTGACGATCGAGT
GGCCGTCCCAGCGACCACTTTCCTCGACCCGCCGCTGTCCCAGGTCGGCATGACGATGCGCCAGGCCCGGGAGTCCGGTC
GCTCCGTGCTCGTGGCAACCAAGGACGTCGCCACGATCGCCGCCATGCCGCGACCTAAGATTGTCGGCCAAACCGAAGGC
GTCATTCGAGTTCTCGTTGATGCCGACGACCACACCGTCCTGGGTGCAACCCTGTGGTGCATTGATTCACAGGAACTGGT
CAACTTTGTCTCACTGGCCATGCGGTTGGGAGTGCGCTACGAAACGTTGCGTGACGGGATCTGGACCCACCCGTCCTCGA
CCGAAGCTTTCAATGAGGTACTCGGAGTACTCGAGCCTCTCACCTGA

Upstream 100 bases:

>100_bases
AACGAGTCTCGCACCGGCACGTATCGGCATCAATACCCGTTACGCGAAATGAGGTTGGCCCGGCCGGGTACCGAGAAAGA
ATGGCATCGTCGGCGCTCCG

Downstream 100 bases:

>100_bases
GAAGTGATCGAAGTCCAGTCATTGTGACCGAGTAGTCACGGCCACAATGACTGGACTTCGTTCGGTTTGACCTCAGGAGG
CCTGGGGAGCTGAGACGACC

Product: pyridine nucleotide-disulphide oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MGHRPPIAYTRKGEPLLNKEFTVDVLVIGWGKAGKTIAGRLAAEGRKVALVERSAQMYGGSCINIACVPTKDLIDSASKR
DGRDPASYFTSAVADRDTLIATLNRTNHAMLEGKVLLLDGVASFTGPHTVKVVAGDDEITVRAETIIVNTGSHPANLPVP
GADGPRVHDSTTIQHVDPLPSQLVIVGGGFIGLEFAQMFARFGSQVTLLEAGETFVPALDTDIAERVRNMLEGEGVTVVT
GAQVTSCDETGDHVDVVTDDQTFAADAVLVAAGRRPATEDLDLTAAGVATDERGYITVDDQLRTNIDGVYAVGDVNGGPQ
FTYISLDDNRVLWDTLHDGPRRRDDRVAVPATTFLDPPLSQVGMTMRQARESGRSVLVATKDVATIAAMPRPKIVGQTEG
VIRVLVDADDHTVLGATLWCIDSQELVNFVSLAMRLGVRYETLRDGIWTHPSSTEAFNEVLGVLEPLT

Sequences:

>Translated_468_residues
MGHRPPIAYTRKGEPLLNKEFTVDVLVIGWGKAGKTIAGRLAAEGRKVALVERSAQMYGGSCINIACVPTKDLIDSASKR
DGRDPASYFTSAVADRDTLIATLNRTNHAMLEGKVLLLDGVASFTGPHTVKVVAGDDEITVRAETIIVNTGSHPANLPVP
GADGPRVHDSTTIQHVDPLPSQLVIVGGGFIGLEFAQMFARFGSQVTLLEAGETFVPALDTDIAERVRNMLEGEGVTVVT
GAQVTSCDETGDHVDVVTDDQTFAADAVLVAAGRRPATEDLDLTAAGVATDERGYITVDDQLRTNIDGVYAVGDVNGGPQ
FTYISLDDNRVLWDTLHDGPRRRDDRVAVPATTFLDPPLSQVGMTMRQARESGRSVLVATKDVATIAAMPRPKIVGQTEG
VIRVLVDADDHTVLGATLWCIDSQELVNFVSLAMRLGVRYETLRDGIWTHPSSTEAFNEVLGVLEPLT
>Mature_467_residues
GHRPPIAYTRKGEPLLNKEFTVDVLVIGWGKAGKTIAGRLAAEGRKVALVERSAQMYGGSCINIACVPTKDLIDSASKRD
GRDPASYFTSAVADRDTLIATLNRTNHAMLEGKVLLLDGVASFTGPHTVKVVAGDDEITVRAETIIVNTGSHPANLPVPG
ADGPRVHDSTTIQHVDPLPSQLVIVGGGFIGLEFAQMFARFGSQVTLLEAGETFVPALDTDIAERVRNMLEGEGVTVVTG
AQVTSCDETGDHVDVVTDDQTFAADAVLVAAGRRPATEDLDLTAAGVATDERGYITVDDQLRTNIDGVYAVGDVNGGPQF
TYISLDDNRVLWDTLHDGPRRRDDRVAVPATTFLDPPLSQVGMTMRQARESGRSVLVATKDVATIAAMPRPKIVGQTEGV
IRVLVDADDHTVLGATLWCIDSQELVNFVSLAMRLGVRYETLRDGIWTHPSSTEAFNEVLGVLEPLT

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=27.4509803921569, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=28.1995661605206, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI148277065, Length=437, Percent_Identity=22.883295194508, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI148277071, Length=437, Percent_Identity=22.883295194508, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI33519430, Length=437, Percent_Identity=22.883295194508, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI33519428, Length=437, Percent_Identity=22.883295194508, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI33519426, Length=437, Percent_Identity=22.883295194508, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI22035672, Length=456, Percent_Identity=26.5350877192982, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI87081717, Length=444, Percent_Identity=42.3423423423423, Blast_Score=342, Evalue=4e-95,
Organism=Escherichia coli, GI1786307, Length=466, Percent_Identity=29.1845493562232, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1789915, Length=435, Percent_Identity=27.5862068965517, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI87082354, Length=460, Percent_Identity=25.6521739130435, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87081763, Length=206, Percent_Identity=30.0970873786408, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789065, Length=185, Percent_Identity=30.2702702702703, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=462, Percent_Identity=26.6233766233766, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17557007, Length=470, Percent_Identity=26.1702127659574, Blast_Score=118, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71983429, Length=473, Percent_Identity=26.0042283298097, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71983419, Length=473, Percent_Identity=26.0042283298097, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71982272, Length=488, Percent_Identity=22.9508196721311, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17559934, Length=201, Percent_Identity=29.3532338308458, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321091, Length=465, Percent_Identity=27.5268817204301, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=26.6524520255864, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6325166, Length=462, Percent_Identity=24.6753246753247, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21358499, Length=458, Percent_Identity=28.6026200873362, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24640553, Length=479, Percent_Identity=25.2609603340292, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24640549, Length=476, Percent_Identity=25.2100840336134, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24640551, Length=476, Percent_Identity=25.2100840336134, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17737741, Length=477, Percent_Identity=24.1090146750524, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 50074; Mature: 49943

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHRPPIAYTRKGEPLLNKEFTVDVLVIGWGKAGKTIAGRLAAEGRKVALVERSAQMYGG
CCCCCCEEEECCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHCCCCEEEEEEHHHHHCCC
SCINIACVPTKDLIDSASKRDGRDPASYFTSAVADRDTLIATLNRTNHAMLEGKVLLLDG
CEEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCEEEECCEEEEEC
VASFTGPHTVKVVAGDDEITVRAETIIVNTGSHPANLPVPGADGPRVHDSTTIQHVDPLP
HHHCCCCEEEEEEECCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCC
SQLVIVGGGFIGLEFAQMFARFGSQVTLLEAGETFVPALDTDIAERVRNMLEGEGVTVVT
CEEEEEECCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEE
GAQVTSCDETGDHVDVVTDDQTFAADAVLVAAGRRPATEDLDLTAAGVATDERGYITVDD
CCEEECCCCCCCEEEEEECCCCHHCCEEEEECCCCCCCCCCCEEEECCEECCCCEEEECH
QLRTNIDGVYAVGDVNGGPQFTYISLDDNRVLWDTLHDGPRRRDDRVAVPATTFLDPPLS
HHHCCCCCEEEEECCCCCCEEEEEEECCCEEEEECCCCCCCCCCCEEEECCHHCCCCCHH
QVGMTMRQARESGRSVLVATKDVATIAAMPRPKIVGQTEGVIRVLVDADDHTVLGATLWC
HHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEE
IDSQELVNFVSLAMRLGVRYETLRDGIWTHPSSTEAFNEVLGVLEPLT
ECHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GHRPPIAYTRKGEPLLNKEFTVDVLVIGWGKAGKTIAGRLAAEGRKVALVERSAQMYGG
CCCCCEEEECCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHCCCCEEEEEEHHHHHCCC
SCINIACVPTKDLIDSASKRDGRDPASYFTSAVADRDTLIATLNRTNHAMLEGKVLLLDG
CEEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCEEEECCEEEEEC
VASFTGPHTVKVVAGDDEITVRAETIIVNTGSHPANLPVPGADGPRVHDSTTIQHVDPLP
HHHCCCCEEEEEEECCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCC
SQLVIVGGGFIGLEFAQMFARFGSQVTLLEAGETFVPALDTDIAERVRNMLEGEGVTVVT
CEEEEEECCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEE
GAQVTSCDETGDHVDVVTDDQTFAADAVLVAAGRRPATEDLDLTAAGVATDERGYITVDD
CCEEECCCCCCCEEEEEECCCCHHCCEEEEECCCCCCCCCCCEEEECCEECCCCEEEECH
QLRTNIDGVYAVGDVNGGPQFTYISLDDNRVLWDTLHDGPRRRDDRVAVPATTFLDPPLS
HHHCCCCCEEEEECCCCCCEEEEEEECCCEEEEECCCCCCCCCCCEEEECCHHCCCCCHH
QVGMTMRQARESGRSVLVATKDVATIAAMPRPKIVGQTEGVIRVLVDADDHTVLGATLWC
HHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEE
IDSQELVNFVSLAMRLGVRYETLRDGIWTHPSSTEAFNEVLGVLEPLT
ECHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]