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The map label for this gene is hepT [H]

Identifier: 50843372

GI number: 50843372

Start: 2080835

End: 2081809

Strand: Reverse

Name: hepT [H]

Synonym: PPA1921

Alternate gene names: 50843372

Gene position: 2081809-2080835 (Counterclockwise)

Preceding gene: 50843373

Following gene: 50843371

Centisome position: 81.31

GC content: 61.95

Gene sequence:

>975_bases
GTGTCGTATAGCGCCAGCAGCGAGTTCACCGATCTGGTGAGCGCCAAACTTGCCCTCATTGAGGACGAGCTGGGTCGTCA
GGCCGGCGCTGACACCCCCTTCGTGACTGAGGCGGCCAACCACATCATTTCTGCCGGTGGCAAGAGGTTCCGCCCGCTGC
TGGTGGTGTTGTGCTCCCAGTTTGGTGACGCGGTGAACGACGCCGACCTGGTGCGTGCCGCTGTTGTCATGGAACTCACC
CACGTTGCCTCGCTGTATCACGATGACGTTATGGACGAGGCGTCTAGGCGTCGCGGTGCCCCTTCAGCGAACCTGCGGTG
GGGCAACTCGGTGGCCATCATGGTGGGCGACTACCTGTTCTCGAAGGCTTCCCTGGCCGTAGCGGAGTTGGGAGTCGACT
TCGTTAAGTTGCAGGCCCGAACGTTCTCCCGCCTGGTACAGGGGCAGATTGCCGAGACCCGTGGTCCTTCGCAGGGGCAA
GATCCGTTGGCCCACTACCTCAAGGTCGTTGCCGATAAGACGGGGTCACTCATTGCAGCCTCTGCTGTCTTTGGGGCGAT
GGTCTCCCATGCGTCCGCCGAGAACGTCGCCGCCTTGGAGCAGTTTGGCGAGGACATCGGGGAGGTATTCCAGCTTGCCG
ATGACCTCATTGACATCACGTCGACGGTGACTGGCAAGACCCCAGGTACTGACCTGCGCGAGAAGGTTCCGACCTTGCCG
ACCCTTTTGCTGCGCGCTTCTGACGATCCGGCGGACGCCGAGCTTAAGGAGATGCTCGATGCTGATCTGTCCGATGACGC
CGTGCTGTCTGATGTATTGGACAAGCTGCGCGCCAACCACGTTATCGACGAGGCTCGTGTCGAGATTCAGCGCCGGGCGG
ACCGCGCCCGTACCCACTTGACTCCGCTGCCTGACGGGGATGCCAAGCAGGCTCTTGAGGCGCTGTGCGACGAGGTGGTT
TCTCGCTCGTCCTGA

Upstream 100 bases:

>100_bases
CGCGAGCACCGTCAAGCCAGTAAAGTGAAAGATGACCAGGCCACGTCGAGGCGACAGCCGGACGAGTACCGGGCGATCGC
TTGGTTGGAAGAGGAGAACT

Downstream 100 bases:

>100_bases
CGCCACGTTCGAAACTACTAAGGAGACATTGTGTCCCGTCGTCTTGACCTCATCGGCATCGGCCCCGGCAACCCGGATTG
GCTGACTTTGGCGGCTGTTG

Product: heptaprenyl diphosphate synthase component II

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MSYSASSEFTDLVSAKLALIEDELGRQAGADTPFVTEAANHIISAGGKRFRPLLVVLCSQFGDAVNDADLVRAAVVMELT
HVASLYHDDVMDEASRRRGAPSANLRWGNSVAIMVGDYLFSKASLAVAELGVDFVKLQARTFSRLVQGQIAETRGPSQGQ
DPLAHYLKVVADKTGSLIAASAVFGAMVSHASAENVAALEQFGEDIGEVFQLADDLIDITSTVTGKTPGTDLREKVPTLP
TLLLRASDDPADAELKEMLDADLSDDAVLSDVLDKLRANHVIDEARVEIQRRADRARTHLTPLPDGDAKQALEALCDEVV
SRSS

Sequences:

>Translated_324_residues
MSYSASSEFTDLVSAKLALIEDELGRQAGADTPFVTEAANHIISAGGKRFRPLLVVLCSQFGDAVNDADLVRAAVVMELT
HVASLYHDDVMDEASRRRGAPSANLRWGNSVAIMVGDYLFSKASLAVAELGVDFVKLQARTFSRLVQGQIAETRGPSQGQ
DPLAHYLKVVADKTGSLIAASAVFGAMVSHASAENVAALEQFGEDIGEVFQLADDLIDITSTVTGKTPGTDLREKVPTLP
TLLLRASDDPADAELKEMLDADLSDDAVLSDVLDKLRANHVIDEARVEIQRRADRARTHLTPLPDGDAKQALEALCDEVV
SRSS
>Mature_323_residues
SYSASSEFTDLVSAKLALIEDELGRQAGADTPFVTEAANHIISAGGKRFRPLLVVLCSQFGDAVNDADLVRAAVVMELTH
VASLYHDDVMDEASRRRGAPSANLRWGNSVAIMVGDYLFSKASLAVAELGVDFVKLQARTFSRLVQGQIAETRGPSQGQD
PLAHYLKVVADKTGSLIAASAVFGAMVSHASAENVAALEQFGEDIGEVFQLADDLIDITSTVTGKTPGTDLREKVPTLPT
LLLRASDDPADAELKEMLDADLSDDAVLSDVLDKLRANHVIDEARVEIQRRADRARTHLTPLPDGDAKQALEALCDEVVS
RSS

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=224, Percent_Identity=33.9285714285714, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1789578, Length=318, Percent_Identity=27.9874213836478, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1786623, Length=229, Percent_Identity=30.5676855895196, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17505681, Length=285, Percent_Identity=28.7719298245614, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319475, Length=299, Percent_Identity=27.4247491638796, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24651612, Length=310, Percent_Identity=29.3548387096774, Blast_Score=120, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 34684; Mature: 34553

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYSASSEFTDLVSAKLALIEDELGRQAGADTPFVTEAANHIISAGGKRFRPLLVVLCSQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
FGDAVNDADLVRAAVVMELTHVASLYHDDVMDEASRRRGAPSANLRWGNSVAIMVGDYLF
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHH
SKASLAVAELGVDFVKLQARTFSRLVQGQIAETRGPSQGQDPLAHYLKVVADKTGSLIAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHH
SAVFGAMVSHASAENVAALEQFGEDIGEVFQLADDLIDITSTVTGKTPGTDLREKVPTLP
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHH
TLLLRASDDPADAELKEMLDADLSDDAVLSDVLDKLRANHVIDEARVEIQRRADRARTHL
HHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TPLPDGDAKQALEALCDEVVSRSS
CCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYSASSEFTDLVSAKLALIEDELGRQAGADTPFVTEAANHIISAGGKRFRPLLVVLCSQ
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
FGDAVNDADLVRAAVVMELTHVASLYHDDVMDEASRRRGAPSANLRWGNSVAIMVGDYLF
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHH
SKASLAVAELGVDFVKLQARTFSRLVQGQIAETRGPSQGQDPLAHYLKVVADKTGSLIAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHH
SAVFGAMVSHASAENVAALEQFGEDIGEVFQLADDLIDITSTVTGKTPGTDLREKVPTLP
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHH
TLLLRASDDPADAELKEMLDADLSDDAVLSDVLDKLRANHVIDEARVEIQRRADRARTHL
HHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TPLPDGDAKQALEALCDEVVSRSS
CCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]