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The map label for this gene is murB

Identifier: 50843346

GI number: 50843346

Start: 2055187

End: 2056317

Strand: Reverse

Name: murB

Synonym: PPA1894

Alternate gene names: 50843346

Gene position: 2056317-2055187 (Counterclockwise)

Preceding gene: 50843347

Following gene: 50843345

Centisome position: 80.32

GC content: 62.42

Gene sequence:

>1131_bases
ATGAGCACCACGGTCATTGGCCCCTACGAGGACGACGACCCCACTGAGGCCTGCAGCACGATTCATCACGAGGTCATTGG
AACGACGACTTGTCTGTCCGGTGGCGAGGACGTGCCGCTGGCCCCCCTGACGACCTTGAAGGTGGGTGGCCCGGCGCGTC
ACCTTGTCATCGCGACGACCCACGACGAACTCTTGGCAACTGTTCGTGACTGTGATCGGCGCGGCGAGCCGTGCCTGGTG
CTCGGCGGTGGCTCGAATGTCCTCGTCGGTGACAATGGGTTCGACGGCACCGTCGTCCGCGTCGCTACCTCGGGACTGTC
CGCGGAGGTGTCATCGTGTGGGGGTGCCTTGGTGACGGTCGCCGCAGGCCAGGTTTGGGACGATTTCGTTGTCCATGCCA
TTGAGCAGGAATGGATCGGCCCGGAGTTTCTCTCTGGCATCCCCGGTCTCGTCGGGTCGACGCCCATCCAGAACGTCGGT
GCGTACGGCGTCGAAGTGGGGGAGTTTATCGCGCGGGTGCGTACGTGGGACCGCGTCGACGATACTCAGCGCACTTTTAC
CGCTGACCAATGTGATTTCGGGTATCGCTCTAGCCGTTTCAAGGCTGAGCCCGATCGCTACGTCGTCCTCGACGTCACCA
TGCAATTCAACCTCGGTACCCGCTCTCTGCCAGTCCGCTACGCCGAATTAGCGCGACGTTTGGGGGTAGAGCCGGGGGAG
AGGGTCGATACCTCCCAGGTGCGTGAGACGGTGTTAGCGGTCCGTGCCGGCAAAGGGATGGTCCTCAACCCCAATGACCA
TGACACCTGGAGTGCCGGGTCCTTTTTCACCAACCCCCTGGTGTCTCCGGACCAGGTTCCGGAAGGGGCCCCGGCCTTCG
CCCAGTCCGACGGTCGGGTCAAGACGAGTGCGGCCTGGCTTATTGACCACGCCGGTTATGGTAAGGGGTTCAAAGTGGCT
GAGGACGCGCCAGCGAGTTTGTCGACCAAACATGTCCTGGCTTTGACGAATCGTGGCGGTGCCAGTTCAGGCGACTTCAC
CACCCTCGCACGCACTGTTATTGACGGAGTCCGCGACGTTTATGGGATCACCTTGGTGCCCGAGCCGCGCTTGATCGGCT
GCACGATCTGA

Upstream 100 bases:

>100_bases
GCAAGGTCAGCGAGGAGGCGGCGACTCTGGCTGTCGACGTCAAGTGCGATGGCCAATCGGTCCTGGGCCGGGTCGAGGTG
GTCGTAAGGCAGGGGGAGCA

Downstream 100 bases:

>100_bases
CGCGTCCTAGCATTGCCAGACGCCACGACCCTTCAAGCCTTACTGCAGCAGGGCTGGAGGGTCGCGTGTTGTCCTGAACT
GGCGAGGGGACAGAATTAGG

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MSTTVIGPYEDDDPTEACSTIHHEVIGTTTCLSGGEDVPLAPLTTLKVGGPARHLVIATTHDELLATVRDCDRRGEPCLV
LGGGSNVLVGDNGFDGTVVRVATSGLSAEVSSCGGALVTVAAGQVWDDFVVHAIEQEWIGPEFLSGIPGLVGSTPIQNVG
AYGVEVGEFIARVRTWDRVDDTQRTFTADQCDFGYRSSRFKAEPDRYVVLDVTMQFNLGTRSLPVRYAELARRLGVEPGE
RVDTSQVRETVLAVRAGKGMVLNPNDHDTWSAGSFFTNPLVSPDQVPEGAPAFAQSDGRVKTSAAWLIDHAGYGKGFKVA
EDAPASLSTKHVLALTNRGGASSGDFTTLARTVIDGVRDVYGITLVPEPRLIGCTI

Sequences:

>Translated_376_residues
MSTTVIGPYEDDDPTEACSTIHHEVIGTTTCLSGGEDVPLAPLTTLKVGGPARHLVIATTHDELLATVRDCDRRGEPCLV
LGGGSNVLVGDNGFDGTVVRVATSGLSAEVSSCGGALVTVAAGQVWDDFVVHAIEQEWIGPEFLSGIPGLVGSTPIQNVG
AYGVEVGEFIARVRTWDRVDDTQRTFTADQCDFGYRSSRFKAEPDRYVVLDVTMQFNLGTRSLPVRYAELARRLGVEPGE
RVDTSQVRETVLAVRAGKGMVLNPNDHDTWSAGSFFTNPLVSPDQVPEGAPAFAQSDGRVKTSAAWLIDHAGYGKGFKVA
EDAPASLSTKHVLALTNRGGASSGDFTTLARTVIDGVRDVYGITLVPEPRLIGCTI
>Mature_375_residues
STTVIGPYEDDDPTEACSTIHHEVIGTTTCLSGGEDVPLAPLTTLKVGGPARHLVIATTHDELLATVRDCDRRGEPCLVL
GGGSNVLVGDNGFDGTVVRVATSGLSAEVSSCGGALVTVAAGQVWDDFVVHAIEQEWIGPEFLSGIPGLVGSTPIQNVGA
YGVEVGEFIARVRTWDRVDDTQRTFTADQCDFGYRSSRFKAEPDRYVVLDVTMQFNLGTRSLPVRYAELARRLGVEPGER
VDTSQVRETVLAVRAGKGMVLNPNDHDTWSAGSFFTNPLVSPDQVPEGAPAFAQSDGRVKTSAAWLIDHAGYGKGFKVAE
DAPASLSTKHVLALTNRGGASSGDFTTLARTVIDGVRDVYGITLVPEPRLIGCTI

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=345, Percent_Identity=34.7826086956522, Blast_Score=156, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_PROAC (Q6A6J8)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056573.1
- ProteinModelPortal:   Q6A6J8
- SMR:   Q6A6J8
- GeneID:   2931422
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1894
- NMPDR:   fig|267747.1.peg.1850
- HOGENOM:   HBG686573
- OMA:   GAAPMQN
- ProtClustDB:   PRK13903
- BioCyc:   PACN267747:PPA1894-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 39916; Mature: 39785

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 196-196 ACT_SITE 274-274 ACT_SITE 368-368

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTVIGPYEDDDPTEACSTIHHEVIGTTTCLSGGEDVPLAPLTTLKVGGPARHLVIATT
CCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEEEEC
HDELLATVRDCDRRGEPCLVLGGGSNVLVGDNGFDGTVVRVATSGLSAEVSSCGGALVTV
HHHHHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCEEEEEEECCCCHHHHHCCCEEEEE
AAGQVWDDFVVHAIEQEWIGPEFLSGIPGLVGSTPIQNVGAYGVEVGEFIARVRTWDRVD
ECCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCC
DTQRTFTADQCDFGYRSSRFKAEPDRYVVLDVTMQFNLGTRSLPVRYAELARRLGVEPGE
CCHHHEECCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHCCCCCC
RVDTSQVRETVLAVRAGKGMVLNPNDHDTWSAGSFFTNPLVSPDQVPEGAPAFAQSDGRV
CCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
KTSAAWLIDHAGYGKGFKVAEDAPASLSTKHVLALTNRGGASSGDFTTLARTVIDGVRDV
EEEEEEEEECCCCCCCCEECCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
YGITLVPEPRLIGCTI
HEEEECCCCCEEEECC
>Mature Secondary Structure 
STTVIGPYEDDDPTEACSTIHHEVIGTTTCLSGGEDVPLAPLTTLKVGGPARHLVIATT
CCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEEEEC
HDELLATVRDCDRRGEPCLVLGGGSNVLVGDNGFDGTVVRVATSGLSAEVSSCGGALVTV
HHHHHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCEEEEEEECCCCHHHHHCCCEEEEE
AAGQVWDDFVVHAIEQEWIGPEFLSGIPGLVGSTPIQNVGAYGVEVGEFIARVRTWDRVD
ECCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCC
DTQRTFTADQCDFGYRSSRFKAEPDRYVVLDVTMQFNLGTRSLPVRYAELARRLGVEPGE
CCHHHEECCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHCCCCCC
RVDTSQVRETVLAVRAGKGMVLNPNDHDTWSAGSFFTNPLVSPDQVPEGAPAFAQSDGRV
CCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
KTSAAWLIDHAGYGKGFKVAEDAPASLSTKHVLALTNRGGASSGDFTTLARTVIDGVRDV
EEEEEEEEECCCCCCCCEECCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
YGITLVPEPRLIGCTI
HEEEECCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA