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The map label for this gene is adk

Identifier: 50843290

GI number: 50843290

Start: 1999544

End: 2000113

Strand: Reverse

Name: adk

Synonym: PPA1834

Alternate gene names: 50843290

Gene position: 2000113-1999544 (Counterclockwise)

Preceding gene: 50843291

Following gene: 50843289

Centisome position: 78.12

GC content: 60.0

Gene sequence:

>570_bases
ATGAGATTGCTGATCATGGGCGCCCCGGGAGCAGGCAAGGGGACTCAGGCCACCGCCATCGCCGAGCATTACAGCGTGCC
CGCGATTTCTACCGGCGATATGTTCCGTACCAATATCAAGAACGGCACCGAGCTGGGCAAGAAGGTCAAGGCCATCATGG
ACGCCGGGGACCTCGTCCCCGACGAGCTAACCGACGCGATCGTTGTTGATCGCCTCAATCAGGACGATGCTGCCAACGGT
TTCCTGCTCGACGGGTACCCCCGCAATATGCACCAGGTCGAGGCCCTTGACGCCTACCTCAAGGAGCATGGCCAGCGGCT
TGACGCCGTCATCAGCCTTGACGTCGATCCTGAGCTGCTCACTCAGCGTCTGTTGAAGCGTGCTGAGATTGAGGGACGTA
CTGACGACAACGAGGAAACTATCCGTAACCGGATGAAGGTCTACTCCTCCCAGACTGAGCCGCTGCTGGAGCACTACCGT
TCGGCCGGCATCCTTGTCCCGGTGGACGGAGTCGGCGAGATCGACGAGGTGCGTCAGCGCATTTTCGCCGCACTCGATTC
CAAGAACTGA

Upstream 100 bases:

>100_bases
GAGGTACGAGCATCCTCATCATCGTGGGTGTGGCGCTGGACACCGTTAAACAGGTCGAAAGCAAGTTGCAGCAACGACAC
TACGAAGGATTCCTGTCATC

Downstream 100 bases:

>100_bases
CGTGTTGGGTCGCAACCGATTCCAGATCAAGACGCCCGACCAGATTCGCACGATGCGACGGGCTGGCCTCGTCGTCGCTG
AGGGGTTGGAAGCCATGAGA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MRLLIMGAPGAGKGTQATAIAEHYSVPAISTGDMFRTNIKNGTELGKKVKAIMDAGDLVPDELTDAIVVDRLNQDDAANG
FLLDGYPRNMHQVEALDAYLKEHGQRLDAVISLDVDPELLTQRLLKRAEIEGRTDDNEETIRNRMKVYSSQTEPLLEHYR
SAGILVPVDGVGEIDEVRQRIFAALDSKN

Sequences:

>Translated_189_residues
MRLLIMGAPGAGKGTQATAIAEHYSVPAISTGDMFRTNIKNGTELGKKVKAIMDAGDLVPDELTDAIVVDRLNQDDAANG
FLLDGYPRNMHQVEALDAYLKEHGQRLDAVISLDVDPELLTQRLLKRAEIEGRTDDNEETIRNRMKVYSSQTEPLLEHYR
SAGILVPVDGVGEIDEVRQRIFAALDSKN
>Mature_189_residues
MRLLIMGAPGAGKGTQATAIAEHYSVPAISTGDMFRTNIKNGTELGKKVKAIMDAGDLVPDELTDAIVVDRLNQDDAANG
FLLDGYPRNMHQVEALDAYLKEHGQRLDAVISLDVDPELLTQRLLKRAEIEGRTDDNEETIRNRMKVYSSQTEPLLEHYR
SAGILVPVDGVGEIDEVRQRIFAALDSKN

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=212, Percent_Identity=38.2075471698113, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI7524346, Length=212, Percent_Identity=38.2075471698113, Blast_Score=148, Evalue=4e-36,
Organism=Homo sapiens, GI4502011, Length=190, Percent_Identity=40, Blast_Score=145, Evalue=1e-35,
Organism=Homo sapiens, GI19923437, Length=215, Percent_Identity=33.953488372093, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI7706497, Length=189, Percent_Identity=30.1587301587302, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI28144897, Length=193, Percent_Identity=32.6424870466321, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI28144899, Length=193, Percent_Identity=32.6424870466321, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI310110345, Length=215, Percent_Identity=28.8372093023256, Blast_Score=97, Evalue=6e-21,
Organism=Homo sapiens, GI53832003, Length=215, Percent_Identity=28.8372093023256, Blast_Score=97, Evalue=6e-21,
Organism=Homo sapiens, GI8051579, Length=215, Percent_Identity=28.8372093023256, Blast_Score=97, Evalue=6e-21,
Organism=Homo sapiens, GI53832001, Length=215, Percent_Identity=28.8372093023256, Blast_Score=97, Evalue=6e-21,
Organism=Homo sapiens, GI209915597, Length=184, Percent_Identity=24.4565217391304, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1786680, Length=210, Percent_Identity=43.3333333333333, Blast_Score=154, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17552384, Length=219, Percent_Identity=34.2465753424658, Blast_Score=136, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17567503, Length=186, Percent_Identity=36.0215053763441, Blast_Score=132, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17550688, Length=192, Percent_Identity=31.7708333333333, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=189, Percent_Identity=30.6878306878307, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25147457, Length=188, Percent_Identity=29.2553191489362, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17537943, Length=200, Percent_Identity=28, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=197, Percent_Identity=38.0710659898477, Blast_Score=137, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322828, Length=169, Percent_Identity=30.7692307692308, Blast_Score=105, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=31.2820512820513, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=35.5450236966825, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24663208, Length=188, Percent_Identity=29.2553191489362, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17647141, Length=188, Percent_Identity=29.2553191489362, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=31.4720812182741, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=31.4720812182741, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI221459597, Length=189, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356893, Length=189, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_PROAC (Q6A6Q4)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056517.1
- ProteinModelPortal:   Q6A6Q4
- SMR:   Q6A6Q4
- GeneID:   2932797
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1834
- NMPDR:   fig|267747.1.peg.1794
- HOGENOM:   HBG630208
- OMA:   EINQPLE
- ProtClustDB:   PRK00279
- BioCyc:   PACN267747:PPA1834-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20830; Mature: 20830

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLIMGAPGAGKGTQATAIAEHYSVPAISTGDMFRTNIKNGTELGKKVKAIMDAGDLVP
CEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCH
DELTDAIVVDRLNQDDAANGFLLDGYPRNMHQVEALDAYLKEHGQRLDAVISLDVDPELL
HHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHH
TQRLLKRAEIEGRTDDNEETIRNRMKVYSSQTEPLLEHYRSAGILVPVDGVGEIDEVRQR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHH
IFAALDSKN
HHHHHCCCC
>Mature Secondary Structure
MRLLIMGAPGAGKGTQATAIAEHYSVPAISTGDMFRTNIKNGTELGKKVKAIMDAGDLVP
CEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCH
DELTDAIVVDRLNQDDAANGFLLDGYPRNMHQVEALDAYLKEHGQRLDAVISLDVDPELL
HHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHH
TQRLLKRAEIEGRTDDNEETIRNRMKVYSSQTEPLLEHYRSAGILVPVDGVGEIDEVRQR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHH
IFAALDSKN
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA