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The map label for this gene is map [H]

Identifier: 50843289

GI number: 50843289

Start: 1998703

End: 1999542

Strand: Reverse

Name: map [H]

Synonym: PPA1833

Alternate gene names: 50843289

Gene position: 1999542-1998703 (Counterclockwise)

Preceding gene: 50843290

Following gene: 50843288

Centisome position: 78.1

GC content: 63.57

Gene sequence:

>840_bases
GTGTTGGGTCGCAACCGATTCCAGATCAAGACGCCCGACCAGATTCGCACGATGCGACGGGCTGGCCTCGTCGTCGCTGA
GGGGTTGGAAGCCATGAGAGCGGTCGCTGTGCCCGGGGCCACCACCGCCGACATCGATAGAGCCGGTCGGGACGTCCTTG
AGCAGCATGGCGCCAGGTCAAACTTCCTCAATTACGGGGGTGACTGGGGTCTGCCGCCCTATCCGGGTGTTGCCTGTGTG
AGCCCTAACGAGACGATCGTCCATGGCATCCCCGGCGAGCGGGAGCTCAAGGACGGCGACATCGTCTCCATCGATTATGG
CGCCATCGTTGATGAGTGGCATGGAGATGCTGCCCGGACCGTCCTCGTGGGAGATGTCAGCGAGGAGGCTCGGACCTTAT
CCGAGGTGACCCGTGAGTCGATGTGGGCCGGTATCGCCAAGGTCGCGCCTGGAGCCCGGATCGGCGACATTTCCGCAGCG
GTGCAGGCATCCCTGGAATCCCATGACGGTGACTACGGCATTATTCGTGAGTACACCGGCCACGGGATCGGTACCGAGAT
GCACATGGATCCGGATGTCCCCAACTGGGGGCGGGCCGGACGTGGCCCGAAGATCGTTGAGGGCATGGTGCTGTGCATCG
AGCCGATGGCCACCCTCGGCACGGAGGTCACCGCGACCCTGGACGACGAGTGGACTGTTGTCACGGTGGACGGCTCGTGG
GCTAGCCACTGGGAGAACACCGTTGCCGTAACCAGTAAAGGTTTGTGGGTGTTGTCGGAGCCCGATGGCGGTCAGGCCGA
ACTCGAGAAGCGCGGAGTGCCATTCGGGCCCCTTGACTGA

Upstream 100 bases:

>100_bases
CACTACCGTTCGGCCGGCATCCTTGTCCCGGTGGACGGAGTCGGCGAGATCGACGAGGTGCGTCAGCGCATTTTCGCCGC
ACTCGATTCCAAGAACTGAC

Downstream 100 bases:

>100_bases
GGTTGATCTGTAGTGCTGCCGGGGCCGTGGGTTCCGGCAGCACTGTGGACTACGGGCGGGACGCGTGCCCTCTGTGTGAG
TTACTGCCGGTGCCCTTTAG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MLGRNRFQIKTPDQIRTMRRAGLVVAEGLEAMRAVAVPGATTADIDRAGRDVLEQHGARSNFLNYGGDWGLPPYPGVACV
SPNETIVHGIPGERELKDGDIVSIDYGAIVDEWHGDAARTVLVGDVSEEARTLSEVTRESMWAGIAKVAPGARIGDISAA
VQASLESHDGDYGIIREYTGHGIGTEMHMDPDVPNWGRAGRGPKIVEGMVLCIEPMATLGTEVTATLDDEWTVVTVDGSW
ASHWENTVAVTSKGLWVLSEPDGGQAELEKRGVPFGPLD

Sequences:

>Translated_279_residues
MLGRNRFQIKTPDQIRTMRRAGLVVAEGLEAMRAVAVPGATTADIDRAGRDVLEQHGARSNFLNYGGDWGLPPYPGVACV
SPNETIVHGIPGERELKDGDIVSIDYGAIVDEWHGDAARTVLVGDVSEEARTLSEVTRESMWAGIAKVAPGARIGDISAA
VQASLESHDGDYGIIREYTGHGIGTEMHMDPDVPNWGRAGRGPKIVEGMVLCIEPMATLGTEVTATLDDEWTVVTVDGSW
ASHWENTVAVTSKGLWVLSEPDGGQAELEKRGVPFGPLD
>Mature_279_residues
MLGRNRFQIKTPDQIRTMRRAGLVVAEGLEAMRAVAVPGATTADIDRAGRDVLEQHGARSNFLNYGGDWGLPPYPGVACV
SPNETIVHGIPGERELKDGDIVSIDYGAIVDEWHGDAARTVLVGDVSEEARTLSEVTRESMWAGIAKVAPGARIGDISAA
VQASLESHDGDYGIIREYTGHGIGTEMHMDPDVPNWGRAGRGPKIVEGMVLCIEPMATLGTEVTATLDDEWTVVTVDGSW
ASHWENTVAVTSKGLWVLSEPDGGQAELEKRGVPFGPLD

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=259, Percent_Identity=31.6602316602317, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI40385867, Length=257, Percent_Identity=32.295719844358, Blast_Score=134, Evalue=8e-32,
Organism=Escherichia coli, GI1786364, Length=256, Percent_Identity=37.890625, Blast_Score=170, Evalue=7e-44,
Organism=Escherichia coli, GI1788728, Length=214, Percent_Identity=27.1028037383178, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789275, Length=222, Percent_Identity=26.1261261261261, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=253, Percent_Identity=34.7826086956522, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6323273, Length=257, Percent_Identity=32.295719844358, Blast_Score=145, Evalue=6e-36,
Organism=Drosophila melanogaster, GI21355531, Length=249, Percent_Identity=34.5381526104418, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24583427, Length=252, Percent_Identity=32.1428571428571, Blast_Score=140, Evalue=7e-34,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29880; Mature: 29880

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGRNRFQIKTPDQIRTMRRAGLVVAEGLEAMRAVAVPGATTADIDRAGRDVLEQHGARS
CCCCCEEEEECCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
NFLNYGGDWGLPPYPGVACVSPNETIVHGIPGERELKDGDIVSIDYGAIVDEWHGDAART
CCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCEEEEECCCCHHHCCCCCEEE
VLVGDVSEEARTLSEVTRESMWAGIAKVAPGARIGDISAAVQASLESHDGDYGIIREYTG
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECC
HGIGTEMHMDPDVPNWGRAGRGPKIVEGMVLCIEPMATLGTEVTATLDDEWTVVTVDGSW
CCCCCEEECCCCCCCCCCCCCCCHHHHHHHHEECCHHHCCCEEEEEECCCEEEEEECCCH
ASHWENTVAVTSKGLWVLSEPDGGQAELEKRGVPFGPLD
HHHCCCEEEEEECCEEEEECCCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLGRNRFQIKTPDQIRTMRRAGLVVAEGLEAMRAVAVPGATTADIDRAGRDVLEQHGARS
CCCCCEEEEECCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
NFLNYGGDWGLPPYPGVACVSPNETIVHGIPGERELKDGDIVSIDYGAIVDEWHGDAART
CCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCEEEEECCCCHHHCCCCCEEE
VLVGDVSEEARTLSEVTRESMWAGIAKVAPGARIGDISAAVQASLESHDGDYGIIREYTG
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECC
HGIGTEMHMDPDVPNWGRAGRGPKIVEGMVLCIEPMATLGTEVTATLDDEWTVVTVDGSW
CCCCCEEECCCCCCCCCCCCCCCHHHHHHHHEECCHHHCCCEEEEEECCCEEEEEECCCH
ASHWENTVAVTSKGLWVLSEPDGGQAELEKRGVPFGPLD
HHHCCCEEEEEECCEEEEECCCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]